β-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease

“Mini-mental state”

Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works

Neuropathological stageing of Alzheimer-related changes.

Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works

The Clinical Dementia Rating (CDR): Current version and scoring rules

Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882 · see citing works

Applied Multiple Regression/Correlation Analysis for the Behavioral Sciences.

Tufte, E. R., Cohen, J., & Cohen, P. (1979) · Journal of the American Statistical Association · doi:10.2307/2286442 · Cited by 5,214 · see citing works

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961 · see citing works

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397 · see citing works

The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects

Blessed, G., Tomlinson, B. E., & Roth, M. (1968) · British Journal of Psychiatry · doi:10.1192/bjp.114.512.797 · Cited by 4,117 · see citing works

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.3.631 · Cited by 2,668 · see citing works

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516 · see citing works

Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity

DeKosky, S. T., & Scheff, S. W. (1990) · Annals of Neurology · doi:10.1002/ana.410270502 · Cited by 2,376 · see citing works

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

Citron, M., Oltersdorf, T., Haass, C., McConlogue, L., Hung, A. Y., Seubert, P., Vigo-Pelfrey, C., Lieberburg, I., & Selkoe, D. J. (1992) · Nature · doi:10.1038/360672a0 · Cited by 1,757 · see citing works

Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease

West, M. J., Coleman, P. D., Flood, D. G., & Troncoso, J. C. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92338-8 · Cited by 1,267 · see citing works

Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques

Katzman, R., Terry, R., DeTeresa, R., Brown, T., Davies, P., Fuld, P., Renbing, X., & Peck, A. (1988) · Annals of Neurology · doi:10.1002/ana.410230206 · Cited by 1,225 · see citing works

Consortium to establish a registry for Alzheimer's disease (CERAD) clinical and neuropsychological assessment of Alzheimer's disease.

Morris, J. C., Mohs, R. C., Rogers, H., Fillenbaum, G. G., & Heyman, A. (1988) · PubMed · Cited by 1,131 · see citing works

The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): socio-demographic correlates, reliability, validity and some norms

Jorm, A. F., & Jacomb, P. A. (1989) · Psychological Medicine · doi:10.1017/s0033291700005742 · Cited by 1,104 · see citing works

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

Loo, D. T., Copani, A., Pike, C. J., Whittemore, E. R., Walencewicz, A. J., & Cotman, C. W. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7951 · Cited by 1,022 · see citing works

Neuron numbers and dendritic extent in normal aging and Alzheimer’s disease

Coleman, P. D., & Flood, D. G. (1987) · Neurobiology of Aging · doi:10.1016/0197-4580(87)90127-8 · Cited by 772 · see citing works

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis.

Greenberg, S. G., & Davies, P. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.15.5827 · Cited by 732 · see citing works

Identification of normal and pathological aging in prospectively studied nondemented elderly humans

Dickson, D. W., Crystal, H. A., Mattiace, L. A., Masur, D. M., Blau, A. D., Davies, P., Yen, S.-H., & Aronson, M. K. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90027-u · Cited by 643 · see citing works

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

Koh, J., Yang, L. L., & Cotman, C. W. (1990) · Brain Research · doi:10.1016/0006-8993(90)91355-k · Cited by 617 · see citing works

Plaques, tangles and dementia

Wilcock, G. K., & Esiri, M. M. (1982) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(82)90155-1 · Cited by 608 · see citing works

Synergistic Effects of Traumatic Head Injury and Apolipoprotein-epsilon4 in Patients With Alzheimer's Disease

Mayeux, R., Ottman, R., Maestre, G., Ngai, C., Tang, M., Ginsberg, H., Chun, M., Tycko, B., & Shelanski, M. (1995) · Neurology · doi:10.1212/wnl.45.3.555 · Cited by 597 · see citing works

β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding

Busciglio, J., Lorenzo, A., Yeh, J., & Yankner, B. A. (1995) · Neuron · doi:10.1016/0896-6273(95)90232-5 · Cited by 595 · see citing works

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death

Mark, R. J., Hensley, K., Butterfield, D. A., & Mattson, M. P. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-09-06239.1995 · Cited by 553 · see citing works

Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau.

