Reduced Risk of Colorectal Cancer among Long-Term Users of Aspirin and Nonaspirin Nonsteroidal Antiinflammatory Drugs
Abstract
Use of nonsteroidal antiinflammatory drugs (NSAIDs) has been associated with a reduced risk of colorectal cancer, but limited information is available on the effect of individual nonaspirin NSAIDs. In addition, the dose-response relation of aspirin in reducing the risk of colorectal cancer has not been described. We carried out a population-based cohort study with secondary case-control analysis to determine the association between the risk of colorectal cancer and use of aspirin and individual NSAIDs, including the role of dose and duration. The General Practice Research Database in the U.K. was the source population. We traced 943,903 persons 40-79 years of age and free of cancer and colorectal adenoma between January 1994 and September 1997. A total of 2,002 incident cases of colorectal cancer were ascertained. The incidence rate of colorectal cancer per 10,000 person-years was 7.3. The risk of colorectal cancer was reduced in users of nonaspirin NSAIDs and became evident after 6 months of continuous treatment. The adjusted relative risk was 0.5 (95% confidence interval = 0.4-0.7). The reduction in risk disappeared completely 1 year after stopping NSAID treatment. The risk of developing colorectal cancer was reduced in long-term users of aspirin at doses of 300 mg daily (relative risk = 0.6; 95% confidence interval = 0.4-0.9). Daily doses of 75 and 150 mg aspirin were not associated with a reduced risk of colorectal cancer. Our data support the existence of an important protective effect of nonaspirin NSAID continuous intake against colorectal cancer and point to a similar reduction in risk for aspirin at doses of at least 300 mg daily. One-year treatment with NSAIDs would prevent one case of colorectal cancer in a population of 1,000 persons 70-79 years of age.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Use of aspirin and nonsteroidal anti-inflammatory drugs reduces colon cancer risk by 40-50%.
“Much data indicates that use of these drugs reduces colon cancer risk by 40–50%”
From Inflammation and cancer (2002) · cites this paper as [58]
Use of aspirin and nonsteroidal anti-inflammatory drugs may be preventative for lung, oesophagus and stomach cancer.
“and may be preventative for lung, oesophagus and stomach cancer57,58.”
From Inflammation and cancer (2002) · cites this paper as [58]
Cites
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552 · see citing works
Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas
Eberhart, C. E., Coffey, R. J., Aramandla, R., Giardiello, F. M., Ferrenbach, S., & DuBois, R. N. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90246-1 · Cited by 2,512 · see citing works
Aspirin and the Risk of Colorectal Cancer in Women
Giovannucci, E. L., Egan, K. M., Hunter, D. J., Stampfer, M. J., Colditz, G. A., Willett, W. C., & Speizer, F. E. (1995) · New England Journal of Medicine · doi:10.1056/nejm199509073331001 · Cited by 1,095 · see citing works
Aspirin use and risk of fatal cancer.
