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Nutraceuticals, A New Challenge for Medicinal Chemistry

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Gut microbiota and bipolar disorder: a review of mechanisms and potential targets for adjunctive therapy

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OliveNet™: a comprehensive library of compounds fromOlea europaea

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Oleocanthal ameliorates amyloid-β oligomers’ toxicity on astrocytes and neuronal cells: In vitro studies

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Olive Oil‐derived Oleocanthal as Potent Inhibitor of Mammalian Target of Rapamycin: Biological Evaluation and Molecular Modeling Studies

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Naturally Occurring Hydroxytyrosol Derivatives: Hydroxytyrosyl Acetate and 3,4-Dihydroxyphenylglycol Modulate Inflammatory Response in Murine Peritoneal Macrophages. Potential Utility as New Dietary Supplements

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Phenolic Melatonin-Related Compounds: Their Role as Chemical Protectors against Oxidative Stress

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Daily Use of Extra Virgin Olive Oil with High Oleocanthal Concentration Reduced Body Weight, Waist Circumference, Alanine Transaminase, Inflammatory Cytokines and Hepatic Steatosis in Subjects with the Metabolic Syndrome: A 2-Month Intervention Study

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Beneficial effects of olive oil and Mediterranean diet on cancer physio-pathology and incidence

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The Polyphenolic Composition of Extracts Derived from Different Greek Extra Virgin Olive Oils Is Correlated with Their Antioxidant Potency

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Geoclimatic, morphological, and temporal effects on Lebanese olive oils composition and classification: A 1H NMR metabolomic study

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An Industrial and Sustainable Platform for the Production of Bioactive Micronized Powders and Extracts Enriched in Polyphenols From Olea europaea L. and Vitis vinifera L. Wastes

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The effect of topical olive oil on the healing of foot ulcer in patients with type 2 diabetes: a double-blind randomized clinical trial study in Iran

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Comparison survey of EVOO polyphenols and exploration of healthy aging-promoting properties of oleocanthal and oleacein

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Evaluation of the neuroprotective and antidiabetic potential of phenol-rich extracts from virgin olive oils by in vitro assays

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Importance of some minor compounds in olive oil authenticity and quality

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Secoiridoids of olive and derivatives as potential coadjuvant drugs in cancer: A critical analysis of experimental studies

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Anti-Proliferative Effects of an Extra-Virgin Olive Oil Extract Enriched in Ligstroside Aglycone and Oleocanthal on Human Liver Cancer Cell Lines

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Improvement of Ferulic Acid Antioxidant Activity by Multiple Emulsions: In Vitro and In Vivo Evaluation

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Preparative isolation of oleocanthal, tyrosol, and hydroxytyrosol from olive oil by HPCCC

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Flash Thermal Conditioning of Olive Pastes during the Oil Mechanical Extraction Process: Cultivar Impact on the Phenolic and Volatile Composition of Virgin Olive Oil

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Plant-food-derived Bioactives in Managing Hypertension: From Current Findings to Upcoming Effective Pharmacotherapies

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Polyphenol-Rich Extracts from Agroindustrial Waste and Byproducts: Results and Perspectives According to the Green Chemistry and Circular Economy

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Olive Oil Consumption and Age-Related Macular Degeneration: The Alienor Study

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Current Insights on the Photoprotective Mechanism of the Macular Carotenoids, Lutein and Zeaxanthin: Safety, Efficacy and Bio-Delivery

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Green Route for the Isolation and Purification of Hyrdoxytyrosol, Tyrosol, Oleacein and Oleocanthal from Extra Virgin Olive Oil

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Olive Oil Consumption can Prevent Non-communicable Diseases and COVID-19: A Review

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(−)-Oleocanthal Combined with Lapatinib Treatment Synergized against HER-2 Positive Breast Cancer In Vitro and In Vivo

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Clustering eating habits: frequent consumption of different dietary patterns among the Italian general population in the association with obesity, physical activity, sociocultural characteristics and psychological factors

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Oleocanthal as a Multifunctional Anti-Cancer Agent: Mechanistic Insights, Advanced Delivery Strategies, and Synergies for Precision Oncology

