Opioid-induced Hyperalgesia: A Qualitative Systematic Review

Acute Opioid Tolerance

Guignard, B., Bossard, A. E., Coste, C., Sessler, D. I., Lebrault, C., Alfonsi, P., Fletcher, D., & CHAUVIN, M. (2000) · Anesthesiology · doi:10.1097/00000542-200008000-00019 · Cited by 885

Evidence from rats that morphine tolerance is a learned response

Siegel, S. (1975) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077058 · Cited by 657

Long-lasting Hyperalgesia Induced by Fentanyl in Rats: Preventive Effect of Ketamine

Célèrier, E., Rivat, C., Jun, Y., Laulin, J.-P., Larcher, A., Reynier, P., & Simonnet, G. (2000) · Anesthesiology · doi:10.1097/00000542-200002000-00029 · Cited by 584

Opioid-induced abnormal pain sensitivity: implications in clinical opioid therapy

Mao, J. (2002) · Pain · doi:10.1016/s0304-3959(02)00422-0 · Cited by 463

Thermal hyperalgesia in association with the development of morphine tolerance in rats: roles of excitatory amino acid receptors and protein kinase C

Mao, J., Price, D. D., & Mayer, D. J. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-04-02301.1994 · Cited by 458

A Role for Proinflammatory Cytokines and Fractalkine in Analgesia, Tolerance, and Subsequent Pain Facilitation Induced by Chronic Intrathecal Morphine

Johnston, I. N., Milligan, E. D., Wieseler‐Frank, J., Frank, M. G., Zapata, V., Campisi, J., Langer, S. J., Martin, D., Green, P., Fleshner, M., et al. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1850-04.2004 · Cited by 440

Short-term infusion of the μ-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal

Angst, M. S., Koppert, W., Pahl, I., Clark, J. D., & Schmelz, M. (2003) · Pain · doi:10.1016/s0304-3959(03)00276-8 · Cited by 424

Chronic Morphine Induces Downregulation of Spinal Glutamate Transporters: Implications in Morphine Tolerance and Abnormal Pain Sensitivity

Mao, J., Sung, B., Ji, R., & Lim, G. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-18-08312.2002 · Cited by 409

Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans

Koppert, W., Sittl, R., Scheuber, K., Alsheimer, M., Schmelz, M., & Schüttler, J. (2003) · Anesthesiology · doi:10.1097/00000542-200307000-00025 · Cited by 352

Acute pain management in patients with prior opioid consumption: a case-controlled retrospective review

Rapp, S. E., Ready, B. L., & Nessly, M. L. (1995) · Pain · doi:10.1016/0304-3959(94)00168-e · Cited by 349

Mitogen-Activated Protein Kinase Signaling Mediates Morphine Induced-Delayed Hyperalgesia

Freitas, B. G., Pereira, L. M., Santa-Cecília, F. V., Hösch, N. G., Picolo, G., Cury, Y., & Zambelli, V. O. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01018 · Cited by 20

Induzieren Opioide Hyperalgesie?

Zöllner, C. (2010) · Der Anaesthesist · doi:10.1007/s00101-010-1803-x · Cited by 20

Analgesic Drugs Combinations in the Treatment of Different Types of Pain

Ortiz, M. I., Molina, M. A. R., Arai, Y.-C. P., & Romanò, C. L. (2012) · Pain Research and Treatment · doi:10.1155/2012/612519 · Cited by 22

Ketamine and Remifentanil Interactions on the Sevoflurane Minimum Alveolar Concentration and Acute Opioid Tolerance in the Rat

Aguado, D., de Abreu, M. B., Benito, J., Fernandez, F., & de Segura, I. Á. G. (2011) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318227517a · Cited by 20

Discovery of Novel Multifunctional Ligands with μ/δ Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain

Giri, A. K., Apostol, C. R., Wang, Y., Forte, B. L., Largent‐Milnes, T. M., Davis, P., Rankin, D. R., Molnar, G., Olson, K. M., Porreca, F., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01170 · Cited by 20

Opioid‐free anesthesia for patients undergoing mastectomy: A matched comparison

King, C. A., Perez‐Alvarez, I. M., Bartholomew, A. J., Bozzuto, L., Griffith, K. F., Sosin, M., Thibodeau, R. M., Gopwani, S. R., Myers, J., Fan, K. L., et al. (2020) · The Breast Journal · doi:10.1111/tbj.13999 · Cited by 21

