Opioid-induced Hyperalgesia: A Qualitative Systematic Review

Acute Opioid Tolerance

Guignard, B., Bossard, A. E., Coste, C., Sessler, D. I., Lebrault, C., Alfonsi, P., Fletcher, D., & CHAUVIN, M. (2000) · Anesthesiology · doi:10.1097/00000542-200008000-00019 · Cited by 885

Evidence from rats that morphine tolerance is a learned response

Siegel, S. (1975) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077058 · Cited by 657

Long-lasting Hyperalgesia Induced by Fentanyl in Rats: Preventive Effect of Ketamine

Célèrier, E., Rivat, C., Jun, Y., Laulin, J.-P., Larcher, A., Reynier, P., & Simonnet, G. (2000) · Anesthesiology · doi:10.1097/00000542-200002000-00029 · Cited by 584

Opioid-induced abnormal pain sensitivity: implications in clinical opioid therapy

Mao, J. (2002) · Pain · doi:10.1016/s0304-3959(02)00422-0 · Cited by 463

Thermal hyperalgesia in association with the development of morphine tolerance in rats: roles of excitatory amino acid receptors and protein kinase C

Mao, J., Price, D. D., & Mayer, D. J. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-04-02301.1994 · Cited by 458

A Role for Proinflammatory Cytokines and Fractalkine in Analgesia, Tolerance, and Subsequent Pain Facilitation Induced by Chronic Intrathecal Morphine

Johnston, I. N., Milligan, E. D., Wieseler‐Frank, J., Frank, M. G., Zapata, V., Campisi, J., Langer, S. J., Martin, D., Green, P., Fleshner, M., et al. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1850-04.2004 · Cited by 440

Short-term infusion of the μ-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal

Angst, M. S., Koppert, W., Pahl, I., Clark, J. D., & Schmelz, M. (2003) · Pain · doi:10.1016/s0304-3959(03)00276-8 · Cited by 424

Chronic Morphine Induces Downregulation of Spinal Glutamate Transporters: Implications in Morphine Tolerance and Abnormal Pain Sensitivity

Mao, J., Sung, B., Ji, R., & Lim, G. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-18-08312.2002 · Cited by 409

Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans

Koppert, W., Sittl, R., Scheuber, K., Alsheimer, M., Schmelz, M., & Schüttler, J. (2003) · Anesthesiology · doi:10.1097/00000542-200307000-00025 · Cited by 352

Acute pain management in patients with prior opioid consumption: a case-controlled retrospective review

Rapp, S. E., Ready, B. L., & Nessly, M. L. (1995) · Pain · doi:10.1016/0304-3959(94)00168-e · Cited by 349

Morphine Induces Hyperalgesia without Involvement of µ-Opioid Receptor or Morphine-3-glucuronide

Swartjes, M., Mooren, R. A. G., Waxman, A. R., Arout, C. A., van de Wetering, K., den Hartigh, J., Beijnen, J. H., Kest, B., & Dahan, A. (2012) · Molecular Medicine · doi:10.2119/molmed.2012.00244 · Cited by 28

Perioperative Management of Patients with an Intrathecal Drug Delivery System for Chronic Pain

Grider, J. S., Re, B., & Colclough, G. W. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318181b818 · Cited by 28

Ephrins and pain

Vasileiou, I., Adamakis, I., Patsouris, E., & Theocharis, S. E. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.801456 · Cited by 28

Physical and psychosocial functioning following motor vehicle trauma: Relationships with chronic pain, posttraumatic stress, and medication use

Clapp, J. D., Masci, J., Bennett, S. A., & Beck, J. G. (2009) · European Journal of Pain · doi:10.1016/j.ejpain.2009.06.007 · Cited by 27

Hemodynamic Responses to Dexmedetomidine in Critically Injured Intubated Pediatric Burned Patients

Shank, E. S., Sheridan, R. L., Ryan, C. M., Keaney, T. J., & Martyn, J. A. J. (2012) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e318257d94a · Cited by 28

Pressure Pain Sensitivity in Patients With Suspected Opioid-Induced Hyperalgesia

Wasserman, R. A., Hassett, A. L., Harte, S. E., Goesling, J., Malinoff, H. L., Berland, D., Zollars, J. W., Moser, S. E., & Brummett, C. M. (2015) · Regional Anesthesia & Pain Medicine · doi:10.1097/aap.0000000000000315 · Cited by 28

