Myostatin Knockout Drives Browning of White Adipose Tissue through Activating the AMPK-PGC1α-Fndc5 Pathway in Muscle

Brown Adipose Tissue: Function and Physiological Significance

CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810

Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member

McPherron, A. C., Lawler, A. M., & Lee, S.-J. (1997) · Nature · doi:10.1038/387083a0 · Cited by 4,013

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

Wu, J., Boström, P., Sparks, L. M., Li, Y., Choi, J. H., Giang, A.-H., Khandekar, M. J., Virtanen, K. A., Nuutila, P., Schaart, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.016 · Cited by 3,406

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

Fisher, F. M., Kleiner, S., Douris, N., Fox, E. C., Mepani, R. J., Verdeguer, F., Wu, J., Kharitonenkov, A., Flier, J. S., Maratos-Flier, E., et al. (2012) · Genes & Development · doi:10.1101/gad.177857.111 · Cited by 1,478

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

Seale, P., Conroe, H. M., Estall, J. L., Kajimura, S., Frontini, A., Ishibashi, J., Cohen, P., Cinti, S., & Spiegelman, B. M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci44271 · Cited by 1,273

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

Tseng, Y.-H., Kokkotou, E., Schulz, T. J., Huang, T. L., Winnay, J. N., Taniguchi, C. M., Tran, T. T., Suzuki, R., Espinoza, D. O., Yamamoto, Y., et al. (2008) · Nature · doi:10.1038/nature07221 · Cited by 1,099

Myostatin, a Negative Regulator of Muscle Growth, Functions by Inhibiting Myoblast Proliferation

Thomas, M., Langley, B., Berry, C., Sharma, M., Kirk, S., Bass, J., & Kambadur, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004356200 · Cited by 1,014

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

Qiang, L., Wang, L., Kon, N., Zhao, W., Lee, S., Zhang, Y., ROSENBAUM, M. S., Zhao, Y., Gu, W. J., Farmer, S. R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.027 · Cited by 816

Myostatin negatively regulates satellite cell activation and self-renewal

McCroskery, S., Thomas, M., Maxwell, L., Sharma, M., & Kambadur, R. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200207056 · Cited by 784

Bone and muscle crosstalk in ageing and disease

Kirk, B., Lombardi, G., & Duque, G. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01088-x · Cited by 89

Exploring the Role of Skeletal Muscle in Insulin Resistance: Lessons from Cultured Cells to Animal Models

Feraco, A., Gorini, S., Armani, A., Camajani, E., Rizzo, M., & Caprio, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179327 · Cited by 78

The role of sex, adiposity, and gonadectomy in the regulation of irisin secretion

Zügel, M., Qiu, S., Laszlo, R., Bosnyák, E., Weigt, C., Müller, D. R., Diel, P. R., Steinacker, J. M., & Schümann, U. (2016) · Endocrine · doi:10.1007/s12020-016-0913-x · Cited by 76

Irisin prevents dexamethasone-induced atrophy in C2C12 myotubes

Chang, J. S., & Kong, I. D. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02367-4 · Cited by 74

Nutrient regulation of somatic growth in teleost fish. The interaction between somatic growth, feeding and metabolism

Canosa, L. F., & Bertucci, J. I. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.111029 · Cited by 72

Regulation of brown adipocyte metabolism by myostatin/follistatin signaling

Singh, R., Braga, M., & Pervin, S. (2014) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2014.00060 · Cited by 71

Irisin in obesity and type 2 diabetes

Højlund, K., & Boström, P. (2013) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2013.04.002 · Cited by 76

The New Role of AMP-Activated Protein Kinase in Regulating Fat Metabolism and Energy Expenditure in Adipose Tissue

Wang, Q., Sun, J., Liu, M., Zhou, Y., Zhang, L., & Li, Y. (2021) · Biomolecules · doi:10.3390/biom11121757 · Cited by 77

The beneficial effects of betaine on dysfunctional adipose tissue and N6-methyladenosine mRNA methylation requires the AMP-activated protein kinase α1 subunit

