Intraoperative Determination of Small Intestinal Viability following Ischemic Injury: A Prospective, Controlled Trial of Two Adjuvant Methods (Doppler and Fluorescein) Compared with Standard Clinical Judgment

BULKLEY, GREGORY B.; ZUIDEMA, GEORGE D.; HAMILTON, STANLEY R.; OʼMARA, CHARLES S.; KLACSMANN, PETER G.; HORN, SUSAN D.

doi:10.1097/00000658-198105000-00014

Cited by 203Abdominal vascular conditions and treatmentsIntestinal and Peritoneal AdhesionsGastrointestinal Bleeding Diagnosis and Treatment

Intraoperative Determination of Small Intestinal Viability following Ischemic Injury: A Prospective, Controlled Trial of Two Adjuvant Methods (Doppler and Fluorescein) Compared with Standard Clinical Judgment

Open access

BULKLEY, GREGORY B., ZUIDEMA, GEORGE D., HAMILTON, STANLEY R., OʼMARA, CHARLES S., KLACSMANN, PETER G., HORN, SUSAN D.·1981·Annals of Surgery

DOI 10.1097/00000658-198105000-00014PMC PMC1345136

Open this paper in CoChat — free account

Abstract

Two adjuvant techniques for the intraoperative assessment of small intestinal viability were compared with standard clinical judgment in a prospective, controlled study of 71 ischemic bowel segments in 28 consecutive patients operated on for acute intestinal ischemic disease. Each segment was independently assessed 15 minutes after surgical correction of the underlying lesion by: 1) standard clinical judgment; 2) Doppler-detected pulsatile mural blood flow; and 3) fluorescein ultraviolet fluorescence pattern. Viability endpoint for each segment was determined objectively by patient follow-up or "blinded" microscopic evaluation of histologically unequivocal resection specimens using criteria established by previous animal studies. Seventeen histologically equivocal specimens were excluded from the final results. Standard clinical judgment proved moderately accurate overall (89%) but would have led to a relatively high rate (46%) of unnecessary bowel resection. The Doppler technique did not increase accuracy in any category of evaluation. The fluorescein fluorescent pattern was correct in all 54 determinant bowel segments, and proved more sensitive specific, predictive, and significantly more accurate overall than either standard clinical judgment or the Doppler method. This controlled study suggests that the fluorescein technique is the method of choice for the prediction of small intestinal recovery following ischemic injury.

Integrity signals

Registry

Crossref · 10.1097/00000658-198105000-00014

Cites

19 of 19 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

THE VALUE OF FLUORESCEIN IN PREDICTING THE VIABILITY OF ARTERIALIZED FLAPS
McCraw, J. B., MYERS, B. M., & SHANKLIN, K. D. (1977) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-197711000-00006 · Cited by 129 · see citing works
Prediction of intestinal viability using Doppler ultrasound technics
Wright, C. B., & Hobson, R. W. (1975) · The American Journal of Surgery · doi:10.1016/0002-9610(75)90337-2 · Cited by 93 · see citing works
Comparison of Methods to Determine Viability of Small Intestine
Bussemaker, J., & Lindeman, J. H. N. (1972) · Annals of Surgery · doi:10.1097/00000658-197207000-00017 · Cited by 64 · see citing works
Determination of viability of ischemic intestine by Doppler ultrasound.
Cooperman, M., Pace, W. G., Martin, E. W., Pflug, B. K., Lm, K., Evans, W. E., & Carey, L. C. (1978) · PubMed · Cited by 53 · see citing works
Anaphylactoid Reaction to Intravenously Administered Fluorescein
LaPiana, F. G., & Penner, R. (1968) · Archives of Ophthalmology · doi:10.1001/archopht.1968.03850040163009 · Cited by 48 · see citing works
New parameters of viability in ischemic bowel disease
Katz, S., Wahab, A., Murray, W., & Williams, L. F. (1974) · The American Journal of Surgery · doi:10.1016/0002-9610(74)90149-4 · Cited by 42 · see citing works
Evaluation of ischemic bowel viability with a fluorescent technique
Stolar, C. J. H., & Randolph, J. G. (1978) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(78)80390-x · Cited by 39 · see citing works
Evaluation of ischemic intestine by Doppler ultrasound
Cooperman, M., Martin, E. W., & Carey, L. C. (1980) · The American Journal of Surgery · doi:10.1016/0002-9610(80)90232-9 · Cited by 35 · see citing works
Electromyography to determine viability of injured small bowel segments: an experimental study with preliminary clinical observations.
Schamaun, M. (1967) · PubMed · Cited by 32 · see citing works
Prediction of the viability of revascularized intestine with radioactive microspheres.
Zarins, C. K., Skinner, D. B., Rhodes, B. A., & James, A. E. (1974) · PubMed · Cited by 30 · see citing works
Reliable intraoperative prediction of intestinal viability using a fluorescent indicator.
Marfuggi, R. A., & Greenspan, M. (1981) · PubMed · Cited by 26 · see citing works
Operative confirmation of Doppler ultrasound in evaluation of intestinal ischemia.
O'Donnell, J. A., & Rw, H. (1980) · PubMed · Cited by 23 · see citing works
Use of Doppler ultrasound in intestinal surgery
Cooperman, M., Martin, E. W., Keith, L. M., & Carey, L. C. (1979) · The American Journal of Surgery · doi:10.1016/0002-9610(79)90311-8 · Cited by 21 · see citing works
Prediction of intestinal viability by intra-arterial dye injection: A simple test
Papachristou, D. N., & Fortner, J. G. (1976) · The American Journal of Surgery · doi:10.1016/0002-9610(76)90344-5 · Cited by 20 · see citing works
Assessment of anastomotic blood supply by Doppler ultrasound in operations upon the colon.
Cooperman, M., Martin, E. W., Evans, W. E., & Carey, L. C. (1979) · PubMed · Cited by 19 · see citing works
Cardiac Arrest Following Fluorescein Angiography
Cunningham, E. E. (1979) · JAMA · doi:10.1001/jama.1979.03300220043023 · Cited by 18 · see citing works
Use of intraperitoneal xenon-133 for imaging of intestinal strangulation in small bowel obstruction
Bulkley, G. B., Gharagozloo, F., Alderson, P. O., Horn, S. D., & Zuidema, G. D. (1981) · The American Journal of Surgery · doi:10.1016/0002-9610(81)90025-8 · Cited by 16 · see citing works
Self-citation
Assessment of small intestinal recovery from ischemic injury after segmental, arterial, venous, and arteriovenous occlusion.
Gb, B., Lg, W., Strandberg, J. D., & Gd, Z. (1979) · PubMed · Cited by 15 · see citing works
Use of vital dyes in the evaluation of the blood supply of the colon.
Mb, M., & Cherry, G. (1969) · PubMed · Cited by 10 · see citing works