Pharmacological sedation management in the paediatric intensive care unit

Baarslag, M. A., Allegaert, K., Knibbe, C. A. J., van Dijk, M., & Tibboel, D. (2016) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12630 · Cited by 28

Effects of ibudilast on oxycodone-induced analgesia and subjective effects in opioid-dependent volunteers

Cooper, Z. D., Johnson, K. W., Vosburg, S. K., Sullivan, M. A., Manubay, J. M., Martínez, D., Jones, J. D., Saccone, P. A., & Comer, S. D. (2017) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2017.04.029 · Cited by 28

2009 Clinical Guidelines from the American Pain Society and the American Academy of Pain Medicine on the use of chronic opioid therapy in chronic noncancer pain

Chou, R. (2009) · Cited by 27

Health Care Guideline Assessment and Management of Chronic Pain

Hooten, W. M., Gaul, J., Myers, C. D., Owens, J., Saeger, L. C., Schweim, K., & Walker, N. J. (2013) · Cited by 27

Opioid-Induced Hyperalgesia: A Diagnostic Dilemma

Carullo, V. P., Fitz-James, I. A., & Delphin, E. S. (2015) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.3109/15360288.2015.1082006 · Cited by 27

Morphine Exacerbates Postfracture Nociceptive Sensitization, Functional Impairment, and Microglial Activation in Mice

Li, W., Irvine, K., Sahbaie, P., Guo, T., Shi, X., Tawfik, V. L., Kingery, W. S., & Clark, J. D. (2018) · Anesthesiology · doi:10.1097/aln.0000000000002495 · Cited by 27

Monitoring an Ongoing Enhanced Recovery After Surgery (ERAS) Program: Adherence Improves Clinical Outcomes in a Comparison of Three Thousand Colorectal Cases.

Wei, I. H., Pappou, E. P., Smith, J. J., Widmar, M., Nash, G. M., Weiser, M. R., Paty, P. B., Guillem, J. G., Afonso, A. M., & García‐Aguilar, J. (2020) · PubMed · Cited by 27

The effect of opioid-free anaesthesia on the quality of recovery after endoscopic sinus surgery

Zhou, F., Cui, Y., Opioid-Free Anesthesia Working Group†, & Cao, L. (2023) · European Journal of Anaesthesiology · doi:10.1097/eja.0000000000001784 · Cited by 27

Evaluation of prescription opioids using operant-based pain measures in rats.

Morgan, D., Carter, C. S., DuPree, J. P., Yezierski, R. P., & Vierck, C. J. (2008) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0013520 · Cited by 27

Opioids Enhance CXCL1 Expression and Function After Incision in Mice

Sun, Y., Sahbaie, P., Liang, D., Li, W., & Clark, J. D. (2014) · Journal of Pain · doi:10.1016/j.jpain.2014.05.003 · Cited by 27

Low doses of α2‐adrenoceptor antagonists augment spinal morphine analgesia and inhibit development of acute and chronic tolerance

Milne, B., Sutak, M., Cahill, C. M., & Jhamandas, K. H. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.353 · Cited by 27

CLINICAL STUDY: Lack of effect of chronic dextromethorphan on experimental pain tolerance in methadone‐maintained patients

Compton, P. A., Ling, W. W., & Torrington, M. A. (2008) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00112.x · Cited by 27

Continuous Intrathecal Morphine Administration for Cancer Pain Management Using an Intrathecal Catheter Connected to a Subcutaneous Injection Port: A Retrospective Analysis of 22 Terminal Cancer Patients in Korean Population

Kim, J., Jung, J. Y., & Cho, M. S. (2013) · The Korean journal of pain · doi:10.3344/kjp.2013.26.1.32 · Cited by 27

Opioid-induced latent sensitization in a model of non-inflammatory viscerosomatic hypersensitivity

Lian, B., Vera–Portocarrero, L. P., King, T. E., Ossipov, M. H., & Porreca, F. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.032 · Cited by 27

Fentanyl-Induced Neurotoxicity and Paradoxic Pain

Okon, T. R., & George, M. L. (2008) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2007.04.023 · Cited by 27

Evaluation of the effect of ketamine on remifentanil-induced hyperalgesia: a double-blind, randomized study