Zhou, X., Chen, J., Chen, J., Wu, W.-C., Wang, X., & Wang, Y. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.08.014 · Cited by 69

Lkb1 Is Indispensable for Skeletal Muscle Development, Regeneration, and Satellite Cell Homeostasis

Shan, T., Zhang, P., Liang, X., Bi, P., Yue, F., & Kuang, S. (2014) · Stem Cells · doi:10.1002/stem.1788 · Cited by 74

Circulating irisin and glucose metabolism in overweight/obese women: effects of α-lipoic acid and eicosapentaenoic acid

Huerta, A. E., Prieto-Hontoria, P. L., Fernández‐Galilea, M., Sáinź, N., Cuervo, M., Martínez, J. A., & Moreno-Aliaga, M. J. (2015) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-015-0400-5 · Cited by 70

Alpha-glucosidase inhibitor 1-Deoxynojirimycin promotes beige remodeling of 3T3-L1 preadipocytes via activating AMPK

Li, A.-N., Chen, J.-J., Li, Q.-Q., Zeng, G.-Y., Chen, Q.-Y., Chen, J.-L., Liao, Z.-M., Jin, P., Wang, K.-S., & Yang, Z.-C. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.01.023 · Cited by 69

Myostatin signals through miR-34a to regulate Fndc5 expression and browning of white adipocytes

Ge, X., Sathiakumar, D., Lua, B.-N., Kukreti, H., Lee, M., & McFarlane, C. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.110 · Cited by 67

Taming the Flames: Targeting White Adipose Tissue Browning in Hypermetabolic Conditions

Abdullahi, A., & Jeschke, M. G. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00163 · Cited by 68

Therapeutic applications and challenges in myostatin inhibition for enhanced skeletal muscle mass and functions

Wetzlich, B., Nyakundi, B. B., & Yang, J. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05120-y · Cited by 74

Irisin mRNA and circulating levels in relation to other myokines in healthy and morbidly obese humans

Vamvini, M. T., Aronis, K. N., Panagiotou, G., Huh, J. Y., Chamberland, J. P., Brinkoetter, M. T., Petrou, M., Christophi, C. A., Kales, S. N., Christiani, D. C., et al. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0276 · Cited by 65

Skeletal muscle as a therapeutic target for delaying type 1 diabetic complications

Coleman, S. K. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i17.1323 · Cited by 67

Effects and Molecular Mechanism of GST-Irisin on Lipolysis and Autocrine Function in 3T3-L1 Adipocytes

Gao, S., Li, F., Li, H., Yi, H., Liu, Y., & Chen, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147480 · Cited by 63

Role of Irisin on the bone–muscle functional unit

Colaianni, G., & Grano, M. (2015) · BoneKEy Reports · doi:10.1038/bonekey.2015.134 · Cited by 58

Combined training, FNDC5/irisin levels and metabolic markers in obese men: A randomised controlled trial

Bonfante, I. L. P., Chacon‐Mikahil, M. P. T., Brunelli, D. T., Gáspari, A. F., Duft, R. G., Lopes, W. A., Bonganha, V., Libardi, C. A., & Cavaglieri, C. R. (2017) · European Journal of Sport Science · doi:10.1080/17461391.2017.1296025 · Cited by 60

Nonmuscle Tissues Contribution to Cancer Cachexia

Argilés, J. M. A., Stemmler, B., López-Soriano, F. J., & Busquets, S. (2015) · Mediators of Inflammation · doi:10.1155/2015/182872 · Cited by 59

Myostatin inhibits glucose uptake via suppression of insulin-dependent and -independent signaling pathways in myoblasts

Liu, X., Bauman, W. A., & Cardozo, C. P. (2018) · Physiological Reports · doi:10.14814/phy2.13837 · Cited by 61

Irisin counteracts high glucose and fatty acid-induced cytotoxicity by preserving the AMPK-insulin receptor signaling axis in C2C12 myoblasts