Flagged first, then by citations

Sorted by citations

ACC/AHA 2005 Practice Guidelines for the Management of Patients With Peripheral Arterial Disease (Lower Extremity, Renal, Mesenteric, and Abdominal Aortic): A Collaborative Report from the American Association for Vascular Surgery/Society for Vascular Surgery,* Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Peripheral Arterial Disease): Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation; National Heart, Lung, and Blood Institute; Society for Vascular Nursing; TransAtlantic Inter-Society Consensus; and Vascular Disease Foundation
Hirsch, A. T., Haskal, Z. J., Hertzer, N. R., Bakal, C. W., Creager, M. A., Halperin, J. L., Hiratzka, L. F., Murphy, W. R. C., Olin, J. W., Puschett, J. B., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.174526 · Cited by 3,708 · see citing works
Acute Mesenteric Ischemia: A Clinical Review
Oldenburg, W. A., Lau, L. L., Rodenberg, T. J., Edmonds, H. J., & Burger, C. D. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.10.1054 · Cited by 714 · see citing works
Editor's Choice – Management of the Diseases of Mesenteric Arteries and Veins
Björck, M., Koelemay, M., Acosta, S., Bastos Goncalves, F., Kölbel, T., Kolkman, J. J., Lees, T., Lefevre, J. H., Menyhei, G., Oderich, G., et al. (2017) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2017.01.010 · Cited by 658 · see citing works
Preoperative recognition of intestinal strangulation obstruction
Sarr, M. G., Bulkley, G. B., & Zuidema, G. D. (1983) · The American Journal of Surgery · doi:10.1016/0002-9610(83)90186-1 · Cited by 306 · see citing works
Self-citation
Acute Mesenteric Ischemia: Diagnostic Approach and Surgical Treatment
Wyers, M. C. (2010) · Seminars in Vascular Surgery · doi:10.1053/j.semvascsurg.2009.12.002 · Cited by 259 · see citing works
How to assess intestinal viability during surgery: A review of techniques
Urbanavičius, L. (2011) · World Journal of Gastrointestinal Surgery · doi:10.4240/wjgs.v3.i5.59 · Cited by 235 · see citing works
Mesenteric venous thrombosis
Harnik, I. G., & Brandt, L. J. (2010) · Vascular Medicine · doi:10.1177/1358863x10379673 · Cited by 210 · see citing works
Current Management of Small-Bowel Obstruction
Hayanga, A. J., Wilkins, K. B., & Bulkley, G. B. (2005) · Advances in Surgery · doi:10.1016/j.yasu.2005.05.001 · Cited by 175 · see citing works
Self-citation
Mesenteric Venous Thrombosis
Hmoud, B., Singal, A. K., & Kamath, P. S. (2014) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2014.03.052 · Cited by 160 · see citing works
Acute mesenteric ischemia: Pathophysiology, diagnosis, and treatment
Benjamin, E., & Oropello, J. M. (1993) · Disease-a-Month · doi:10.1016/0011-5029(93)90023-v · Cited by 150 · see citing works
Indocyanine green for the prevention of anastomotic leaks following esophagectomy: a meta-analysis
Ladak, F., Dang, J. T., Switzer, N. J., Mocanu, V., Tian, C., Birch, D. W., Turner, S. R., & Karmali, S. (2018) · Surgical Endoscopy · doi:10.1007/s00464-018-6503-7 · Cited by 148 · see citing works
Management of Ischemic Colitis
Washington, C., & Carmichael, J. C. (2012) · Clinics in Colon and Rectal Surgery · doi:10.1055/s-0032-1329534 · Cited by 138 · see citing works
INTESTINAL (MESENTERIC) VASCULOPATHY I
Cappell, M. S. (1998) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(05)70033-9 · Cited by 127 · see citing works
ACC/AHA 2005 Guidelines for the Management of Patients With Peripheral Arterial Disease (Lower Extremity, Renal, Mesenteric, and Abdominal Aortic): A Collaborative Report from the American Association for Vascular Surgery/Society for Vascular Surgery,⁎Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Peripheral Arterial Disease)
Hirsch, A. T., Haskal, Z. J., HERTZER, N. R., Bakal, C. W., Creager, M. A., Halperin, J. L., Hiratzka, L. F., Murphy, W. R. C., Olin, J. W., Puschett, J. B., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.02.024 · Cited by 127 · see citing works
Gastrointestinal Perforation and the Acute Abdomen
Langell, J. T., & Mulvihill, S. J. (2008) · Medical Clinics of North America · doi:10.1016/j.mcna.2007.12.004 · Cited by 125 · see citing works
Operative Assessment of Intestinal Viability
Horgan, P. G., & Gorey, T. F. (1992) · Surgical Clinics of North America · doi:10.1016/s0039-6109(16)45632-x · Cited by 117 · see citing works
