The DOI matches its Crossref record, with a small difference in title or year; 176 of the 176 references it cites were found in a registry or an index.
Opioid-induced Hyperalgesia: A Qualitative Systematic Review
Open accessAbstract
Opioids are the cornerstone therapy for the treatment of moderate to severe pain. Although common concerns regarding the use of opioids include the potential for detrimental side effects, physical dependence, and addiction, accumulating evidence suggests that opioids may yet cause another problem, often referred to as opioid-induced hyperalgesia. Somewhat paradoxically, opioid therapy aiming at alleviating pain may render patients more sensitive to pain and potentially may aggravate their preexisting pain. This review provides a comprehensive summary of basic and clinical research concerning opioid-induced hyperalgesia, suggests a framework for organizing pertinent information, delineates the status quo of our knowledge, identifies potential clinical implications, and discusses future research directions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In humans and animal models, withdrawal from chronic opioid self-administration produces hyperalgesia (i.e., lower pain thresholds; Tilson et al., 1973;Angst and Clark, 2006).”
From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Angst and Clark, 2006
Experimental — accuracy not yet measuredIn the citing paper
“This may be due to greater preoperative severity of pain, opioid-induced hyperalgesia and central or peripheral sensitisation to pre-existing nociception.23 69”
From Preoperative predictors of poor acute postoperative pain control: a systematic review and meta-analysis (2019) · cites this paper as [69]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Guignard, B., Bossard, A. E., Coste, C., Sessler, D. I., Lebrault, C., Alfonsi, P., Fletcher, D., & CHAUVIN, M. (2000) · Anesthesiology · doi:10.1097/00000542-200008000-00019 · Cited by 885
Evidence from rats that morphine tolerance is a learned response
Siegel, S. (1975) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077058 · Cited by 657
Long-lasting Hyperalgesia Induced by Fentanyl in Rats: Preventive Effect of Ketamine
Célèrier, E., Rivat, C., Jun, Y., Laulin, J.-P., Larcher, A., Reynier, P., & Simonnet, G. (2000) · Anesthesiology · doi:10.1097/00000542-200002000-00029 · Cited by 584
Opioid-induced abnormal pain sensitivity: implications in clinical opioid therapy
Mao, J. (2002) · Pain · doi:10.1016/s0304-3959(02)00422-0 · Cited by 463
Mao, J., Price, D. D., & Mayer, D. J. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-04-02301.1994 · Cited by 458
Johnston, I. N., Milligan, E. D., Wieseler‐Frank, J., Frank, M. G., Zapata, V., Campisi, J., Langer, S. J., Martin, D., Green, P., Fleshner, M., et al. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1850-04.2004 · Cited by 440
Angst, M. S., Koppert, W., Pahl, I., Clark, J. D., & Schmelz, M. (2003) · Pain · doi:10.1016/s0304-3959(03)00276-8 · Cited by 424
Self-citationMao, J., Sung, B., Ji, R., & Lim, G. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-18-08312.2002 · Cited by 409
Koppert, W., Sittl, R., Scheuber, K., Alsheimer, M., Schmelz, M., & Schüttler, J. (2003) · Anesthesiology · doi:10.1097/00000542-200307000-00025 · Cited by 352