Yano, N., Zhang, L., Wei, D., Dubielecka, P. M., Lei, W., Zhuang, S., Zhu, P., Qin, G., Liu, P. Y., Chin, Y. E., et al. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00219.2019 · Cited by 59

The weight of nutrients: kynurenine metabolites in obesity and exercise

Dadvar, S., Ferreira, D. M. S., Červenka, I., & Ruas, J. L. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12830 · Cited by 59

Low Dietary n-6/n-3 PUFA Ratio Regulates Meat Quality, Reduces Triglyceride Content, and Improves Fatty Acid Composition of Meat in Heigai Pigs

Nong, Q., Wang, L., Zhou, Y., Sun, Y., Chen, W., Xie, J., Zhu, X., & Shan, T. (2020) · Animals · doi:10.3390/ani10091543 · Cited by 57

FNDC5: A novel player in metabolism and metabolic syndrome.

Cao, R. Y., Zheng, H., Redfearn, D., & Yang, J. (2019) · Biochimie · doi:10.1016/j.biochi.2019.01.001 · Cited by 49

Combination of Capsaicin and Capsiate Induces Browning in 3T3-L1 White Adipocytes via Activation of the Peroxisome Proliferator-Activated Receptor γ/β3-Adrenergic Receptor Signaling Pathways

Fan, L., Xu, H., Yang, R., Zang, Y., Chen, J., & Qin, H. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b02191 · Cited by 57

Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease

Caria, A. C. I., Nonaka, C. K. V., Cavalcante, B. R. R., Sousa, R. A. L. D., Aras, R., & Souza, B. S. D. F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144977 · Cited by 57

Cordycepin promotes browning of white adipose tissue through an AMP-activated protein kinase (AMPK)-dependent pathway

Qi, G., Zhou, Y., Zhang, X., Yu, J., Li, X., Cao, X., Wu, C., & Guo, P. (2018) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2018.10.004 · Cited by 54

Follistatin targets distinct pathways to promote Brown adipocyte characteristics in Brown and white adipose tissues

Singh, R., Braga, M., Reddy, S. T., Lee, S.-J., Parveen, M., Grijalva, V., Vergnes, L., & Pervin, S. (2017) · Endocrinology · doi:10.1210/en.2016-1607 · Cited by 54

Cryptotanshinone promotes commitment to the brown adipocyte lineage and mitochondrial biogenesis in C3H10T1/2 mesenchymal stem cells via AMPK and p38-MAPK signaling

Imran, K. M., Rahman, N., Yoon, D., Jeon, M., Lee, B., & Kim, Y. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.08.001 · Cited by 54

Regulation of angiopoietin-like protein 4 production during and after exercise

Norheim, F., Hjorth, M., Langleite, T. M., Lee, S., Holen, T., Bindesbøll, C., Stadheim, H. K., Gulseth, H. L., Birkeland, K. I., Kielland, A., et al. (2014) · Physiological Reports · doi:10.14814/phy2.12109 · Cited by 53

Magnolol promotes thermogenesis and attenuates oxidative stress in 3T3-L1 adipocytes

Parray, H. A., Lone, J. B., Park, J. P., Choi, J. W., & Yun, J. W. (2018) · Nutrition · doi:10.1016/j.nut.2018.01.017 · Cited by 54

Current Evidence of the Role of the Myokine Irisin in Cancer

Tsiani, E., Tsakiridis, N., Kouvelioti, R., Jaglanian, A., & Klentrou, P. (2021) · Cancers · doi:10.3390/cancers13112628 · Cited by 52

High Serum Irisin Level as an Independent Predictor of Diabetes Mellitus

Huh, J. H., Ahn, S. V., Choi, J. H., Koh, S. B., & Chung, C. H. (2016) · Medicine · doi:10.1097/md.0000000000003742 · Cited by 51

Natural alkaloid bouchardatine ameliorates metabolic disorders in high‐fat diet‐fed mice by stimulating the sirtuin 1/liver kinase B‐1/AMPK axis

Rao, Y., Yu, H., Gao, L., Lu, Y., Zhao, X. D., Liu, H., Gu, L., Ye, J., & Huang, Z. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13855 · Cited by 51