Current Management of Small Bowel Obstruction
Zielinski, M. D., & Bannon, M. P. (2011) · Advances in Surgery · doi:10.1016/j.yasu.2011.03.017 · Cited by 108 · see citing works
INTESTINAL (MESENTERIC) VASCULOPATHY II
Cappell, M. S. (1998) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(05)70034-0 · Cited by 100 · see citing works
Mesenteric ischemia
Schneider, T. A., Longo, W. E., Ure, T., & Vernava, A. M. (1994) · Diseases of the Colon & Rectum · doi:10.1007/bf02049824 · Cited by 89 · see citing works
Mesenteric Ischemia
Williams, L. F. (1988) · Surgical Clinics of North America · doi:10.1016/s0039-6109(16)44481-6 · Cited by 83 · see citing works
Ischemic bowel disease in 2021.
Ahmed, M. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i29.4746 · Cited by 77 · see citing works
Indocyanine green fluorescence angiographyversusstandard intraoperative methods for prevention of anastomotic leak in colorectal surgery: meta-analysis
Trastulli, S., Munzi, G., Desiderio, J., Cirocchi, R., Rossi, M., & Parisi, A. (2021) · British journal of surgery · doi:10.1093/bjs/znaa139 · Cited by 75 · see citing works
Acute mesenteric ischemia after cardio-pulmonary bypass surgery
Abboud, B., Daher, R., & Jaoude, J. B. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.5361 · Cited by 69 · see citing works
Acute mesenteric ischemia after cardiopulmonary bypass
Gennaro, M., Ascer, E., Matano, R., Jacobowitz, I. J., Cunningham, J. N., & Uceda, P. V. (1993) · The American Journal of Surgery · doi:10.1016/s0002-9610(05)81062-1 · Cited by 66 · see citing works
Intraperitoneal and intraluminal microdialysis in the detection of experimental regional intestinal ischaemia
Sommer, T., & Larsen, J. F. (2004) · British journal of surgery · doi:10.1002/bjs.4586 · Cited by 66 · see citing works
The novel use of intraoperative laser-induced fluorescence of indocyanine green tissue angiography for evaluation of the gastric conduit in esophageal reconstructive surgery
Pacheco, P. E., Hill, S. M., Henriques, S. M., Paulsen, J. K., & Anderson, R. C. (2013) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2012.11.005 · Cited by 64 · see citing works
Qualitative and quantitative fluorescein fluorescence in determining intestinal viability
Carter, M. S., Fantinl, G. A., Sammartano, R. J., Mttsudo, S., Silverman, D. G., & Boley, S. J. (1984) · The American Journal of Surgery · doi:10.1016/0002-9610(84)90044-8 · Cited by 61 · see citing works
The Role of Intravenous Fluorescein in the Detection of Colon Ischemia During Aortic Reconstruction
Bergman, R., Gloviczki, P., Welch, T. J., Naessens, J. M., Bower, T. C., Hallett, J. W., Pairolero, P. C., & Cherry, K. J. (1992) · Annals of Vascular Surgery · doi:10.1007/bf02000672 · Cited by 58 · see citing works
Intramural pH
Senagore, A. J., Milsom, J. W., Walshaw, R. K., Dunstan, R. W., Mazier, P. W., & Chaudry, I. H. (1990) · Diseases of the Colon & Rectum · doi:10.1007/bf02134174 · Cited by 51 · see citing works
Doppler Ultrasound, Laser Doppler, and Perfusion Fluorometry in Bowel Ischemia
Lynch, T. G. (1988) · Archives of Surgery · doi:10.1001/archsurg.1988.01400280093017 · Cited by 51 · see citing works
Techniques for intraoperative evaluation of bowel viability in mesenteric ischemia: A review
Bryski, M. G., Sulyok, L. G. F., Kaplan, L. J., Singhal, S. K., & Keating, J. J. (2020) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2020.01.042 · Cited by 50 · see citing works
Does near-infrared (NIR) fluorescence angiography modify operative strategy during emergency procedures?
Liot, E., Assalino, M., Buchs, N. C., Schiltz, B., Douissard, J., Morel, P., & Ris, F. (2018) · Surgical Endoscopy · doi:10.1007/s00464-018-6226-9 · Cited by 48 · see citing works
Noninvasive Diagnosis of Mesenteric Ischemia Using a SQUID Magnetometer
Richards, W. O., Garrard, C. L., Allos, S. H., Bradshaw, L. A., Staton, D. J., & Wikswo, J. P. (1995) · Annals of Surgery · doi:10.1097/00000658-199506000-00009 · Cited by 48 · see citing works
Validation of IC-VIEW fluorescence videography in a rabbit model of mesenteric ischaemia and reperfusion
Toens, C., Krones, C. J., Blum, U., Fernandez, V., Grommes, J., Hoelzl, F., Stumpf, M., Klinge, U., & Schumpèlick, V. (2005) · International Journal of Colorectal Disease · doi:10.1007/s00384-005-0017-1 · Cited by 45 · see citing works