Rapp, S. E., Ready, B. L., & Nessly, M. L. (1995) · Pain · doi:10.1016/0304-3959(94)00168-e · Cited by 349
Cited by
Sorted by citations
Items 901–1,000 of 1,001
Puri, N. (2024) · International Journal of Pain Management · doi:10.14302/issn.2688-5328.ijp-24-5319 · Cited by 1
Morphine-induced hyperalgesia impacts small extracellular vesicle microRNA composition and function
Reddy, D., Lin, Z., Ramanathan, S., Luo, X., Pande, R., Tian, Y., Side, C. M., Barker, J. M., Saçan, A., Blendy, J. A., et al. (2025) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2025.103398 · Cited by 2
Two‐Phase Inpatient Withdrawal Programme for Long‐Term Opioid Use in Non‐Cancer Pain
Streitberger, K., Harnik, M. A., Saliba, A., Bischoff, N., Blättler, L. T., Schwegler, K., Baumgartner, C., Sutter, N., & Wertli, M. M. (2025) · European Journal of Pain · doi:10.1002/ejp.70010 · Cited by 1
Opioid-associated syndromes and comorbidities
Wester, G. C., Perilloux, D. M., Boullion, J. A., Roberts, C. J., Shekoohi, S., & Kaye, A. D. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-26504-4.00002-8 · Cited by 1
Du, J., Li, C., Huang, M., & Qin, X. (2026) · Drug Design Development and Therapy · doi:10.2147/dddt.s574516 · Cited by 1
Chronic postsurgical pain: risk assessment and mitigation
Cheatle, M. D., Rosales, I., Chang, K.-H., & Lee, Y. (2026) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000001684 · Cited by 1
Prescription Drugs: Implications for the Chronic Pain Patient
Aloysi, A. S., & Bryson, E. O. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0170-4_12 · Cited by 1
Corder, G. F. (2013) · UKnowledge (University of Kentucky) · Cited by 1
Therapie chronischer Schmerzen in der neurologischen Praxis
Sternberg, S., Birklein, F., & May, A. (2008) · Der Nervenarzt · doi:10.1007/s00115-008-2504-4 · Cited by 1
Management of patients with chronic alcohol or drug use
Gutstein, H. B. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511781933.068 · Cited by 1
Ballantyne, J. C. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3375-0_18 · Cited by 1
Hypericum perforatum L. as Adjuvant to Opioid Analgesia in an Animal Model of Migraine
Galeotti, N. (2014) · Journal of Advances in Medicine and Medical Research · doi:10.9734/bjmmr/2014/7138 · Cited by 1
Hiperalgesia en sujetos tratados con opioides
Centeno, C., & Olier, C. (2009) · Medicina Clínica · doi:10.1016/j.medcli.2008.11.006 · Cited by 1
Cocaine, Methamphetamine, MDMA, and Heroin
Bryson, E. O. (2014) · Springer eBooks · doi:10.1007/978-1-4614-8948-1_37 · Cited by 1
Analgesia postoperatoria en el adulto (excluida la cirugía ambulatoria)
Viel, E., Jaber, S., Ripart, J., Navarro, F., & Eledjam, J. J. (2007) · EMC - Anestesia-Reanimación · doi:10.1016/s1280-4703(07)70481-4 · Cited by 1
Bourguignon, J., Simonnet, G., & Simonin, F. (2006) · médecine/sciences · doi:10.1051/medsci/20062267579 · Cited by 1
The Issues Around Opioid Prescribing in HIV-Related Pain
Cox, S. (2013) · Pain Management · doi:10.2217/pmt.13.36 · Cited by 1
Survey on the use of buprenorphine patches in the palliative care practice
Bourne, F. M., & Żylicz, Z. (2010) · Advances in Palliative Medicine · Cited by 1
Breakthrough pain: the importance of baseline analgesic regimen with opioids.