Greenberg, S. G., Davies, P., Schein, J., & Binder, L. I. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48531-6 · Cited by 542 · see citing works

Neocortical Neurofibrillary Tangles Correlate With Dementia Severity in Alzheimer's Disease

Bierer, L. M., Hof, P. R., Purohit, D. P., Carlin, L., Schmeidler, J., Davis, K. L., & Perl, D. P. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540250089017 · Cited by 514 · see citing works

The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice

LaFerla, F. M., Tinkle, B. T., Bieberich, C. J., Haudenschild, C. C., & Jay, G. (1995) · Nature Genetics · doi:10.1038/ng0195-21 · Cited by 513 · see citing works

Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloids.

Kitamoto, T., Ogomori, K., Tateishi, J., & Prusiner, S. B. (1987) · PubMed · Cited by 472 · see citing works

A NEW DEFINITION OF ALZHEIMER'S DISEASE: A HIPPOCAMPAL DEMENTIA

Ball, M. J., Hachinski, V., Fox, A. J., Kirshen, A. J., Fisman, M., Blume, W. T., Kral, V. A., Fox, H., & Merskey, H. (1985) · The Lancet · doi:10.1016/s0140-6736(85)90965-1 · Cited by 427 · see citing works

The toxicity in vitro of β-amyloid protein

Iversen, L. L., Mortishire‐Smith, R. J., Pollack, S. J., & Shearman, M. S. (1995) · Biochemical Journal · doi:10.1042/bj3110001 · Cited by 425 · see citing works

A rapid method for isolation of synaptosomes on Percoll gradients

Dunkley, P. R., Jarvie, P. E., Heath, J. W., Kidd, G. J., & Rostas, J. A. P. (1986) · Brain Research · doi:10.1016/0006-8993(86)91464-2 · Cited by 418 · see citing works

Correlations of synaptic and pathological markers with cognition of the elderly

Dickson, D. W., Crystal, H. A., Bevona, C., Honer, W., Vincent, I., & Davies, P. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00013-5 · Cited by 410 · see citing works

Neuritic pathology and dementia in alzheimer's disease

McKee, A. C., Kosik, K. S., & Kowall, N. W. (1991) · Annals of Neurology · doi:10.1002/ana.410300206 · Cited by 358 · see citing works

A4POE*4-associated Alzheimer's disease risk is modified by α1–antichymotrypsin polymorphism

Kamboh, M. I., Sanghera, D. K., Ferrell, R. E., & DeKosky, S. T. (1995) · Nature Genetics · doi:10.1038/ng0895-486 · Cited by 336 · see citing works

The Lack of Accumulation of Senile Plaques or Amyloid Burden in Alzheimer's Disease Suggests a Dynamic Balance Between Amyloid Deposition and Resolution

Hyman, B., Marzloff, K., & Arriagada, P. (1993) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199311000-00006 · Cited by 294 · see citing works

Relative Roles of Plaques and Tangles in the Dementia of Alzheimer's Disease: Correlations Using Three Sets of Neuropathological Criteria

Nagy, Z., Esiri, M. M., Jobst, K. A., Morris, J. H., King, E. M.-F., McDonald, B., Litchfield, S., Smith, A. D., Barnetson, L. P. D., & Smith, A. D. (1995) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106918 · Cited by 283 · see citing works

The canine as an animal model of human aging and dementia

Cummings, B. J., Head, E., Ruehl, W. W., Milgram, N. W., & Cotman, C. W. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(95)02060-8 · Cited by 280 · see citing works

Longitudinal evaluation of dementia of the Alzheimer type

Salmon, D. P., Thal, L. J., Butters, N., & Heindel, W. C. (1990) · Neurology · doi:10.1212/wnl.40.8.1225 · Cited by 274 · see citing works

Image analysis of β-amyloid load in Alzheimer's disease and relation to dementia severity

Cummings, B. J., & Cotman, C. W. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92053-6 · Cited by 260 · see citing works

Neuropathological Indexes of Alzheimer's Disease in Demented and Nondemented Persons Aged 80 Years and Older

Berg, L., McKeel, D. W., Miller, J. P., Baty, J., & Morris, J. C. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540040011008 · Cited by 257 · see citing works

Cognitive functions and aging in the dog: Acquisition of nonspatial visual tasks.