Thun, M. J., Namboodiri, M. M., Calle, E. E., Flanders, W. D., & Heath, C. W. (1993) · PubMed · Cited by 870 · see citing works
Jick, H., Jick, S. S., & Derby, L. E. (1991) · BMJ · doi:10.1136/bmj.302.6779.766 · Cited by 839 · see citing works
Aspirin Use and the Risk for Colorectal Cancer and Adenoma in Male Health Professionals
Giovannucci, E. L., Rimm, E. B., Stampfer, M. J., Colditz, G. A., Ascherio, A., & Willett, W. C. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-121-4-199408150-00001 · Cited by 784 · see citing works
Aspirin Use and Lung, Colon, and Breast Cancer Incidence in a Prospective Study
Schreinemachers, D. M., & Everson, R. B. (1994) · Epidemiology · doi:10.1097/00001648-199403000-00003 · Cited by 738 · see citing works
Kune, G. A., Kune, S., & Watson, L. F. (2007) · International Journal of Epidemiology · doi:10.1093/ije/dym193 · Cited by 654 · see citing works
Incidence of Cancer Among Patients With Rheumatoid Arthritis
Gridley, G., McLaughlin, J. K., Ekbom, A., Klareskog, L., Adami, H., Hacker, D. G., Hoover, R. N., & Fraumeni, J. F. (1993) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/85.4.307 · Cited by 580 · see citing works
Prophylactic aspirin and risk of peptic ulcer bleeding
Weil, J., Colin-Jones, D. G., Langman, M. J. S., Lawson, D. H., Logan, R., Murphy, M. S., Rawlins, M. D., Vessey, M. P., & Wainwright, P. (1995) · BMJ · doi:10.1136/bmj.310.6983.827 · Cited by 563 · see citing works
Use of the UK General Practice Research Database for pharmacoepidemiology
Rodríguez, L. A. G., & Perez‐Gutthann, S. (1998) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1998.00701.x · Cited by 559 · see citing works
A Hypothesis: Nonsteroidal Anti-Inflammatory Drugs Reduce the Incidence of Large-Bowel Cancer
Rosenberg, L. A., Palmer, J. R., Zauber, A. G., Warshauer, M. E., Stolley, P. D., & Shapiro, S. (1991) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/83.5.355 · Cited by 500 · see citing works
Aspirin use and chronic diseases: a cohort study of the elderly.
Paganini‐Hill, A., Chao, A., Ross, R. K., & Henderson, B. E. (1989) · BMJ · doi:10.1136/bmj.299.6710.1247 · Cited by 394 · see citing works
Rodriguez, L. A. G., Cattaruzzi, C., Troncon, M. G., & Agostinis, L. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.1.33 · Cited by 334 · see citing works
Aspirin Use and Colorectal Cancer: Post-Trial Follow-up Data from the Physicians' Health Study
Stürmer, T., Glynn, R. J., Lee, I.-M. M., Manson, J. E., Buring, J. E., & Hennekens, C. H. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-128-9-199805010-00003 · Cited by 288 · see citing works
Use of Nonsteroidal Anti-inflammatory Drugs and Incidence of Colorectal Cancer
Smalley, W. E., Ray, W. A., Daugherty, J. R., & Griffin, M. R. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.2.161 · Cited by 263 · see citing works
Aspirin and Nonsteroidal Anti-inflammatory Drug Use and the Risk of Subsequent Colorectal Cancer
Peleg, I. I. (1994) · Archives of Internal Medicine · doi:10.1001/archinte.1994.00420040050009 · Cited by 206 · see citing works
Forsyth, P. A., Shaw, E. G., Scheithauer, B. W., O'Fallon, J. R., Layton, D. D., & Katzmann, J. A. (1993) · Cancer · doi:10.1002/1097-0142(19930815)72:4 · Cited by 173 · see citing works
Dalton, W. S., Crowley, J. J., Salmon, S., Grogan, T. M., Laufman, L. R., Weiss, G. R., & Bonnet, J. D. (1995) · Cancer · doi:10.1002/1097-0142(19950201)75:3 · Cited by 156 · see citing works
Colorectal cancer prevention by non-steroidal anti-inflammatory drugs: effects of dosage and timing
Collet, J., Sharpe, C., Belzile, É., Boivin, J. ‐., Hanley, J. A., & Abenhaim, L. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690651 · Cited by 152 · see citing works
Onda, K., Davis, R. L., Shibuya, M., Wilson, C. B., & Hoshino, T. (1994) · Cancer · doi:10.1002/1097-0142(19941001)74:7 · Cited by 120 · see citing works
Nonsteroidal anti-inflammatory drug use and protection against colorectal cancer in women.