Clinical and neuroscience evidence supports the critical importance of patient expectations and agency in opioid tapering

Darnall, B. D., & Fields, H. L. (2021) · Pain · doi:10.1097/j.pain.0000000000002443 · Cited by 19

Caralluma tuberculata exhibits analgesic and anti-arthritic potential by downregulating pro-inflammatory cytokines and attenuating oxidative stress

Haider, S. I., Asif, A., Rasheed, H. M. F., Akram, A., & Jabeen, Q. (2022) · Inflammopharmacology · doi:10.1007/s10787-022-00949-5 · Cited by 19

GABAB receptor-mediated tonic inhibition of noradrenergic A7 neurons in the rat

Wu, Y., Wang, H.-Y., Lin, C.-C. J., Lu, H.-C., Cheng, S., Chen, C., Yang, H., & Min, M. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00459.2010 · Cited by 19

Neuron-restrictive silencer factor in periaqueductal gray contributes to remifentanil-induced postoperative hyperalgesia via repression of the mu-opioid receptor

Lu, C., Shi, L., Zhang, J., Kong, M., Liu, Y., Zhou, Y., Xu, L., He, J., Ma, Z., & Gu, X. (2015) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2015.03.018 · Cited by 19

Systemic Opioid Elimination After Implantation of an Intrathecal Drug Delivery System Significantly Reduced Health-Care Expenditures

Hatheway, J. A., Caraway, D. L., David, G., Gunnarsson, C., Hinnenthal, J. A., Ernst, A. R., & Saulino, M. F. (2015) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.12278 · Cited by 19

Opioids for the Management of Severe Chronic Nonmalignant Pain in Children: A Retrospective 1-Year Practice Survey in a Children's Hospital

Slater, M.-E., de Lima, J., Campbell, K., Lane, L., & Collins, J. (2009) · Pain Medicine · doi:10.1111/j.1526-4637.2009.00754.x · Cited by 19

Evaluating the Use of Ketamine for Pain Control With Sickle Cell Crisis in Pregnancy

Gimovsky, A. C., Fritton, K., Viscusi, E. R., & Roman, A. (2017) · A&A Practice · doi:10.1213/xaa.0000000000000624 · Cited by 19

Review of the efficacy and safety of remifentanil for the prevention and treatment of pain during and after procedures and surgery

Davis, P. J., & Sivak (2010) · Local and Regional Anesthesia · doi:10.2147/lra.s7709 · Cited by 19

Functional Outcomes in Patients with Chronic Nonmalignant Pain on Long‐Term Opioid Therapy

Soin, A., Cheng, J., Brown, L. L., Moufawad, S., & Mekhail, N. A. (2008) · Pain Practice · doi:10.1111/j.1533-2500.2008.00233.x · Cited by 19

The effect of analgesics on stimulus evoked pain-like behaviour in animal models for chemotherapy induced peripheral neuropathy- a meta-analysis

Hooijmans, C. R., Draper, D., Ergün, M., & Scheffer, G. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-54152-8 · Cited by 17

Opioid-induced Neurotoxicity in Patients with Cancer Pain

Mercadante, S. (2023) · Current Treatment Options in Oncology · doi:10.1007/s11864-023-01117-9 · Cited by 18

Exogenous and Endogenous Opioid‐Induced Pain Hypersensitivity in Different Rat Strains

Laboureyras, E., Aubrun, F., Monsaingeon, M., Corcuff, J., Laulin, J., & Simonnet, G. (2014) · Pain Research and Management · doi:10.1155/2014/285308 · Cited by 18

Central sensitization associated with low fetal hemoglobin levels in adults with sickle cell anemia

Darbari, D. S., Vaughan, K., Roskom, K., Seamon, C., Diaw, L., Quinn, M., Conrey, A. K., Schechter, A. N., Haythornthwaite, J. A., Waclawiw, M. A., et al. (2017) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2017.08.001 · Cited by 18

Optimal Pain Control in Abdominal Wall Reconstruction

Khansa, I., Jefferson, R. C., Khansa, L., & Janis, J. E. (2018) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000004870 · Cited by 18

