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Cited by 192Pneumonia and Respiratory InfectionsInfluenza Virus Research StudiesRespiratory viral infections research

Influenza A virus facilitates Streptococcus pneumoniae transmission and disease

Diavatopoulos, Dimitri A., Short, Kirsty R., Price, John T., Wilksch, Jonathan J., Brown, Lorena E., Briles, David E., Strugnell, Richard A., Wijburg, Odilia L.·2010·The FASEB Journal
DOI 10.1096/fj.09-146779
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Abstract

Streptococcus pneumoniae (the pneumococcus) kills approximately 1.6 million people annually. Pneumococcal infections predominantly manifest as pneumonia, sepsis, meningitis, and otitis media. S. pneumoniae is also a member of the normal nasopharyngeal flora, colonizing up to 80% of children. Infection with influenza A virus (IAV) has been associated with both pneumococcal disease and transmission. However, to date no animal model has been available to investigate the role of IAV in the spread of S. pneumoniae. Here we investigate pneumococcal-influenza synergism with a particular focus on the role of IAV on pneumococcal transmission. Infant mice were colonized with S. pneumoniae and subsequently infected with IAV 3 d later. Using this novel model we show increased pneumococcal colonization and disease in the presence of IAV. Notably, in vivo imaging showed that IAV was essential for the transmission of S. pneumoniae from colonized ("index") mice to their naive cohoused littermates ("contacts"). Transmission occurred only when all mice were infected with IAV and was prevented when an IAV-neutralizing antibody was used to inhibit IAV replication in either index mice or contact mice. Together, these data provide novel insights into pneumococcal-influenza synergism and may indicate a previously unappreciated role of IAV in the spread of S. pneumoniae.

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Crossref · 10.1096/fj.09-146779

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  • In experimental in vitro models, viral infections increase the colonization rates of various bacteria in the URT, including S. pneumoniae and H. influenzae.

    “In experimental in vitro models, viral infections increase the colonization rates of various bacteria in the URT (90–95), including S. pneumoniae and H. influenzae (86–88).”

    From Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia. (2018) · cites this paper as [95]

  • In a study of mice colonized with S. pneumoniae and then infected with influenza A virus 3 days after, S. pneumoniae transmission occurred only when all mice were infected with influenza and was blocked by an influenza-neutralizing antibody.

    “In a study of mice colonized with S. pneumoniae and then infected with influenza A virus 3 days after, S. pneumoniae transmission occurred only when all mice were infected with influenza and was blocked by an influenza-neutralizing antibody”

    From Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia. (2018) · cites this paper as [95]

  • Animal studies using murine models have shown that influenza predisposes to bacterial pneumonia.

    “Animal studies using murine models have shown that influenza predisposes to bacterial pneumonia.”

    From Bacterial and viral infections associated with influenza (2013) · cites this paper as [9]

  • In another study using infant mice, influenza virus was shown to be essential for pneumococcal transmission in a co-housed group.

    “In another study using infant mice, influenza virus was shown to be essential for pneumococcal transmission in a co‐housed group”

    From Bacterial and viral infections associated with influenza (2013) · cites this paper as [9]

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Authors
Diavatopoulos, D. A., Short, K. R., Price, J. T., Wilksch, J. J., Brown, L. E., Briles, D. E., Strugnell, R. A., & Wijburg, O. L.
Affiliations
  • The University of Melbourne (AU)
  • Monash University (AU)
  • University of Alabama at Birmingham (US)
Corresponding author
Diavatopoulos, Dimitri A.
ORCID
Venue
The FASEB Journal
Publisher
Wiley
Published
2010-01-22
Volume
24
Issue
6
Pages
1789-1798
ISSN
  • 0892-6638 (ISSN-L)
  • 1530-6860
DOI
10.1096/fj.09-146779
OpenAlex
W2145411867
Cited by
192
References
46
Citations by year
2026: 5 · 2025: 8 · 2024: 7 · 2023: 15 · 2022: 8 · 2021: 12 · 2020: 10 · 2019: 9 · 2018: 13 · 2017: 16 · 2016: 17 · 2015: 13 · 2014: 16 · 2013: 23 · 2012: 10
FWCI
9.77
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • The FASEB Journal (publishedVersion)
  • PubMed (publishedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
Keywords
Streptococcus pneumoniae, influenza A virus, pneumococcal transmission, nasopharyngeal carriage, neonatal mice, animal models, in vivo imaging, bacterial co-infection, pneumococcal infection
MeSH terms
Animals, Animals, Newborn, Cells, Cultured, Dogs, Female, Kidney, Lung, Mice, Inbred C57BL, Nasopharynx, Influenza A virus, Pneumonia, Pneumococcal, Streptococcus pneumoniae, Virus Replication, Viral Load, Mice

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