Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy

Hydroperoxide metabolism in mammalian organs.

Chance, B., Sies, H., & Boveris, A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.527 · Cited by 5,827 · see citing works

Molecular characterization of mitochondrial apoptosis-inducing factor

Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., Brothers, G. M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., et al. (1999) · Nature · doi:10.1038/17135 · Cited by 4,060 · see citing works

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026 · see citing works

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy · doi:10.4161/auto.19496 · Cited by 3,996 · cited 1× · see citing works

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

Du, C., Fang, M., Li, Y., Li, L., & Wang, X. (2000) · Cell · doi:10.1016/s0092-8674(00)00008-8 · Cited by 3,513 · see citing works

Autophagy and the Integrated Stress Response

Kroemer, G., Mariño, G., & Levine, B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.023 · Cited by 3,506 · see citing works

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300 · see citing works

Mechanisms of mitophagy

Youle, R. J., & Narendra, D. P. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3028 · Cited by 3,273 · see citing works

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

Twig, G., Elorza, A., Molina, A. J. A., Mohamed, H., Wikstrom, J. D., Walzer, G., Stiles, L., Haigh, S. E., Katz, S., Las, G., et al. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601963 · Cited by 3,082 · see citing works

Calcium, ATP, and ROS: a mitochondrial love-hate triangle

Brookes, P. S., Yoon, Y., Robotham, J. L., Anders, M. W., & Sheu, S.-S. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00139.2004 · Cited by 2,575 · see citing works

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

Baines, C. P., Kaiser, R. A., Purcell, N. H., Blair, N. S., Osinska, H., Hambleton, M. A., Brunskill, E. W., Sayen, M. R., Gottlieb, R. A., Dorn, G. W., et al. (2005) · Nature · doi:10.1038/nature03434 · Cited by 2,280 · see citing works

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

Kujoth, G. C., Hiona, A., Pugh, T. D., Someya, S., Panzer, K., Wohlgemuth, S. E., Hofer, T., Seo, A. Y., Sullivan, R., Jobling, W. A., et al. (2005) · Science · doi:10.1126/science.1112125 · Cited by 2,165 · see citing works

The Biologic Clock: The Mitochondria?

Harman, D. (1972) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1972.tb00787.x · Cited by 1,991 · see citing works

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

Matsuda, N., Sato, S., Shiba, K., Okatsu, K., Saisho, K., Gautier, C. A., Sou, Y.-S., Saiki, S., Kawajiri, S., Sato, F., et al. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200910140 · Cited by 1,969 · see citing works

FoxO3 Controls Autophagy in Skeletal Muscle In Vivo

Mammucari, C., Milan, G., Romanello, V., Masiero, E., Rudolf, R., Del Piccolo, P., Burden, S. J., Di Lisi, R., Sandri, C., Zhao, J., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.001 · Cited by 1,953 · see citing works

Dynamin-related Protein Drp1 Is Required for Mitochondrial Division in Mammalian Cells

Smirnova, E., Griparić, L., Shurland, D., & van der Bliek, A. M. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.8.2245 · Cited by 1,938 · see citing works

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

Yakes, F. M., & Van Houten, B. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.514 · Cited by 1,854 · see citing works

Endonuclease G is an apoptotic DNase when released from mitochondria

Li, L. Y., Luo, X., & Wang, X. (2001) · Nature · doi:10.1038/35083620 · Cited by 1,787 · see citing works

The Role of Dynamin-Related Protein 1, a Mediator of Mitochondrial Fission, in Apoptosis

Frank, S., Gaume, B., Bergmann-Leitner, E. S., Leitner, W. W., Robert, E. G., Catez, F., Smith, C. L., & Youle, R. J. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00055-7 · Cited by 1,755 · see citing works

OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion

Frezza, C., Cipolat, S., Martins de Brito, O., Micaroni, M., Beznoussenko, G. V., Rudka, T., Bartoli, D., Polishuck, R. S., Danial, N. N., De Strooper, B., et al. (2006) · Cell · doi:10.1016/j.cell.2006.06.025 · Cited by 1,673 · see citing works

FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells.

Zhao, J., Brault, J. J., Schild, A., Cao, P., Sandri, M., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.004 · Cited by 1,489 · see citing works

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling.

Lee, J., Giordano, S., & Zhang, J. (2012) · Biochemical Journal · doi:10.1042/bj20111451 · Cited by 1,438 · see citing works

Reactive Oxygen Species (Ros-Induced) Ros Release

Zorov, D. B., Filburn, C. R., Klotz, L.-O., Zweier, J. L., & Sollott, S. J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1001 · Cited by 1,412 · see citing works

Decline in skeletal muscle mitochondrial function with aging in humans

Short, K. R., Bigelow, M. L., Kahl, J., Singh, R., Coenen-Schimke, J., Raghavakaimal, S., & Nair, K. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501559102 · Cited by 1,333 · see citing works

Autophagy is required to maintain muscle mass.

Masiero, E., Agatea, L., Mammucari, C., Blaauw, B., Loro, E., Komatsu, M., Metzger, D., Reggiani, C., Schiaffino, S., & Sandri, M. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.10.008 · Cited by 1,282 · see citing works

Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations

Chen, H., Vermulst, M., Wang, Y. E., Chomyn, A., Prolla, T. A., McCaffery, J. M., & Chan, D. C. (2010) · Cell · doi:10.1016/j.cell.2010.02.026 · Cited by 1,211 · see citing works

Mitophagy: mechanisms, pathophysiological roles, and analysis

Ding, W.-X., & Yin, X.-M. (2012) · bchm · doi:10.1515/hsz-2012-0119 · Cited by 1,032 · see citing works

How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

Chipuk, J. E., & Green, D. R. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.01.007 · Cited by 982 · see citing works

Mitochondrial Dynamics in Mammalian Health and Disease

Liesa, M., Palacín, M., & Zorzano, A. (2009) · Physiological Reviews · doi:10.1152/physrev.00030.2008 · Cited by 953 · see citing works

Mitochondrial role in cell aging

Miquel, J., Economos, A. C., Fleming, J., & Johnson, J. E. (1980) · Experimental Gerontology · doi:10.1016/0531-5565(80)90010-8 · Cited by 937 · see citing works

Biochemical properties of subsarcolemmal and interfibrillar mitochondria isolated from rat cardiac muscle

Palmer, J. W., Tandler, B., & Hoppel, C. L. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75283-1 · Cited by 830 · see citing works

Mitochondrial membrane potential regulates matrix configuration and cytochrome c release during apoptosis

Gottlieb, E., Armour, S. M., Harris, M. H., & Thompson, C. B. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401231 · Cited by 790 · see citing works

Dynamics of mitochondrial morphology in healthy cells and during apoptosis

Karbowski, M., & Youle, R. J. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401260 · Cited by 759 · see citing works