Heterogeneous lineage origin underlies phenotypic and molecular differences of white and beige adipocytes

Liu, W., Shan, T., Yang, X., Liang, S., Zhang, P., Liu, Y., Liu, X., & Kuang, S. (2013) · Journal of Cell Science · doi:10.1242/jcs.124321 · Cited by 50

Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions

Wang, T., Zhou, D., & Hong, Z. (2025) · MedComm · doi:10.1002/mco2.70030 · Cited by 46

Loss-of-function myostatin mutation increases insulin sensitivity and browning of white fat in Meishan pigs

Cai, C., Qian, L., Jiang, S., Sun, Y., Wang, Q., Ma, D., Xiao, G., Li, B., Xie, S., Gao, T., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.16822 · Cited by 51

Whole Body Vibration: A Valid Alternative Strategy to Exercise?

Bonanni, R., Cariati, I., Romagnoli, C., D’Arcangelo, G., Annino, G., & Tancredi, V. (2022) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk7040099 · Cited by 48

Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers

Wang, B., Nie, W., Fu, X., de Avila, J. M., Ma, Y., Zhu, M. J., Maquivar, M., Parish, S. M., Busboom, J. R., Nelson, M. L., et al. (2018) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-018-0296-3 · Cited by 50

Myostatin/Activin Receptor Ligands in Muscle and the Development Status of Attenuating Drugs

Rodgers, B. D., & Ward, C. W. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnab030 · Cited by 111

Irisin treatment improves healing of dystrophic skeletal muscle

Reza, M. M., Sim, C. M., Subramaniyam, N., Ge, X., Sharma, M., Kambadur, R., & McFarlane, C. (2017) · Oncotarget · doi:10.18632/oncotarget.21636 · Cited by 45

Locus Characterization and Gene Expression of Bovine FNDC5: Is the Myokine Irisin Relevant in Cattle?

Komolka, K., Albrecht, E., Schering, L., Brenmoehl, J., Hoeflich, A., & Maak, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088060 · Cited by 44

Breaking BAT: can browning create a better white?

Warner, A., & Mittag, J. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0408 · Cited by 45

Novel Roles of Follistatin/Myostatin in Transforming Growth Factor-β Signaling and Adipose Browning: Potential for Therapeutic Intervention in Obesity Related Metabolic Disorders

Pervin, S., Reddy, S. T., & Singh, R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.653179 · Cited by 42

The Role of Crosstalk between Adipose Cells and Myocytes in the Pathogenesis of Sarcopenic Obesity in the Elderly

Zamboni, M. M., Mazzali, G., Brunelli, A., Saatchi, T., Urbani, S., Giani, A., Rossi, A. P., Zoico, E., & Fantin, F. (2022) · Cells · doi:10.3390/cells11213361 · Cited by 47

Impact of exercise on muscle and nonmuscle organs

Boström, P., Graham, E. L., Georgiadi, A., & Ma, X. (2013) · IUBMB Life · doi:10.1002/iub.1209 · Cited by 50

IMB0901 inhibits muscle atrophy induced by cancer cachexia through MSTN signaling pathway

Liu, D., Qiao, X., Ge, Z., Shang, Y., Li, Y., Wang, W., Chen, M., Si, S., & Chen, S. (2019) · Skeletal Muscle · doi:10.1186/s13395-019-0193-2 · Cited by 42

Muscle-Bone Crosstalk in Chronic Obstructive Pulmonary Disease

Zhang, L., & Sun, Y. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.724911 · Cited by 42

Exercise-Induced Muscle–Fat Crosstalk: Molecular Mediators and Their Pharmacological Modulation for the Maintenance of Metabolic Flexibility in Aging

Tero-Vescan, A., Degens, H., Matsakas, A., Ștefănescu, R., Ősz, B. E., & Slevin, M. (2025) · Pharmaceuticals · doi:10.3390/ph18081222 · Cited by 44

Effects of a Phosphodiesterase inhibitor on the Browning of Adipose Tissue in Mice

