The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Endothelial microRNAs regulating the NF‐κB pathway and cell adhesion molecules during inflammation
Abstract
The surface of endothelial cells is covered with cell adhesion molecules, including E‐selectin, intercellula adhesion molecule 1 (ICAM‐1), and vascular cell adhesion molecule 1 (VCAM‐ 1), that mediate the adhesion an extravasation of leukocytes and play pivotal roles in inflammatory response. microRNAs (miRNAs) regulate th expression of these important cell adhesion molecules through two distinct major mechanisms, namely via mod ulating the proinflammatory NF‐κB pathway, which controls their transcription, and via directly targeting them The present review highlights the role of various miRNAs in controlling the expression of E‐selectin, ICAM‐1, an VCAM‐1: a type of regulation that can be harnessed for therapeutic prevention of inflammation‐associated disease such as atherosclerosis and sepsis. The roles of secreted miRNAs as paracrine regulators, and cell adhesio molecule‐based miRNA delivery are also addressed.—Zhong, L., Simard, M. J., Huot, J. Endothelial microRNA regulating the NF‐κB pathway and cell adhesion molecules during inflammation. FASEB J . 32, 4070‐4084 (2018) www.fasebj.org
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The functions of animal microRNAs
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HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells
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ICAM-1 and VCAM-1: Gatekeepers in various inflammatory and cardiovascular disorders
Singh, V., Kaur, R., Kumari, P., Pasricha, C., & Singh, R. (2023) · Clinica Chimica Acta · doi:10.1016/j.cca.2023.117487 · Cited by 432
The effects of sepsis on endothelium and clinical implications
Dolmatova, E. V., Wang, K., Mandavilli, R., & Griendling, K. K. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvaa070 · Cited by 317
Passing the Vascular Barrier: Endothelial Signaling Processes Controlling Extravasation
Wettschureck, N., Strilic, B., & Offermanns, S. (2019) · Physiological Reviews · doi:10.1152/physrev.00037.2018 · Cited by 286
Giuliani, A., Gaetani, S., Sorgentoni, G., Agarbati, S., Laggetta, M., Matacchione, G., Gobbi, M., Rossi, T., Galeazzi, R., Piccinini, G., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.647015 · Cited by 41
PCSK9 inhibition attenuates alcohol-associated neuronal oxidative stress and cellular injury
Wagner, J., Park, L. M., Mukhopadhyay, P., Matyas, C., Trojnar, E., Damadzic, R., Jung, J., Bell, A. S., Mavromatis, L. A., Hamandi, A. M., et al. (2024) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2024.04.022 · Cited by 26
Metadata
- Authors
- Zhong, L., Simard, M. J., & Huot, J.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2018-03-22
- Volume
- 32
- Issue
- 8
- Pages
- 4070-4084
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2792128273
- Cited by
- 207
- References
- 9
- FWCI
- 4.94
- Type
- journal article
- Language
- en
- Open access
- closed
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