The mitochondrial‐lysosomal axis theory of aging

Brunk, U. T., & Terman, A. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.02869.x · Cited by 729 · see citing works

Dnm1p Gtpase-Mediated Mitochondrial Fission Is a Multi-Step Process Requiring the Novel Integral Membrane Component Fis1p

Mozdy, A. D., McCaffery, J. M., & Shaw, J. M. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.2.367 · Cited by 725 · see citing works

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

Deng, H., Dodson, M. W., Huang, H., & Guo, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803998105 · Cited by 683 · see citing works

Nuclear volume control by nucleoskeletal DNA, selection for cell volume and cell growth rate, and the solution of the DNA C-value paradox

Cavalier‐Smith, T. (1978) · Journal of Cell Science · doi:10.1242/jcs.34.1.247 · Cited by 683 · see citing works

Mitochondrial fusion, fission and autophagy as a quality control axis: The bioenergetic view

Twig, G., Hyde, B. B., & Shirihai, O. S. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.05.001 · Cited by 646 · see citing works

Role of Bax and Bak in mitochondrial morphogenesis

Karbowski, M., Norris, K. L., Cleland, M. M., Jeong, S.-Y., & Youle, R. J. (2006) · Nature · doi:10.1038/nature05111 · Cited by 625 · see citing works

Mitochondrial fission and remodelling contributes to muscle atrophy

Romanello, V., Guadagnin, E., Gomes, L., Roder, I., Sandri, C., Petersen, Y., Milan, G., Masiero, E., Del Piccolo, P., Foretz, M., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.60 · Cited by 596 · see citing works

Redox regulation of mitochondrial function

Handy, D. E., & Loscalzo, J. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4123 · Cited by 588 · see citing works

Oxidative stress caused by mitochondrial calcium overload

Peng, T., & Jou, M. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05634.x · Cited by 569 · see citing works

New insights into the role of mitochondria in aging: mitochondrial dynamics and more

Seo, A. Y., Joseph, A.-M., Dutta, D., Hwang, J. C. Y., Aris, J. P., & Leeuwenburgh, C. (2010) · Journal of Cell Science · doi:10.1242/jcs.070490 · Cited by 522 · cited 2× · see citing works

Skeletal Muscle Is a Primary Target of SOD1G93A-Mediated Toxicity

Dobrowolny, G., Aucello, M., Rizzuto, E., Beccafico, S., Mammucari, C., Bonconpagni, S., Belia, S., Wannenes, F., Nicoletti, C., Del Prete, Z., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.09.002 · Cited by 513 · see citing works

Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging

Terman, A., Kurz, T., Navratil, M., Arriaga, E. A., & Brunk, U. T. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2598 · Cited by 490 · see citing works

Selective degradation of oxidatively modified protein substrates by the proteasome

Grune, T., Merker, K., Sandig, G., & Davies, K. J. A. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00809-x · Cited by 471 · see citing works

Apoptosome: a platform for the activation of initiator caspases

Bao, Q., & Shi, Y. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402028 · Cited by 467 · see citing works

Two mitofusin proteins, mammalian homologues of FZO, with distinct functions are both required for mitochondrial fusion

Eura, Y. (2003) · Journal of Biochemistry · doi:10.1093/jb/mvg150 · Cited by 445 · cited 2× · see citing works

Mitochondrial DNA–Deletion Mutations Accumulate Intracellularly to Detrimental Levels in Aged Human Skeletal Muscle Fibers

Bua, E., Johnson, J., Herbst, A., Delong, B., McKenzie, D., Salamat, S., & Aiken, J. M. (2006) · The American Journal of Human Genetics · doi:10.1086/507132 · Cited by 442 · see citing works

The contribution of reactive oxygen species to sarcopenia and muscle ageing

Fulle, S., Protasi, F., Tano, G. D., Pietrangelo, T., Beltramin, A., Boncompagni, S., Vecchiet, L., & Fanò, G. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.09.012 · Cited by 439 · see citing works

Mitochondrial function and apoptotic susceptibility in aging skeletal muscle

Chabi, B., Ljubicic, V., Menzies, K. J., Huang, J. H., Saleem, A., & Hood, D. A. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2007.00347.x · Cited by 437 · see citing works

Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria

Ono, T., Isobe, K., Nakada, K., & Hayashi, J.-I. (2001) · Nature Genetics · doi:10.1038/90116 · Cited by 420 · see citing works

Lipofuscin: Formation, Distribution, and Metabolic Consequences

JUNG, T., BADER, N., & GRUNE, T. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1404.008 · Cited by 415 · see citing works

Ganglioside-induced differentiation associated protein 1 is a regulator of the mitochondrial network

Niemann, A., Rüegg, M., Padula, V. L., Schenone, A. E., & Suter, U. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200507087 · Cited by 402 · see citing works

Skeletal muscle autophagy and apoptosis during aging: Effects of calorie restriction and life-long exercise

Wohlgemuth, S. E., Seo, A. Y., Marzetti, E., Lees, H. A., & Leeuwenburgh, C. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2009.11.002 · Cited by 397 · see citing works

Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia

WANAGAT, J., CAO, Z., PATHARE, P., & AIKEN, J. M. (2001) · The FASEB Journal · doi:10.1096/fj.00-0320com · Cited by 378 · see citing works

Apoptosis in skeletal muscle with aging

Dirks, A., & Leeuwenburgh, C. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00458.2001 · Cited by 377 · see citing works

Reactive oxygen species affect mitochondrial electron transport complex I activity through oxidative cardiolipin damage

Paradies, G., Petrosillo, G., Pistolese, M., & Ruggiero, F. M. (2002) · Gene · doi:10.1016/s0378-1119(01)00814-9 · Cited by 372 · see citing works

Coordination of metabolic plasticity in skeletal muscle

Hood, D. A., Irrcher, I., Ljubicic, V., & Joseph, A.-M. (2006) · Journal of Experimental Biology · doi:10.1242/jeb.02182 · Cited by 370 · see citing works

Hindlimb unloading increases oxidative stress and disrupts antioxidant capacity in skeletal muscle

Lawler, J. M. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00186-2 · Cited by 370 · see citing works

Apoptosis: a mechanism contributing to remodeling of skeletal muscle in response to hindlimb unweighting

Allen, D. L., Linderman, J. K., Roy, R. R., Bigbee, A. J., Grindeland, R. E., Mukku, V. R., & Edgerton, V. R. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.273.2.c579 · Cited by 364 · see citing works

Skeletal muscle apoptosis, sarcopenia and frailty at old age

Marzetti, E., & Leeuwenburgh, C. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.08.011 · Cited by 346 · see citing works

Myonuclei acquired by overload exercise precede hypertrophy and are not lost on detraining