Milgram, N. W., Head, E., Weiner, E., & Thomas, E. (1994) · Behavioral Neuroscience · doi:10.1037//0735-7044.108.1.57 · Cited by 251 · see citing works

β-Amyloid Accumulation Correlates with Cognitive Dysfunction in the Aged Canine

Cummings, B. J., Head, E., Afagh, A., Milgram, N. W., & Cotman, C. W. (1996) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.0039 · Cited by 243 · see citing works

Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome).

Hyman, B. T., West, H. L., Rebeck, G. W., Buldyrev, S. V., Mantegna, R. N., Ukleja, M., Havlin, S., & Stanley, H. E. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.8.3586 · Cited by 212 · see citing works

Diffuse plaques do not accentuate synapse loss in Alzheimer's disease.

(1990) · Europe PMC (PubMed Central) · Cited by 209 · see citing works

Cognitive functions and aging in the dog: Acquisition of nonspatial visual tasks.

Milgram, N. W., Head, E., Weiner, E., et al. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.1.57 · Cited by 203 · see citing works

β-Amyloid accumulation in aged canine brain: A model of early plaque formation in Alzheimer's disease

Cummings, B. J., Su, J. H., Cotman, C. W., White, R. G., & Russell, M. J. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90038-d · Cited by 187 · see citing works

Large amounts of neocortical βA4 deposits without neuritic plaques nor tangles in a psychometrically assessed, non-demented person

Delaère, P., Duyckaerts, C., Masters, C., Beyreuther, K., Piette, F., & Hauw, J.-J. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90391-l · Cited by 186 · see citing works

Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in alzheimer's disease

Heinonen, O., Soininen, H., Sorvari, H., Kosunen, O., Paljärvi, L., Koivisto, E., & Riekkinen, P. J. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00422-2 · Cited by 186 · see citing works

Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease

Okuizumi, K., Onodera, O., Namba, Y., Ikeda, K., Yamamoto, T. T., Seki, K., Ueki, A., Nanko, S., Tanaka, H., Takahashi, H., et al. (1995) · Nature Genetics · doi:10.1038/ng1095-207 · Cited by 183 · see citing works

A comparative study of histological and immunohistochemical methods for neurofibrillary tangles and senile plaques in Alzheimer's disease

Vallet, P. G., Guntern, R., Hof, P. R., Golaz, J., Delacourte, A., Robakis, N. K. R. K., & Bouras, C. (1992) · Acta Neuropathologica · doi:10.1007/bf00308476 · Cited by 170 · see citing works

Alzheimer's disease

Thal, L. J., Grundman, M., & Golden, R. (1986) · Neurology · doi:10.1212/wnl.36.2.262 · Cited by 162 · see citing works

Senile plaques as aberrant sprout-stimulating structures

Geddes, J. W., Anderson, K. J., & Cotman, C. W. (1986) · Experimental Neurology · doi:10.1016/0014-4886(86)90254-2 · Cited by 161 · see citing works

THE TOPOGRAPHY OF PLAQUES AND TANGLES IN DOWN'S SYNDROME PATIENTS OF DIFFERENT AGES

Mann, D. M. A., Yates, P. O., Marcyniuk, B., & Ravindra, C. (1986) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1986.tb00053.x · Cited by 161 · see citing works

Interlaboratory Comparison of Neuropathology Assessments in Alzheimerʼs Disease: A Study of the Consortium to Establish a Registry for Alzheimerʼs Disease (CERAD)

MIRRA, S. S., GEARING, M., MCKEEL, D. W., CRAIN, B. J., HUGHES, J. P., BELLE, G. V., & HEYMAN, A. (1994) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199405000-00012 · Cited by 156 · see citing works

Spatial learning and memory as a function of age in the dog.

