The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Calcineurin‐dependent cardiomyopathy is activated by TRPC in the adult mouse heart
Open accessAbstract
The manner in which Ca 2+ ‐sensitive signaling proteins are activated in contracting cardiomyocytes is an intriguing theoretical problem given that the cytoplasm is continually bathed with systolic Ca 2+ concentrations that should maximally activate most Ca 2+ ‐sensitive signaling kinases and phosphatases. Store‐operated Ca 2+ entry, partially attributed to transient receptor potential (TRP) proteins, can mediate activation of the Ca 2+ ‐sensitive phosphatase calcineurin in nonexcitable cells. Here we investigated the gain‐of‐function phenotype associated with TRPC3 expression in the mouse heart using transgenesis to examine the potential role of store‐operated Ca 2+ entry in regulating cardiac calcineurin activation and ensuing hypertrophy/myopathy. Adult myocytes isolated from TRPC3 transgenic mice showed abundant store‐operated Ca 2+ entry that was inhibited with SKF96365 but not verapamil or KB‐R7943. Associated with this induction in store‐operated Ca 2+ entry, TRPC3 transgenic mice showed increased calcineurin‐nuclear factor of activated T cells (NFAT) activation in vivo , cardiomyopathy, and increased hypertrophy after neuroendocrine agonist or pressure overload stimulation. The cardiomyopathic phenotype and increased hypertrophy after pressure overload stimulation were blocked by targeted disruption of the calcineurin Aβ gene. Thus, enhanced store‐operated Ca 2+ entry in the heart can regulate calcineurin‐NFAT signaling in vivo , which could secondarily impact the hypertrophic response and cardiomyopathy.—Nakayama, H., Wilkin, B. J., Bodi, I., Molkentin, J. D. Calcineurin‐dependent cardiomyopathy is activated by TRPC in the adult mouse heart. FASEB J. 20, 1660–1670 (2006)
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Citations
Cites
Calcium's Role in Mechanotransduction during Muscle Development
Benavides Damm, T., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,502
TRP channels as cellular sensors
Clapham, D. E. (2003) · Nature · doi:10.1038/nature02196 · Cited by 2,779
A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy
Molkentin, J. D., Lu, J.-R., Antos, C. L., Markham, B., Richardson, J., Robbins, J., Grant, S. R., & Olson, E. N. (1998) · Cell · doi:10.1016/s0092-8674(00)81573-1 · Cited by 2,566
Self-citationStore-Operated Calcium Channels
Parekh, A. B., & Putney, J. W. (2005) · Physiological Reviews · doi:10.1152/physrev.00057.2003 · Cited by 2,089
Transcriptional regulation by calcium, calcineurin, and NFAT
Hogan, P. G., Chen, L., Nardone, J., & Rao, A. (2003) · Genes & Development · doi:10.1101/gad.1102703 · Cited by 1,991
Calcium oscillations increase the efficiency and specificity of gene expression
Dolmetsch, R. E., Xu, K., & Lewis, R. S. (1998) · Nature · doi:10.1038/31960 · Cited by 1,893
Differential activation of transcription factors induced by Ca2+ response amplitude and duration
Dolmetsch, R. E., Lewis, R. S., Goodnow, C. C., & Healy, J. I. (1997) · Nature · doi:10.1038/386855a0 · Cited by 1,752
Differential activation of transcription factors induced by Ca2+ response amplitude and duration
Dolmetsch, R. E., Lewis, R. S., Goodnow, C. C., & Healy, J. I. (1997) · Nature · doi:10.1038/40912 · Cited by 1,521
Crabtree, G. R., & Olson, E. N. (2002) · Cell · doi:10.1016/s0092-8674(02)00699-2 · Cited by 1,323
Regulation of the Calmodulin-stimulated Protein Phosphatase, Calcineurin
Klee, C. B., Ren, H., & Wang, X. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.13367 · Cited by 898
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Signaling effectors underlying pathologic growth and remodeling of the heart
van Berlo, J. H., Maillet, M., & Molkentin, J. D. (2013) · Journal of Clinical Investigation · doi:10.1172/jci62839 · Cited by 445
Self-citationTransient receptor potential (TRP) channels: a clinical perspective
Kaneko, Y., & Szallasi, A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12414 · Cited by 370
TRPC channels are necessary mediators of pathologic cardiac hypertrophy
Wu, X., Eder, P., Chang, B., & Molkentin, J. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001825107 · Cited by 272
Self-citationAtrogin-1 deficiency promotes cardiomyopathy and premature death via impaired autophagy
Zaglia, T., Milan, G., Ruhs, A., Franzoso, M., Bertaggia, E., Pianca, N., Carpi, A., Carullo, P., Pesce, P., Sacerdoti, D., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci66339 · Cited by 147
Metadata
- Authors
- Nakayama, H., Wilkin, B. J., Bodi, I., & Molkentin, J. D.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2006-08
- Volume
- 20
- Issue
- 10
- Pages
- 1660-1670
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1986866353
- Cited by
- 272
- References
- 31
- FWCI
- 6.88
- Type
- journal article
- Language
- en
- Open access
- green
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