Bruusgaard, J. C., Johansen, I. B., Egner, I. M., Rana, Z. A., & Gundersen, K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913935107 · Cited by 327 · see citing works

Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance

Lee, H.-Y., Choi, C. S., Birkenfeld, A. L., Alves, T. C., Jornayvaz, F. R., Jurczak, M. J., Zhang, D., Woo, D. K., Shadel, G. S., Ladiges, W., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.004 · Cited by 319 · see citing works

Hydrogen peroxide stimulates ubiquitin-conjugating activity and expression of genes for specific E2 and E3 proteins in skeletal muscle myotubes

Li, Y.-P., Chen, Y., Li, A. S., & Reid, M. B. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00129.2003 · Cited by 313 · see citing works

Cardiolipin: Setting the beat of apoptosis

Gonzalvez, F., & Gottlieb, E. (2007) · APOPTOSIS · doi:10.1007/s10495-007-0718-8 · Cited by 311 · see citing works

Reactive oxygen in skeletal muscle. III. Contractility of unfatigued muscle

Reid, M. B., Khawli, F. A., & Moody, M. R. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.75.3.1081 · Cited by 297 · see citing works

Downstream of Akt: FoxO3 and mTOR in the regulation of autophagy in skeletal muscle

Mammucari, C., Schiaffino, S., & Sandri, M. (2008) · Autophagy · doi:10.4161/auto.5905 · Cited by 295 · see citing works

A comprehensive glossary of autophagy-related molecules and processes (2ndedition)

Klionsky, D. J., Baehrecke, E. H., Brumell, J. H., Chu, C. T., Codogno, P., Cuervo, A. M., Debnath, J., Deretic, V. P., Elazar, Z., Eskelinen, E., et al. (2011) · Autophagy · doi:10.4161/auto.7.11.17661 · Cited by 293 · see citing works

Regulation of Mitochondrial Morphology and Inheritance by Mdm10p, a Protein of the Mitochondrial Outer Membrane

Sogo, L. F., & Yaffe, M. P. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.126.6.1361 · Cited by 284 · see citing works

P38 MAPK Links Oxidative Stress to Autophagy-Related Gene Expression in Cachectic Muscle Wasting

McClung, J. M., Judge, A. R., Powers, S. K., & Yan, Z. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00192.2009 · Cited by 277 · see citing works

Formation of elongated giant mitochondria in DFO‐induced cellular senescence: Involvement of enhanced fusion process through modulation of Fis1

Yoon, Y., Yoon, D., Lim, I. K., Yoon, S., Chung, H., Rojo, M., Malka, F., Jou, M., Martinou, J., & Yoon, G. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20753 · Cited by 275 · see citing works

Mitochondrial DNA Mutations Induce Mitochondrial Dysfunction, Apoptosis and Sarcopenia in Skeletal Muscle of Mitochondrial DNA Mutator Mice

Hiona, A., Sanz, A., Kujoth, G. C., Pamplona, R., Seo, A. Y., Hofer, T., Someya, S., Miyakawa, T., Chie, N., Samhan-Arias, A. K., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011468 · Cited by 269 · see citing works

Mitochondrial-targeted antioxidants protect skeletal muscle against immobilization-induced muscle atrophy

Min, K., Smuder, A. J., Kwon, O.-S., Kavazis, A. N., Szeto, H. H., & Powers, S. K. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00591.2011 · Cited by 265 · see citing works

Decreased complex III activity in mitochondria isolated from rat heart subjected to ischemia and reperfusion: role of reactive oxygen species and cardiolipin

Petrosillo, G., Francesca, M. R., Di Venosa, N., & Paradies, A. G. (2003) · The FASEB Journal · doi:10.1096/fj.02-0729fje · Cited by 261 · see citing works

Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weakness*

Powers, S. K., Hudson, M. B., Nelson, W. B., Talbert, E. E., Min, K., Szeto, H. H., Kavazis, A. N., & Smuder, A. J. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182190b62 · Cited by 255 · see citing works

Loss of Molecular Interaction between Cytochrome c and Cardiolipin Due to Lipid Peroxidation

Shidoji, Y., Hayashi, K., KOMURA, S., Ohishi, N., & Yagi, K. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1410 · Cited by 250 · see citing works

Nuclear domains in muscle cells

Hall, Z. W., & Ralston, E. (1989) · Cell · doi:10.1016/0092-8674(89)90597-7 · Cited by 249 · see citing works

Mitochondrial quality control: An integrated network of pathways

Fischer, F., Hamann, A., & Osiewacz, H. D. (2012) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2012.02.004 · Cited by 248 · see citing works

The role of mitochondrial DNA mutations in aging and sarcopenia: Implications for the mitochondrial vicious cycle theory of aging

HIONA, A. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2007.10.001 · Cited by 247 · see citing works

Aging: Central role for autophagy and the lysosomal degradative system

Rajawat, Y. S., Hilioti, Z., & Bossis, I. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.05.001 · Cited by 247 · see citing works

Mitochondrial signaling contributes to disuse muscle atrophy

Powers, S. K., Wiggs, M. P., Duarte, J. A., Zergeroğlu, A. M., & Demirel, H. A. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00609.2011 · Cited by 244 · see citing works

Mitochondrial membrane permeabilization: the sine qua non for cell death

Armstrong, J. S. (2006) · BioEssays · doi:10.1002/bies.20370 · Cited by 243 · see citing works

Is the Mitochondrial Free Radical Theory of Aging Intact?

Sanz, A., Pamplona, R., & Barja, G. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.582 · Cited by 240 · see citing works

Effect of denervation on mitochondrially mediated apoptosis in skeletal muscle.

Adhihetty, P. J., O'Leary, M. F. N., Chabi, B., Wicks, K. L., & Hood, D. A. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00768.2006 · Cited by 240 · see citing works

Age-related differences in apoptosis with disuse atrophy in soleus muscle

Leeuwenburgh, C., Gurley, C. M., Strotman, B. A., & Dupont-Versteegden, E. E. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00576.2004 · Cited by 231 · see citing works

Mitochondrial Network Determines Intracellular ROS Dynamics and Sensitivity to Oxidative Stress through Switching Inter-Mitochondrial Messengers

Park, J., Lee, J., & Choi, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023211 · Cited by 230 · see citing works

Rat hindlimb unloading: soleus histochemistry, ultrastructure, and electromyography

Riley, D. A., Slocum, G. R., Bain, J. L. W., Sedlák, F., Sowa, T. E., & Mellender, J. W. (1990) · Journal of Applied Physiology · doi:10.1152/jappl.1990.69.1.58 · Cited by 229 · see citing works

A tale of two mitochondrial channels, MAC and PTP, in apoptosis

Kinnally, K. W., & Antonsson, B. E. (2007) · APOPTOSIS · doi:10.1007/s10495-007-0722-z · Cited by 224 · see citing works