Seo, D. H., Shin, E., Lee, Y., Park, S., Nam, K. T., Kim, J. W., & Soo, B. (2022) · Biomedicines · doi:10.3390/biomedicines10081852 · Cited by 41

A focused review of myokines as a potential contributor to muscle hypertrophy from resistance-based exercise

Cornish, S. M., Bugera, E. M., Duhamel, T. A., Peeler, J. D., & Anderson, J. E. (2020) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04337-1 · Cited by 43

Brown and beige adipose tissues: phenotype and metabolic potential in mice and men

Chechi, K., Lichtenbelt, W. D. V. M., & Richard, D. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00021.2017 · Cited by 40

Muscle-Bone Crosstalk in Chronic Kidney Disease: The Potential Modulatory Effects of Exercise

Leal, D. V., Ferreira, A., Watson, E. L., Wilund, K. R., & Viana, J. L. (2021) · Calcified Tissue International · doi:10.1007/s00223-020-00782-4 · Cited by 40

CRISPR/Cas9 system-based myostatin-targeted disruption promotes somatic growth and adipogenesis in loach, Misgurnus anguillicaudatus

Tao, B., Tan, J., Chen, L., Xu, Y., Liao, X., Li, Y., Chen, J., Song, Y., & Hu, W. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.737097 · Cited by 40

Skeletal Muscle as a Mediator of Interorgan Crosstalk During Exercise: Implications for Aging and Obesity

Shero, J. A., Lindholm, M. E., Sandri, M. F., & Stanford, K. I. (2025) · Circulation Research · doi:10.1161/circresaha.124.325614 · Cited by 45

Effects of dapagliflozin on the serum levels of fibroblast growth factor 21 and myokines and muscle mass in Japanese patients with type 2 diabetes: A randomized, controlled trial

Yamakage, H., Tanaka, M., Inoue, T., Odori, S., Kusakabe, T., & Satoh‐Asahara, N. (2019) · Journal of Diabetes Investigation · doi:10.1111/jdi.13179 · Cited by 39

Adiponectin/SIRT1 Axis Induces White Adipose Browning After Vertical Sleeve Gastrectomy of Obese Rats with Type 2 Diabetes

Liu, L., Zhang, T., Hu, J., Ma, R., He, B., Wang, M., & Wang, Y. (2019) · Obesity Surgery · doi:10.1007/s11695-019-04295-4 · Cited by 40

Beige Adipocyte as the Flame of White Adipose Tissue: Regulation of Browning and Impact of Obesity

Altınova, A. E. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab921 · Cited by 39

Lkb1 Deletion Promotes Ectopic Lipid Accumulation in Muscle Progenitor Cells and Mature Muscles

Shan, T., Zhang, P., Bi, P., & Kuang, S. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24831 · Cited by 37

Serum irisin and myostatin levels after 2 weeks of high-altitude climbing

Śliwicka, E., Cisoń, T., Kasprzak, Z., Nowak, A., & Pilaczyńska-Szczȩśniak, Ł. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181259 · Cited by 36

Mammalian target of rapamycin is essential for cardiomyocyte survival and heart development in mice

Zhang, P., Shan, T., Liang, X., Deng, C., & Kuang, S. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.08.046 · Cited by 35

Irisin regulates cardiac physiology in zebrafish

Sundarrajan, L., Yeung, C., Hahn, L., Weber, L. P., & Unniappan, S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181461 · Cited by 35

Muscle fiber-type conversion in the transgenic pigs with overexpression of PGC1α gene in muscle

Fei, Y., Zhang, L., Bu, G., Xiong, Y., & Zuo, B. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.10.113 · Cited by 35

AMP-activated protein kinase is required for the anti-adipogenic effects of alpha-linolenic acid

Zhou, X., Wu, W.-C., Chen, J., Wang, X., & Wang, Y. (2015) · Nutrition & Metabolism · doi:10.1186/s12986-015-0006-5 · Cited by 34

The Heating Microenvironment: Intercellular Cross Talk Within Thermogenic Adipose Tissue

Knights, A. J., Wu, J., & Tseng, Y. (2020) · Diabetes · doi:10.2337/db20-0303 · Cited by 35

Do Bariatric Surgeries Enhance Brown/Beige Adipose Tissue Thermogenesis?