Reeves, M. J., Newcomb, P. A., Trentham‐Dietz, A., Storer, B. E., & Remington, P. (1996) · PubMed · Cited by 100 · see citing works
Vecchia, C. L., Negri, E., Franceschi, S., Conti, E., Montella, M., Giacosa, A., Falcini, F., & Decarli, A. (1997) · British Journal of Cancer · doi:10.1038/bjc.1997.444 · Cited by 97 · see citing works
Informed consent in the childrens cancer group
Childrens Cancer Group, Kodish, E. D., Pentz, R. D., Noll, R. B., Ruccione, K., Buckley, J. D., & Lange, B. J. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19980615)82:12 · Cited by 91 · see citing works
Peleg, I. I., Lubin, M. F., Cotsonis, G., Clark, W. S., & Wilcox, C. M. (1996) · Digestive Diseases and Sciences · doi:10.1007/bf02088554 · Cited by 90 · see citing works
FRIEDMAN, G. D., Coates, A. O., Potter, J. D., & Slattery, M. L. (1998) · Pharmacoepidemiology and Drug Safety · doi:10.1002/(sici)1099-1557(199803/04)7:2 · Cited by 57 · see citing works
Aspirin and nonsteroidal anti-inflammatory drug use and the risk of subsequent colorectal cancer
Peleg, I. I. (1994) · Archives of Internal Medicine · doi:10.1001/archinte.154.4.394 · Cited by 57 · see citing works
Coogan, P. F., Rosenberg, L. A., Louik, C., Zauber, A. G., Stolley, P. D., Strom, B. L., & Shapiro, S. (2000) · Cancer Causes & Control · doi:10.1023/a:1008931708716 · Cited by 51 · see citing works
Vainio, H., Morgan, G., & Kleihues, P. (1997) · PubMed · Cited by 32 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111 · see citing works
Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer
Ostrand‐Rosenberg, S., & Sinha, P. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802740 · Cited by 1,733 · see citing works
Thun, M. J., Henley, S. J., & Patrono, C. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.4.252 · Cited by 1,430 · see citing works
Sandler, R. S., Halabi, S., Baron, J. A., Budinger, S., Paskett, E. D., Keresztes, R. S., Petrelli, N. J., Pipas, J. M., Karp, D. D., Loprinzi, C. L., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021633 · Cited by 1,133 · see citing works
Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies
Huxley, R., Ansary-Moghaddam, A., Berrington de González, A., Barzi, F., & Woodward, M. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602619 · Cited by 1,105 · see citing works
TUMOR STROMA AND REGULATION OF CANCER DEVELOPMENT
Tlsty, T. D., & Coussens, L. M. (2006) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.1.110304.100224 · Cited by 981 · see citing works
Flossmann, E., & Rothwell, P. M. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60747-8 · Cited by 820 · see citing works
Statins and the Risk of Colorectal Cancer
Poynter, J. N., Gruber, S. B., Higgins, P., Almog, R., Bonner, J. D., Rennert, H. S., Low, M., Greenson, J. K., & Rennert, G. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043792 · Cited by 806 · see citing works
Cook, N. R., Lee, I.-M., Gaziano, J. M., Gordon, D., Ridker, P. M., Manson, J. E., Hennekens, C. H., & Buring, J. E. (2005) · JAMA · doi:10.1001/jama.294.1.47 · Cited by 796 · see citing works
Meta-analyses of colorectal cancer risk factors
Johnson, C. M., Wei, C., Ensor, J. E., Smolenski, D. J., Amos, C. I., Levin, B., & Berry, D. A. (2013) · Cancer Causes & Control · doi:10.1007/s10552-013-0201-5 · Cited by 779 · see citing works
Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment
Basnet, P., & Škalko‐Basnet, N. (2011) · Molecules · doi:10.3390/molecules16064567 · Cited by 733 · see citing works
Primary Prevention of Colorectal Cancer
Chan, A. T., & Giovannucci, E. L. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.01.057 · Cited by 729 · see citing works
Cuzick, J. M., Otto, F., Baron, J. A., Brown, P. H., Burn, J., Greenwald, P., Jankowski, J. A., Vecchia, C. L., Meyskens, F. L., Senn, H. J., et al. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70035-x · Cited by 713 · see citing works