Head, E., Mehta, R., Hartley, J., Kameka, M., Cummings, B. J., Cotman, C. W., Ruehl, W. W., & Milgram, N. W. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.5.851 · Cited by 155 · see citing works

β-Amyloid-induced changes in cultured astrocytes parallel reactive astrocytosis associated with senile plaques in Alzheimer's disease

Pike, C. J., Cummings, B. J., Monzavi, R., & Cotman, C. W. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90547-9 · Cited by 153 · see citing works

Tau, paired helical filaments and amyloid in the neocortex: a morphometric study of 15 cases with graded intellectual status in aging and senile dementia of Alzheimer type

D�laere, P., Duyckaerts, C. J., Brion, J., Poulain, V., & Hauw, J. (1989) · Acta Neuropathologica · doi:10.1007/bf00687893 · Cited by 135 · see citing works

β-Amyloid induces neuritic dystrophy in vitro: similarities with Alzheimer pathology

Pike, C. J., Cummings, B. J., & Cotman, C. W. (1992) · Neuroreport · doi:10.1097/00001756-199209000-00012 · Cited by 131 · see citing works

Intracellular Aβ1-42 Aggregates Stimulate the Accumulation of Stable, Insoluble Amyloidogenic Fragments of the Amyloid Precursor Protein in Transfected Cells

Yang, A. J., Knauer, M. F., Burdick, D., & Glabe, C. G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.24.14786 · Cited by 126 · see citing works

The Ca2+ influx induced by β‐amyloid peptide 25–35 in cultured hippocampal neurons results from network excitation

Brorson, J. R., Bindokas, V. P., Iwama, T., Marcuccilli, C. J., Chisholm, J. C., & Miller, R. J. (1995) · Journal of Neurobiology · doi:10.1002/neu.480260305 · Cited by 124 · see citing works

β-amyloid peptide decreases membrane fluidity

Müller, W. E., Koch, S., Eckert, A., Hartmann, H., & Scheuer, K. (1995) · Brain Research · doi:10.1016/0006-8993(94)01463-r · Cited by 124 · see citing works

Comparison of four staining methods on the detection of neuritic plaques

Wı́sniewski, H. M., Wen, G. Y., & Kim, K. S. (1989) · Acta Neuropathologica · doi:10.1007/bf00687398 · Cited by 124 · see citing works

Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in alzheimer's disease

Cummings, B. J., Su, J. H., Geddes, J. W., Van Nostrand, W. E., Wagner, S. L., Cunningham, D. D., & Cotman, C. W. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90265-4 · Cited by 120 · see citing works

Clinicopathologic Correlates in Alzheimer Disease

Kazee, A. M., Eskin, T. A., Lapham, L. W., Gabriel, K., McDaniel, K. D., & Hamill, R. W. (1993) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199307030-00004 · Cited by 111 · see citing works

Quantitative Assessment of the Synaptophysin Immuno-Reactivity of the Cortical Neuropil in Various Neurodegenerative Disorderswith Dementia

Zhan, S., Beyreuther, K. T., & Schmitt, H. P. (1993) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000107299 · Cited by 110 · see citing works

Rating of the lesions in senile dementia of the Alzheimer type: concordance between laboratories A European multicenter study under the auspices of EURAGE

Duyckaerts, C. J., Delaère, P., Hauw, J., Abbamondi-Pinto, A. L., Sorbi, S., Allen, I. E., Brion, J., Flament-Durand, J., Duchen, L. W., Kauss, J., et al. (1990) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(90)90226-d · Cited by 99 · see citing works

Synaptophysin gene expression in human brain: A quantitative in situ hybridization and immunocytochemical study