Risk factors for postoperative pain in the first three weeks after arthroscopic or open shoulder surgery

de Boer, F. A., Schouten, T. T. J., Boekestein, E. P., van Eijk, F., van Kampen, P. M., Bazuin, R., & Huijsmans, P. E. (2019) · Orthopaedics & Traumatology Surgery & Research · doi:10.1016/j.otsr.2018.08.018 · Cited by 18

Positive allosteric modulation of the cannabinoid type-1 receptor (CB1R) in periaqueductal gray (PAG) antagonizes anti-nociceptive and cellular effects of a mu-opioid receptor agonist in morphine-withdrawn rats

Datta, U., Kelley, L. K., Middleton, J. W., & Gilpin, N. W. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05650-5 · Cited by 18

Transcutaneous electric acupoint stimulation alleviates remifentanil-induced hyperalgesia in patients undergoing thyroidectomy: a randomized controlled trial.

Chen, Y., Yao, Y., Wu, Y., Dai, D., Zhao, Q., & Qiu, L. (2015) · PubMed Central · Cited by 18

Opioids for Persistent Noncancer Pain

McCleane, G. J., & Smith, H. S. (2007) · Medical Clinics of North America · doi:10.1016/j.mcna.2006.10.013 · Cited by 18

Social environment alters opioid‐induced hyperalgesia and antinociceptive tolerance in adolescent mice

Bates, M. L. S., Emery, M. A., Wellman, P. J., & Eitan, S. (2016) · European Journal of Pain · doi:10.1002/ejp.825 · Cited by 16

Fundamental sex differences in morphine withdrawal-induced neuronal plasticity

Hadschieff, V., Drdla-Schutting, R., Springer, D. N., Siegert, A., Schroeder, H., & Sandkühler, J. (2020) · Pain · doi:10.1097/j.pain.0000000000001901 · Cited by 18

Short-chain fatty acid, butyrate prevents morphine-and paclitaxel-induced nociceptive hypersensitivity

Jessup, D., Woods, K., Thakker, S., Damaj, M. I., & Akbarali, H. I. (2023) · Scientific Reports · doi:10.1038/s41598-023-44857-2 · Cited by 17

Are opioids effective analgesics and is physiological opioid dependence benign? Revising current assumptions to effectively manage long‐term opioid therapy and its deprescribing

Manhapra, A., MacLean, R. R., Rosenheck, R. A., & Becker, W. C. (2023) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.15972 · Cited by 17

Patients with Chronic Pain

Salama-Hanna, J., & Chen, G. L. (2013) · Medical Clinics of North America · doi:10.1016/j.mcna.2013.07.005 · Cited by 17

C-Fos activation in the periaqueductal gray following acute morphine-3β-d-glucuronide or morphine administration

Arout, C. A., Caldwell, M., McCloskey, D. P., & Kest, B. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.02.056 · Cited by 17

Pain Medicine

Ballantyne, J. C. (2011) · Anesthesiology · doi:10.1097/aln.0b013e3182039f87 · Cited by 17

Preprotachykinin-A Gene Disruption Attenuates Nociceptive Sensitivity After Opioid Administration and Incision by Peripheral and Spinal Mechanisms in Mice

Sahbaie, P., Shi, X., Li, X., Liang, D., Guo, T., Qiao, Y., Yeomans, D. C., Kingery, W. S., & Clark, J. D. (2012) · Journal of Pain · doi:10.1016/j.jpain.2012.07.009 · Cited by 17

Long-term Consequences of Acute Pain for Patients under Methadone or Buprenorphine Maintenance Treatment

Lapeyre‐Mestre, M. (2013) · Pain Physician · doi:10.36076/ppj.2013/16/e739 · Cited by 17

Widespread Pressure Pain Hypersensitivity, Health History, and Trigger Points in Patients with Chronic Neck Pain: A Preliminary Study

Castaldo, M., Catena, A., Fernández‐de‐las‐Peñas, C., & Arendt‐Nielsen, L. (2019) · Pain Medicine · doi:10.1093/pm/pnz035 · Cited by 17

Carbamazepine Potentiates the Effectiveness of Morphine in a Rodent Model of Neuropathic Pain

Due, M. R., Yang, X.-F., Allette, Y. M., Randolph, A. L., Ripsch, M. S., Wilson, S. M., Dustrude, E. T., Khanna, R., & White, F. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107399 · Cited by 17