Jannati, S., Patel, A., Patnaik, R., & Banerjee, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125521 · Cited by 33 · see citing works

Ripening and storage conditions of Chétoui and Arbequina olives: Part II. Effect on olive endogenous enzymes and virgin olive oil secoiridoid profile determined by high resolution mass spectrometry

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Assessing the influence of preconception diet on female fertility: a systematic scoping review of observational studies

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Novel c-Met inhibitory olive secoiridoid semisynthetic analogs for the control of invasive breast cancer

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The Role of Olive Oil in Cardiometabolic Risk

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Nutraceutical Potential of Phenolics from ′Brava′ and ′Mansa′ Extra-Virgin Olive Oils on the Inhibition of Enzymes Associated to Neurodegenerative Disorders in Comparison with Those of ′Picual′ and ′Cornicabra′

Figueiredo-González, M., Reboredo‐Rodríguez, P., González‐Barreiro, C., Carrasco‐Pancorbo, A., Simal‐Gándara, J., & Cancho-Grande, B. (2018) · Molecules · doi:10.3390/molecules23040722 · Cited by 26 · see citing works

Olive oil in pharmacological and cosmetic traditions

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Anticancer molecular mechanisms of oleocanthal

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Biological effects of olive oil phenolic compounds on mitochondria

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The oleocanthal-based homovanillyl sinapate as a novel c-Met inhibitor

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Application of Optical Spectroscopic Techniques and Multivariate Statistical Analysis as a Method of Determining the Percentage and Type of Adulteration of Extra Virgin Olive Oil

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Protective Effects and Benefits of Olive Oil and Its Extracts on Women’s Health

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Dietary EVOO Polyphenols and Gut Microbiota Interaction: Are There Any Sex/Gender Influences?

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Neuroprotective effects of oleocanthal, a compound in virgin olive oil, in a rat model of traumatic brain injury

Mete, M., Aydemir, I., Ünsal, Ü. Ü., Çöllü, F., Vatandas, G., Gürcü, B., Duransoy, Y. K., Taneli, F., Tuğlu, M. İ., & Selçukı, M. (2017) · Turkish Neurosurgery · doi:10.5137/1019-5149.jtn.21417-17.2 · Cited by 21 · see citing works

Assessing the topical application efficiency of two biological agents in managing chemotherapy-induced oral mucositis in children: A randomized clinical trial

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The Benefits of the Mediterranean Diet on Inflamm-Aging in Childhood Obesity

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Evaluation of total phenolic fraction derived from extra virgin olive oil for its antileishmanial activity

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Bioactive Olive Oil Polyphenols in the Promotion of Health

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(-)-Oleocanthal Nutraceuticals for Alzheimer’s Disease Amyloid Pathology: Novel Oral Formulations, Therapeutic, and Molecular Insights in 5xFAD Transgenic Mice Model

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Extra virgin olive oil polyphenols: biological properties and antioxidant activity

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Detection of olive oil adulteration with vegetable oils by ultra‐performance convergence chromatography‐quadrupole time‐of‐flight mass spectrometry (UPC 2 ‐QTOF MS) coupled with multivariate data analysis based on the differences of triacylglycerol compositions

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The Secrets of the Mediterranean Diet. Does [Only] Olive Oil Matter?

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Adherencia a la dieta mediterránea y su relación con la calidad del desayuno en estudiantes de la Universidad de Murcia

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Recent data on Mediterranean diet, cardiovascular disease, cancer, diabetes and life expectancy

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Dry Olive Leaf Extract in Combination with Methotrexate Reduces Cell Damage in Early Rheumatoid Arthritis Patients-A Pilot Study

Pirković, A., Živković, L., Borozan, S. Z., Zlatković‐Švenda, M., Dekanski, D., Jančić, I., Radak-Perović, M., Bajić, V., & Spremo‐Potparević, B. (2016) · Phytotherapy Research · doi:10.1002/ptr.5662 · Cited by 18 · see citing works

Comparative Gene Signature of (−)-Oleocanthal Formulation Treatments in Heterogeneous Triple Negative Breast Tumor Models: Oncological Therapeutic Target Insights

Qusa, M. H., Abdelwahed, K. S., Siddique, A. B., & Sayed, K. A. E. (2021) · Nutrients · doi:10.3390/nu13051706 · Cited by 15 · see citing works

