Skeletal muscle atrophy during short-term disuse: Implications for age-related sarcopenia

Wall, Benjamin T.; Dirks, Marlou L.; van Loon, Luc J.C.

doi:10.1016/j.arr.2013.07.003

Cited by 401Muscle Physiology and DisordersMuscle metabolism and nutritionNutrition and Health in Aging

Skeletal muscle atrophy during short-term disuse: Implications for age-related sarcopenia

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Wall, Benjamin T., Dirks, Marlou L., van Loon, Luc J.C.·2013·Ageing Research Reviews

DOI 10.1016/j.arr.2013.07.003

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Abstract

Situations such as the recovery from injury and illness can lead to enforced periods of muscle disuse or unloading. Such circumstances lead to rapid skeletal muscle atrophy, loss of functional strength and a multitude of related negative health consequences. The elderly population is particularly vulnerable to the acute challenges of muscle disuse atrophy. Any loss of skeletal muscle mass must be underpinned by a chronic imbalance between muscle protein synthesis and breakdown rates. It is recognized that muscle atrophy during prolonged (>10 days) disuse is brought about primarily by declines in post-absorptive and post-prandial muscle protein synthesis rates, without a clear contribution from changes in muscle protein breakdown. Few data are available on the impact of short-term disuse (<10 days) on muscle protein turnover in humans. However, indirect evidence indicates that considerable muscle atrophy occurs during this early phase, and is likely attributed to a rapid increase in muscle protein breakdown accompanied by the characteristic decline in muscle protein synthesis. Short-term disuse atrophy is of particular relevance in the development of sarcopenia, as it has been suggested that successive short periods of muscle disuse, due to sickness or injury, accumulate throughout an individual's lifespan and contributes considerably to the net muscle loss observed with aging. Research is warranted to elucidate the physiological and molecular basis for rapid muscle loss during short periods of disuse. Such mechanistic insight will allow the characterization of nutritional, exercise and/or pharmacological interventions to prevent or attenuate muscle loss during periods of disuse and therefore aid in the treatment of age-related sarcopenia.