Review of Cancer Pain Management in Patients Receiving Maintenance Methadone Therapy

Rowley, D., McLean, S., O’Gorman, A., Ryan, K., & McQuillan, R. (2010) · American Journal of Hospice and Palliative Medicine® · doi:10.1177/1049909110380897 · Cited by 17

Anesthesia and Treatment of Chronic Pain

Stein, C., & Köpf, A. (2010) · Elsevier eBooks · doi:10.1016/b978-0-443-06959-8.00058-3 · Cited by 17

Measuring Pain Avoidance‐Like Behavior in Drug‐Dependent Rats

Pahng, A. R., & Edwards, S. (2018) · Current Protocols in Neuroscience · doi:10.1002/cpns.53 · Cited by 17

The Median Effective Dose of Ketamine and Gabapentin in Opioid-Induced Hyperalgesia in Rats

Elstraete, A. C. V., Sitbon, P., Benhamou, D., & Mazoit, J. (2011) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3182222b59 · Cited by 17

Understanding and Managing Patients with Chronic Pain

Szumita, R. P., Szumita, P. M., & Just, N. (2010) · Oral and Maxillofacial Surgery Clinics of North America · doi:10.1016/j.coms.2010.07.005 · Cited by 16

Statistical Fragility of Ketamine Infusion During Scoliosis Surgery to Reduce Opioid Tolerance and Postoperative Pain

Gupta, A., Mo, K., Movsik, J., & Farii, H. A. (2022) · World Neurosurgery · doi:10.1016/j.wneu.2022.04.121 · Cited by 17

Attitudes and Beliefs of Working and Work-Disabled People with Chronic Pain Prescribed Long-Term Opioids

Robinson, J. P., Dansie, E. J., Wilson, H., Rapp, S. E., & Turk, D. C. (2015) · Pain Medicine · doi:10.1111/pme.12770 · Cited by 16

Intersection of chronic pain treatment and opioid analgesic misuse: causes, treatments, and policy strategies

Wachholtz, A., Gonzalez, Boyer, A., Naqvi, Rosenbaum, V., & Ziedonis (2011) · Substance Abuse and Rehabilitation · doi:10.2147/sar.s12944 · Cited by 16

A micro-imaging study linking bone cancer pain with tumor growth and bone resorption in a rat model

Doré-Savard, L., Beaudet, N., Tremblay, L., Xiao, Y., Lepage, M., & Sarret, P. (2012) · Clinical & Experimental Metastasis · doi:10.1007/s10585-012-9530-0 · Cited by 16

Epigenetic regulation of G protein coupled receptor signaling and its implications in psychiatric disorders

Dogra, S., Sona, C., Kumar, A., & Yadav, P. N. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.03.012 · Cited by 17

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Yap, R. J., Nassif, G. J., Hwang, G. S., Mendez, A., Erkan, A., Kelly, J. J., deBeche-Adams, T., Albert, M. R., & Monson, J. R. T. (2020) · Digestive Surgery · doi:10.1159/000505516 · Cited by 16

Serotonin Plays a Key Role in the Development of Opioid-Induced Hyperalgesia in Mice

Sasaki, M., Kamiya, Y., Bamba, K., Onishi, T., Matsuda, K., Kohno, T., Kurabe, M., Furutani, K., & Yanagimura, H. (2021) · Journal of Pain · doi:10.1016/j.jpain.2020.12.008 · Cited by 17

Antinociceptive effect of hydroalcoholic extract and isoflavone isolated from Polygala molluginifolia in mice: evidence for the involvement of opioid receptors and TRPV1 and TRPA1 channels

Nucci-Martins, C., do Nascimento, L. F., Venzke, D., Brethanha, L. C., Sako, A. V. F., de Oliveira, A. S., Brighente, I. M. C., Micke, G. A., Pizzolatti, M. G., & Santos, A. R. S. (2016) · Phytomedicine · doi:10.1016/j.phymed.2016.02.002 · Cited by 16

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Sanna, M. D., Ghelardini, C., & Galeotti, N. (2016) · Pain Medicine · doi:10.1093/pm/pnw241 · Cited by 16