Nutritional interventions for osteoarthritis: targeting the metabolism-inflammation-oxidative stress axis—clinical evidence and translational practice

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Next-generation sequencing reveals altered gene expression and enriched pathways in triple-negative breast cancer cells treated with oleuropein and oleocanthal

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Cold storage of ‘Manzanilla de Sevilla’ and ‘Manzanilla Cacereña’ mill olives from super-high density orchards

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Natural Phytoestrogens

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Optimization of Taste-Masked (–)-Oleocanthal Effervescent Formulation with Potent Breast Cancer Progression and Recurrence Suppressive Activities

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Bioactive compounds in Spanish extra virgin olive oils: Migration and stability according to the culinary technique used

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The Southern European Atlantic Diet and Its Supplements: The Chemical Bases of Its Anticancer Properties

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Foods of the Mediterranean diet: Lacto-fermented food, the food pyramid and food combinations

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Effects of AIDiet intervention to improve diet quality, immuno-metabolic health in normal and overweight PCOS girls: a pilot study

Mizgier, M., Więckowska, B., Formanowicz, D., Lombardi, G., Brożek, A., Nowicki, M., Durkalec‐Michalski, K., Kędzia, W., & Jarząbek‐Bielecka, G. (2024) · Scientific Reports · doi:10.1038/s41598-024-54100-1 · Cited by 12 · see citing works

Functional Foods and Adapted Physical Activity as New Adjuvant Therapy for Chronic Kidney Disease Patients

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Alzheimer's Disease May Benefit from Olive Oil Polyphenols: A Systematic Review on Preclinical Evidence Supporting the Effect of Oleocanthal on Amyloid-β Load

Zupo, R., Castellana, F., Panza, F., Solfrizzi, V., Lozupone, M., Tardugno, R., Cicero, N., Corbo, F., Crupi, P., Sardone, R., et al. (2024) · Current Neuropharmacology · doi:10.2174/011570159x327650241021115228 · Cited by 12 · see citing works

Topical treatment with oleocanthal extract in reducing inflammatory reactions after photodynamic therapy: a prospective quasi-experimental pilot study

Palacios, J. M. S., Blazquez-Sanchez, N., Rivas‐Ruiz, F., Bernier, M. A., López, B. R., Sánchez, M. E. F., & de Troya-Martín, M. (2018) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2018.12.003 · Cited by 12 · see citing works

Evaluation of the effectiveness of olive oil to prevent chemotherapy induced oral mucositis: A randomized controlled clinical trial

Alkhouli, M., Laflouf, M., & Alhaddad, M. (2019) · Pediatric Dental Journal · doi:10.1016/j.pdj.2019.08.001 · Cited by 12 · see citing works

Effect of omega-3 polyunsaturated fatty acid on endometriosis

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The effect of olive cream on pain and healing of caesarean section wounds: a randomised controlled clinical trial

Taheri, M., Amiri‐Farahani, L., Haghani, S., Shokrpour, M., & Shojaii, A. (2022) · Journal of Wound Care · doi:10.12968/jowc.2022.31.3.244 · Cited by 10 · see citing works

Green synthesis and two-step chromatographic separation of thiocanthal and thiocanthol: Two novel biologically active sulfur derivatives of oleocanthal and oleacein from extra virgin olive oil

Risola, D. D., Mattioli, R., Federico, R., Pascarella, G., Fontana, M., Dainese, E., Dufrusine, B., Ciogli, A., Gasparrini, F., Morea, V., et al. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.141296 · Cited by 9 · see citing works

Oleocanthal alleviated lipopolysaccharide-induced acute lung injury in chickens by inhibiting TLR4/NF-κB pathway activation

Miao, F., Shan, C., Geng, S., & Ning, D. (2022) · Poultry Science · doi:10.1016/j.psj.2022.102458 · Cited by 8 · see citing works

Olive oil limited motor disruption and neuronal damage in parkinsonism induced by MPTP administration

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Synergistic analgesic, anti‐pyretic and anti‐inflammatory effects of extra virgin olive oil and ibuprofen in different experimental models of albino mice

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