Zampi, M., Morabito, A., Fabiana, S., & Vinciguerra, A. (2012) · Europe PMC (PubMed Central) · Cited by 1
Planning for Perioperative Pain Management
Dale, R., Chen, T. T., & Ballantyne, J. C. (2016) · Hospital Medicine Clinics · doi:10.1016/j.ehmc.2015.11.001 · Cited by 1
Computational genetic discoveries that could improve perioperative medicine
Zheng, M., Dill, D. L., Clark, J. D., & Peltz, G. (2012) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e32835561f9 · Cited by 1
Self-citationOpioid-Induced Neurotoxicity in the Hospice Patient
Kozlov, M., Anderson, M. A., & Sparbel, K. J. H. (2011) · Journal of Hospice and Palliative Nursing · doi:10.1097/njh.0b013e3182271932 · Cited by 1
Headache in Buprenorphine Detoxification Treatment
Bostani, A. (2013) · Journal of Addiction Research & Therapy · doi:10.4172/2155-6105.1000142 · Cited by 1
Nonpharmacological Approaches for Acute Pain Management
Erceg, S., & Chung, K. S. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511576706.026 · Cited by 2
Norton, C. S., Williams, J., Taylor, C., Nunwa, A., & Whayman, K. (2008) · Oxford University Press eBooks · doi:10.1093/med/9780199298655.003.0021 · Cited by 1
Long-Term Management Problems in Restless Legs Syndrome (RLS)/Willis-Ekbom Disease (WED)
Chokroverty, S. (2016) · Springer eBooks · doi:10.1007/978-3-319-46437-4_12 · Cited by 1
Ağrının İletilmesinde N-Metil D- Aspartat Reseptörlerinin Rolü
Güneş, Y., Mert, T., Özcengiz, D., & Günay, İ. (2012) · DergiPark (Istanbul University) · doi:10.17826/cutf.45941 · Cited by 1
Opioid-Induced Hyperalgesia After Surgery: Clinical Relevance
Richebé, P., & Rivat, C. (2017) · Springer eBooks · doi:10.1007/978-3-319-47609-4_42 · Cited by 1
Opioids: Heroin and Prescription Drugs
White, J. M. (2010) · Springer eBooks · doi:10.1007/978-1-4419-0338-9_51 · Cited by 1
Understanding the Agent, Part II: Adverse Effects
McAnally, H. B. (2017) · Springer eBooks · doi:10.1007/978-3-319-47497-7_3 · Cited by 1
Pain management for trauma patients
Inoue, A., Hifumi, T., & Kuroda, Y. (2018) · Journal of the Japanese Society of Intensive Care Medicine · doi:10.3918/jsicm.25_421 · Cited by 1
Risk stratification and management of opioids
Webster, L. R., & Dove, B. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-2242-0.00022-5 · Cited by 1
Postoperative Multimodal Pain Management
de Boer, H. D. (2020) · Springer eBooks · doi:10.1007/978-3-030-33443-7_24 · Cited by 1
Nagpal, A., Boies, B. T., Clements, N. D., & Vydra, D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-72216-2.00016-8 · Cited by 1
Bakhet, W. Z., Fiky, L. M. E., & Debis, H. (2021) · Ain-Shams Journal of Anaesthesiology · doi:10.1186/s42077-021-00153-7 · Cited by 1
Principles of Emergency and Trauma Surgery
Giannou, C., & Paix, B. (2020) · Cambridge University Press eBooks · doi:10.1017/9781316181454.004 · Cited by 1
Total Intravenous Anesthesia in Disaster Medicine
Blum, P., & Graves, M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781316181454.005 · Cited by 1
Interventional approaches for chronic pain
Swarm, R. A., Καρανικόλας, Μ., Rao, L. K., & Shah, R. K. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780198821328.003.0043 · Cited by 1
Rohrig, T. P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815163-1.00015-0 · Cited by 1