Validity of the General Practice Research Database
Jick, S. S., Kaye, J. A., Vasilakis‐Scaramozza, C., Rodríguez, L. A. G., Ruigómez, A., Meier, C. R., Schlienger, R. G., Black, C., & Jick, H. (2003) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.23.5.686.32205 · Cited by 584 · see citing works
COX-2: A Molecular Target for Colorectal Cancer Prevention
Brown, J. R., & DuBois, R. N. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.09.051 · Cited by 529 · see citing works
Cancer and the tumor microenvironment: a review of an essential relationship
Mbeunkui, F., & Johann, D. J. (2008) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-008-0881-9 · Cited by 476 · see citing works
Long-term Use of Aspirin and Nonsteroidal Anti-inflammatory Drugs and Risk of Colorectal Cancer
Chan, A. T. (2005) · JAMA · doi:10.1001/jama.294.8.914 · Cited by 474 · see citing works
Coussens, L. M., & Werb, Z. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.6.f23 · Cited by 384 · see citing works
Patrono, C., Patrignani, P., & Rodríguez, L. A. G. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113418 · Cited by 362 · see citing works
Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patients
Yang, Y., Hennessy, S., & Lewis, J. D. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.07.011 · Cited by 350 · see citing works
Rostom, A., Dubé, C., Lewin, G., Tsertsvadze, A., Barrowman, N. J., Code, C., Sampson, M., & Moher, D. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-5-200703060-00010 · Cited by 343 · see citing works
Lewis, J. D., Bilker, W. B., Weinstein, R. B., & Strom, B. L. (2005) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1115 · Cited by 342 · see citing works
Dubé, C., Rostom, A., Lewin, G., Tsertsvadze, A., Barrowman, N. J., Code, C., Sampson, M., & Moher, D. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-5-200703060-00009 · Cited by 335 · see citing works
Harris, R. E. (2009) · Inflammopharmacology · doi:10.1007/s10787-009-8049-8 · Cited by 329 · see citing works
Understanding NSAIDs: From aspirin to COX-2
Green, G. A. (2001) · Clinical cornerstone · doi:10.1016/s1098-3597(01)90069-9 · Cited by 308 · see citing works
Proton-Pump Inhibitor Use and the Risk for Community-Acquired Pneumonia
Sarkar, M., Hennessy, S., & Yang, Y. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-149-6-200809160-00005 · Cited by 301 · see citing works
Aspirin and cancer risk: a quantitative review to 2011
Bosetti, C., Rosato, V., Gallus, S., Cuzick, J. M., & Vecchia, C. L. (2012) · Annals of Oncology · doi:10.1093/annonc/mds113 · Cited by 297 · see citing works
The Macrophage Growth Factor CSF-1 in Mammary Gland Development and Tumor Progression
Lin, E. Y., Gouon–Evans, V., Nguyen, A., & Pollard, J. W. (2002) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1020399802795 · Cited by 291 · see citing works
Effect of aspirin and NSAIDs on risk and survival from colorectal cancer
Din, F. V. N., Τheodoratou, E., Farrington, S. M., Tenesa, A., Barnetson, R. A., Cetnarskyj, R., Stark, L. A., Porteous, M. E., Campbell, H., & Dunlop, M. G. (2010) · Gut · doi:10.1136/gut.2009.203000 · Cited by 282 · see citing works
Wang, W. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djg106 · Cited by 268 · see citing works
Boursi, B., Mamtani, R., Haynes, K., & Yang, Y. (2015) · European Journal of Cancer · doi:10.1016/j.ejca.2015.08.015 · Cited by 263 · see citing works
Jung, M. R., Park, Y. K., Jeong, O., Seon, J. W., Ryu, S. Y., Kim, D. Y., & Kim, Y. J. (2011) · Journal of Surgical Oncology · doi:10.1002/jso.21986 · Cited by 251 · see citing works
Calprotectin (S100A8/S100A9): a key protein between inflammation and cancer
