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Cited by 67Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityBariatric Surgery and Outcomes

Weight loss reduces adipose tissue cathepsin S and its circulating levels in morbidly obese women

Taleb, Soraya, Cancello, Raffaella, Poitou, Christine, Rouault, Christine, Sellam, Philippe, Levy, Patrick, Bouillot, Jean-Luc, Coussieu, Christiane +4 more·2006·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2005-1601
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Abstract

CONTEXT: Human adipose tissue produces several adipokines, including the newly identified protein cathepsin S (CTSS), a cysteine protease involved in the pathogenesis of atherosclerosis. Obesity is characterized by high levels of CTSS in the circulation and in sc white adipose tissue (scWAT). OBJECTIVE: We investigated the effect of surgery-induced weight loss on circulating CTSS and its protein expression in scWAT. DESIGN: Fifty morbidly obese women before and 3 months after surgery and 10 healthy lean women were studied. We analyzed the relationships between circulating CTSS and clinical and biological parameters. Immunohistochemistry of the CTSS protein variations in scWAT was performed. RESULTS: Weight loss decreased by 42% (P < 0.0001) the circulating CTSS levels, which correlated with changes in body weight (P = 0.03). We observed a significant decrease in CTSS enzymatic activity by 25% after weight loss (P = 0.001). Adipose tissue CTSS content was reduced by 30% (P = 0.002) after surgery. The variations in CTSS expression in scWAT after surgery correlated with changes in circulating CTSS serum levels (P = 0.03). Most of the correlations between CTSS and clinical and biological parameters disappeared after adjustment for body mass index, emphasizing the strong link between CTSS and corpulence in humans. CONCLUSIONS: Changes in CTSS scWAT might contribute to serum variations in CTSS during weight loss. The decrease in CTSS concentrations in the circulation may contribute to vascular improvement in obese subjects after weight loss.

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  • Among adipose-secreted candidates, increases in IL-6, IL-8 and MCP-1 and decreases in adiponectin are considered particularly important.

    “Among the candidates secreted by the adipose tissue, the increase in IL-6, IL-8 and MCP-1 and the decrease in adiponectin are considered to be particularly important (101,102) .”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [101]

  • Relationships between abnormal cardiac function in obese subjects, abdominal fat accumulation and low-grade inflammation have been suggested.

    “Relationships between abnormalities of cardiac function in obese subjects, the accumulation of abdominal fat and low-grade inflammation have been suggested (101,102) .”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [101]

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Authors
Taleb, S., Cancello, R., Poitou, C., Rouault, C., Sellam, P., Levy, P., Bouillot, J.-L., Coussieu, C., Basdevant, A., Guerre-Millo, M., Lacasa, D., & Clement, K.
Affiliations
  • Inserm (FR)
  • Assistance Publique – Hôpitaux de Paris (FR)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2006-03
Volume
91
Issue
3
Pages
1042-1047
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2005-1601
OpenAlex
W2148564394
Cited by
67
References
33
Citations by year
2026: 1 · 2025: 4 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 6 · 2013: 3 · 2012: 5
FWCI
3.17
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
Keywords
cathepsin S, morbid obesity, weight loss, bariatric surgery, subcutaneous white adipose tissue, adipokines, cysteine protease, body mass index
MeSH terms
Adipose Tissue, Adult, Blood Vessels, Body Weight, Cathepsins, Female, Humans, Obesity, Morbid, Reference Values, Thinness, Weight Loss, Body Mass Index, Cell Culture Techniques

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