Pharmacology of analgesia: basic principles
Inturrisi, C. E. (2001) · Cambridge University Press eBooks · doi:10.1017/cbo9780511642357.010 · Cited by 1
Heesen, M. A., Orbach‐Zinger, S., Gosteli, M., Hoshen, M., Halpern, S. H., Leo, C., & Klimek, M. (2022) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd014818 · Cited by 1
Culletta, G., Almerico, A. M., & Tutone, M. (2023) · Recent Advances in Inflammation & Allergy Drug Discovery · doi:10.2174/2772270817666230320124000 · Cited by 1
Standardizing Opioids Prescribed at Discharge in Trauma Surgery
Seo, C. H., Howe, K. L., McAllister, K. B., McDaniel, B. L., Sharp, H. D., Lucktong, T. A., Bower, K. L., Collier, B., & Gillen, J. R. (2023) · Journal of Surgical Research · doi:10.1016/j.jss.2023.03.049 · Cited by 1
Trübenbacher, L., Lindenberg, N., Graf, B. M., Backmund, M., Unglaub, W., & Lassen, C. L. (2024) · Journal of Pain Research · doi:10.2147/jpr.s421841 · Cited by 1
Koç, Z., Baytar, Ç., Bollucuoğlu, K., Köksal, B. G., Okyay, R. D., Pişkin, Ö., & Ayoğlu, H. (2025) · Journal of Clinical Monitoring and Computing · doi:10.1007/s10877-025-01330-x · Cited by 1
Gβγ Signaling: Lessons Across the Cellular Multiverse
Qayum, S., Pétrin, D., Tanny, J. C., & Hébert, T. E. (2025) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-062124-033726 · Cited by 1
Intrathecal Opiates for Cancer Pain
Sol, J., Verdié, J. C., & Lazorthes, Y. R. (2009) · Springer eBooks · doi:10.1007/978-3-540-69960-6_129 · Cited by 1
Penning, J. P. (2014) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-014-0153-6 · Cited by 1
Barnard, A., & Ganca, L. (2011) · CME/Continuing medical education · Cited by 1
Lumbar Degenerative Disk Disease: Workup and Conservative Treatment
Beckworth, W. J., Sodiq, D. K., Foster, L. G., & Sussman, W. I. (2015) · Springer eBooks · doi:10.1007/978-3-662-47756-4_15 · Cited by 1
Grossi, P., Grilli, E., & Repaci, S. (2016) · Springer eBooks · doi:10.1007/978-3-032-14327-3_4 · Cited by 1
Cohen, S. P. (2018) · Anesthesiology · doi:10.1097/aln.0000000000002329 · Cited by 1
Treatment Innovation in Orthopedic Surgery: A Case Study from Hospital for Special Surgery
Waldman, S. A., Schottenfeld, J. R., & Gluck, A. R. (2018) · The Journal of Law Medicine & Ethics · doi:10.1177/1073110518782924 · Cited by 1
Berrahal, I., Mâamri, A., Ayadi, B., Kissi, Y. E., & Haddad, M. (2018) · Sexologies · doi:10.1016/j.sexol.2018.10.001 · Cited by 1
Two Cases of Opioid-Induced Hyperalgesia in Cancer Patients Treated with Opioids for Pain Management
Hong, S., Kwon, J. H., & Han, S. J. (2019) · The Korean Journal of Hospice and Palliative Care · doi:10.14475/kjhpc.2019.22.2.100 · Cited by 1
Malchow, A. J., Baker, J. W., & Yost, A. P. (2019) · Journal of Anesthesia & Clinical Research · Cited by 1
Machi, A. T. (2020) · Springer eBooks · doi:10.1007/978-3-030-39982-5_2 · Cited by 1
OPIOID-INDUCED HYPERALGESIA IN PATIENTS WITH CHRONIC PAIN SYNDROME OF ONCOLOGICAL GENESIS
Боброва, О. П., Shnayder, N. A., Dykhno, Y. A., & Петрова, М. М. (2018) · Russian Journal of Oncology · doi:10.18821/1028-9984-2018-23-2-107-112 · Cited by 1
Jackson, T., & Pena, M. S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781316181454.017 · Cited by 1
Novel Non-Opioid Based Therapeutics for Chronic Neuropathic Pain.
