Opioid-induced Hyperalgesia: A Qualitative Systematic Review

Acute Opioid Tolerance

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Opioid-induced hyperalgesia—Pathophysiology and clinical relevance

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Systemic Lidocaine Inhibits Remifentanil-induced Hyperalgesia via the Inhibition of cPKCgamma Membrane Translocation in Spinal Dorsal Horn of Rats

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Acute Morphine Induces Matrix Metalloproteinase-9 Up-Regulation in Primary Sensory Neurons to Mask Opioid-Induced Analgesia in Mice

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Opioid-Induced Hyperalgesia: Is It Clinically Relevant for the Treatment of Pain Patients?

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Does Opioid Pain Medication Use Affect the Outcome of Patients With Lumbar Disc Herniation?

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Dronabinol and chronic pain: importance of mechanistic considerations

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Nitrous oxide (N2O) prevents latent pain sensitization and long-term anxiety-like behavior in pain and opioid-experienced rats

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Neonatal morphine enhances nociception and decreases analgesia in young rats

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Regionally selective activation of ERK and JNK in morphine paradoxical hyperalgesia: A step toward improving opioid pain therapy

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Pediatric Islet Autotransplantation: Indication, Technique, and Outcome

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Prevention of Remifentanil Induced Postoperative Hyperalgesia by Dexmedetomidine via Regulating the Trafficking and Function of Spinal NMDA Receptors as well as PKC and CaMKII Level In Vivo and In Vitro

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Opioid-free anaesthesia in three dogs

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Interdisciplinary team-based care for patients with chronic pain on long-term opioid treatment in primary care (PPACT) – Protocol for a pragmatic cluster randomized trial

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An Evidence-Based Opioid-Free Anesthetic Technique to Manage Perioperative and Periprocedural Pain

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Psychosocial intervention and the reward system in pain and opioid misuse: new opportunities and directions

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Rational use of opioids for management of chronic nonterminal pain.

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Pain in neuropsychiatry: Insights from animal models

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The Effects of Low Dose Naltrexone on Opioid Induced Hyperalgesia and Fibromyalgia

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Low‐dose ketamine as a potential adjuvant therapy for painful vaso‐occlusive crises in sickle cell disease

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MicroRNAs Are Involved in the Development of Morphine-Induced Analgesic Tolerance and Regulate Functionally Relevant Changes in Serpini1

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Morphine-6β-glucuronide Rapidly Increases Pain Sensitivity Independently of Opioid Receptor Activity in Mice and Humans

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Perioperative Opioid Usage

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Continuous Opioid Therapy (COT) is Rarely Advisable for Refractory Chronic Daily Headache: Limited Efficacy, Risks, and Proposed Guidelines

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Action of Phα1β, a Peptide From the Venom of the Spider Phoneutria nigriventer, on the Analgesic and Adverse Effects Caused by Morphine in Mice

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Randomised, double-blind controlled trial by dose reduction of implanted intrathecal morphine delivery in chronic non-cancer pain

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Gi-protein–coupled 5-HT1B/D receptor agonist sumatriptan induces type I hyperalgesic priming

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Effect of Ketamine Added to Ropivacaine in Nerve Block for Postoperative Pain Management in Patients Undergoing Anterior Cruciate Ligament Reconstruction: A Randomized Trial

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Chronic Morphine-Induced Changes in Signaling at the A3 Adenosine Receptor Contribute to Morphine-Induced Hyperalgesia, Tolerance, and Withdrawal

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Laminitic Pain: Parallels with Pain States in Humans and Other Species

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Opioid and chronic non-cancer pain

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Postoperative hyperalgesia—A clinically applicable narrative review

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Pain and Opioid-Induced Gut Microbial Dysbiosis

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Control of Chronic Pain by the Ubiquitin–Proteasome System in the Spinal Cord

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Comparison of pain models to detect opioid-induced hyperalgesia

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Opioid induced hyperalgesia in anesthetic settings

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TRV0109101, a G Protein-Biased Agonist of the µ-Opioid Receptor, Does Not Promote Opioid-Induced Mechanical Allodynia following Chronic Administration

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Effects of opioid-free anesthesia on postoperative morphine consumption after bariatric surgery

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Glial cell activation in the spinal cord and dorsal root ganglia induced by surgery in mice

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Development of a Peptidomimetic Antagonist of Neuropeptide FF Receptors for the Prevention of Opioid-Induced Hyperalgesia

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The use of opioids at the end of life: the knowledge level of Dutch physicians as a potential barrier to effective pain management

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Postoperative analgesia with parecoxib, acetaminophen, and the combination of both: a randomized, double-blind, placebo-controlled trial in patients undergoing thyroid surgery

