Cited by 261Cardiac Ischemia and ReperfusionMitochondrial Function and PathologyAutophagy in Disease and Therapy

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Decreased complex III activity in mitochondria isolated from rat heart subjected to ischemia and reperfusion: role of reactive oxygen species and cardiolipin

Petrosillo, Giuseppe, Francesca, M. Ruggiero, Di Venosa, Nicola, Paradies, And Giuseppe·2003·The FASEB Journal

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Abstract

Reactive oxygen species (ROS) are considered an important factor in ischemia‐reperfusion injury to cardiac myocites. We have examined the effects of ischemia (30 min) and ischemia followed by reperfusion (15 min) of rat hearts on the activity of complex III and on the cardiolipin content in isolated mitochondria. Mitochondrial production of H 2 O 2 and lipid peroxidation was also measured. The capacity of mitochondria to produce both H 2 O 2 and lipid peroxidation increased upon reperfusion. The activity of complex III was 22% and 46% lower in ischemic and reperfused rat heart mitochondria, respectively, than that of controls. These changes in complex III activity were associated to parallel changes in state 3 respiration. The mitochondrial content of cardiolipin, which is required for optimal activity of complex III, decreased by 28% and by 50% as a function of ischemia and reperfusion, respectively. The lower complex III activity in mitochondria from reperfused rat hearts could be completely restored to the level of normal hearts by exogenously added cardiolipin. It is proposed that the loss of complex III activity in reperfused rat hearts can be mainly ascribed to a loss of cardiolipin content, due to oxidative attack by oxygen free radicals.

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Authors: Petrosillo, G., Francesca, M. R., Di Venosa, N., & Paradies, A. G.
Affiliations: University of Bari Aldo Moro (IT)
Department of Emergency and Transplantation University of Bari Bari Italy
Department of Biochemistry and Molecular Biology CNR Unit for the Study of Mitochondria and Bioenergetics University of Bari Bari Italy
ORCID: Petrosillo, Giuseppe
Venue: The FASEB Journal
Publisher: Wiley
Published: 2003-02-05
Volume: 17
Issue: 6
Pages: 714-716
ISSN: 0892-6638 (ISSN-L)
1530-6860
DOI: 10.1096/fj.02-0729fje
OpenAlex: W2158719453
Cited by: 261
References: 50
Citations by year: 2026: 1 · 2025: 2 · 2024: 7 · 2023: 5 · 2022: 11 · 2021: 9 · 2020: 7 · 2019: 11 · 2018: 9 · 2017: 12 · 2016: 13 · 2015: 13 · 2014: 10 · 2013: 14 · 2012: 17
FWCI: 7.90
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The FASEB Journal (publishedVersion)
PubMed (publishedVersion)
Funders: Consiglio Nazionale delle Ricerche
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: cytochrome bc1 complex, mitochondrial respiratory chain, ischemia-reperfusion injury, cardiolipin, reactive oxygen species, hydrogen peroxide, lipid peroxidation, state 3 respiration, heart mitochondria, oxidative damage
MeSH terms: Animals, Cardiolipins, Hydrogen Peroxide, Mitochondria, Heart, Phospholipids, Electron Transport Complex III, Myocardial Reperfusion Injury, Myocardial Ischemia, Reactive Oxygen Species, Rats

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Decreased complex III activity in mitochondria isolated from rat heart subjected to ischemia and reperfusion: role of reactive oxygen species and cardiolipin

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