Doyle, T. M., Braden, K., Harada, C. M., Mufti, F., Schafer, R. M., & Salvemini, D. (2021) · PubMed Central · Cited by 1
Shank, E. S., Coté, C. J., & Martyn, J. A. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-42974-0.00036-7 · Cited by 1
Interventional approaches for chronic pain
Swarm, R. A., Καρανικόλας, Μ., Rao, L. K., & Cousins, M. J. (2015) · doi:10.1093/med/9780199656097.003.0098 · Cited by 1
Slagmulder, S., Mauermann, E., & Vandenheuvel, M. (2022) · Acta Anaesthesiologica Belgica · doi:10.56126/73.2.14 · Cited by 1
Anesthetic Considerations during Laparoscopic and Robotic Surgery
Butler, A. L., Cordero, K., & Capua, J. D. (2012) · doi:10.1002/9781444345148.ch69 · Cited by 1
Perioperative Management of the Opioid-Tolerant Patient
Viscomi, C. M., & Pearson, J. K. (2009) · Advances in Anesthesia · doi:10.1016/j.aan.2009.07.004 · Cited by 1
Analgesia postoperatoria nell’adulto (esclusa quella ambulatoriale)
Viel, E., Jaber, S., Ripart, J., Navarro, F., & Eledjam, J. J. (2007) · EMC - Anestesia-Rianimazione · doi:10.1016/s1283-0771(07)70310-9 · Cited by 1
Fakultet, M. (2016) · Cited by 1
Koppert, W. (2010) · Der Anaesthesist · doi:10.1007/s00101-010-1810-y · Cited by 1
Predicting poor postoperative pain control after elective spine surgery
Yang, M.-H. M. (2019) · doi:10.11575/prism/36670 · Cited by 1
CanIsoNet: A Database to Study the Functional Impact of Isoform Switching Events in DiseasesPreprint
Karakulak, T., Szklarczyk, D., Saylan, C. C., Moch, H., von Mering, C., & Kahraman, A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.17.460795 · Cited by 1
Davis, M. P., & Angst, M. S. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.17.4185 · Cited by 1
Self-citationBubb, M. (2024) · Arthritis Care & Research · doi:10.1002/acr.25379 · Cited by 1
Sedation in the Emergency Department: A Complex and Multifactorial Challenge
Kennedy, R. M. (2021) · Pediatric Sedation Outside of the Operating Room · doi:10.1007/978-3-030-58406-1_22 · Cited by 1
Functional regulation of opioid receptor signaling
Tumati, S. (2009) · UA Campus Repository (The University of Arizona)
Acute Management of the Opioid-Dependent Patient
Bottiger, B., Orme, D. C., & Gordin, V. (2012) · Springer eBooks · doi:10.1007/978-1-4614-1560-2_12
EXAMINING CHRONIC NON-CANCER PAIN AMONG A SAMPLE OF INDIVIDUALS IN OPIOID TREATMENT PROGRAMS
Stevenson, E. (2012) · UKnowledge (University of Kentucky)
Kaye, A. D., & Shah, R. V. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107281950.012
CHRONIC OPIOID USE IN FIBROMYALGIA SYNDROME: CHARACTERISTICS AND OUTCOMES
Painter, J. T. (2012) · UKnowledge (University of Kentucky)
Richebé, P., Brulotte, V., & Fortier, L. (2014) · Douleur et Analgésie · doi:10.1007/s11724-014-0394-8
Molecular Modulation of In Vivo Tolerance
Inturrisi, C. E., & Gregus, A. M. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-993-2_16
Cameron, D. A. (2011) · CME/Continuing medical education
Pharmacology of Novel Non-NSAID Analgesics
Lavand'homme, P. M., & Kock, M. F. D. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511576706.009
Pain in the Battlefield Injured
Dragovich, A., & Cohen, S. P. (2011) · Springer eBooks · doi:10.1007/978-1-4419-1651-8_14
Adapt, Survive or Die - Metabolic Imbalances and the Enteric Nervous System
Voss, U. (2013) · Lund University Publications (Lund University)