Histochemical characteristics of human skeletal muscle during aging

LARSSON, L. (1983) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1983.tb00024.x · Cited by 219 · see citing works

Oxidation enhances myofibrillar protein degradation via calpain and caspase-3

Smuder, A. J., Kavazis, A. N., Hudson, M. B., Nelson, W. B., & Powers, S. K. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.06.025 · Cited by 217 · see citing works

Mitochondria-associated apoptotic signalling in denervated rat skeletal muscle

Siu, P. M., & Alway, S. E. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.081083 · Cited by 216 · see citing works

Molecular Characterization of a Superoxide-Generating NAD(P)H Oxidase in the Ventilatory Muscles

Javeshghani, D., Magder, S. A., Barreiro, E., Quinn, M. T., & Hussain, S. N. A. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.3.2103028 · Cited by 215 · see citing works

Apoptosis in muscle atrophy: Relevance to sarcopenia

Dupont‐Versteegden, E. E. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.04.003 · Cited by 207 · see citing works

Mechanistic Links Between Oxidative Stress and Disuse Muscle Atrophy

Powers, S. K., Smuder, A. J., & Criswell, D. S. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.3973 · Cited by 199 · see citing works

Autophagy in Health and Disease

Gözüaçık, D. (2013) · Elsevier eBooks · doi:10.1016/c2010-0-66523-0 · Cited by 194 · see citing works

The Physical and Biological Characterization of a Frail Mouse Model

Walston, J. D., Fedarko, N. S., Yang, H., Leng, S. X., Beamer, B. A., Espinoza, S. E., Lipton, A., Zheng, H., & Becker, K. G. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.4.391 · Cited by 192 · see citing works

Mechanisms of mitochondria and autophagy crosstalk

Rambold, A. S., & Lippincott‐Schwartz, J. (2011) · Cell Cycle · doi:10.4161/cc.10.23.18384 · Cited by 191 · see citing works

Aging and lifelong calorie restriction result in adaptations of skeletal muscle apoptosis repressor, apoptosis-inducing factor, X-linked inhibitor of apoptosis, caspase-3, and caspase-12

Dirks, A. J., & Leeuwenburgh, C. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.10.003 · Cited by 190 · see citing works

Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle

Wang, X., Blagden, C., Fan, J., Nowak, S. J., Taniuchi, I., Littman, D. R., & Burden, S. J. (2005) · Genes & Development · doi:10.1101/gad.1318305 · Cited by 177 · see citing works

Mitochondrial death effectors: Relevance to sarcopenia and disuse muscle atrophy

Marzetti, E., Hwang, J. C. Y., Lees, H. A., Wohlgemuth, S. E., Dupont-Versteegden, E. E., Carter, C. S., Bernabei, R., & Leeuwenburgh, C. (2010) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.05.007 · Cited by 174 · see citing works

Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle

Marzetti, E., Wohlgemuth, S. E., Lees, H. A., Chung, H.-Y., Giovannini, S., & Leeuwenburgh, C. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.05.005 · Cited by 172 · see citing works

Prevention of unloading-induced atrophy by vitamin E supplementation: Links between oxidative stress and soleus muscle proteolysis?

Servais, S., Letexier, D., Favier, R. J. M., Duchamp, C., & Dominique Desplanches, C. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.12.001 · Cited by 170 · see citing works

Apoptotic responses to hindlimb suspension in gastrocnemius muscles from young adult and aged rats

Siu, P. M., Pistilli, E. E., & Alway, S. E. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00198.2005 · Cited by 170 · see citing works

Mitochondrial DNA mutations, energy metabolism and apoptosis in aging muscle

Dirks, A. J., Hofer, T., Marzetti, E., Pahor, M., & Leeuwenburgh, C. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2006.03.002 · Cited by 169 · see citing works

Potential role for Id myogenic repressors in apoptosis and attenuation of hypertrophy in muscles of aged rats

Alway, S. E., Degens, H., Krishnamurthy, G., & Smith, C. A. S. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00598.2001 · Cited by 164 · see citing works

In vivo time-lapse microscopy reveals no loss of murine myonuclei during weeks of muscle atrophy

Bruusgaard, J. C., & Gundersen, K. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34022 · Cited by 162 · see citing works

Differential susceptibility of subsarcolemmal and intermyofibrillar mitochondria to apoptotic stimuli

Adhihetty, P. J., Ljubicic, V., Menzies, K. J., & Hood, D. A. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00031.2005 · Cited by 161 · see citing works

Intracellular Ca2+ transients in mouse soleus muscle after hindlimb unloading and reloading

Ingalls, C. P., Warren, G. L., & Armstrong, R. B. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.1.386 · Cited by 160 · see citing works

Apoptosis in Skeletal Myocytes: A Potential Target for Interventions against Sarcopenia and Physical Frailty – A Mini-Review

Marzetti, E., Calvani, R., Bernabei, R., & Leeuwenburgh, C. (2011) · Gerontology · doi:10.1159/000330064 · Cited by 159 · see citing works

Mechanism of oxidative stress in skeletal muscle atrophied by immobilization

Kondo, H., Nakagaki, I., Sasaki, S., Hori, S., & Itokawa, Y. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.6.e839 · Cited by 158 · see citing works

Exercise training attenuates age-induced changes in apoptotic signaling in rat skeletal muscle

Song, W., Kwak, H.-B., & Lawler, J. M. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.517 · Cited by 155 · see citing works

Primary Structure of a Dynamin-related Mouse Mitochondrial GTPase and Its Distribution in Brain, Subcellular Localization, and Effect on Mitochondrial Morphology

Misaka, T., Miyashita, T., & Kubo, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109260200 · Cited by 153 · see citing works

Autophagy in health and disease. 3. Involvement of autophagy in muscle atrophy

Sandri, M. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00531.2009 · Cited by 152 · see citing works

Autophagy: More Than a Nonselective Pathway

Reggiori, F., Komatsu, M., Finley, K. D., & Simonsen, A. (2012) · International Journal of Cell Biology · doi:10.1155/2012/219625 · Cited by 152 · see citing works

Oxidative stress in skeletal muscle atrophied by immobiIization

KONDO, H., MIURA, M., & ITOKAWA, Y. (1991) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1991.tb09191.x · Cited by 150 · see citing works

Alterations in intrinsic mitochondrial function with aging are fiber type‐specific and do not explain differential atrophy between muscles

Picard, M. A., Ritchie, D., Thomas, M. M., Wright, K. J., & Hepple, R. T. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00745.x · Cited by 145 · see citing works

Knockdown of MTP18, a Novel Phosphatidylinositol 3-Kinase-dependent Protein, Affects Mitochondrial Morphology and Induces Apoptosis

Tondera, D., Santel, A., Schwarzer, R., Dames, S., Giese, K., Klippel, A., & Kaufmann, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404704200 · Cited by 143 · see citing works

Nuclear domains during muscle atrophy: nuclei lost or paradigm lost?