Eastwood, S. L., Burnet, P. W. J., McDonald, B., Clinton, J., & Harrison, P. J. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90292-5 · Cited by 95 · see citing works

Quantitative Assessment of Synaptic Density in the Outer Molecular Layer of the Hippocampal Dentate Gyrus in Alzheimer's Disease

Scheff, S. W., Sparks, D. L., & PRICE, D. A. (1996) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106884 · Cited by 95 · see citing works

Synaptic Pathology of Alzheimer's Diseasea

Lassmann, H., Fischer, P. A., & Jellinger, K. A. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb23028.x · Cited by 90 · see citing works

Differential correlation between neurochemical deficits, neuropathology, and cognitive status in Alzheimer's disease

Dournaud, P., Delaère, P., Hauw, J., & Epelbaum, J. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00086-t · Cited by 83 · see citing works

Quantitative assessment of synaptic density in the entorhinal cortex in Alzheimer's disease

Scheff, S. W., Sparks, D. L., & PRICE, D. A. (1993) · Annals of Neurology · doi:10.1002/ana.410340309 · Cited by 82 · see citing works

COMPARISON OF SEVEN STAINING METHODS FOR SENILE PLAQUES AND NEUROFIBRILLARY TANGLES IN A PROSPECTIVE SERIES OF 15 ELDERLY PATIENTS

Lamy, C., Duyckaerts, C. J., Delaère, P., PAYAN, C., Fermanian, J., Poulain, V., & Hauw, J. (1989) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1989.tb01255.x · Cited by 81 · see citing works

Induction of β-Amyloid-Containing Polypeptides in Hippocampus: Evidence for a Concomitant Loss of Synaptic Proteins and Interactions with an Excitotoxin

Bahr, B. A., Abai, B., Gall, C. M., Vanderklish, P. W., Hoffman, K. B., & LYNCH, G. S. (1994) · Experimental Neurology · doi:10.1006/exnr.1994.1149 · Cited by 72 · see citing works

Amyloid β protein-induced irreversible current in rat cortical neurones

Furukawa, K., Abe, Y., & Akaike, N. (1994) · Neuroreport · doi:10.1097/00001756-199410270-00006 · Cited by 67 · see citing works

Does amyloid precede paired helical filaments in the senile plaque? A study of 15 cases with graded intellectual status in aging and Alzheimer disease

Duyckaerts, C., Delaère, P., Poulain, V., Brion, J.-P., & Hauw, J.-J. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90706-9 · Cited by 65 · see citing works

A simple dot-immunobinding assay for quantification of synaptophysin-like immunoreactivity in human brain.

Alford, M. F., Masliah, E., Hansen, L. A., & Terry, R. D. (1994) · Journal of Histochemistry & Cytochemistry · doi:10.1177/42.2.8288869 · Cited by 63 · see citing works

Topographical relationship between beta-amyloid and tau protein epitopes in tangle-bearing cells in Alzheimer disease.

Spillantini, M. G., Goedert, M., Jakes, R., & Klug, A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.10.3952 · Cited by 62 · see citing works

Topographical distribution of synaptic-associated proteins in the neuritic plaques of Alzheimer's disease hippocampus

Masliah, E., Honer, W. G., Mallory, M. E., Voigt, M., Kushner, P. D., Hansen, L. A., & Terry, R. D. (1994) · Acta Neuropathologica · doi:10.1007/bf00296182 · Cited by 56 · see citing works

β-amyloid increases choline conductance of PC12 cells: possible mechanism of toxicity in Alzheimer's disease

Galdzicki, Z., Fukuyama, R., Wadhwani, K. C., Rapoport, S. I., & Ehrenstein, G. (1994) · Brain Research · doi:10.1016/0006-8993(94)90101-5 · Cited by 54 · see citing works

Ageing in higher functioning adults with Down's syndrome: an interim report in a longitudinal study

Devenny, D. A., HILL, A. L., Patxot, O. F., Silverman, W. P., & Wisniewski, K. E. (1992) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.1992.tb00511.x · Cited by 53 · see citing works

Amyloid beta-protein activates tachykinin receptors and inositol trisphosphate accumulation by synergy with glutamate.