Leal, P. D. C., Salomão, R., Brunialti, M. K. C., & Sakata, R. K. (2015) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2015.02.002 · Cited by 26

Assessment of the Effect of Ketamine in Combination with Remifentanil on Postoperative Pain

Leal, P. D. C., Sakata, R. K., Salomão, R., Sadatsune, E. J., & Issy, A. M. (2013) · Brazilian Journal of Anesthesiology (English Edition) · doi:10.1016/j.bjane.2012.02.005 · Cited by 26

Opioid-induced hypernociception is associated with hyperexcitability and altered tetrodotoxin-resistant Na+ channel function of dorsal root ganglia

Ross, G. R., Gade, A. R., Dewey, W. L., & Akbarali, H. I. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00171.2011 · Cited by 26

The Economic Impact of Opioid Use in the Management of Chronic Nonmalignant Pain

Lipman, A. G., & Webster, L. R. (2015) · Journal of Managed Care & Specialty Pharmacy · doi:10.18553/jmcp.2015.21.10.891 · Cited by 26

In Vitro Nociceptor Neuroplasticity Associated with In Vivo Opioid-Induced Hyperalgesia

Khomula, E. V., Araldi, D., & Levine, J. D. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1191-19.2019 · Cited by 26

Perioperative systemische Schmerztherapie bei Kindern

Messerer, B., Grögl, G., Stromer, W., & Jaksch, W. (2014) · Der Schmerz · doi:10.1007/s00482-013-1384-0 · Cited by 27

Role of Melatonin in the Prevention of Morphine-Induced Hyperalgesia and Spinal Glial Activation in Rats: Protein Kinase C Pathway Involved

Xin, W., Wang, C., Lin, L., & Wei, W. (2011) · International Journal of Neuroscience · doi:10.3109/00207454.2011.635828 · Cited by 26

The Use of Ketamine in Severe Cases of Refractory Pain Syndromes in the Palliative Care Setting: A Case Series

Kerr, C., Holahan, T. J., & Milch, R. A. (2011) · Journal of Palliative Medicine · doi:10.1089/jpm.2010.0424 · Cited by 26

The Netrin-1 receptor DCC is a regulator of maladaptive responses to chronic morphine administration

Liang, D., Zheng, M., Sun, Y., Sahbaie, P., Low, S. A., Peltz, G., Scherrer, G., Flores, C., & Clark, J. D. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-345 · Cited by 26

Remifentanil-induced hyperalgesia: the current state of affairs

Vitin, A. A., & Egan, T. D. (2024) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000001400 · Cited by 25

β-Arrestin-2-Biased Agonism of Delta Opioid Receptors Sensitizes Transient Receptor Potential Vanilloid Type 1 (TRPV1) in Primary Sensory Neurons

Rowan, M. P., Szteyn, K., Doyle, A. P., Gómez, R. S., Henry, M. A., & Jeske, N. A. (2014) · Molecular Pain · doi:10.1186/1744-8069-10-50 · Cited by 25

Burden of increasing opioid use in the treatment of migraine: Results from the Migraine in America Symptoms and Treatment Study

Lipton, R. B., Buse, D. C., Dodick, D. W., Schwedt, T. J., Singh, P., Munjal, S., Fanning, K. M., Bostic, R. C., & Reed, M. L. (2020) · Headache The Journal of Head and Face Pain · doi:10.1111/head.14018 · Cited by 25

Development of opioid-induced hyperalgesia depends on reactive astrocytes controlled by Wnt5a signaling

Liu, X., Bae, C., Liu, B., Zhang, Y., Zhou, X., Zhang, D., Zhou, C., DiBua, A., Schutz, L., Kaczocha, M., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01815-0 · Cited by 25

The YTHDF1–TRAF6 pathway regulates the neuroinflammatory response and contributes to morphine tolerance and hyperalgesia in the periaqueductal gray

Ouyang, H., Zhang, J., Chi, D., Zhang, K., Huang, Y., Huang, J., Huang, W., & Bai, X. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02672-y · Cited by 25

Duration of spinal anesthesia with bupivacaine in chronic opium abusers undergoing lower extremity orthopedic surgery.