Gundersen, K., & Bruusgaard, J. C. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.154369 · Cited by 140 · see citing works

Generation of Reactive Oxygen and Nitrogen Species in Contracting Skeletal Muscle

Reid, M. B., & Durham, W. J. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02087.x · Cited by 140 · see citing works

Chapter 13 Cytosolic LC3 Ratio as a Quantitative Index of Macroautophagy

Kadowaki, M., & Karim, M. R. (2009) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)03613-6 · Cited by 133 · see citing works

Ros‐mediated activation of NF‐κB and Foxo during muscle disuse

Dodd, S. L., Gagnon, B. J., Senf, S. M., Hain, B. A., & Judge, A. R. (2010) · Muscle & Nerve · doi:10.1002/mus.21526 · Cited by 131 · see citing works

Cyclophilin D is required for mitochondrial removal by autophagy in cardiac cells

Carreira, R., Lee, Y., Ghochani, M., Gustafsson, Å. B., & Gottlieb, R. A. (2010) · Autophagy · doi:10.4161/auto.6.4.11553 · Cited by 127 · see citing works

The role of oxidized cytochrome c in regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia

Pasdois, P., Parker, J. E., Griffiths, E. J., & Halestrap, A. P. (2011) · Biochemical Journal · doi:10.1042/bj20101957 · Cited by 127 · see citing works

Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice

Braga, M., Hikim, A. P. S., Datta, S., Ferrini, M. G., Brown, D. L., Kovacheva, E. L., González-Cadavid, N. F., & Sinha‐Hikim, I. (2008) · APOPTOSIS · doi:10.1007/s10495-008-0216-7 · Cited by 125 · see citing works

Mitochondrial iron accumulation with age and functional consequences

Seo, A. Y., Xu, J., Servais, S., Hofer, T., Marzetti, E., Wohlgemuth, S. E., Knutson, M. D., Chung, H. Y., & Leeuwenburgh, C. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00418.x · Cited by 123 · see citing works

Skeletal muscle metabolism and ultrastructure in relation to age in sedentary men

Örlander, J., Kiessling, K., Larsson, L., Karlsson, J., & ANIANSSON, A. (1978) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1978.tb06277.x · Cited by 121 · see citing works

Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy

Lee, C. M., Lopez, M. E., Weindruch, R. H., & Aiken, J. M. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00185-3 · Cited by 121 · see citing works

Nuclear translocation of EndoG at the initiation of disuse muscle atrophy and apoptosis is specific to myonuclei

Dupont‐Versteegden, E. E., Strotman, B. A., Gurley, C. M., Gaddy, D., Knox, M., Fluckey, J. D., & Peterson, C. A. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00176.2006 · Cited by 120 · see citing works

Age-related alterations in expression of apoptosis regulatory proteins and heat shock proteins in rat skeletal muscle

Chung, L. H., & Ng, Y.-C. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2005.08.003 · Cited by 112 · see citing works

Degeneration of different types of skeletal muscle fibres. I. Denervation.

Tomanek, R. J., & Lund, D. D. (1973) · PubMed · Cited by 111 · see citing works

Effect of voluntary exercise on H2O2 release by subsarcolemmal and intermyofibrillar mitochondria

Servais, S. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00177-1 · Cited by 111 · see citing works

Cell proliferation in rat skeletal muscle during early stages of compensatory hypertrophy

Schiaffino, S., Bormioli, S. P., & Aloisi, M. (1972) · Virchows Archiv B Cell Pathology Including Molecular Pathology · doi:10.1007/bf02889406 · Cited by 108 · see citing works

Mitochondrial dysfunction and age

Conley, K. E., Marcinek, D. J., & Villarin, J. J. (2007) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3282f0dbfb · Cited by 106 · see citing works

Bcl-2 family interaction with the mitochondrial morphogenesis machinery

Harwig, M. C., Norris, K. L., Karbowski, M., Wang, C., Suen, D., Jiao, S., George, N. M., Luo, X., Li, Z., & Youle, R. J. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.89 · Cited by 106 · see citing works

Aging impairs skeletal muscle mitochondrial bioenergetic function

Figueiredo, P. A., Powers, S. K., Ferreira, R. M., Appell, H. J., & Duarte, J. A. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/gln048 · Cited by 102 · see citing works

Denervation-induced mitochondrial dysfunction and autophagy in skeletal muscle of apoptosis-deficient animals

O′Leary, M. F. N., Vainshtein, A., Carter, H. N., Zhang, Y., & Hood, D. A. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00451.2011 · Cited by 98 · see citing works

MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging

Lustgarten, M. S., Jang, Y. C., Liu, Y., Qi, W., Qin, Y., Dahia, P. L. M., Shi, Y., Bhattacharya, A., Müller, F. L., Shimizu, T., et al. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00695.x · Cited by 92 · see citing works

Nuclear DNA fragmentation and morphological alterations in adult rabbit skeletal muscle after short-term immobilization

Smith, H. K., Maxwell, L., Martyn, J. A., & Bass, J. J. (2000) · Cell and Tissue Research · doi:10.1007/s004410000280 · Cited by 91 · see citing works

Degeneration of different types of skeletal muscle fibres. II. Immobilization.

Tomanek, R. J., & Lund, D. D. (1974) · PubMed · Cited by 90 · see citing works

Skeletal Muscle Apoptotic Signaling Predicts Thigh Muscle Volume and Gait Speed in Community-Dwelling Older Persons: An Exploratory Study

Marzetti, E., Lees, H. A., Manini, T. M., Buford, T. W., Aranda, J. M., Calvani, R., Capuani, G., Marsiske, M., Lott, D. J., Vandenborne, K., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032829 · Cited by 90 · see citing works

Denervation Induces Cytosolic Phospholipase A2-mediated Fatty Acid Hydroperoxide Generation by Muscle Mitochondria

Bhattacharya, A., Müller, F. L., Liu, Y., Sabia, M., Liang, H., Song, W. J., Jang, Y. C., Ran, Q., & Remmen, H. V. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806311200 · Cited by 90 · see citing works

8-oxo-deoxyguanosine levels in heart and brain mitochondrial and nuclear DNA of two mammals and three birds in relation to their different rates of aging

Herrero, A., & Barja, G. (1999) · Aging Clinical and Experimental Research · doi:10.1007/bf03339803 · Cited by 90 · see citing works

Absence of caspase-3 protects against denervation-induced skeletal muscle atrophy

Plant, P. J., Bain, J. R., Correa, J., Woo, M., & Batt, J. A. E. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90932.2008 · Cited by 90 · see citing works