Low-Dose Ketamine Infusion for Postoperative Pain Management

Rakic, A. M., & Golembiewski, J. (2009) · Journal of PeriAnesthesia Nursing · doi:10.1016/j.jopan.2009.05.097 · Cited by 16

Intentional Intrathecal Opioid Detoxification in 3 Patients: Characterization of the Intrathecal Opioid Withdrawal Syndrome

Jackson, T. P., Lonergan, D. F., Todd, R. D., & Martin, P. (2012) · Pain Practice · doi:10.1111/j.1533-2500.2012.00584.x · Cited by 16

Mechanisms of Remifentanil-Induced Postoperative Hyperalgesia: A Comprehensive Review

Zhu, K., Wen, X., Mei, X., Fang, F., & Zhang, T. (2025) · Drug Design Development and Therapy · doi:10.2147/dddt.s550335 · Cited by 21

Preoperative opioids before adult spinal deformity surgery associated with increased reoperations and high rates of chronic postoperative opioid use at 3-year follow-up

Samuel, A. M., Morse, K. W., Pompeu, Y. A., Vaishnav, A. S., Gang, C. H., Kim, H. J., & Qureshi, S. A. (2022) · Spine Deformity · doi:10.1007/s43390-021-00450-z · Cited by 15

Perioperative management of the child on long‐term opioids

Geary, T., Negus, A., Anderson, B. J., & Zernikow, B. (2011) · Pediatric Anesthesia · doi:10.1111/j.1460-9592.2011.03737.x · Cited by 15

Feasibility of dexmedetomidine as sole analgesic agent during robotic urological surgery: A pilot study

Ramachandran, R., Selvaraj, B. J., Rewari, V., Trikha, A., Chandralekha, Kumar, R., & Dogra, P. N. (2017) · Journal of Anaesthesiology Clinical Pharmacology · doi:10.4103/0970-9185.209753 · Cited by 15

Comparative analysis of duration of postoperative analgesia between levobupivacaine and levobupivacaine with clonidine after ultrasound-guided transversus abdominis plane block in patients undergoing lower segment cesarean section

Baksi, R., Acharya, R., & Mohapatra, P. (2018) · Anesthesia Essays and Researches · doi:10.4103/aer.aer_163_18 · Cited by 15

Fentanyl-induced hyperalgesia and analgesic tolerance in male rats: common underlying mechanisms and prevention by a polyamine deficient diet

Laboureyras, E., Boujema, M. B., Mauborgne, A., Simmers, J., Pohl, M., & Simonnet, G. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01200-5 · Cited by 15

Serum IL-10 involved in morphine tolerance development during adjuvant-induced arthritis

Zaringhalam, J., Hormozi, A., Tekieh, E., Razavi, J., Khanmohammad, R., & Golabi, S. (2014) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-014-0330-7 · Cited by 15

Drug Class Review: Long-Acting Opioid Analgesics

Carson, S., Thakurta, S., Low, A., Smith, B., & Chou, R. (2011) · Cited by 15

Protective effects of dexmedetomidine combined with flurbiprofen axetil on remifentanil-induced hyperalgesia: A randomized controlled trial

Yu, Z., Wu, W., Wu, X., Lei, H., Gong, C., & Xu, S. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3687 · Cited by 15

Postoperative analgesia for shoulder surgery

Desai, N. (2017) · British Journal of Hospital Medicine · doi:10.12968/hmed.2017.78.9.511 · Cited by 15

Attitudes Towards and Management of Opioid-induced Hyperalgesia

Kum, E., Buckley, N., de León-Casasola, O. A., Lema, M. J., & Busse, J. W. (2020) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000814 · Cited by 15

Opioid-Induced Hyperalgesia and Rapid Opioid Detoxification After Tacrolimus Administration

Pinna, A. D., Piraccini, E., Miklosova, Z., Taddei, S., Faenza, S., & Martinelli, G. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181602c3e · Cited by 15

Opioids

Fukuda, K. (2010) · Elsevier eBooks · doi:10.1016/b978-0-443-06959-8.00027-3 · Cited by 14

Narcotic analgesics

Buchanan, W. W., Rainsford, K. D., Kean, C. A., & Kean, W. F. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01304-y · Cited by 14

Independent and joint contributions of physical disability and chronic pain to incident opioid use disorder and opioid overdose among Medicaid patients