Shabani, F., Farasat, A., Mahdavi, M., & Gheibi, N. (2018) · Inflammation Research · doi:10.1007/s00011-018-1173-4 · Cited by 251 · see citing works
The Inflammatory Tumor Microenvironment and Its Impact on Cancer Development
de Visser, K. E., & Coussens, L. M. (2006) · KARGER eBooks · doi:10.1159/000092969 · Cited by 247 · see citing works
Aspirin Dose and Duration of Use and Risk of Colorectal Cancer in Men
Chan, A. T., Giovannucci, E. L., Meyerhardt, J. A., Schernhammer, E. S., Wu, K., & Fuchs, C. S. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.09.035 · Cited by 241 · see citing works
Wang, D., Luo, H., Qiu, M., Wang, Z., Zhang, D.-S., Wang, F.-H., Li, Y.-H., & Xu, R. (2012) · Medical Oncology · doi:10.1007/s12032-012-0226-8 · Cited by 225 · see citing works
Risk of cancer in a large cohort of nonaspirin NSAID users: a population-based study
Sørensen, H. T., Friis, S., Nørgård, B. M., Mellemkjær, L., Blot, W. J., McLaughlin, J. K., Ekbom, A., & Baron, J. A. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6600945 · Cited by 221 · see citing works
Mohammed, S. I., Bennett, P. F., Craig, B. Α., Glickman, N. W., Mutsaers, A. J., Snyder, P. W., Widmer, W. R., DeGortari, A. E., Bonney, P. L., & Knapp, D. W. (2002) · PubMed · Cited by 197 · see citing works
Lian, W.-J., Wang, X., Xie, C., Tian, H., Song, X., Pan, H., Qiao, X., & Xu, J. (2016) · Dalton Transactions · doi:10.1039/c6dt00461j · Cited by 192 · see citing works
Cyclooxygenase-2 (COX-2) and the Inflammogenesis of Cancer
Harris, R. E. (2007) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/1-4020-5688-5_4 · Cited by 181 · see citing works
O’Connor, M. J., Kellett, A., McCann, M., Rosair, G. M., McNamara, M. E., Howe, O. L., Creaven, B. S., McClean, S., Kia, A. F.-A., O′Shea, D., et al. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm201041d · Cited by 170 · see citing works
Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies
Qiao, Y., Yang, T., Gan, Y., Li, W., Wang, C., Gong, Y., & Lu, Z. (2018) · BMC Cancer · doi:10.1186/s12885-018-4156-5 · Cited by 164 · see citing works
Epidemiology of Non-Steroidal Anti-Inflammatory Drugs and Cancer
Baron, J. A. (2003) · KARGER eBooks · doi:10.1159/000071364 · Cited by 161 · see citing works
Zhao, R., Coker, O. O., Wu, J., Zhou, Y., Zhao, L., Nakatsu, G., Bian, X., Wei, H., Chan, A. W. H., Sung, J. J. �., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.05.004 · Cited by 161 · see citing works
Low-Dose Aspirin or Nonsteroidal Anti-inflammatory Drug Use and Colorectal Cancer Risk
Friis, S., Riis, A. H., Erichsen, R., Baron, J. A., & Sørensen, H. T. (2015) · Annals of Internal Medicine · doi:10.7326/m15-0039 · Cited by 159 · see citing works
Parkinson, L., & Keast, R. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150712323 · Cited by 156 · see citing works
Non-Steroidal Anti-Inflammatory Drugs and Colorectal Cancer Risk in a Large, Prospective Cohort
Ruder, E. H., Laiyemo, A. O., Graubard, B. I., Hollenbeck, A. R., Schatzkin, A. G., & Cross, A. J. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2011.38 · Cited by 151 · see citing works
Friis, S., Sørensen, H. T., McLaughlin, J. K., Johnsen, S. P., Blot, W. J., & Olsen, J. H. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6600760 · Cited by 151 · see citing works
Exposure-measurement error is frequently ignored when interpreting epidemiologic study results
Jurek, A. M., Maldonado, G., Greenland, S., & Church, T. R. (2006) · European Journal of Epidemiology · doi:10.1007/s10654-006-9083-0 · Cited by 147 · see citing works
Inflammation, carcinogenesis and cancer
Fitzpatrick, F. A. (2001) · International Immunopharmacology · doi:10.1016/s1567-5769(01)00102-3 · Cited by 145 · see citing works
U.S. Preventive Services Task Force* (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-5-200703060-00008 · Cited by 140 · see citing works