Studies on giant mitochondria

TANDLER, B., & HOPPEL, C. L. (1986) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1986.tb46548.x · Cited by 89 · see citing works

Denervation-induced oxidative stress and autophagy signaling in muscle

O′Leary, M. F. N., & Hood, D. A. (2009) · Autophagy · doi:10.4161/auto.5.2.7391 · Cited by 81 · see citing works

Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity

Lustgarten, M. S., Jang, Y. C., Liu, Y., Müller, F. L., Qi, W., Steinhelper, M. E., Brooks, S. V., Larkin, L. M., Shimizu, T., Shirasawa, T., et al. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00372.2009 · Cited by 78 · see citing works

The emerging role of iron dyshomeostasis in the mitochondrial decay of aging

Xu, J., Marzetti, E., Seo, A. Y., Kim, J., Prolla, T. A., & Leeuwenburgh, C. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.04.007 · Cited by 77 · see citing works

Bowman-Birk inhibitor concentrate prevents atrophy, weakness, and oxidative stress in soleus muscle of hindlimb-unloaded mice

Arbogast, S., Smith, J. L., Matuszczak, Y., Hardin, B. J., Moylan, J. S., Smith, J. D., Ware, J. H., Kennedy, A. R., & Reid, M. B. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00538.2006 · Cited by 77 · see citing works

N-Acetylcysteine protects the rat diaphragm from the decreased contractility associated with controlled mechanical ventilation*

Agten, A., Maes, K., Smuder, A. J., Powers, S. K., Decramer, M., & Gayan‐Ramirez, G. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e318206cca9 · Cited by 74 · see citing works

Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging

Marzetti, E., Privitera, G., Simili, V., Wohlgemuth, S. E., Aulisa, L., Pahor, M., & Leeuwenburgh, C. (2010) · The Scientific World JOURNAL · doi:10.1100/tsw.2010.27 · Cited by 74 · see citing works

DNA-fragmentation and expression of apoptosis-related proteins in experimentally denervated and reinnervated rat facial muscle

Tews, D. S., Goebel, H. H., Schneider, I., Gunkel, A. R., Stennert, E., & Neiss, W. F. (1997) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1997.tb01196.x · Cited by 73 · see citing works

Muscle denervation promotes opening of the permeability transition pore and increases the expression of cyclophilin D

Csukly, K., Ascah, A., Matas, J., Gardiner, P. F., Fontaine, E. M., & Burelle, Y. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.109702 · Cited by 68 · see citing works

Molecular Regulation of Apoptosis in Fast Plantaris Muscles of Aged Rats

Pistilli, E. E., Siu, P. M., & Alway, S. E. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.3.245 · Cited by 67 · see citing works

Effect of denervation-induced muscle disuse on mitochondrial protein import

Singh, K., & Hood, D. A. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00181.2010 · Cited by 67 · see citing works

An Exploratory Analysis of the Effects of a Weight Loss Plus Exercise Program on Cellular Quality Control Mechanisms in Older Overweight Women

Wohlgemuth, S. E., Lees, H. A., Marzetti, E., Manini, T. M., Aranda, J. M., Daniels, M. J., Pahor, M., Perri, M. G., Leeuwenburgh, C., & Anton, S. D. (2011) · Rejuvenation Research · doi:10.1089/rej.2010.1132 · Cited by 65 · see citing works

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Schinner, S. (2009) · Yearbook of Endocrinology · doi:10.1016/s0084-3741(09)79294-7 · Cited by 64 · see citing works

Hydroxyl radical generation in skeletal muscle atrophied by immobilization

Kondo, H., Nishino, K., & Itokawa, Y. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00641-5 · Cited by 63 · see citing works

Deficiency of the Bax gene attenuates denervation-induced apoptosis

Siu, P. M., & Alway, S. E. (2006) · APOPTOSIS · doi:10.1007/s10495-006-6315-4 · Cited by 61 · see citing works

Mitochondrial Protein Quality Control Systems in Aging and Disease

Luce, K., Weil, A. C., & Osiewacz, H. D. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-7002-2_9 · Cited by 59 · see citing works

Muscle apoptosis in humans occurs in normal and denervated muscle, but not in myotonic dystrophy, dystrophinopathies or inflammatory disease

Migheli, A., Mongini, T., Doriguzzi, C., Chiado'-Piat, L., Piva, R., Ugo, I., & Palmucci, L. (1997) · Neurogenetics · doi:10.1007/s100480050012 · Cited by 57 · see citing works

Degeneration of different types of skeletal muscle fibres

Tomanek, R. J., & Lund, D. D. (1975) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-197502000-00096 · Cited by 56 · see citing works

Evidences of apoptosis during the early phases of soleus muscle atrophy in hindlimb suspended mice

Ferreira, R. M., Neuparth, M. J., Vitorino, R. M. P., Appell, H.-J., Amado, F. M. L., & Duarte, J. (2008) · Physiological Research · doi:10.33549/physiolres.931272 · Cited by 56 · see citing works

Age-dependent upregulation of p53 and cytochrome c release and susceptibility to apoptosis in skeletal muscle fiber of aged rats: Role of carnitine and lipoic acid

Jayavelu, T., Jayaraman, G., Sivarajan, K., & Panneerselvam, C. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.08.028 · Cited by 54 · see citing works

Sarcopenia-related apoptosis is regulated differently in fast- and slow-twitch muscles of the aging F344/N×BN rat model

Rice, K. M., & Blough, E. R. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.03.005 · Cited by 52 · see citing works

The Physiological Role of Mitophagy: New Insights into Phosphorylation Events

Hirota, Y., Kang, D., & Kanki, T. (2012) · International Journal of Cell Biology · doi:10.1155/2012/354914 · Cited by 50 · see citing works

Interaction Theory of Mammalian Mitochondria

Nakada, K., Inoue, K., & Hayashi, J. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5838 · Cited by 47 · see citing works

Structure of cristae in cardiac mitochondria of aged rat

Riva, A., Tandler, B., Lesnefsky, E. J., et al. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.09.002 · Cited by 45 · see citing works

Elevated caspase and AIF gene expression correlate with progression of sarcopenia during aging in male F344BN rats

Baker, D. J., & Hepple, R. T. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.08.007 · Cited by 42 · see citing works

Mitochondria in Skeletal Muscle

Adhihetty, P. J., O′Leary, M. F. N., & Hood, D. A. (2008) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e31817be7b7 · Cited by 41 · see citing works

Impact of genome instability on transcription regulation of aging and senescence

Vijg, J. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.07.004 · Cited by 38 · see citing works

Expression of nuclear-encoded genes involved in mitochondrial biogenesis and dynamics in experimentally denervated muscle

Wagatsuma, A., Kotake, N., Mabuchi, K., & Yamada, S. (2011) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-011-0083-5 · Cited by 38 · see citing works

