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Sestrin2 promotes LKB1‐mediated AMPK activation in the ischemic heart
Abstract
The regulation of AMPK in the ischemic heart remains incompletely understood. Recent evidence implicates the role of Sestrin2 in the AMPK signaling pathway, and it is hypothesized that Sestrin2 plays an influential role during myocardial ischemia to promote AMPK activation. Sestrin2 protein was found to be expressed in adult cardiomyocytes and accumulated in the heart during ischemic conditions. Sestrin2 knockout (KO) mice were used to determine the importance of Sestrin2 during ischemia and reperfusion (I/R) injury. When wild‐type (WT) and Sestrin2 KO mice were subjected to in vivo I/R, myocardial infarct size was significantly greater in Sestrin2 KO compared with WT hearts. Similarly, Langendorff perfused hearts indicated exacerbated postischemic contractile function in Sestrin2 KO hearts compared with WT. Ischemic AMPK activation was found to be impaired in the Sestrin2 KO hearts. Immunoprecipitation of Sestrin2 demonstrated an association with AMPK. Moreover, liver kinase B1 (LKB1), a major AMPK upstream kinase, was associated with the Sestrin2‐AMPK complex in a time‐dependent manner during ischemia, whereas this interaction was nearly abolished in Sestrin2 KO hearts. Thus, Sestrin2 plays an important role in cardioprotection against I/R injury, serving as an LKB1‐AMPK scaffold to initiate AMPK activation during ischemic insults.—Morrison, A., Chen, L. Wang, J., Zhang, M., Yang, H., Ma, Y., Budanov, A., Lee, J. H., Karin, M., Li, J. Sestrin2 promotes LKB1‐mediated AMPK activation in the ischemic heart. FASEB J . 29, 408‐417 (2015). www.fasebj.org
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“Mutant p53 has been proven to inhibit autophagy via different mechanisms.163–166”
From p53: from understanding its structure to advances in therapeutic targeting (2026) · cites this paper as [164]
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“Sestrin-1 and Sestrin-2 can interact with the AMPK complex and promote its phosphorylation.164”
From p53: from understanding its structure to advances in therapeutic targeting (2026) · cites this paper as [164]
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“The second pathway involves the transcriptional inhibition of AMPK activators such as Sestrin-1/Sestrin-2 by mutant p53.”
From p53: from understanding its structure to advances in therapeutic targeting (2026) · cites this paper as [164]
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Shaw, R. J., Kosmatka, M., Bardeesy, N., Hurley, R. L., Witters, L. A., DePinho, R. A., & Cantley, L. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308061100 · Cited by 1,797
Antman, E. M., Tanasijevic, M. J., Thompson, B., Schactman, M., McCabe, C. H., Cannon, C. P., Fischer, G. A., Fung, A. Y., Thompson, C., Wybenga, D., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610313351802 · Cited by 1,749
Claycomb, W. C., Lanson, N. A., Stallworth, B. S., Egeland, D. B., Delcarpio, J. B., Bahinski, A., & Izzo, N. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.2979 · Cited by 1,546
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Self-citationRussell, R. R., Li, J., Coven, D. L., Pypaert, M., Zechner, C., Palmeri, M., Giordano, F. J., Mu, J., Birnbaum, M. J., & Young, L. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19297 · Cited by 738
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Lee, J. H., Budanov, A. V., Talukdar, S., Park, E. J., Park, H. L., Park, H.-W., Bandyopadhyay, G., Li, N., Aghajan, M., Jang, I., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.08.004 · Cited by 295
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Self-citationMa, H., Wang, J., Thomas, D. P., Tong, C., Leng, L., Wang, W., Merk, M., Zierow, S., Bernhagen, J., Ren, J., et al. (2010) · Circulation · doi:10.1161/circulationaha.110.953208 · Cited by 164
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Research works printed but not linked: 30
- 10.1016/j.bcp.2011.04.004 · DOI
- 10.1016/j.apsb.2012.06.001 · DOI
- 10.1161/CIRCULATIONAHA.112.000862 · DOI
- 10.1111/j.1538-7836.2012.04833.x · DOI
- 10.1152/ajpendo.00234.2004 · DOI · Paper page
- 10.1016/j.yjmcc.2011.03.003 · DOI · Paper page
- 10.1161/01.RES.0000261924.76669.36 · DOI · Paper page
- 10.1074/jbc.271.44.27879 · DOI · Paper page
- 10.1161/01.RES.0000155723.53868.d2 · DOI
- 10.1042/bj3450437 · DOI · Paper page
- 10.1152/ajpendo.00443.2005 · DOI · Paper page
- 10.1074/jbc.M411810200 · DOI
- 10.1038/sj.onc.1205877 · DOI · Paper page
- 10.1016/j.febslet.2009.10.017 · DOI
- 10.1152/ajplung.00250.2011 · DOI
- 10.1016/j.lfs.2014.01.006 · DOI
- 10.1152/ajpheart.00137.2011 · DOI
- 10.1111/j.1538-7836.2011.04331.x · DOI
- 10.1096/fj.12-216473 · DOI
- 10.1161/01.RES.0000187458.77026.10 · DOI · Paper page
- 10.1111/jth.12243 · DOI
- 10.1007/s00439-003-0917-5 · DOI
- 10.1161/01.CIR.66.6.1146 · DOI · Paper page
- 10.1016/S0960-9822(00)00742-9 · DOI · Paper page
- 10.1371/journal.pone.0032035 · DOI
- 10.1073/pnas.96.16.9248 · DOI · Paper page
- 10.4161/cc.8.10.8498 · DOI · Paper page
- 10.1126/science.1095569 · DOI · Paper page
- 10.1038/sj.onc.1210411 · DOI · Paper page
- 10.1111/j.1748-1716.2009.01978.x · DOI
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Metadata
- Authors
- Morrison, A., Chen, L., Wang, J., Zhang, M., Yang, H., Ma, Y., Budanov, A., Lee, J. H., Karin, M., & Li, J.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2014-11-03
- Volume
- 29
- Issue
- 2
- Pages
- 408-417
- ISSN
- 0892-6638
- 1530-6860
- Cited by
- 157
- References
- 11
- Language
- en
- Funders
- American Heart Association (12GRNT11620029, 14IRG18290014)
- National Natural Science Foundation of China (81200195)
- Lawrence Ellison Foundation
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