Cited by 106Renin-Angiotensin System StudiesSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Angiotensin‐converting enzyme 2 in severe acute respiratory syndrome coronavirus and SARS‐CoV‐2: A double‐edged sword?

Open access
Yan, Tiantian, Xiao, Rong, Lin, Guoan·2020·The FASEB Journal

Abstract

Human angiotensin‐converting enzyme 2 (ACE2) facilitates cellular entry of severe acute respiratory syndrome coronavirus (SARS‐CoV) and SARS‐CoV‐2 as their common receptor. During infection, ACE2‐expressing tissues become direct targets, resulting in serious pathological changes and progressive multiple organ failure or even death in severe cases. However, as an essential component of renin‐angiotensin system (RAS), ACE2 confers protective effects in physiological circumstance, including maintaining cardiovascular homeostasis, fluid, and electrolyte balance. The absence of protective role of ACE2 leads to dysregulated RAS and thus acute changes under multiple pathological scenarios including SARS. This potentially shared mechanism may also be the molecular explanation for pathogenesis driven by SARS‐CoV‐2. We reasonably speculate several potential directions of clinical management including host‐directed therapies aiming to restore dysregulated RAS caused by ACE2 deficiency. Enriched knowledge of ACE2 learned from SARS and COVID‐19 outbreaks can provide, despite their inherent tragedy, informative clues for emerging pandemic preparedness.

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Crossref · 10.1096/fj.202000782

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Authors
Yan, T., Xiao, R., & Lin, G.
Affiliations
Military Burn Center the 990th Hospital of People's Liberation Army Zhumadian China
Corresponding author
Yan, Tiantian
Venue
The FASEB Journal
Publisher
Wiley
Published
2020-04-19
Volume
34
Issue
5
Pages
6017-6026
ISSN
  • 0892-6638 (ISSN-L)
  • 1530-6860
OpenAlex
W3016340352
Cited by
106
References
54
Citations by year
2025: 6 · 2024: 3 · 2023: 10 · 2022: 14 · 2021: 31 · 2020: 42
FWCI
4.11
Type
journal article
Language
en
Open access
Locations
  • The FASEB Journal (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Keywords
angiotensin-converting enzyme 2, SARS-CoV, SARS-CoV-2, COVID-19 pandemic, renin-angiotensin system, viral receptor, host-directed therapy, multiple organ failure, cardiovascular homeostasis, pandemic preparedness
MeSH terms
Betacoronavirus, Angiotensin-Converting Enzyme 2, COVID-19, SARS-CoV-2, Humans, Peptidyl-Dipeptidase A, Pneumonia, Viral, Drug Delivery Systems, Coronavirus Infections, Severe Acute Respiratory Syndrome, Severe acute respiratory syndrome-related coronavirus, Virus Internalization, Pandemics

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