Dabbagh, A., Dahi, M., Elyasi, H., Vosoughian, M., Malek, B., Rajaei, S., & Maftuh, H. (2007) · PubMed · Cited by 25

Antinociceptive effects of high dose remifentanil in male methadone‐maintained patients

Hay, J. L., White, J. M., Bochner, F., & Somogyi, A. A. (2008) · European Journal of Pain · doi:10.1016/j.ejpain.2007.12.012 · Cited by 25

Opioids for Persistent Noncancer Pain

McCleane, G. J., & Smith, H. S. (2007) · Anesthesiology Clinics · doi:10.1016/j.anclin.2007.08.002 · Cited by 25

Hyperalgesia in Patients With a History of Opioid Use Disorder

Trøstheim, M., & Eikemo, M. (2024) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2024.2176 · Cited by 27

Predictors of Improvements in Pain Intensity in a National Cohort of Older Veterans With Chronic Pain

Dobscha, S. K., Lovejoy, T. I., Morasco, B. J., Kovas, A. E., Peters, D., Hart, K. D., Williams, J. L., & McFarland, B. H. (2016) · Journal of Pain · doi:10.1016/j.jpain.2016.03.006 · Cited by 24

Experimental considerations for the assessment of in vivo and in vitro opioid pharmacology

Hill, R., & Canals, M. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107961 · Cited by 25

μ-Opioid Receptor Gene A118 G Variants and Persistent Pain Symptoms Among Men and Women Experiencing Motor Vehicle Collision

Linnstaedt, S. D., Hu, J., Bortsov, A. V., Soward, A. C. M., Swor, R. A., Jones, J. S., Lee, D., Peak, D. A., Domeier, R. M., Rathlev, N. K., et al. (2015) · Journal of Pain · doi:10.1016/j.jpain.2015.03.011 · Cited by 24

Efficacy and safety of morphine‐6‐glucuronide (M6G) for postoperative pain relief: A randomized, double‐blind study

Smith, T. W., Binning, A. R., & Dahan, A. (2008) · European Journal of Pain · doi:10.1016/j.ejpain.2008.04.015 · Cited by 24

Sciatic Nerve Block Fails in Preventing the Development of Late Stress-Induced Hyperalgesia When High-Dose Fentanyl Is Administered Perioperatively in Rats

Méleine, M., Rivat, C., Laboureyras, E., Cahana, A., & Richebé, P. (2012) · Regional Anesthesia & Pain Medicine · doi:10.1097/aap.0b013e318257a87a · Cited by 24

A Review of Opioids for In-Hospital Pain Management

Viscusi, E. R., & Pappagallo, M. (2012) · Hospital Practice · doi:10.3810/hp.2012.02.955 · Cited by 24

Effects of Opium Addiction on Level of Sensory Block in Spinal Anesthesia With Bupivacaine for Lower Abdomen and Limb Surgery: a Case-Control Study

Karbasy, S. H., & Derakhshan, P. (2014) · Anesthesiology and Pain Medicine · doi:10.5812/aapm.21571 · Cited by 24

Automated analgesic drugs delivery guided by vagal tone evaluation: Interest of the Analgesia Nociception Index (ANI)

Jonckheere, J. D., Delecroix, M., Jeanne, M., Keribedj, A., Couturier, N., & Logier, R. (2013) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2013.6609910 · Cited by 24

The Effect of Nefopam Infusion during Laparascopic Cholecystectomy on Postoperative Pain

Kim, E. M., Jeon, J. H., Chung, M. H., Choi, E. M., Baek, S. H., Jeon, P. H., & Lee, M. H. (2017) · International Journal of Medical Sciences · doi:10.7150/ijms.19021 · Cited by 24

Racial differences in presentations and predictors of acute pain after motor vehicle collision

Beaudoin, F. L., Gutman, R., Zhai, W., Merchant, R. C., Clark, M. A., Bollen, K. A., Hendry, P. L., Kurz, M. C., Lewandowski, C., Pearson, C., et al. (2018) · Pain · doi:10.1097/j.pain.0000000000001186 · Cited by 26

Aminoguanidine Hydrazone Derivatives as Nonpeptide NPFF1 Receptor Antagonists Reverse Opioid Induced Hyperalgesia

Hammoud, H., Elhabazi, K., Quillet, R., Bertin, I., Utard, V., Laboureyras, E., Bourguignon, J., Bihel, F. J. ‐., Simonnet, G., Simonin, F., et al. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00099 · Cited by 24