Type 2 Diabetes Mellitus and the Risk of Colorectal Cancer
Yang, Y., Hennessy, S., & Lewis, J. D. (2005) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(05)00152-7 · Cited by 140 · see citing works
Williams, J., Borgo, S., Hasan, I., Castillo, E., Traganos, F., & Rigas, B. (2001) · PubMed · Cited by 137 · see citing works
Exposure to statins and risk of common cancers: a series of nested case-control studies
Vinogradova, Y., Coupland, C., & Hippisley-Cox, J. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-409 · Cited by 135 · see citing works
Spitz, G. A., Furtado, C. M., Sola‐Penna, M., & Zancan, P. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.09.020 · Cited by 130 · see citing works
Depression as a Risk Factor for Cancer: From Pathophysiological Advances to Treatment Implications
Currier, M. B., & Nemeroff, C. B. (2014) · Annual Review of Medicine · doi:10.1146/annurev-med-061212-171507 · Cited by 126 · see citing works
Chronic Proton Pump Inhibitor Therapy and the Risk of Colorectal Cancer
Yang, Y., Hennessy, S., Propert, K., Hwang, W., Sedarat, A., & Lewis, J. D. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.06.022 · Cited by 125 · see citing works
Anderson, L. A., Johnston, B. T., Watson, R. G. P., Murphy, S., Ferguson, H. R., Comber, H., McGuigan, J., Reynolds, J. V., & Murray, L. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4253 · Cited by 123 · see citing works
Wang, D., Ren, C., Qiu, M., Luo, H., Wang, Z., Zhang, D.-S., Wang, F.-H., Li, Y.-H., & Xu, R. (2011) · Tumor Biology · doi:10.1007/s13277-011-0285-z · Cited by 122 · see citing works
COX-2, VEGF and tumour angiogenesis
Toomey, D. P., Murphy, J. F., & Conlon, K. C. (2009) · The Surgeon · doi:10.1016/s1479-666x(09)80042-5 · Cited by 122 · see citing works
Chun, K. (2003) · Carcinogenesis · doi:10.1093/carcin/bgh076 · Cited by 121 · see citing works
Aspirin and cancer risk: an updated quantitative review to 2005
Bosetti, C., Gallus, S., & Vecchia, C. L. (2006) · Cancer Causes & Control · doi:10.1007/s10552-006-0033-7 · Cited by 117 · see citing works
Chang, C., & Ulrich, C. M. (2003) · Diabetologia · doi:10.1007/s00125-003-1109-5 · Cited by 115 · see citing works
Olive Oil Effects on Colorectal Cancer
Borzì, A. M., Biondi, A., Basile, F., Luca, S., Vicari, E. S. D., & Vacante, M. (2018) · Nutrients · doi:10.3390/nu11010032 · Cited by 113 · see citing works
Salicylic acid: a link between aspirin, diet and the prevention of colorectal cancer
Paterson, J. R. (2001) · QJM · doi:10.1093/qjmed/94.8.445 · Cited by 112 · see citing works
Clinical Implication of Inflammation-Based Prognostic Score in Pancreatic Cancer
Yamada, S., Fujii, T., Yabusaki, N., Murotani, K., Iwata, N., Kanda, M., Tanaka, C., Nakayama, G., Sugimoto, H., Koike, M., et al. (2016) · Medicine · doi:10.1097/md.0000000000003582 · Cited by 106 · see citing works
Yao, M., Lam, E., Kelly, C. R., Zhou, W., & Wolfe, M. M. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601489 · Cited by 106 · see citing works
Drug development against metastasis-related genes and their pathways: A rationale for cancer therapy
Iiizumi, M., Liu, W., Pai, S. K., Furuta, E., & Watabe, K. (2008) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2008.07.002 · Cited by 105 · see citing works
Using prescription claims data for drugs available over‐the‐counter (OTC)
Yood, M. U., Campbell, U. B., Rothman, K. J., Jick, S. S., Lang, J. M., Wells, K. E., Jick, H., & Johnson, C. C. (2007) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1454 · Cited by 102 · see citing works
Meier, C. R., Schmitz, S., & Jick, H. (2002) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.22.5.303.33189 · Cited by 99 · see citing works
Inflammation in prostate cancer progression and therapeutic targeting.
