Skeletal muscle hypertrophy adaptations predominate in the early stages of resistance exercise training, matching deuterium oxide‐derived measures of muscle protein synthesis and mechanistic target of rapamycin complex 1 signaling

Brook, Matthew S.; Wilkinson, Daniel J.; Mitchell, William K.; Lund, Jonathan N.; Szewczyk, Nathaniel J.; Greenhaff, Paul L.; Smith, Ken; Atherton, Philip J.

doi:10.1096/fj.15-273755

Skeletal muscle hypertrophy adaptations predominate in the early stages of resistance exercise training, matching deuterium oxide‐derived measures of muscle protein synthesis and mechanistic target of rapamycin complex 1 signaling

Resistance exercise training (RET) is widely used to increase muscle mass in athletes and also aged/cachectic populations. However, the time course and metabolic and molecular control of hypertrophy remain poorly defined. Using newly developed deuterium oxide (D 2 O)‐tracer techniques, we investi…