Small bowel obstruction: a review of 264 cases and suggestions for management
Deutsch, A. A., Eviatar, E., Gutman, H., & Reiss, R. (1989) · Postgraduate Medical Journal · doi:10.1136/pgmj.65.765.463 · Cited by 45 · see citing works
Mesenteric vascular insufficiency
Montgomery, R. A., Venbrux, A. C., & Bulkley, G. B. (1997) · Current Problems in Surgery · doi:10.1016/s0011-3840(97)80009-3 · Cited by 45 · see citing works
Self-citation
Mesenteric Ischemia in the Elderly
Ruotolo, R. A., & Evans, S. R. T. (1999) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(18)30047-8 · Cited by 44 · see citing works
Xanthine oxidase formation during experimental ischemia of the equine small intestine.
Prichard, M. A., Ducharme, N. G., Wilkins, P. A., Erb, H. N., & Butt, M. (1991) · Europe PMC (PubMed Central) · Cited by 44 · see citing works
Colonic complications of acute pancreatitis and pancreatic abscess
RUSSELL, J. C., Welch, J. P., & Clark, D. G. (1983) · The American Journal of Surgery · doi:10.1016/0002-9610(83)90288-x · Cited by 43 · see citing works
Ischemia/reperfusion injury in porcine intestine - Viability assessment
Strand-Amundsen, R. J., Reims, H. M., Reinholt, F. P., Ruud, T. E., Yang, R., Høgetveit, J. O., & Tønnessen, T. I. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i18.2009 · Cited by 42 · see citing works
Review: Acute superior mesenteric artery embolism
Liao, G., Chen, S., Cao, H., Wang, W., & Gao, Q. (2019) · Medicine · doi:10.1097/md.0000000000014446 · Cited by 40 · see citing works
The use of indocyanine green fluorescence to define bowel microcirculation during laparoscopic surgery for acute small bowel obstruction
Guerra, F., Coletta, D., Greco, P. A., Eugeni, E., & Patriti, A. (2021) · Colorectal Disease · doi:10.1111/codi.15680 · Cited by 36 · see citing works
Surgical therapy for acute superior mesenteric artery embolism
Bingöl, H., Zeybek, N., Cíngöz, F., Yılmaz, A. T., Tatar, H., & Şen, D. (2004) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2003.10.022 · Cited by 33 · see citing works
Quantification of fluorescein distribution to strangulated rat ileum
Silverman, D. G., Hurford, W. E., Cooper, H. S., Robinson, M., & Brousseau, D. A. (1983) · Journal of Surgical Research · doi:10.1016/0022-4804(83)90058-6 · Cited by 33 · see citing works
Mesenteric Infarction after Aortoiliac Surgery on the Basis of 1752 Operations from the National Vascular Registry
Järvinen, O., Laurikka, J. O., Salenius, J. ‐., Lepäntalo, M., & Finnvasc Study Group (1999) · World Journal of Surgery · doi:10.1007/pl00013190 · Cited by 33 · see citing works
Intraoperative Laser Doppler Flowmetry: A Predictor of Ischemic Injury in Acute Mesenteric Infarction
Redaelli, C. A., Schilling, M. K., & Büchler, M. W. (1998) · Digestive Surgery · doi:10.1159/000018587 · Cited by 32 · see citing works
Preservation of ovarian tissue in adnexal torsion with fluorescein
Mchutchison, L. B., Koonings, P. P., Ballard, C. A., & dʼAblaing, G. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(11)90769-8 · Cited by 31 · see citing works
Acute Mesenteric Ischemia
Lendzion, R. J., Frahm‐Jensen, G., & Keck, J. O. (2022) · Clinics in Colon and Rectal Surgery · doi:10.1055/s-0042-1743283 · Cited by 30 · see citing works
Management of Conduit Necrosis Following Esophagectomy
Dickinson, K. J., & Blackmon, S. H. (2015) · Thoracic surgery clinics/Thorac. surg. clin. · doi:10.1016/j.thorsurg.2015.07.008 · Cited by 30 · see citing works
Identification of cartilage injury using quantitative multiphoton microscopy
Novakofski, K. D., Williams, R. M., Fortier, L. A., Mohammed, H. O., Zipfel, W. R., & Bonassar, L. J. (2013) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2013.10.008 · Cited by 27 · see citing works
Fluorescence angiography vs. direct palpation for bowel viability evaluation with strangulated bowel obstruction
Ryu, S., Hara, K., Goto, K., Okamoto, A., Kitagawa, T., Marukuchi, R., Ito, R., & Nakabayashi, Y. (2021) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-021-02358-8 · Cited by 27 · see citing works
Laparoscopic Diagnostics of Acute Bowel Ischemia Using Ultraviolet Light and Fluorescein Dye: An Experimental Study