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Skeletal muscle performance and ageing
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Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms
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Skeletal Muscle Regulates Metabolism via Interorgan Crosstalk: Roles in Health and Disease
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Does nutrition play a role in the prevention and management of sarcopenia?
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One Week of Bed Rest Leads to Substantial Muscle Atrophy and Induces Whole-Body Insulin Resistance in the Absence of Skeletal Muscle Lipid Accumulation
Dirks, M. L., Wall, B. T., van de Valk, B., Holloway, T. M., Holloway, G. P., Chabowski, A., Goossens, G. H., & van Loon, L. J. C. (2016) · Diabetes · doi:10.2337/db15-1661 · Cited by 391 · see citing works
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Satellite cells in human skeletal muscle plasticity
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Substantial skeletal muscle loss occurs during only 5 days of disuse
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Management of disease-related malnutrition for patients being treated in hospital
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Sarcopenia: Current Concepts and Imaging Implications
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Skeletal muscle mitochondrial remodeling in exercise and diseases
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Physical inactivity: a risk factor and target for intervention in renal care
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Recommendations on Physical Activity and Exercise for Older Adults Living in Long-Term Care Facilities: A Taskforce Report
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Short-Term Preoperative High-Intensity Interval Training in Patients Awaiting Lung Cancer Surgery: A Randomized Controlled Trial
Licker, M. J., Karenovicŝ, W., Diaper, J., Frésard, I., Triponez, F., Ellenberger, C., Schorer, R., Kayser, B., & Bridevaux, P. (2016) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2016.09.125 · Cited by 257 · see citing works
Neuromuscular electrical stimulation prevents muscle disuse atrophy during leg immobilization in humans
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Sarcopenic obesity: time to meet the challenge
Barazzoni, R., Bischoff, S. C., Boirie, Y., Busetto, L., Cederholm, T., Dicker, D., Toplak, H., Van Gossum, A., Yumuk, V., & Vettor, R. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.04.018 · Cited by 260 · see citing works
Sarcopenic obesity: time to meet the challenge
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Post-COVID-19 acute sarcopenia: physiopathology and management
Piotrowicz, K., Gąsowski, J., Michel, J., & Veronese, N. (2021) · Aging Clinical and Experimental Research · doi:10.1007/s40520-021-01942-8 · Cited by 251 · see citing works
Muscle loss: The new malnutrition challenge in clinical practice
Landi, F., Camprubi-Robles, M., Bear, D. E., Cederholm, T., Malafarina, V., Welch, A. A., & Cruz-Jentoft, A. J. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.11.021 · Cited by 235 · see citing works
Advances in muscle health and nutrition: A toolkit for healthcare professionals
Prado, C. M., Landi, F., Chew, S. T. H., Atherton, P. J., Molinger, J., Ruck, T., & Gonzalez, M. C. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.07.041 · Cited by 237 · see citing works
Age-related differences in lean mass, protein synthesis and skeletal muscle markers of proteolysis after bed rest and exercise rehabilitation
Tanner, R. E., Brunker, L. B., Agergaard, J., Barrows, K. M., Briggs, R. A., Kwon, O. S., Young, L. M., Hopkins, P. N., Volpi, E., Marcus, R. L., et al. (2015) · The Journal of Physiology · doi:10.1113/jp270699 · Cited by 223 · see citing works
Mitochondrial dysfunction induces muscle atrophy during prolonged inactivity: A review of the causes and effects
Hyatt, H. W., Deminice, R., Yoshihara, T., & Powers, S. K. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.11.005 · Cited by 219 · see citing works
Sarcopenia: imaging assessment and clinical application
Chianca, V., Albano, D., Messina, C., Gitto, S., Ruffo, G., Guarino, S., Grande, F. D., & Sconfienza, L. M. (2021) · Abdominal Radiology · doi:10.1007/s00261-021-03294-3 · Cited by 207 · see citing works
Protein intake and muscle function in older adults
Deer, R. R., & Volpi, E. (2015) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0000000000000162 · Cited by 206 · see citing works
Age-related deficits in skeletal muscle recovery following disuse are associated with neuromuscular junction instability and ER stress, not impaired protein synthesis
Baehr, L. M., West, D. W. D., Marcotte, G. R., Marshall, A. G., de Sousa, L. G. O., Baar, K., & Bodine, S. C. (2016) · Aging · doi:10.18632/aging.100879 · Cited by 205 · see citing works
Dietary protein and muscle in older persons
Paddon-Jones, D., & Leidy, H. (2014) · Current opinion in clinical nutrition and metabolic care · doi:10.1097/mco.0000000000000011 · Cited by 199 · see citing works
Muscle metabolism and atrophy: let’s talk about sex
