Cited by 1,188Pain Management and Opioid UseAnesthesia and Pain ManagementOpioid Use Disorder Treatment

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Opioid-induced Hyperalgesia: A Qualitative Systematic Review

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Angst, Martin S., Clark, J David·2006·Anesthesiology

DOI 10.1097/00000542-200603000-00025

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Abstract

Opioids are the cornerstone therapy for the treatment of moderate to severe pain. Although common concerns regarding the use of opioids include the potential for detrimental side effects, physical dependence, and addiction, accumulating evidence suggests that opioids may yet cause another problem, often referred to as opioid-induced hyperalgesia. Somewhat paradoxically, opioid therapy aiming at alleviating pain may render patients more sensitive to pain and potentially may aggravate their preexisting pain. This review provides a comprehensive summary of basic and clinical research concerning opioid-induced hyperalgesia, suggests a framework for organizing pertinent information, delineates the status quo of our knowledge, identifies potential clinical implications, and discusses future research directions.

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Authors: Angst, M. S., & Clark, J. D.
Affiliations: Stanford Medicine (US)
VA Palo Alto Health Care System (US)
ORCID: Angst, Martin S.
Venue: Anesthesiology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2006-03-01
Volume: 104
Issue: 3
Pages: 570-587
ISSN: 0003-3022 (ISSN-L)
DOI: 10.1097/00000542-200603000-00025
OpenAlex: W2005703418
Cited by: 1,188
References: 176
Citations by year: 2026: 30 · 2025: 34 · 2024: 26 · 2023: 37 · 2022: 34 · 2021: 49 · 2020: 98 · 2019: 55 · 2018: 59 · 2017: 45 · 2016: 62 · 2015: 80 · 2014: 84 · 2013: 77 · 2012: 83
FWCI: 10.46
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Anesthesiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Pain Management
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Keywords: opioid-induced hyperalgesia, opioids, pain sensitivity, analgesic side effects, chronic pain, opioid analgesia
MeSH terms: Analgesics, Opioid, Animals, Humans, Hyperalgesia, Opioid-Related Disorders

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Opioid-induced Hyperalgesia: A Qualitative Systematic Review

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