Jiri, P., Alexander, F., Michal, P., Jan, R., Dimitar, H.-N., David, D., & Vendelin, C. (2007) · Surgical Laparoscopy, Endoscopy & Percutaneous Techniques · doi:10.1097/sle.0b013e3180dc9376 · Cited by 27 · see citing works
The Pathophysiology of Small Intestinal Foreign Body Obstruction and Intraoperative Assessment of Tissue Viability in Dogs: A Review
Mullen, K. M., Regier, P. J., Ellison, G. W., & Londoño, L. A. (2020) · Topics in companion animal medicine · doi:10.1016/j.tcam.2020.100438 · Cited by 26 · see citing works
The relationship between the adenine nucleotide metabolism and the conversion of the xanthine oxidase enzyme system in ischemia-reperfusion of the rat small intestine
Hirata, Y., Taguchi, T., Nakao, M., Yamada, T., Hirose, R., & Suita, S. (1996) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(96)90231-6 · Cited by 26 · see citing works
In vivo characterization of ischemic small intestine using bioimpedance measurements
Strand-Amundsen, R. J., Tronstad, C., Kalvøy, H., Gundersen, Y., Krohn, C. D., Aasen, A. O., Holhjem, L., Reims, H. M., Martinsen, Ø. G., Høgetveit, J. O., et al. (2016) · Physiological Measurement · doi:10.1088/0967-3334/37/2/257 · Cited by 25 · see citing works
Outcome Comparison of Endovascular and Open Surgery for the Treatment of Acute Superior Mesenteric Artery Embolism: A Retrospective Study
Li, W., Cao, S., Zhang, Z., Zhu, R., Chen, X., Liu, B., & Feng, H. (2022) · Frontiers in Surgery · doi:10.3389/fsurg.2022.833464 · Cited by 25 · see citing works
Mesenteric Vascular Disease: A Review of Diagnostic Methods and Therapies
Geelkerken, R. H., & van Bockel, J. H. (1995) · Cardiovascular Surgery · doi:10.1016/0967-2109(95)93872-m · Cited by 25 · see citing works
Mesenteric Artery Occlusive Disease
Moore, W. M., & Moore, L. H. (1991) · Cardiology Clinics · doi:10.1016/s0733-8651(18)30290-x · Cited by 25 · see citing works
Clinical features of patients with hepatic portal venous gas
Fujii, M., Yamashita, S., Tanaka, M., Tashiro, J., Takenaka, Y., Yamasaki, K., & Masaki, Y. (2020) · BMC Surgery · doi:10.1186/s12893-020-00973-8 · Cited by 24 · see citing works
Intraoperative Doppler Assessment of Gastric Tube Perfusion in Esophagogastroplasty
Tsekov, C., Belyaev, O., Tcholakov, O., & Tcherveniakov, A. (2005) · Journal of Surgical Research · doi:10.1016/j.jss.2005.07.037 · Cited by 24 · see citing works
Mesenteric arterial ischaemia: diagnosis and therapeutic options
Cleveland, T. J., Nawaz, S., & Gaines, P. A. (2002) · Vascular Medicine · doi:10.1191/1358863x02vm454ra · Cited by 24 · see citing works
Usefulness of blood flow evaluation with indocyanine green fluorescence imaging during laparoscopic surgery for strangulated bowel obstruction: A cohort study
Nakashima, K., Ryu, S., Okamoto, A., Hara, K., Ishida, K., Ito, R., & Nakabayashi, Y. (2021) · Asian Journal of Surgery · doi:10.1016/j.asjsur.2021.08.020 · Cited by 23 · see citing works
Serum lactate and phosphate as biomarkers of intestinal ischemia in a Ugandan tertiary hospital: a cross-sectional study
Kintu-Luwaga, R., Galukande, M., & Owori, F. N. (2013) · International Journal of Emergency Medicine · doi:10.1186/1865-1380-6-44 · Cited by 23 · see citing works
Acute mesenteric ischaemia
Corder, A. P., & Taylor, I. (1993) · Postgraduate Medical Journal · doi:10.1136/pgmj.69.807.1 · Cited by 23 · see citing works
Intestinal Obstruction
Holder, W. D. (1988) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(21)00365-4 · Cited by 23 · see citing works
Should intestinal continuity be restored after massive intestinal resection?
Nguyen, B.-L. T., Blatchford, G. J., Thompson, J. S., & Bragg, L. E. (1989) · The American Journal of Surgery · doi:10.1016/0002-9610(89)90197-9 · Cited by 22 · see citing works
Etiology of cecal and hepatic lesions in mice after administration of gas-carrier contrast agents used in ultrasound imaging☆
Rasmussen, H., Dirven, H. A. A. M., Grant, D., Johnsen, H., & Midtvedt, T. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(03)00101-7 · Cited by 22 · see citing works
Investigating viability of intestine using spectroscopy: a pilot study
Karakaş, B. R., Sırcan-Küçüksayan, A., Elpek, G. Ö., & Murat Canpolat, A. (2014) · Journal of Surgical Research · doi:10.1016/j.jss.2014.03.052 · Cited by 21 · see citing works