Hoffman, K. L., Milazzo, F., Williams, N., Samples, H., Olfson, M., Diaz, I. M., Doan, L., Cerdá, M., Crystal, S., & Rudolph, K. E. (2023) · Psychological Medicine · doi:10.1017/s003329172300332x · Cited by 14

Microglial Nrf2/HO-1 signaling gates remifentanil-induced hyperalgesia via suppressing TRPV4-mediated M1 polarization

Liu, X., Cai, H., Liang, P., Ma, H., Yan, Y., Li, W., & Zhao, J. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.01.047 · Cited by 14

Oral and Parenteral Opioid Analgesics for Acute Pain Management

Sinatra, R. S. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511576706.015 · Cited by 14

Ceasing Intrathecal Therapy in Chronic Non-Cancer Pain: An Invitation to Shift from Biomedical Focus to Active Management

Hayes, C., Jordan, M., Hodson, F. J., & Ritchard, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049124 · Cited by 13

Profound Reduction in Sedation and Analgesic Requirements Using Extended Dexmedetomidine Infusions in a Patient With an Open Abdomen

Wallace, S., Mecklenburg, B. W., & Hanling, S. R. (2009) · Military Medicine · doi:10.7205/milmed-d-00-6009 · Cited by 14

Effects of remifentanil versus nitrous oxide on postoperative nausea, vomiting, and pain in patients receiving thyroidectomy

Kim, M. K., Yi, M. S., Kang, H., & Choi, G.-J. (2016) · Medicine · doi:10.1097/md.0000000000005135 · Cited by 14

Comparison of effects of desflurane and sevoflurane on postoperative nausea, vomiting, and pain in patients receiving opioid-based intravenous patient-controlled analgesia after thyroidectomy

Yoon, I. J., Kang, H., Baek, C. W., Choi, G. J., Park, Y., Jung, Y. H., Woo, Y. C., & Lee, S. (2017) · Medicine · doi:10.1097/md.0000000000006681 · Cited by 14

Social & psychological factors associated with oral analgesic use in knee osteoarthritis management

Vina, E. R., Hausmann, L. R. M., Obrosky, D. S., Youk, A. O., Ibrahim, S. A., Weiner, D. K., Gallagher, R. M., & Kwoh, C. K. (2019) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2019.01.010 · Cited by 14

Opioid Taper is Associated with Improved Experimental Pain Tolerance in Patients with Chronic Pain: An Observational Study

Compton, P. A., Halabicky, O. M., Aryal, S., & Badiola, I. J. (2022) · Pain and Therapy · doi:10.1007/s40122-021-00348-8 · Cited by 14

Improving acute pain management in emergency medicine

Pollack, C. V., & Viscusi, E. R. (2015) · Hospital Practice · doi:10.1080/21548331.2015.1000794 · Cited by 14

Physician introduction to opioids for pain among patients with opioid dependence and depressive symptoms

Tsui, J. I., Herman, D. S., Kettavong, M., Alford, D. P., Anderson, B. J., & Stein, M. D. (2010) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2010.06.012 · Cited by 14

Efficacy of arthroscopically placed pain catheter adjacent to the suprascapular nerve (continuous arthroscopically assisted suprascapular nerve block) following arthroscopic rotator-cuff repair

Yamakado, K. (2014) · Open Access Journal of Sports Medicine · doi:10.2147/oajsm.s63345 · Cited by 14

Opioid-Induced Hyperalgesia

(2015) · Journal of Pain & Relief · doi:10.4172/2167-0846.1000183 · Cited by 14

Hydrocodone is More Effective than Morphine or Oxycodone in Suppressing the Development of Burn-Induced Mechanical Allodynia

Emery, M. A., Bates, M. L. S., Wellman, P. J., & Eitan, S. (2017) · Pain Medicine · doi:10.1093/pm/pnx050 · Cited by 14

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Rash, J. A., Buckley, N., Busse, J. W., Campbell, T. S., Corace, K., Cooper, L., Flusk, D., Iorio, A., Lavoie, K., Poulin, P. A., et al. (2018) · Systematic Reviews · doi:10.1186/s13643-018-0858-7 · Cited by 14