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Opioid-Induced Hyperalgesia in the Nonsurgical Setting: A Systematic Review

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EGFR Signaling Causes Morphine Tolerance and Mechanical Sensitization in Rats

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Brief review: Perioperative management of the patient with chronic non-cancer pain

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Inhibitory Effect of Bacopasides on Spontaneous Morphine Withdrawal Induced Depression in Mice

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Spontaneous nociceptive behaviour in female mice with Freund's complete adjuvant- and carrageenan-induced monoarthritis

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Morphine- and buprenorphine-induced analgesia and antihyperalgesia in a human inflammatory pain model: a double-blind, randomized, placebo-controlled, five-arm crossover study

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Influence of Clonidine and Ketamine on m-RNA Expression in a Model of Opioid-Induced Hyperalgesia in Mice

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Altered Signaling in the Descending Pain-modulatory System after Short-Term Infusion of the μ-Opioid Agonist Remifentanil

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Effects of Ketamine on Postoperative Pain After Remifentanil-Based Anesthesia for Major and Minor Surgery in Adults: A Systematic Review and Meta-Analysis

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Influence of dexmedetomidine and lidocaine on perioperative opioid consumption in laparoscopic intestine resection: a randomized controlled clinical trial

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Prospective Case Series on the Use of Peripheral Nerve Stimulation for Focal Mononeuropathy Treatment

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Opioid-induced Hyperalgesia in Patients With Chronic Pain

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Complex Persistent Opioid Dependence—an Opioid-induced Chronic Pain Syndrome

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Increased Spinal Dynorphin Levels and Phospho-Extracellular Signal-Regulated Kinases 1 and 2 and c-Fos Immunoreactivity after Surgery under Remifentanil Anesthesia in Mice

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Refractory Migraine – A Review

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Reduced Cold Pain Tolerance in Chronic Pain Patients Following Opioid Detoxification

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Effects of sevoflurane on carrageenan- and fentanyl-induced pain hypersensitivity in Sprague-Dawley rats

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Adenosine-A1 receptor agonist induced hyperalgesic priming type II

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Low-dose ketamine adjuvant treatment for refractory pain in children, adolescents and young adults with cancer: a pilot study

Courade, M., Bertrand, A., Guerrini‐Rousseau, L., Pagnier, A., Lévy, D., Lervat, C., Cojean, N., Ribrault, A., Dugué, S., Thouvenin, S., et al. (2019) · BMJ Supportive & Palliative Care · doi:10.1136/bmjspcare-2018-001739 · Cited by 30

Drug-specific differences in the ability of opioids to manage burn pain

Emery, M. A., & Eitan, S. (2019) · Burns · doi:10.1016/j.burns.2019.03.028 · Cited by 31

Intravenous Infusion of Remifentanil Induces Transient Withdrawal Hyperalgesia Depending on Administration Duration in Rats

Ishida, R., Nikai, T., Hashimoto, T., Tsumori, T., & Saito, Y. (2011) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318237f678 · Cited by 30

Selective impairment of spinal mu-opioid receptor mechanism by plasticity of serotonergic facilitation mediated by 5-HT2A and 5-HT2B receptors

Aira, Z., Buesa, I., del Caño, G. G., Salgueiro, M., Mendiable, N., Mingo, J., Aguilera, L., Bilbao, J., & Azkue, J. J. (2012) · Pain · doi:10.1016/j.pain.2012.03.017 · Cited by 30

Abnormal heat and pain perception in remitted heroin dependence months after detoxification from methadone-maintenance

Prosser, J. M., Steinfeld, M., Cohen, L. J., Derbyshire, S. W. G., Eisenberg, D. P., Cruciani, R. A., & GALYNKER, I. I. (2008) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.01.012 · Cited by 30

Efficacy Of Intraoperative Methadone And Clonidine In Pain Control In The Immediate Postoperative Period After The Use Of Remifentanil

Simoni, R. F., Cangiani, L. M., Pereira, A. M. S. A., de Abreu, M. P., Cangiani, L. H., & Zemi, G. (2009) · Brazilian Journal of Anesthesiology · doi:10.1590/s0034-70942009000400004 · Cited by 30

Patient and Disease Characteristics Associate With Sensory Testing Results in Chronic Pancreatitis

Kuhlmann, L., Olesen, S. S., Grønlund, D., Olesen, A. E., Phillips, A. E., Faghih, M., & Drewes, A. M. (2019) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000740 · Cited by 29

Morphine and HIV-1 gp120 cooperatively promote pathogenesis in the spinal pain neural circuit

Shi, Y., Yuan, S., & Tang, S. (2019) · Molecular Pain · doi:10.1177/1744806919868380 · Cited by 29

Dim Light at Night Exposure Induces Cold Hyperalgesia and Mechanical Allodynia in Male Mice