Hankir, M. K., & Seyfried, F. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00275 · Cited by 34

Myostatin inhibition therapy for insulin-deficient type 1 diabetes

Coleman, S. K., Rebalka, I. A., D’Souza, D. M., Deodhare, N., Desjardins, E. M., & Hawke, T. J. (2016) · Scientific Reports · doi:10.1038/srep32495 · Cited by 34

AMP-Activated Kinase (AMPK) Activation by AICAR in Human White Adipocytes Derived from Pericardial White Adipose Tissue Stem Cells Induces a Partial Beige-Like Phenotype

Abdul-Rahman, O., Kristóf, E., Doan‐Xuan, Q., Vida, A., Nagy, L., Horváth, A., Simon, J., Maros, T., Szentkirályi, I., Palotás, L., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157644 · Cited by 32

Exercise‐Induced cytokines, diet, and inflammation and their role in adipose tissue metabolism

Al‐Ibraheem, A. M. T., Hameed, A. A. Z., Marsool, M. D. M., Jain, H., Prajjwal, P., Khazmi, I., Nazzal, R., Al-Najati, H. M. H., Al‐Zuhairi, B. H. Y. K., Razzaq, M., et al. (2024) · Health Science Reports · doi:10.1002/hsr2.70034 · Cited by 33

Combined Strategies for Maintaining Skeletal Muscle Mass and Function in Aging: Myostatin Inactivation and AICAR-Associated Oxidative Metabolism Induction

Pauly, M., Chabi, B., Favier, F. B., Vanterpool, F., Matecki, S., Fouret, G., Bonafos, B., Vernus, B., Feillet‐Coudray, C., Coudray, C., et al. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu147 · Cited by 29

Myostatin Attenuation In Vivo Reduces Adiposity, but Activates Adipogenesis

Li, N., Yang, Q., Walker, R. G., Thompson, T. B., Du, ‬., & Rodgers, B. D. (2015) · Endocrinology · doi:10.1210/en.2015-1546 · Cited by 29

From Exercise to Cognitive Performance: Role of Irisin

Pesce, M., Fratta, I. L., Paolucci, T., Grilli, A., Patruno, A., Agostini, F., Bernetti, A., Mangone, M., Paoloni, M., Invernizzi, M., et al. (2021) · Applied Sciences · doi:10.3390/app11157120 · Cited by 29

Induced expression of Fndc5 significantly increased cardiomyocyte differentiation rate of mouse embryonic stem cells

Rabiee, F., Forouzanfar, M., Zadegan, F. G., Tanhaei, S., Ghaedi, K., Motovali-Bashi, M., Baharvand, H., & Nasr‐Esfahani, M. H. (2014) · Gene · doi:10.1016/j.gene.2014.08.045 · Cited by 29

Irisin promotes the browning of white adipocytes tissue by AMPKα1 signaling pathway

Luo, X., Li, J., Zhang, H., Wang, Y., Shi, H., Ge, Y., Yu, X., Wang, H., & Dong, Y. (2022) · Research in Veterinary Science · doi:10.1016/j.rvsc.2022.08.025 · Cited by 25

The key role of myostatin b in somatic growth in fishes derived from distant hybridization

Liu, Q., Duan, L., Li, B., Zhang, X., Liu, F., Yu, J., Shu, Y., Hu, F., Lin, J., Xiong, X., et al. (2024) · Science China Life Sciences · doi:10.1007/s11427-023-2487-8 · Cited by 26

Local myostatin inhibition improves skeletal muscle glucose uptake in insulin-resistant high-fat diet-fed mice

Eilers, W., Chambers, D. J., Cleasby, M. E., & Foster, K. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00185.2019 · Cited by 29