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Kurklinsky, S., Boone, M. K., Candler, S. A., Schwab, A., & Ghazi, S. M. (2019) · Pain Medicine · doi:10.1093/pm/pnz295 · Cited by 14

Intrathecal injection of KN93 attenuates paradoxical remifentanil-induced postoperative hyperalgesia by inhibiting spinal CaMKII phosphorylation in rats

Jiang, M., Zhang, W., Cheng, C., Ma, Z., & Gu, X. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.04.015 · Cited by 14

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Dattatri, R., Jain, V. K., Iyengar, K. P., Vaishya, R., & Garg, R. K. (2020) · Journal of Clinical Orthopaedics and Trauma · doi:10.1016/j.jcot.2020.10.022 · Cited by 13

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Yamakita, S., Fujita, D., Sudo, K., Ishikawa, D., Kushimoto, K., Horii, Y., & Amaya, F. (2023) · Molecular Pain · doi:10.1177/17448069231181973 · Cited by 13

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Weisman, S. M., Ciavarra, G., & Cooper, G. (2024) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.3389/jpps.2024.12384 · Cited by 15

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Carrascosa, A. J., Navarrete, F., Saldaña, R., García‐Gutiérrez, M. S., Moreno, B. M., Navarro, D., Gómez-Guijarro, F. M., Gasparyan, A., Murcia-Sánchez, E., Torregrosa, A. B., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116268 · Cited by 16

Opioid consumption in the first 30 days after surgery was independently associated with new persistent opioid use

Ervin-Sikhondze, B. A., Gunaseelan, V., Chua, K., Bicket, M. C., Waljee, J. F., Englesbe, M. J., & Brummett, C. M. (2024) · Regional Anesthesia & Pain Medicine · doi:10.1136/rapm-2024-106068 · Cited by 13

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Rech, R. H., Mokler, D. J., & Briggs, S. L. (2012) · Pain Research and Treatment · doi:10.1155/2012/145965 · Cited by 13

Phosphorylation of the GluN1 subunit in dorsal horn neurons by remifentanil: a mechanism for opioid-induced hyperalgesia

Zhang, C., Li, S., Zhao, N., & Yu, C. (2015) · Genetics and Molecular Research · doi:10.4238/2015.march.13.13 · Cited by 13

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Kock, M. D. (2007) · Annales Françaises d Anesthésie et de Réanimation · doi:10.1016/j.annfar.2007.04.009 · Cited by 13

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Blomqvist, K. J., Viisanen, H., Ahlström, F. H. G., Jokinen, V., Sidorova, Y. A., Suleymanova, I., Rauhala, P. V., Kalso, E. A., & Lilius, T. O. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173021 · Cited by 13

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Noori, A., Sprague, S., Bzovsky, S., Schemitsch, E. H., Poolman, R. W., Frihagen, F., Axelrod, D. E., Heels‐Ansdell, D., Bhandari, M., Busse, J. W., et al. (2020) · Journal of Orthopaedic Trauma · doi:10.1097/bot.0000000000001929 · Cited by 13

Perioperative Pain Management in the Opioid-Tolerant Individual

Gordon, D., Inturrisi, C. E., Greensmith, J. E., Brennan, T. J., Goble, L. A., & Kerns, R. D. (2008) · Journal of Pain · doi:10.1016/j.jpain.2008.01.331 · Cited by 13

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Tan, G., Dao, T., Smith, D., Robinson, A., & Jensen, M. (2010) · Psychological Services · doi:10.1037/a0020304 · Cited by 16

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Wilder‐Smith, O. H. G. (2013) · doi:10.13052/rp-9788793102545 · Cited by 13

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Ballantyne, J. C. (2009) · CRC Press eBooks · doi:10.3109/9781420089004-6 · Cited by 2

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Tompkins, D. A., & Campbell, C. M. (2011) · Current Pain and Headache Reports · doi:10.1007/s11916-010-0171-1 · Cited by 117

Opioid-Induced Hyperalgesia Syndrome in the Rehabilitation Patient

Scarfo, K. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-16784-8_31

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Brush, D. E. (2012) · Journal of Medical Toxicology · doi:10.1007/s13181-012-0260-0 · Cited by 101

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Raffa, R. B., & Pergolizzi, J. V. (2011) · Pain Management Nursing · doi:10.1016/j.pmn.2011.04.002 · Cited by 40