Bumgarner, J. R., Walker, W. H., Liu, J. A., Walton, J. C., & Nelson, R. J. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.03.022 · Cited by 29

Continuous Interscalene Analgesia for Rotator Cuff Repair: A Retrospective Comparison of Effectiveness and Cost in 205 Patients from a Multi-Provider Private Practice Setting

Fredrickson, M. J., & Stewart, A. W. (2008) · Anaesthesia and Intensive Care · doi:10.1177/0310057x0803600606 · Cited by 29

Successful Discontinuation of Systemic Opioids After Implantation of an Intrathecal Drug Delivery System

Caraway, D. L., Walker, V., Becker, L. K., & Hinnenthal, J. A. (2015) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.12318 · Cited by 29

When Opioids Fail in Chronic Pain Management

Berland, D., Malinoff, H. L., Weiner, M. A., & Przybylski, R. (2013) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e31827ab599 · Cited by 29

Opioid Tolerance Blunts the Reduction in the Sevoflurane Minimum Alveolar Concentration Produced by Remifentanil in the Rat

de Segura, I. Á. G., Benito, J., & Aguado, D. (2009) · Anesthesiology · doi:10.1097/aln.0b013e31819dadaf · Cited by 29

Neurobiological Correlates of Pain Avoidance-Like Behavior in Morphine-Dependent and Non-Dependent Rats

Pahng, A. R., Paulsen, R. I., McGinn, M. A., Edwards, K. N., & Edwards, S. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.09.055 · Cited by 29

Reactive Oxygen Species (ROS) are Critical for Morphine Exacerbation of HIV-1 gp120-Induced Pain

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Curative-like analgesia in a neuropathic pain model: Parametric analysis of the dose and the duration of treatment with a high-efficacy 5-HT1A receptor agonist

Deseure, K. R., Bréand, S., & Colpaert, F. C. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.04.022 · Cited by 29

New trends in regional anesthesia for shoulder surgery: Avoiding devastating complications

BOEZAART, A., & Tighe, P. J. (2010) · International Journal of Shoulder Surgery · doi:10.4103/0973-6042.68410 · Cited by 28

MMPI Disability Profile Is Associated With Degree of Opioid Use in Chronic Work-related Musculoskeletal Disorders

Kidner, C. L., Gatchel, R. J., & Mayer, T. G. (2009) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e3181af13ed · Cited by 28

Effect of Intraoperative High-Dose Remifentanil on Postoperative Pain: A Prospective, Double Blind, Randomized Clinical Trial

Zhang, Y., Ou, P., Lu, X.-H., Chen, Y., Xu, J., & Dai, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091454 · Cited by 28

Intravenous paracetamol: a review of efficacy and safety in therapeutic use

Malaise, O., Bruyère, O., & Reginster, J. (2007) · Future Neurology · doi:10.2217/14796708.2.6.673 · Cited by 28

The Effects of Intraoperative Adenosine Infusion on Acute Opioid Tolerance and Opioid Induced Hyperalgesia Induced by Remifentanil in Adult Patients Undergoing Tonsillectomy

Lee, C., Song, Y. K., Lee, J. H., & Ha, S. M. (2011) · The Korean journal of pain · doi:10.3344/kjp.2011.24.1.7 · Cited by 28

Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents

Doyle, T. M., Janes, K., Chen, Z., Grace, P. M., Esposito, E., Cuzzocrea, S., Largent‐Milnes, T. M., Neumann, W. L., Watkins, L. R., Spiegel, S., et al. (2020) · Pain · doi:10.1097/j.pain.0000000000001888 · Cited by 28

Cannabinoids and orthopedic surgery: a systematic review of therapeutic studies

Vivace, B. J., Sanders, A. N., Glassman, S. D., Carreon, L. Y., Laratta, J. L., & Gum, J. L. (2021) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-021-02205-y · Cited by 28

Opioid Tolerance, Dependence and Hyperalgesia

Ballantyne, J. C. (2009) · CRC Press eBooks · doi:10.3109/9781420089004-6 · Cited by 2

Opioid-Induced Hyperalgesia: Clinically Relevant or Extraneous Research Phenomenon?

Tompkins, D. A., & Campbell, C. M. (2011) · Current Pain and Headache Reports · doi:10.1007/s11916-010-0171-1 · Cited by 117

Opioid-Induced Hyperalgesia Syndrome in the Rehabilitation Patient

Scarfo, K. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-16784-8_31

Complications of Long-Term Opioid Therapy for Management of Chronic Pain: the Paradox of Opioid-Induced Hyperalgesia

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Opioid-Induced Hyperalgesia: Is It Clinically Relevant for the Treatment of Pain Patients?

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