Molecular pathways regulating the formation of brown‐like adipocytes in white adipose tissue

Fu, J., Li, Z., Zhang, H., Mao, Y., Wang, A., Wang, X., Zou, Z., & Zhang, X. (2014) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2600 · Cited by 29

Intraperitoneal administration of follistatin promotes adipocyte browning in high-fat diet-induced obese mice

Li, H., Zhang, C., Liu, J., Xie, W., Xu, W., Liang, F., Huang, K., & He, X. (2019) · PLoS ONE · doi:10.1371/journal.pone.0220310 · Cited by 26

The Controversial Role of Irisin in Clinical Management of Coronary Heart Disease

Ou-Yang, W.-L., Guo, B., Xu, F., Lin, X., Li, F., Shan, S., Wu, F., Wang, Y., Zheng, M.-H., Xu, Q.-S., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.678309 · Cited by 25

Whole Body Vibration Improves Brain and Musculoskeletal Health by Modulating the Expression of Tissue-Specific Markers: FNDC5 as a Key Regulator of Vibration Adaptations

Cariati, I., Bonanni, R., Pallone, G., Romagnoli, C., Rinaldi, A. M., Annino, G., D’Arcangelo, G., & Tancredi, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810388 · Cited by 25

Contribution of High-Intensity Interval Exercise in the Fasted State to Fat Browning: Potential Roles of Lactate and β-Hydroxybutyrate

Kim, S., Park, D., LEE, S.-H., Kwak, H., & Kang, J. (2023) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003136 · Cited by 25

Fighting obesity: When muscle meets fat

Yang, X., Bi, P., & Kuang, S. (2014) · Adipocyte · doi:10.4161/21623945.2014.964075 · Cited by 25

Irisin and Fibronectin Type III Domain-Containing 5 Responses to Exercise in Different Environmental Conditions

Bubak, M. P., Heesch, M., Shute, R. J., Dinan, N. E., Laursen, T. L., Salle, D. T. L., & Slivka, D. R. (2017) · International journal of exercise science · doi:10.70252/xkmw8211 · Cited by 24

Irisin Serum Levels and Skeletal Muscle Assessment in a Cohort of Charcot-Marie-Tooth Patients

Colaianni, G., Oranger, A., Dicarlo, M., Lovero, R., Storlino, G., Pignataro, P., Fontana, A., Serio, F. D., Ingravallo, A., Caputo, G., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.886243 · Cited by 25

Serum myostatin levels are associated with abdominal aortic calcification in dialysis patients

Lee, S. M., Kim, S. E., Lee, J. Y., Jeong, H. J., Son, Y. K., & An, W. S. (2019) · Kidney Research and Clinical Practice · doi:10.23876/j.krcp.19.019 · Cited by 23

Myostatin inhibits porcine intramuscular preadipocyte differentiation in vitro

Sun, W. X., Dodson, M. V., Jiang, Z., Yu, S., Chu, W., & Chen, J. (2015) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2015.10.005 · Cited by 23

Myostatin regulates energy homeostasis through autocrine- and paracrine-mediated microenvironment communication

Wang, H., Guo, S., Gao, H., Ding, J., Li, H., Kong, X., Zhang, S., He, M., Feng, Y., Wu, W., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci178303 · Cited by 22

Physical Activity and Post-Transcriptional Regulation of Aging Decay: Modulation of Pathways in Postmenopausal Osteoporosis

Vita, F., Gangemi, S., Pioggia, G., Trimarchi, F., & Mauro, D. D. (2022) · Medicina · doi:10.3390/medicina58060767 · Cited by 20

Altered bone‐regulating myokine expression in skeletal muscle Of Duchenne muscular dystrophy mouse models

Zhou, S., Qian, B., Wang, L., Zhang, C., Hogan, M. V., & Li, H. (2018) · Muscle & Nerve · doi:10.1002/mus.26195 · Cited by 22

Dysregulated myokines and signaling pathways in skeletal muscle dysfunction in a cigarette smoke–induced model of chronic obstructive pulmonary disease

