The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Disuse atrophy and exercise rehabilitation in humans profoundly affects the expression of genes associated with the regulation of skeletal muscle mass
Abstract
Skeletal muscle atrophy occurs as a consequence of injury, illness, surgery, and muscle disuse, impacting appreciably on health care costs and patient quality of life, particularly in the absence of appropriate rehabilitation. The molecular mechanisms that regulate muscle mass during atrophy and rehabilitation in humans have not been elucidated, despite several robust candidate pathways being identified. Here, we induced skeletal muscle atrophy in healthy volunteers using two weeks of limb immobilization, and then stimulated the restoration of muscle mass with six weeks of supervised exercise rehabilitation. We determined muscle mass and function and performed targeted gene expression analysis at prescribed time points during immobilization and rehabilitation. For the first time, we have identified novel changes in gene expression following immobilization‐induced atrophy and during a program of rehabilitative exercise that restored muscle mass and function. Furthermore, we have shown that exercise performed immediately following immobilization induces profound changes in the expression of a number of genes in favor of the restoration of muscle mass, within 24 h. This information will be of considerable importance to our understanding of how immobilization and contraction stimulate muscle atrophy and hypertrophy, respectively, and to the development of novel therapeutic strategies aimed at maintaining or restoring muscle mass.
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Cites
Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member
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Identification of ubiquitin ligases required for skeletal muscle atrophy.
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Bodine, S. C., Stitt, T. N., Gonzalez, M., Kline, W. O., Stover, G. L., Bauerlein, R., Zlotchenko, E., Scrimgeour, A., Lawrence, J. C., Glass, D. J., et al. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1014 · Cited by 2,752
Rommel, C., Bodine, S. C., Clarke, B. A., Rossman, R., Nunez, L., Stitt, T. N., Yancopoulos, G. D., & Glass, D. J. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1009 · Cited by 1,583
Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression
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Signalling pathways that mediate skeletal muscle hypertrophy and atrophy
Glass, D. J. (2003) · Nature Cell Biology · doi:10.1038/ncb0203-87 · Cited by 694
What do we really know about the ubiquitin-proteasome pathway in muscle atrophy?
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Cited by
The Molecular Bases of Training Adaptation
Coffey, V. G., & Hawley, J. A. (2007) · Sports Medicine · doi:10.2165/00007256-200737090-00001 · Cited by 756
Louis, E., Raue, U., Yang, Y., Jemiolo, B., & Trappe, S. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00679.2007 · Cited by 478
Effects of aging on human skeletal muscle after immobilization and retraining
Suetta, C., Hvid, L. G., Justesen, L., Christensen, U., Neergaard, K., Simonsen, L., Ortenblad, N., Magnusson, S. P., Kjaer, M., & Aagaard, P. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00290.2009 · Cited by 400
Skeletal muscle atrophy during short-term disuse: Implications for age-related sarcopenia
Wall, B. T., Dirks, M. L., & van Loon, L. J. C. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.07.003 · Cited by 400
Brower, R. G. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181b6e30a · Cited by 387
Metadata
- Authors
- Jones, S. W., Hill, R. J., Krasney, P. A., O'Conner, B., Peirce, N., & Greenhaff, P. L.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2004-04-14
- Volume
- 18
- Issue
- 9
- Pages
- 1025-1027
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2045577106
- Cited by
- 407
- References
- 7
- FWCI
- 6.23
- Type
- journal article
- Language
- en
- Open access
- closed
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