Transcatheter thrombolysis centered stepwise management strategy for acute superior mesenteric venous thrombosis
Yang, S., Wu, X., & Li, J. (2014) · International Journal of Surgery · doi:10.1016/j.ijsu.2014.03.015 · Cited by 20 · see citing works
Infrared imaging contribution for intestinal ischemia detection in wound healing
Malafaia, O., Brioschi, M. L., Aoki, S. M. S., Dias, F., Gugelmin, B. S., Aoki, M. S., & Aoki, Y. (2008) · Acta Cirúrgica Brasileira · doi:10.1590/s0102-86502008000600008 · Cited by 20 · see citing works
Prospects of Intraoperative Multimodal OCT Application in Patients with Acute Mesenteric Ischemia
Kiseleva, E. B., Ryabkov, M. G., Baleev, M. S., Львовна, Б. Е., Shilyagin, P. A., Moiseev, A. A., Beschastnov, V. V., Romanov, I., Gelikonov, G. V., & Gladkova, N. D. (2021) · Diagnostics · doi:10.3390/diagnostics11040705 · Cited by 19 · see citing works
Detection thresholds of nonocclusive intestinal hypoperfusion by Doppler ultrasound, photoplethysmography, and fluorescein
Whitehill, T. A., Pearce, W. H., Rosales, C., Yano, T., Way, C. W. V., & Rutherford, R. B. (1988) · Journal of Vascular Surgery · doi:10.1016/0741-5214(88)90239-x · Cited by 19 · see citing works
Laparoscopic evaluation of intestinal ischemia using fluorescein and ultraviolet light in a porcine model
McGinty, J. J., Hogle, N., & Fowler, D. L. (2003) · Surgical Endoscopy And Other Interventional Techniques · doi:10.1007/s00464-001-8255-y · Cited by 18 · see citing works
Ischemic small intestine— in vivo versus ex vivo bioimpedance measurements
Strand-Amundsen, R. J., Reims, H. M., Tronstad, C., Kalvøy, H., Martinsen, Ø. G., Høgetveit, J. O., Ruud, T. E., & Tønnessen, T. I. (2017) · Physiological Measurement · doi:10.1088/1361-6579/aa67b7 · Cited by 17 · see citing works
Machine learning for intraoperative prediction of viability in ischemic small intestine
Strand-Amundsen, R. J., Tronstad, C., Reims, H. M., Reinholt, F. P., Høgetveit, J. O., & Tønnessen, T. I. (2018) · Physiological Measurement · doi:10.1088/1361-6579/aae0ea · Cited by 17 · see citing works
Retrospective Study on Risk Factors and Short-Term Outcome of Horses Referred for Colic from 2016 to 2022
Straticò, P., Varasano, V., Palozzo, A., Guerri, G., Celani, G., Revelant, O., & Petrizzi, L. (2022) · Veterinary Sciences · doi:10.3390/vetsci9100545 · Cited by 17 · see citing works
Intraoperative Assessment of Bowel Viability
Holmes, N. J., Cazi, G., Reddell, M. T., Gorman, J. H., Fedorciw, B. J., Semmlow, J. L., & Brolin, R. E. (1993) · Journal of Investigative Surgery · doi:10.3109/08941939309141610 · Cited by 17 · see citing works
The mucosal blood flow in pelvic pouches in man
Perbeck, L. G., Lindquist, K., & Liljeqvist, L. (1985) · Diseases of the Colon & Rectum · doi:10.1007/bf02554310 · Cited by 17 · see citing works
Infrared laser Doppler flowmeter in the determination of small bowel perfusion after ischemic injury: Comparison with the clearance of locally generated hydrogen and fluorescein angiography
DiResta, G. R., Corbally, M. T., Sigurdson, E. R., Haumschild, D. J., Ridge, R., & Brennan, M. F. (1994) · Journal of Pediatric Surgery · doi:10.1016/0022-3468(94)90114-7 · Cited by 17 · see citing works
Small intestinal ischemia and reperfusion—bioimpedance measurements
Strand-Amundsen, R. J., Tronstad, C., Kalvøy, H., Ruud, T. E., Høgetveit, J. O., Martinsen, Ø. G., & Tønnessen, T. I. (2018) · Physiological Measurement · doi:10.1088/1361-6579/aaa576 · Cited by 16 · see citing works
Fluorescein-assisted laparoscopy in the identification of arterial mesenteric ischemia
Kam, D., & Scheeres, D. E. (1993) · Surgical Endoscopy · doi:10.1007/bf00704381 · Cited by 16 · see citing works
Intraoperative Determination of Intestinal Viability by Pulse Oximetry
Tollefson, D. F. J., Wright, D. J., Reddy, D. J., & Kintanar, E. B. (1995) · Annals of Vascular Surgery · doi:10.1007/bf02139407 · Cited by 16 · see citing works
Assessment of intestinal viability using a non-contact laser tissue blood flowmeter
Ando, M., Ito, M., Nihei, Z., & Sugihara, K. (2000) · The American Journal of Surgery · doi:10.1016/s0002-9610(00)00444-x · Cited by 16 · see citing works
Non-occlusive mesenteric ischemia: two case reports and a short review of the literature