Zhang, L., Li, C., Xiong, J., Chang, C. H., & Sun, Y. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.929926 · Cited by 22

Skeletal muscle AMPK is essential for the maintenance of FNDC5 expression

Lally, J., Ford, R. J., Johar, J., Crane, J. D., Kemp, B. E., & Steinberg, G. R. (2015) · Physiological Reports · doi:10.14814/phy2.12343 · Cited by 21

Role and Functions of Irisin: A Perspective on Recent Developments and Neurodegenerative Diseases

Minuti, A., Raffaele, I., Scuruchi, M., Lui, M., Muscarà, C., & Calabrò, M. (2025) · Antioxidants · doi:10.3390/antiox14050554 · Cited by 27

Unlocking the Therapeutic Potential of Irisin: Harnessing Its Function in Degenerative Disorders and Tissue Regeneration

Zhang, Y., Wang, L., Kang, H., Lin, C.-Y. J., & Fan, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076551 · Cited by 21

Mitochondria-associated regulation in adipose tissues and potential reagents for obesity intervention

Zheng, Y., Ni, Y., Pang, Y., Gong, Y., Yang, H., Ding, W., & Yang, H. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1132342 · Cited by 20

Findings as a starting point to unravel the underlying mechanisms of in vivo interactions involving Wnt10a in bone, fat and muscle

Tsukamoto, M., Wang, K., Tasaki, T., Murata, Y., Okada, Y., Yamanaka, Y., Nakamura, E., Yamada, S., Izumi, H., Zhou, Q., et al. (2018) · Bone · doi:10.1016/j.bone.2018.10.009 · Cited by 20

Maternal inheritance of circulating irisin in humans

Al‐Daghri, N. M., Al-Attas, O. S., Alokail, M. S., Alkharfy, K. M., Yousef, M., Vinodson, B., Amer, O. E., Alnaami, A. M., Sabico, S., Tripathi, G., et al. (2014) · Clinical Science · doi:10.1042/cs20130426 · Cited by 18

Natural constituents from food sources: potential therapeutic agents against muscle wasting

Shen, S., Yu, H., Gan, L., Yang, Y., & Lin, L. (2019) · Food & Function · doi:10.1039/c9fo00912d · Cited by 20

Endocrine Mechanisms Connecting Exercise to Brown Adipose Tissue Metabolism: a Human Perspective

Méndez-Gutiérrez, A., Osuna‐Prieto, F. J., Aguilera, C. M., Ruiz, J. R., & Sánchez‐Delgado, G. (2020) · Current Diabetes Reports · doi:10.1007/s11892-020-01319-7 · Cited by 17

Myostatin signals through miR-34a to regulate Fndc5 expression and browning of white adipocytes

Ge, X., Sathiakumar, D., Lua, B.-N., Kukreti, H., Lee, M., & McFarlane, C. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.110 · Cited by 67

Effects of Myostatin Gene Knockout on White Fat Browning and Related Gene Expression in Type 2 Diabetic Mice

Cheng, J., Lee, J., Liu, Y., Wang, Y., Duan, M., & Zeng, Z. (2023) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/171300 · Cited by 7

Skeletal muscle-secreted myokine interleukin-6 induces white adipose tissue conversion into beige adipose tissue in myostatin gene knockout pigs

Xuan, M., Luo, Z., Han, S., Li, Z., Gao, K., Liu, X.-Y., Chang, S.-Y., Jin, Z., Choe, H., Paek, H., et al. (2021) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2021.106679 · Cited by 16

Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice

Zhang, C., McFarlane, C., Lokireddy, S., Masuda, S., Ge, X., Gluckman, P. D., Sharma, M., & Kambadur, R. (2012) · Diabetologia · doi:10.1007/s00125-011-2304-4 · Cited by 192

Effect of Myostatin Gene Knockout on Browning of White Fat and Related Gene Expression Levels in a Mouse Model of Type 2 Diabetes Mellitus

Jingwei CHENG, Y. L. (2022) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.12114/j.issn.1007-9572.2022.0178