Magnesium modifies fentanyl-induced local antinociception and hyperalgesia

Mert, T., Güneş, Y., Özcengiz, D., & Günay, İ. (2009) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-009-0447-3 · Cited by 24

Sustained Morphine Treatment Augments Capsaicin-Evoked Calcitonin Gene-Related Peptide Release from Primary Sensory Neurons in a Protein Kinase A- and Raf-1-Dependent Manner

Tumati, S., Yamamura, H. I., Vanderah, T. W., Roeske, W. R., & Varga, E. V. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.151704 · Cited by 24

Opioid-Induced Hyperalgesia (OIH)

Leal, P. D. C., Clivatti, J., Garcia, J. B. S., & Sakata, R. K. (2010) · Brazilian Journal of Anesthesiology · doi:10.1016/s0034-7094(10)70080-5 · Cited by 24

Preemptive Antihyperalgesia to Improve Preemptive Analgesia

Simonnet, G. (2008) · Anesthesiology · doi:10.1097/aln.0b013e3181650edd · Cited by 24

Enhancement of meditation analgesia by opioid antagonist in experienced meditators

May, L. M., Kosek, P., Zeidan, F., & Berkman, E. T. (2018) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000580 · Cited by 24

Withdrawal-associated injury site pain (WISP): a descriptive case series of an opioid cessation phenomenon

Rieb, L. M., Norman, W. V., Martin, R. E., Berkowitz, J., Wood, E., McNeil, R., & Milloy, M. (2016) · Pain · doi:10.1097/j.pain.0000000000000710 · Cited by 22

OPRM1 and COMT Polymorphisms: Implications on Postoperative Acute, Chronic and Experimental Pain After Cardiac Surgery

Matić, M., de Hoogd, S., de Wildt, S. N., Tibboel, D., Knibbe, C. A. J., & van Schaik, R. H. (2020) · Pharmacogenomics · doi:10.2217/pgs-2019-0141 · Cited by 23

Facilitating mGluR4 activity reverses the long-term deleterious consequences of chronic morphine exposure in male mice

Becker, J. A. J., Pellissier, L. P., Corde, Y., Laboute, T., Léauté, A., Gandía, J., & Merrer, J. L. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-00927-x · Cited by 21

Preparation of uniform-sized GeXIVA[1,2]-loaded PLGA microspheres as long-effective release system with high encapsulation efficiency

Li, L., Li, Z., Guo, Y., Zhang, K., Mi, W., & Liu, J. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2089297 · Cited by 23

Astrocyte PERK and IRE1 Signaling Contributes to Morphine Tolerance and Hyperalgesia through Upregulation of Lipocalin-2 and NLRP3 Inflammasome in the Rodent Spinal Cord

Wang, B., Wang, L., Wu, B., Guo, R., Zhang, L., Zhang, J., Wang, Z., Wu, F., Feng, Y. Y., Liu, H., et al. (2023) · Anesthesiology · doi:10.1097/aln.0000000000004858 · Cited by 23

Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude

Gerhold, K. J., Drdla-Schutting, R., Honsek, S. D., Forsthuber, L., & Sandkühler, J. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0731-14.2015 · Cited by 23

Factors That Might Impact Intrathecal Drug Delivery ( IDD ) Dose Escalation: A Longitudinal Study

Mekhail, N. A., Mahboobi, R., Deroee, A. F., Costandi, S. J., Dalton, J. E., Guirguis, M. N., & Mehta, P. (2013) · Pain Practice · doi:10.1111/papr.12096 · Cited by 23

Opioids for chronic pain: promise and pitfalls

Stannard, C. (2011) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e3283458fbc · Cited by 22

The healing power of well-being

Mathew, J., & Paulose, C. S. (2011) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2011.00578.x · Cited by 23

Reduced Response to the Thermal Grill Illusion in Chronic Pain Patients

Sumracki, N. M., Buisman‐Pijlman, F. T. A., Hutchinson, M. R., Gentgall, M., & Rolan, P. E. (2014) · Pain Medicine · doi:10.1111/pme.12379 · Cited by 25

Remifentanil Compared With Sufentanil Does Not Enhance Fast-Track Possibilities in Cardiac Surgery—A Randomized Study

Bhavsar, R. P., Ryhammer, P. K., Greisen, J. R., Rasmussen, L. A., & Jakobsen, C.-J. (2015) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2015.12.021 · Cited by 23