Versyck, G., de Gheldere, C., & Vanclooster, P. (2017) · Acta chirurgica Belgica · doi:10.1080/00015458.2017.1408280 · Cited by 15 · see citing works
Conversion of xanthine dehydrogenase to xanthine oxidase during ischemia of the rat small intestine and the effect of trifluoperazine on the conversion
Hirata, Y., Ishii, K., Taguchi, T., Suita, S., & Takeshige, K. (1993) · Journal of Pediatric Surgery · doi:10.1016/0022-3468(93)90668-b · Cited by 14 · see citing works
Embolization of the Mesenteric Arteries: Surgical Treatment in Twenty-Three Consecutive Cases
Lazaro, T., Sierra, L., Gesto, R. B., Villafana, W., Fonseca, J., Porto, J., & Lozano-Vilardell, P. (1986) · Annals of Vascular Surgery · doi:10.1016/s0890-5096(06)60125-8 · Cited by 14 · see citing works
Ischaemia/Reperfusion Contributes to Colonic Injury Following Experimental Aortic Surgery
Reber, P. U., Peter, M., Patel, A. G., Stauffer, E., Printzen, G., Mettler, D., Hakki, H., & Kniemeyer, H. W. (2001) · European Journal of Vascular and Endovascular Surgery · doi:10.1053/ejvs.2000.1264 · Cited by 14 · see citing works
Surgical management and outcome in acute ischemic colitis.
(2011) · PubMed Central · Cited by 13 · see citing works
A new technique for evaluating cutaneous vascularity in complicated conjoined twins
Ross, A. J., O’Neill, J. A., Silverman, D. G., Brousseau, D. A., Gatti, J. E., & Templeton, J. M. (1985) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(85)80037-3 · Cited by 13 · see citing works
Intestinal ischemia: Treatment by peritoneal lavage with oxygenated perfluorochemical
Floyd, T. F., Boroughs, A., Garvey, C., Dasher, J., Ikeda, C. B., Sloviter, H. A., & Ziegler, M. M. (1987) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(87)80736-4 · Cited by 13 · see citing works
Laparoscopic procedures for small bowel disease
Duh, Q. (1993) · Baillière s Clinical Gastroenterology · doi:10.1016/0950-3528(93)90018-n · Cited by 13 · see citing works
Utility of indocyanine green fluorescent dye in emergency general surgery: a review of the contemporary literature
Khalaf, M. H., Abdelrahman, H., El-Menyar, A. A., Afifi, I., Kloub, A. G., Al‐Hassani, A., Rizoli, S. B., & Al-Thani, H. A. S. (2024) · Frontiers in Surgery · doi:10.3389/fsurg.2024.1345831 · Cited by 12 · see citing works
Preoperative factors associated with resection and anastomosis in horses presenting with strangulating lesions of the small intestine
Pye, J. L., Espinosa‐Mur, P., Roca, R. Y., Kilcoyne, I., Nieto, J. E., & Dechant, J. E. (2019) · Veterinary Surgery · doi:10.1111/vsu.13184 · Cited by 12 · see citing works
Assessment of Intestinal Ischemia–Reperfusion Injury Using Diffuse Reflectance VIS-NIR Spectroscopy and Histology
Hou, J., Ness, S. S., Tschudi, J., O’Farrell, M., Veddegjerde, R., Martinsen, Ø. G., Tønnessen, T. I., & Strand-Amundsen, R. J. (2022) · Sensors · doi:10.3390/s22239111 · Cited by 12 · see citing works
Evaluation of jejunal microvasculature of healthy anesthetized dogs with sidestream dark field video microscopy
Mullen, K. M., Regier, P. J., Londoño, L. A., Millar, K., & Groover, J. (2020) · American Journal of Veterinary Research · doi:10.2460/ajvr.81.11.888 · Cited by 12 · see citing works
Comparison of ischemic and reperfusion injury in canine bowel viability assessment
Brolin, R. E., Bibbo, C., Petschenik, A. J., Reddell, M. T., & Semmlow, J. L. (1997) · Journal of Gastrointestinal Surgery · doi:10.1016/s1091-255x(97)80066-2 · Cited by 12 · see citing works
Does glucagon improve the viability of ischemic intestine?
Oshima, A., Kitajima, M., Sakai, N., & Ando, N. (1990) · Journal of Surgical Research · doi:10.1016/0022-4804(90)90178-5 · Cited by 12 · see citing works
Infrarenal Aortic Aneurysmectomy
Smead, W. L., & Vaccaro, P. S. (1983) · Surgical Clinics of North America · doi:10.1016/s0039-6109(16)43188-9 · Cited by 12 · see citing works
Intestinal strangulation after elective ovariohysterectomy
Kuan, S., Ticehurst, K., Hoffmann, K., Crosby, D., & Barrs, V. R. (2010) · Journal of Feline Medicine and Surgery · doi:10.1016/j.jfms.2009.09.003 · Cited by 11 · see citing works
Real‐time ancillary diagnostics for intraoperative assessment of intestinal viability in horses–looking for answers across species
Verhaar, N., & Geburek, F. (2025) · Veterinary Surgery · doi:10.1111/vsu.14248 · Cited by 10 · see citing works