Kimura, H., & Schubert, D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.16.7508 · Cited by 51 · see citing works

Microwave antigen retrieval for immunocytochemistry on formalin‐fixed, paraffin‐embedded post‐mortem CNS tissue

McQuaid, S., McConnell, R. S., McMahon, J. M., & Herron, B. M. (1995) · The Journal of Pathology · doi:10.1002/path.1711760215 · Cited by 50 · see citing works

Alzheimer disease A68 proteins injected into rat brain induce codeposits of beta-amyloid, ubiquitin, and alpha 1-antichymotrypsin.

Shin, R., Bramblett, G. T., Lee, V. M., & Trojanowski, J. Q. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6825 · Cited by 45 · see citing works

Constructional apraxia in Alzheimer's disease correlates with neuritic neuropathology in occipital cortex

Nielson, K. A., Cummings, B. J., & Cotman, C. W. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00983-3 · Cited by 41 · see citing works

Two distinct ubiquitin immunoreactive senile plaques in Alzheimer's disease: relationship with the intellectual status in 29 cases

He, Y., Delaère, P., Duyckaerts, C. J., Wąsowicz, M., Piette, F., & Hauw, J. (1993) · Acta Neuropathologica · doi:10.1007/bf00454909 · Cited by 33 · see citing works

Tissue fixation methods alter the immunhistochemical demonstrability of neurofilament proteins, synpatophysin, and glial fibrillary acidic protein in human cerebellum

Smitt, P. A. E. S., van der Loos, C. M., de Jong, J. M. B. V., & Troost, D. (1993) · Acta Histochemica · doi:10.1016/s0065-1281(11)80381-8 · Cited by 32 · see citing works

Clinical and Neuropathological Correlates of Apolipoprotein E Genotype in Alzheimer's Disease ‐ Window on Molecular Epidemiologya

Hyman, B. T., Gómez‐Isla, T., WEST, H., Briggs, M. E., Chung, H., Growdon, J. H., & Rebeck, G. W. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb34414.x · Cited by 31 · see citing works

Alzheimer's lesions labelled by anti‐ubiquitin antibodies: comparison with other staining techniques. A study of 15 cases with graded intellectual status in ageing and Alzheimer's disease

He, Y., Duyckaerts, C. J., Delaère, P., Piette, F., & Hauw, J. J. (1993) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1993.tb00453.x · Cited by 26 · see citing works

Primitive Plaques and Memory Dysfunction in Normal and Impaired Elderly Persons

Fuld, P. A., Dickson, D. W., Crystal, H., & Aronson, M. K. (1987) · New England Journal of Medicine · doi:10.1056/nejm198703193161219 · Cited by 23 · see citing works

Color image analysis in neuroanatomical research: Application to senile plaque subtype quantification in Alzheimer's disease

deFigueiredo, R. J. P., Cummings, B. J., Mundkur, P. Y., & Cotman, C. W. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(94)00151-0 · Cited by 22 · see citing works

The Amyloid .BETA. Protein Precursor Mutations Linked to Familial Alzheimer's Disease Alter Processing in a Way That Fosters Amyloid Deposition.

Younkin, S. G. (1994) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.174.217 · Cited by 20 · see citing works

Subpopulations of dystrophic neuritis in Alzheimer's brain with distinct immunocytochemical and argentophilic characteristics

Su, J. H., Cummings, B. J., & Cotman, C. W. (1994) · Brain Research · doi:10.1016/0006-8993(94)91214-9 · Cited by 15 · see citing works

Flow cytometric analysis on cytotoxic action of amyloid β protein fragment 25–35 on brain neurons dissociated from the rats

Furukawa, K., Oyama, Y., Chikahisa, L., Hatakeyama, Y., & Akaike, N. (1994) · Brain Research · doi:10.1016/0006-8993(94)90822-2 · Cited by 10 · see citing works

Alzheimer’s Disease, a Cerebral Form of Amyloidosis

Wı́sniewski, H. M., Currie, J. R., Barcikowska, M., Robakis, N. K. R. K., & Miller, D. L. (1988) · Springer eBooks · doi:10.1007/978-3-642-46634-2_1 · Cited by 8 · see citing works

Behavioral, cellular, and molecular biological studies of aged nonhuman primates.