Analgesic reduction during an interdisciplinary pain management programme: treatment effects and processes of change

Guildford, B. J., Daly-Eichenhardt, A., Hill, B., Sanderson, K., & McCracken, L. M. (2017) · British Journal of Pain · doi:10.1177/2049463717734016 · Cited by 24

Palliative Care for the Cancer Patient

Reville, B., Axelrod, D. J., & Maury, R. (2009) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2009.07.010 · Cited by 23

Pain after Discontinuation of Morphine Treatment Is Associated with Synaptic Increase of GluA4-Containing AMPAR in the Dorsal Horn of the Spinal Cord

Cabañero, D., Baker, A., Zhou, S., Hargett, G. L., Irie, T., Xia, Y., Beaudry, H., Gendron, L., Melyan, Z., Carlton, S. M., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.46 · Cited by 22

Induction of c-Fos and zif268 in the nociceptive amygdala parallel abstinence hyperalgesia in rats briefly exposed to morphine

Hamlin, A. S., McNally, G. P., & Osborne, P. B. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.05.017 · Cited by 24

Current Concepts of Pain Pathways: A Brief Review of Anatomy, Physiology, and Medical Imaging

Gonzalez-Hermosillo, D.-C., González-Hermosillo, L.-M., Villaseñor-Almaraz, M., Herrera, D. B., Moreno‐Jiménez, S., Corona-Cedillo, R., Velasco‐Campos, F., Carrillo-Ruiz, J. D., & Roldán-Valadéz, E. (2023) · Current Medical Imaging Formerly Current Medical Imaging Reviews · doi:10.2174/1573405620666230519144112 · Cited by 22

New opioid side effects and implications for long-term therapy

Raghavan, S., Harvey, A., & Humble, S. R. (2010) · Trends in Anaesthesia and Critical Care · doi:10.1016/j.cacc.2010.06.003 · Cited by 24

Behavioral characterization, potential clinical relevance and mechanisms of latent pain sensitization

Gerum, M., & Simonin, F. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108032 · Cited by 22

Low-Dose Ketamine in Chronic Critical Illness

Moitra, V. K., Patel, M. K., Darrah, D., Moitra, A., & Wunsch, H. (2015) · Journal of Intensive Care Medicine · doi:10.1177/0885066615587868 · Cited by 22

Grounding Frequent Flyers, Not Abandoning Them: Drug Seekers in the ED

Millard, W. B. (2007) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2007.02.013 · Cited by 22

Pancreatectomy and Autologous Islet Transplantation for Painful Chronic Pancreatitis: Indications and Outcomes

Bellin, M. D., Sutherland, D. E. R., & Robertson, R. P. (2012) · Hospital Practice · doi:10.3810/hp.2012.08.992 · Cited by 22

The effect of adjuvant midazolam compared with fentanyl on the duration of spinal anesthesia with 0.5% bupivacaine in opium abusers

Safari, F., Dabbagh, A., & Sharifnia, M. (2012) · Korean Journal of Anesthesiology · doi:10.4097/kjae.2012.63.6.521 · Cited by 22

The multiple PDZ domain protein Mpdz/MUPP1 regulates opioid tolerance and opioid-induced hyperalgesia

Donaldson, R., Sun, Y., Liang, D., Zheng, M., Sahbaie, P., Dill, D. L., Peltz, G., Buck, K. J., & Clark, J. D. (2016) · BMC Genomics · doi:10.1186/s12864-016-2634-1 · Cited by 22

Effectiveness of long-term opioid therapy among chronic non-cancer pain patients attending multidisciplinary pain treatment clinics: A Quebec Pain Registry study

Saïdi, H., Pagé, M. G., Boulanger, A., Ware, M. A., & Choinière, M. (2018) · Canadian Journal of Pain · doi:10.1080/24740527.2018.1451252 · Cited by 24

Inhalation sedation for postoperative patients in the intensive care unit: initial sevoflurane concentration and comparison of opioid use with propofol sedation

Jung, S., Na, S., Kim, H.-B., Joo, H. J., & Kim, J. (2020) · Acute and Critical Care · doi:10.4266/acc.2020.00213 · Cited by 22

Relief of Cancer Pain by Glycine Transporter Inhibitors

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