Spahn, V. (2011) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-7050
Perioperative Analgesia by Opioids: Rationale and Practical Basics
Robard, S. (2014) · Springer eBooks · doi:10.1007/978-3-319-04322-7_7
Ashrafioun, L. (2014) · ScholarWorks@BGSU (Bowling Green State University)
Kulyk, V. B., Chyzhmakov, I. V., Volkova, T. M., & Kryshtal’, O. A. (2015) · Neurophysiology · doi:10.1007/s11062-015-9519-9
Analgésie péri-opératoire par opioïdes: rationnel et bases pratiques
Robard, S. (2013) · Springer eBooks · doi:10.1007/978-2-8178-0026-4_8
Anestesia en cirugía ortopédica
Carlès, M., Blay, M., & Gaertner, É. (2011) · EMC - Anestesia-Reanimación · doi:10.1016/s1280-4703(11)71074-x
Differences in Prescription of Narcotic Pain Medication Between Hospitals in Different Countries
van Geffen, G., Wiilder-Smith, O., & Poelhekke, L. M. S. J. (2009) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e3181be75ea
Use, T., Sakai, T., Shimamoto, H., Fukano, T., & Sumikawa, K. (2013) · Open Journal of Anesthesiology · doi:10.4236/ojanes.2013.33044
Anestesia in chirurgia ortopedica
Carlès, M., Blay, M., & Gaertner, É. (2011) · EMC - Anestesia-Rianimazione · doi:10.1016/s1283-0771(11)70649-1
Elstraete, A. C. V., Sitbon, P., & Tirault, M. (2007) · Le Praticien en Anesthésie Réanimation · doi:10.1016/s1279-7960(07)78603-5
Utilización de fentanilo oral como premedicación en pacientes pediátricos
Tornero, C., Escamilla, B., Laredo, M., León, I., & Bilbao, M. L. E. (2010) · Revista de la Sociedad Española del Dolor · doi:10.1016/j.resed.2010.08.004
La tolérance aiguë aux opiacés : ses implications cliniques en anesthésie
Richebé, P., Janvier, G., & Simonnet, G. (2008) · Le Praticien en Anesthésie Réanimation · doi:10.1016/j.pratan.2008.01.006
Evaluación del Efecto de la Cetamina Asociada con el Remifentanilo en el Dolor Postoperatorio
Leal, P. C., Sakata, R. K., Salomão, R., Sadatsune, E. J., & Issy, A. M. (2013) · Brazilian Journal of Anesthesiology (Edicion en Espanol) · doi:10.1016/j.bjanes.2012.02.005
Remifentanil: Clinical Pearls and Pitfalls
Kiyama, S. (2008) · THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA · doi:10.2199/jjsca.28.375
Hypersensibilités postopératoires : conséquences cliniques
Richebé, P., Janvier, G., & Simonnet, G. (2008) · Douleurs Évaluation - Diagnostic - Traitement · doi:10.1016/j.douler.2008.02.002
Metadata
- Authors
- Angst, M. S., & Clark, J. D.
- Affiliations
- Stanford Medicine (US)
- VA Palo Alto Health Care System (US)
- ORCID
- Angst, Martin S.
- Venue
- Anesthesiology
- Published
- 2006-03-01
- Volume
- 104
- Issue
- 3
- Pages
- 570-587
- ISSN
- 0003-3022 (ISSN-L)
- OpenAlex
- W2005703418
- Cited by
- 1,188
- References
- 176
- Citations by year
- 2026: 30 · 2025: 34 · 2024: 26 · 2023: 37 · 2022: 34 · 2021: 49 · 2020: 98 · 2019: 55 · 2018: 59 · 2017: 45 · 2016: 62 · 2015: 80 · 2014: 84 · 2013: 77 · 2012: 83
- FWCI
- 10.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Anesthesiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Pain Management
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Keywords
- opioid-induced hyperalgesia, opioids, pain sensitivity, analgesic side effects, chronic pain, opioid analgesia
- MeSH terms
- Analgesics, Opioid, Animals, Humans, Hyperalgesia, Opioid-Related Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review