The age-dependent induction of apoptosis-inducing factor (AIF) in the human semitendinosus skeletal muscle

Park, S., Kim, H., Lee, J., Yoon, K., Chang, M., & Park, S. (2009) · Cellular & Molecular Biology Letters · doi:10.2478/s11658-009-0030-4 · Cited by 37 · see citing works

Antioxidants and Skeletal Muscle Performance: “Common Knowledge” vs. Experimental Evidence

Hernández, A., Cheng, A. J., & Westerblad, H. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00046 · Cited by 33 · see citing works

Skeletal Muscle Is a Primary Target of SOD1G93A-Mediated Toxicity

Dobrowolny, G., Aucello, M., Rizzuto, E., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.003 · Cited by 33 · see citing works

Expression patterns of initiator and effector caspases in denervated human skeletal muscle

Tews, D. S., Behrhof, W., & Schindler, S. (2004) · Muscle & Nerve · doi:10.1002/mus.20253 · Cited by 30 · see citing works

Emerging roles of mitochondrial membrane dynamics in health and disease

Schäfer, A., & Reichert, A. S. (2009) · Biological Chemistry · doi:10.1515/bc.2009.086 · Cited by 30 · see citing works

Acetaminophen Improves Protein Translational Signaling in Aged Skeletal Muscle

Wu, M., Liu, H., Fannin, J. C., Katta, A., Wang, Y., Arvapalli, R. K., Paturi, S., Karkala, S. K., Rice, K. M., & Blough, E. R. (2010) · Rejuvenation Research · doi:10.1089/rej.2009.1015 · Cited by 27 · see citing works

Altered myoplasmic Ca2+ handling in rat fast-twitch skeletal muscle fibres during disuse atrophy

Weiss, N., Andrianjafiniony, T., Dupré-Aucouturier, S., Pouvreau, S., Dominique Desplanches, C., & Jacquemond, V. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0764-x · Cited by 25 · see citing works

The Possible Role of Intracellular Ca2+Accumulation for the Development of Immobilization Atrophy

Soares, J. M. C., Duarte, J. A., Carvalho, J., & Appell, H.-J. (1993) · International Journal of Sports Medicine · doi:10.1055/s-2007-1021206 · Cited by 25 · see citing works

Increased mitochondrial matrix-directed superoxide production by fatty acid hydroperoxides in skeletal muscle mitochondria

Bhattacharya, A., Lustgarten, M. S., Shi, Y., Liu, Y., Jang, Y. C., Pulliam, D. A., Jernigan, A., & Remmen, H. V. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.12.014 · Cited by 22 · see citing works

Mitochondria and aging: innocent bystanders or guilty parties?

Tońska, K., Sołyga, A., & Bartnik, E. (2009) · Journal of Applied Genetics · doi:10.1007/bf03195653 · Cited by 10 · see citing works

Oxidative stress in skeletal muscle atrophied by immobilization

近藤, 久. (1994) · Medical Entomology and Zoology · doi:10.11501/3074820 · Cited by 8 · see citing works

SMAC-expression in Denervated Human Skeletal Muscle as a Potential Inhibitor of Coexpressed Inhibitor-of-apoptosis Proteins

Tews, D. S., Behrhof, W., & Schindler, S. (2008) · Applied immunohistochemistry & molecular morphology · doi:10.1097/pai.0b013e318030b32e · Cited by 6 · see citing works

Untitled work

(1999) · doi:10.1002/(sici)1097-4598(199910)22:10

Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials

Marzetti, E., Calvani, R., Cesari, M., Buford, T. W., Lorenzi, M., Behnke, B. J., & Leeuwenburgh, C. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.06.024 · Cited by 627 · see citing works

Sarcopenia, frailty and their prevention by exercise

Nascimento, C. M., Ingles, M., Salvador-Pascual, A., Cominetti, M. R., Gomez-Cabrera, M. C., & Viña, J. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.08.035 · Cited by 396 · see citing works

Physical activity and exercise as countermeasures to physical frailty and sarcopenia

on behalf of the SPRINTT Consortium, Marzetti, E., Calvani, R., Tosato, M., Cesari, M., Di Bari, M., Cherubini, A., Broccatelli, M., Savera, G., D’Elia, M., et al. (2017) · Aging Clinical and Experimental Research · doi:10.1007/s40520-016-0705-4 · Cited by 362 · see citing works

Successful aging: Advancing the science of physical independence in older adults

Anton, S. D., Woods, A. J., Ashizawa, T., Barb, D., Buford, T. W., Carter, C. S., Clark, D. J., Cohen, R. A., Corbett, D. B., Cruz-Almeida, Y., et al. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.09.005 · Cited by 292 · see citing works

Skeletal muscle aging: influence of oxidative stress and physical exercise

Gomes, M. J., Martinez, P. F., Pagan, L. U., Damatto, R. L., Mariano Cezar, M. D., Ruiz Lima, A. R., Okoshi, K., & Okoshi, M. P. (2017) · Oncotarget · doi:10.18632/oncotarget.14670 · Cited by 285 · see citing works

Frailty and sarcopenia - newly emerging and high impact complications of diabetes

Sinclair, A. J., Abdelhafiz, A. H., & Rodríguez-Mañas, L. (2017) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2017.05.003 · Cited by 276 · see citing works

Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength

Palla, A. R., Ravichandran, M., Wang, Y. X., Alexandrova, L., Yang, A. V., Kraft, P., Holbrook, C. A., Schürch, C. M., Ho, A. T. V., & Blau, H. M. (2021) · Science · doi:10.1126/science.abc8059 · Cited by 232 · see citing works

Role of Age-Related Mitochondrial Dysfunction in Sarcopenia

Ferri, E., Marzetti, E., Calvani, R., Picca, A., Cesari, M., & Arosio, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155236 · Cited by 224 · see citing works

Beneficial effects of exercise on age‐related mitochondrial dysfunction and oxidative stress in skeletal muscle

Joseph, A., Adhihetty, P. J., & Leeuwenburgh, C. (2016) · The Journal of Physiology · doi:10.1113/jp270659 · Cited by 186 · see citing works

Tomatidine Enhances Lifespan and Healthspan in C. elegans through Mitophagy Induction Via the SKN-1/Nrf2 Pathway

Fang, E. F., Waltz, T. B., Kassahun, H., Lu, Q., Kerr, J. S., Morevati, M., Fivenson, E. M., Wollman, B. N., Marosi, K., Wilson, M. A., et al. (2017) · Scientific Reports · doi:10.1038/srep46208 · Cited by 187 · see citing works

Skeletal muscle oxidative stress and inflammation in aging: Focus on antioxidant and anti-inflammatory therapy

Chen, M., Wang, Y., Deng, S., Lian, Z., & Yu, K. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.964130 · Cited by 187 · see citing works

Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging.