Assessment of standard clinical criteria and fluorescein dye technique for intraoperative prediction of small intestinal viability in dogs
Tank, P. H., Balasubramanian, N., & David, W. P. A. (2003) · Indian Journal of Veterinary Surgery
Operative Assessment of Intestinal Viability
Horgan, P. G., & Gorey, T. F. (1992) · Surgical Clinics of North America · doi:10.1016/s0039-6109(16)45632-x · Cited by 117 · see citing works
The recovery of intestine after ischaemic injury
GOREY, T. F. (1980) · British journal of surgery · doi:10.1002/bjs.1800671006 · Cited by 25 · see citing works
Prediction of Intestinal Recovery after Ischaemic Injury Due to Arterial, Venous and Mixed Arterial and Venous Occlusions
GOREY, T. F. (1980) · Journal of the Royal Society of Medicine · doi:10.1177/014107688007300906 · Cited by 5 · see citing works
Evaluation of ischemic bowel viability with a fluorescent technique
Stolar, C. J. H., & Randolph, J. G. (1978) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(78)80390-x · Cited by 39 · see citing works

Authors: BULKLEY, G. B., ZUIDEMA, G. D., HAMILTON, S. R., OʼMARA, C. S., KLACSMANN, P. G., & HORN, S. D.
Affiliations: Johns Hopkins University (US)
ORCID: HAMILTON, STANLEY R.
HORN, SUSAN D.
Venue: Annals of Surgery
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1981-05
Volume: 193
Issue: 5
Pages: 628-637
ISSN: 0003-4932 (ISSN-L)
DOI: 10.1097/00000658-198105000-00014
PMC: PMC1345136
OpenAlex: W2049022052
Cited by: 203
References: 19
Citations by year: 2026: 3 · 2025: 6 · 2024: 6 · 2023: 6 · 2022: 7 · 2021: 11 · 2020: 6 · 2019: 4 · 2018: 7 · 2017: 7 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 3 · 2012: 5
FWCI: 6.15
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Annals of Surgery (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
Keywords: intestinal ischemia, intraoperative assessment, Doppler flow, bowel resection, histological evaluation
MeSH terms: Adolescent, Adult, Aged, Auscultation, Clinical Trials as Topic, Female, Humans, Intestine, Small, Intraoperative Period, Ischemia, Male, Middle Aged, Photofluorography, Prospective Studies, Ultrasonography

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Intraoperative Determination of Small Intestinal Viability following Ischemic Injury: A Prospective, Controlled Trial of Two Adjuvant Methods (Doppler and Fluorescein) Compared with Standard Clinical Judgment

Abstract

Integrity signals

Claims the paper makes

Self-check

Cites

Cited by

Related

Record

About these checks