Stark, T., Livas, L. I., & Kyprianou, N. (2015) · PubMed Central · doi:10.3978/j.issn.2223-4683.2015.04.12 · Cited by 100 · see citing works
Cholecystectomy and the Risk of Colorectal Cancer
Shao, T. H., & Yang, Y. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41610.x · Cited by 97 · see citing works
Prostaglandin E2 promotes degranulation-independent release of MCP-1 from mast cells
Nakayama, T., Mutsuga, N., Yao, L., & Tosato, G. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0405226 · Cited by 93 · see citing works
No Increased Risk of Myocardial Infarction Among Patients With Ulcerative Colitis or Crohn's Disease
Osterman, M. T., Yang, Y., Brensinger, C. M., Forde, K. A., Lichtenstein, G. R., & Lewis, J. D. (2011) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2011.06.032 · Cited by 93 · see citing works
Vinogradova, Y., Hippisley‐Cox, J., Coupland, C. A. C., & Logan, R. F. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.05.023 · Cited by 91 · see citing works
Angiotensin-Converting Enzyme Inhibitor Therapy and Colorectal Cancer Risk
Makar, G. A., Holmes, J. H., & Yang, Y. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djt374 · Cited by 90 · see citing works
Activity of the non-steroidal anti-inflammatory drug indomethacin against colorectal cancer
Hull, M. A., Gardner, S. H., & Hawcroft, G. (2003) · Cancer Treatment Reviews · doi:10.1016/s0305-7372(03)00014-8 · Cited by 87 · see citing works
Up-regulation of Endothelial Cyclooxygenase-2 and Prostanoid Synthesis by Platelets
Caughey, G. E., Cleland, L. G., Gamble, J. R., & James, M. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010606200 · Cited by 87 · see citing works
The Use of Metformin and the Incidence of Lung Cancer in Patients With Type 2 Diabetes
Smiechowski, B., Azoulay, L., Yin, H., Pollak, M., & Suissa, S. (2012) · Diabetes Care · doi:10.2337/dc12-0740 · Cited by 86 · see citing works
Potential use of routine databases in health technology assessment
Raftery, J. P., Roderick, P. J., & Stevens, A. J. (2005) · Health Technology Assessment · doi:10.3310/hta9200 · Cited by 85 · see citing works
Aspirin, NSAIDs, and Colorectal Cancer: Possible Involvement in an Insulin-Related Pathway
Slattery, M. L., Samowitz, W. S., Hoffman, M. D., Ne, K., Levin, T. R., & Neuhausen, S. L. (2004) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.538.13.4 · Cited by 85 · see citing works
Influence of the Mediterranean Diet on Healthy Aging
Andreo-López, M. C., Contreras-Bolívar, V., Muñoz‐Torres, M., García-Fontana, B., & García‐Fontana, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054491 · Cited by 87 · see citing works
Whitt, J. D., Nan, L., Tinsley, H. N., Chen, X., Zhang, W., Li, Y., Gary, B. D., Keeton, A. B., Xi, Y., Abadi, A., et al. (2012) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0559 · Cited by 83 · see citing works
Yu, H. ‐., Huang, J., Yang, Y. ‐., Huang, H., Luo, H., Yu, J., Meier, J. J., Schrader, H., Bastian, A., Schmidt, W. E., et al. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2002.01080.x · Cited by 82 · see citing works
Bardia, A., Ebbert, J. O., Vierkant, R. A., Limburg, P. J., Anderson, K., Wang, A. H., Olson, J. E., Vachon, C., & Cerhan, J. R. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djk200 · Cited by 81 · see citing works
Deb, J., Majumder, J., Bhattacharyya, S., & Jana, S. S. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-567 · Cited by 80 · see citing works
Hoffmeister, M., Chang-Claude, J. C., & Brenner, H. (2007) · International Journal of Cancer · doi:10.1002/ijc.22796 · Cited by 80 · see citing works