Price, D. L., Koo, E. H., Wagster, M. V., Walker, L. C., Wenk, G. L., Applegate, M. D., Kitt, C. A., & Cork, L. C. (1990) · PubMed · Cited by 8 · see citing works

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

Nelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825018f7 · Cited by 2,050 · see citing works

High-Level Neuronal Expression of Aβ_1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

Mucke, L., Masliah, E., Yu, G.-Q., Mallory, M., Rockenstein, E. M., Tatsuno, G., Hu, K., Kholodenko, D., Johnson-Wood, K., & McConlogue, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04050.2000 · Cited by 1,856 · see citing works

Adult-derived neural precursors transplanted into multiple regions in the adult brain

Herrera, D. G., García‐Verdugo, J. M., & Álvarez-Buylla, A. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199912)46:6 · Cited by 204 · see citing works

Oligomeric and fibrillar species of amyloid-β peptides differentially affect neuronal viability

Dahlgren, K. N., Manelli, A. M., Stine, W. B., Baker, L. K., Krafft, G. A., & LaDu, M. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201750200 · Cited by 1,452 · see citing works

Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline

Näslund, J. (2000) · JAMA · doi:10.1001/jama.283.12.1571 · Cited by 1,268 · see citing works

Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models

Hsia, A. Y., Masliah, E., McConlogue, L., Yu, G.-Q., Tatsuno, G., Hu, K., Kholodenko, D., Malenka, R. C., Nicoll, R. A., & Mucke, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3228 · Cited by 1,123 · see citing works

Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease

Giannakopoulos, P., Herrmann, F. R., Bussière, T., Bouras, C., Kövari, E., Perl, D. P., Morrison, J. H., Gold, G., & Hof, P. R. (2003) · Neurology · doi:10.1212/01.wnl.0000063311.58879.01 · Cited by 1,118 · see citing works

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

Lu, J., Qiang, W., Yau, W., Schwieters, C. D., Meredith, S. C., & Tycko, R. (2013) · Cell · doi:10.1016/j.cell.2013.08.035 · Cited by 1,087 · see citing works

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

Selkoe, D. J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.016 · Cited by 1,038 · see citing works

Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695

Chishti, M. A., Yang, D.-S., Janus, C., Phinney, A. L., Horne, P., Pearson, J., Strome, R., Zuker, N., Loukides, J., French, J., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100710200 · Cited by 955 · see citing works

The Alzheimer's Disease Centers' Uniform Data Set (UDS)

Weıntraub, S., Salmon, D. P., Mercaldo, N. D., Ferris, S. H., Graff‐Radford, N. R., Chui, H. C., Cummings, J. L., DeCarli, C. S., Foster, N. L., Galasko, D. R., et al. (2009) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e318191c7dd · Cited by 885 · see citing works

Alzheimer's disease: experimental models and reality

Drummond, E., & Wisniewski, T. (2017) · Acta Neuropathologica · doi:10.1007/s00401-016-1662-x · Cited by 810 · see citing works

-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease

Pike, K. E., Savage, G., Villemagne, V. L., Ng, S., Moss, S. A., Maruff, P., Mathis, C. A., Klunk, W. E., Masters, C. L., & Rowe, C. C. (2007) · Brain · doi:10.1093/brain/awm238 · Cited by 789 · see citing works

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

Webster, S. J., Bachstetter, A. D., Nelson, P. T., Schmitt, F. A., & Van Eldik, L. J. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00088 · Cited by 755 · see citing works