Rosa-Caldwell, M. E., & Greene, N. P. (2019) · Biology of Sex Differences · doi:10.1186/s13293-019-0257-3 · Cited by 202 · see citing works
Skeletal muscle homeostasis and plasticity in youth and ageing: impact of nutrition and exercise
Brook, M. S., Wilkinson, D. J., Phillips, B. E., Pérez‐Schindler, J., Philp, A., Smith, K., & Atherton, P. J. (2015) · Acta Physiologica · doi:10.1111/apha.12532 · Cited by 193 · see citing works
Fourteen days of bed rest induces a decline in satellite cell content and robust atrophy of skeletal muscle fibers in middle-aged adults
Arentson‐Lantz, E. J., English, K. L., Paddon‐Jones, D., & Fry, C. S. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00799.2015 · Cited by 183 · see citing works
Disuse Impairs the Muscle Protein Synthetic Response to Protein Ingestion in Healthy Men
Wall, B. T., Snijders, T., Senden, J. M., Ottenbros, C. L. P., Gijsen, A. P., Verdijk, L. B., & van Loon, L. J. C. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2098 · Cited by 178 · see citing works
Self-citation
Short-term muscle disuse lowers myofibrillar protein synthesis rates and induces anabolic resistance to protein ingestion
Wall, B. T., Dirks, M. L., Snijders, T., van Dijk, J., Fritsch, M., Verdijk, L. B., & van Loon, L. J. C. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00227.2015 · Cited by 160 · see citing works
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Integrin signaling: linking mechanical stimulation to skeletal muscle hypertrophy
Boppart, M. D., & Mahmassani, Z. S. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00009.2019 · Cited by 157 · see citing works
Nutritional Supplements in Support of Resistance Exercise to Counter Age-Related Sarcopenia
Phillips, S. M. (2015) · Advances in Nutrition · doi:10.3945/an.115.008367 · Cited by 144 · see citing works
Skeletal muscle disuse atrophy is not attenuated by dietary protein supplementation in healthy older men
Dirks, M. L., Wall, B. T., Nilwik, R., Weerts, D. H. J. M., Verdijk, L. B., & van Loon, L. J. C. (2014) · The Journal of Nutrition · doi:10.3945/jn.114.194217 · Cited by 137 · see citing works
Self-citation
Improving rehabilitation in sarcopenia: a randomized‐controlled trial utilizing a muscle‐targeted food for special medical purposes
Rondanelli, M., Cereda, E., Klersy, C., Faliva, M. A., Peroni, G., Nichetti, M., Gasparri, C., Iannello, G., Spadaccini, D., Infantino, V., et al. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12532 · Cited by 135 · see citing works
Let thy food be thy medicine….when possible
Witkamp, R. F., & van Norren, K. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.06.026 · Cited by 130 · see citing works
Prehabilitation in thoracic surgery
Sánchez-Lorente, D., Navarro‐Ripoll, R., Guzmán, R., Moisés, J., Gimeno, E., Boada, M., & Molins, L. (2018) · Journal of Thoracic Disease · doi:10.21037/jtd.2018.08.18 · Cited by 126 · see citing works
Strategies to maintain skeletal muscle mass in the injured athlete: Nutritional considerations and exercise mimetics
Wall, B. T., Morton, J. P., & van Loon, L. J. C. (2014) · European Journal of Sport Science · doi:10.1080/17461391.2014.936326 · Cited by 122 · see citing works
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Muscle-specific and age-related changes in protein synthesis and protein degradation in response to hindlimb unloading in rats
Baehr, L. M., West, D. W. D., Marshall, A. G., Marcotte, G. R., Baar, K., & Bodine, S. C. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00703.2016 · Cited by 119 · see citing works
Failed Recovery of Glycemic Control and Myofibrillar Protein Synthesis With 2 wk of Physical Inactivity in Overweight, Prediabetic Older Adults
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Authors: Wall, B. T., Dirks, M. L., & van Loon, L. J. C.
Affiliations: Maastricht University Medical Centre (NL)
ORCID: Wall, Benjamin T.
Dirks, Marlou L.
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2013-09
Volume: 12
Issue: 4
Pages: 898-906
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2013.07.003
OpenAlex: W2159802435
Cited by: 400
References: 131
Citations by year: 2026: 27 · 2025: 25 · 2024: 33 · 2023: 37 · 2022: 37 · 2021: 45 · 2020: 38 · 2019: 27 · 2018: 34 · 2017: 31 · 2016: 29 · 2015: 19 · 2014: 12 · 2013: 6
FWCI: 2.07
Type: journal article
Language: en
Open access: green
research.wur.nl
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion)
Research Bank (Australian Catholic University) (submittedVersion)
Socio-Environmental Systems Modeling (submittedVersion)
VUBIR (Vrije Universiteit Brussel) (submittedVersion)
Research Publications (Maastricht University) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Keywords: skeletal muscle atrophy, muscle disuse, age-related sarcopenia, muscle protein synthesis, muscle protein degradation, muscle protein turnover, muscle unloading, aging, sarcopenia prevention
MeSH terms: Aged, Aging, Humans, Muscular Atrophy, Muscle, Skeletal, Muscular Disorders, Atrophic, Sarcopenia

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Skeletal muscle atrophy during short-term disuse: Implications for age-related sarcopenia

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