Goswami, B., Rajappa, M., SHARMA, M., & Sharma, A. (2007) · International Journal of Gynecological Cancer · doi:10.1111/j.1525-1438.2007.01089.x · Cited by 80 · see citing works
Prognostic Impact of Cyclooxygenase-2 in Breast Cancer
Denkert, C., Winzer, K., & Hauptmann, S. (2004) · Clinical Breast Cancer · doi:10.3816/cbc.2004.n.006 · Cited by 79 · see citing works
Mamtani, R., Lewis, J. D., Scott, F. I., Ahmad, T., Goldberg, D. S., Datta, J., Yang, Y., & Boursi, B. (2016) · PLoS Medicine · doi:10.1371/journal.pmed.1002007 · Cited by 78 · see citing works
Castellani, P., Balza, E., & Rubartelli, A. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.5164 · Cited by 77 · see citing works
Role of TLR2‐dependent inflammation in metastatic progression
Kim, S.-H., & Karin, M. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05882.x · Cited by 78 · see citing works
Tan, X., Lombardo, K. M. R., Bamlet, W. R., Oberg, A. L., Robinson, D. P., Anderson, K. E., & Petersen, G. M. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0146 · Cited by 77 · see citing works
Lung injury, inflammation and Akt signaling following inhalation of particulate hexavalent chromium
Beaver, L. M., Stemmy, E. J., Constant, S. L., Schwartz, A. M., Little, L. G., Gigley, J. P., Chun, G., Sugden, K. D., Ceryak, S. M., & Patierno, S. R. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.11.018 · Cited by 76 · see citing works
MacArthur, M., Sharp, L., Hold, G., Little, J., & El-Omar, E. (2004) · Cancer Epidemiology, Biomarkers and Prevention · doi:10.1158/1055-9965.epi-04-0878 · Cited by 84 · see citing works
Schrör, K. (2011) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2011.10.016 · Cited by 76 · see citing works
Cyclooxygenase-2 in Cancer and Angiogenesis
Sahin, M. A., Şahın, E., & Gümüşlü, S. (2008) · Angiology · doi:10.1177/0003319708318378 · Cited by 76 · see citing works
Yang, J., Guo, X., Wang, M., Ma, X., Ye, X., & Lin, P. (2017) · Scientific Reports · doi:10.1038/s41598-017-17130-6 · Cited by 76 · see citing works
Aspirin and the Risk of Hodgkin's Lymphoma in a Population-Based Case-Control Study
Chang, E. T., Zheng, T., Weir, E. G., Borowitz, M. J., Mann, R. B., Spiegelman, D. L., & Mueller, N. E. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh038 · Cited by 76 · see citing works
Use of nonsteroidal anti‐inflammatory drugs and the risk of first‐time acute myocardial infarction
Schlienger, R. G., Jick, H., & Meier, C. R. (2002) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2002.01637.x · Cited by 75 · see citing works
- Authors
- García Rodríguez, L. A., & Huerta-Alvarez, C.
- Venue
- Epidemiology
- Published
- 2001-01
- Volume
- 12
- Issue
- 1
- Pages
- 88-93
- ISSN
- 1044-3983 (ISSN-L)
- OpenAlex
- W1971370481
- Cited by
- 359
- References
- 29
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 8 · 2022: 4 · 2021: 5 · 2020: 11 · 2019: 6 · 2018: 11 · 2017: 10 · 2016: 16 · 2015: 15 · 2014: 11 · 2013: 14 · 2012: 19
- FWCI
- 16.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Keywords
- colorectal cancer, aspirin, nonsteroidal anti-inflammatory drugs, chemoprevention, dose-response relationship, long-term drug use, cancer incidence, colorectal adenoma
- MeSH terms
- Adenoma, Adult, Aged, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Female, United Kingdom, Humans, Male, Middle Aged, Risk Factors, Colorectal Neoplasms, Cohort Studies, Incidence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