Joseph, A.-M., Adhihetty, P. J., Wawrzyniak, N. R., Wohlgemuth, S. E., Picca, A., Kujoth, G. C., Prolla, T. A., & Leeuwenburgh, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069327 · Cited by 161 · see citing works

Mitochondria initiate and regulate sarcopenia

Alway, S. E., Mohamed, J. S., & Myers, M. J. (2017) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000101 · Cited by 153 · see citing works

Effects of High-Intensity Resistance Training on Osteopenia and Sarcopenia Parameters in Older Men with Osteosarcopenia-One-Year Results of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial (FrOST)

Kemmler, W., Kohl, M., Fröhlich, M., Jakob, F., Engelke, K., von Stengel, S., & Schoene, D. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4027 · Cited by 139 · see citing works

Muscle wasting and aging: Experimental models, fatty infiltrations, and prevention

Brioche, T., Pagano, A. F., Py, G., & Chopard, A. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.04.006 · Cited by 129 · see citing works

Systemic Nutrient and Stress Signaling via Myokines and Myometabolites

Rai, M., & Demontis, F. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105305 · Cited by 123 · see citing works

Update on mitochondria and muscle aging: All wrong roads lead to sarcopenia

Picca, A., Calvani, R., Bossola, M., Allocca, E., Menghi, A., Pesce, V., Lezza, A. M. S., Bernabei, R., Landi, F., & Marzetti, E. (2018) · Biological Chemistry · doi:10.1515/hsz-2017-0331 · Cited by 116 · see citing works

Autophagy as a Potential Target for Sarcopenia: AUTOPHAGY REGULATION IN SARCOPENIA

Fan, J., Kou, X., Jia, S., Yang, X., Yang, Y., & Chen, N. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25260 · Cited by 101 · see citing works

Mitochondrial maintenance via autophagy contributes to functional skeletal muscle regeneration and remodeling

Nichenko, A. S., Southern, W. M., Atuan, M., Luan, J., Peissig, K. B., Foltz, S. J., Beedle, A. M., Warren, G. L., & Call, J. A. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00066.2016 · Cited by 80 · see citing works

Antioxidant Apigenin Relieves Age-Related Muscle Atrophy by Inhibiting Oxidative Stress and Hyperactive Mitophagy and Apoptosis in Skeletal Muscle of Mice

Wang, D., Yang, Y., Zou, X., Zhang, J., Zheng, Z., & Wang, Z. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa214 · Cited by 87 · see citing works

Pgc-1α overexpression Via local transfection attenuates mitophagy pathway in muscle disuse atrophy

Kang, C., & Ji, L. L. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.12.032 · Cited by 83 · see citing works

Chronological Age Does not Influence<i>Ex-vivo</i>Mitochondrial Respiration and Quality Control in Skeletal Muscle

Distefano, G., Standley, R. A., Dubé, J. J., Carnero, E. A., Ritov, V. B., Stefanovic-Racic, M., Toledo, F. G. S., Piva, S. R., Goodpaster, B. H., & Coen, P. M. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glw102 · Cited by 76 · see citing works

Role of PGC-1α in sarcopenia: Etiology and potential intervention—A mini-review

Ji, L. L., & Kang, C. (2015) · Gerontology · doi:10.1159/000365947 · Cited by 77 · see citing works

Green tea extract attenuates muscle loss and improves muscle function during disuse, but fails to improve muscle recovery following unloading in aged rats

Alway, S. E., Bennett, B. T., Wilson, J. C., Sperringer, J., Mohamed, J. S., Edens, N. K., & Pereira, S. L. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00674.2014 · Cited by 73 · see citing works

Changes in Redox Signaling in the Skeletal Muscle with Aging

Szentesi, P., Csernoch, L., Dux, L., & Keller-Pintér, A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/4617801 · Cited by 71 · see citing works

The lifecycle of skeletal muscle mitochondria in obesity

Pileggi, C. A., Parmar, G., & Harper, M. (2021) · Obesity Reviews · doi:10.1111/obr.13164 · Cited by 61 · see citing works

l-Carnitine Supplementation in Older Women. A Pilot Study on Aging Skeletal Muscle Mass and Function

Sawicka, A., Hartmane, D., Lipinska, P., Wojtowicz, E., Lysiak-Szydlowska, W., & Olek, R. (2018) · Nutrients · doi:10.3390/nu10020255 · Cited by 49 · see citing works

The link between Mitochondria and Sarcopenia

Kamarulzaman, N. T., & Makpol, S. (2025) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-024-01062-7 · Cited by 33 · see citing works

Mitochondrial dynamics signaling is shifted toward fusion in muscles of very old hip-fractured patients: results from the Sarcopenia in HIp FracTure (SHIFT) exploratory study

Picca, A., Calvani, R., Lorenzi, M., Menghi, A., Galli, M., Vitiello, R., Randisi, F., Bernabei, R., Landi, F., & Marzetti, E. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.06.005 · Cited by 32 · see citing works

Relationship between Mitochondrial Quality Control Markers, Lower Extremity Tissue Composition, and Physical Performance in Physically Inactive Older Adults

Picca, A., Triolo, M., Wohlgemuth, S. E., Martenson, M. S., Mankowski, R. T., Anton, S. D., Marzetti, E., Leeuwenburgh, C., & Hood, D. A. (2023) · Cells · doi:10.3390/cells12010183 · Cited by 23 · see citing works

Organotypic cultures as aging associated disease models

Sanchez, M. M., Bagdasarian, I. A., Darch, W., & Morgan, J. T. (2022) · Aging · doi:10.18632/aging.204361 · Cited by 12 · see citing works

Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy

Buford, T. W., Anton, S. D., Judge, A. R., Marzetti, E., Wohlgemuth, S. E., Carter, C. S., Leeuwenburgh, C., Pahor, M., & Manini, T. M. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.04.004 · Cited by 295 · see citing works

Testosterone reduced methylprednisolone-induced muscle atrophy in spinal cord-injured rats

Wu, Y., Collier, L., Pan, J., et al. (2011) · Spinal Cord · doi:10.1038/sc.2011.91 · Cited by 16 · see citing works

Muscle Atrophy Classification: The Need for a Pathway-Driven Approach

Zizzo, J. (2021) · Current Pharmaceutical Design · doi:10.2174/1381612824666210316102413 · Cited by 9 · see citing works

Exercise and Muscle Atrophy

He, N., & Ye, H. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-1792-1_17 · Cited by 47 · see citing works

Cold-induced muscle atrophy in zebrafish: Insights from swimming activity and gene expression analysisPreprint

Ikeda, D., Fujita, S., Toda, K., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.03.553941 · Cited by 1 · see citing works