The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease

Westerman, M. A., Cooper-Blacketer, D., Mariash, A., Kotilinek, L., Kawarabayashi, T., Younkin, L. H., Carlson, G. A., Younkin, S. G., & Ashe, K. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01858.2002 · Cited by 714 · see citing works

Neuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship

Nelson, P. T., Braak, H., & Markesbery, W. R. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181919a48 · Cited by 643 · see citing works

Clinicopathologic Studies in Cognitively Healthy Aging and Alzheimer Disease: Relation of Histologic Markers to Dementia Severity, Age, Sex, and Apolipoprotein E Genotype

Berg, L., McKeel, D. W., Miller, J. P., Storandt, M., Rubin, E. H., Morris, J. C., Baty, J., Coats, M., Norton, J., Goate, A. M., et al. (1998) · Archives of Neurology · doi:10.1001/archneur.55.3.326 · Cited by 657 · see citing works

Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: The emerging role of oligomeric assemblies

Kirkitadze, M. D., Bitan, G., & Teplow, D. B. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10328 · Cited by 582 · see citing works

Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches

Tsai, J., Grutzendler, J., Duff, K., & Gan, W.-B. (2004) · Nature Neuroscience · doi:10.1038/nn1335 · Cited by 561 · see citing works

The Levels of Soluble versus Insoluble Brain Aβ Distinguish Alzheimer's Disease from Normal and Pathologic Aging

Wang, J., Dickson, D. W., Trojanowski, J. Q., & Lee, V. M.-Y. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7085 · Cited by 567 · see citing works

Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

Rissman, R. A., Poon, W. W., Blurton-Jones, M., Oddo, S., Torp, R., Vitek, M. P., LaFerla, F. M., Rohn, T. T., & Cotman, C. W. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420640 · Cited by 543 · see citing works

Molecular structure of amyloid fibrils: insights from solid-state NMR

Tycko, R. (2006) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583506004173 · Cited by 529 · see citing works

Amyloid, hypometabolism, and cognition in Alzheimer disease: An [11C]PIB and [18F]FDG PET study

Edison, P., Archer, H. A., Hinz, R., Hammers, A., Pavese, N., Tai, Y. F., Hotton, G., Cutler, D., Fox, N., Kennedy, A., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000244749.20056.d4 · Cited by 518 · see citing works

Pathologic Correlates of Nondemented Aging, Mild Cognitive Impairment, and Early-Stage Alzheimer's Disease

Morris, J. C., & Price, J. L. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:17:2:101 · Cited by 513 · see citing works

Amyloid β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer's disease patients

Li, R., Lindholm, K., Yang, L., Yue, X., Citron, M., Yan, R., Beach, T. G., Sue, L. I., Sabbagh, M. N., Cai, H., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0205689101 · Cited by 493 · see citing works

The importance of neuritic plaques and tangles to the development and evolution of AD

Tiraboschi, P., Hansen, L. A., Thal, L. J., & Corey-Bloom, J. (2004) · Neurology · doi:10.1212/01.wnl.0000129697.01779.0a · Cited by 477 · see citing works

β-Amyloid Activates the Mitogen-Activated Protein Kinase Cascade via Hippocampal α7 Nicotinic Acetylcholine Receptors:<i>In Vitro</i>and<i>In Vivo</i>Mechanisms Related to Alzheimer's Disease

Dineley, K. T., Westerman, M., Bui, D., Bell, K., Ashe, K. H., & Sweatt, J. D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-12-04125.2001 · Cited by 462 · see citing works

In-vitro Inhibition of Human Erythrocyte Acetylcholinesterase by Salvia lavandulaefolia Essential Oil and Constituent Terpenes

Perry, N. S. L., Houghton, P. J., Theobald, A. E., Jenner, P. G., & Perry, E. K. (2000) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357001774598 · Cited by 458 · see citing works

Neuroplasticity Failure in Alzheimer's Disease

Mesulam, M.-M. (1999) · Neuron · doi:10.1016/s0896-6273(00)81109-5 · Cited by 449 · see citing works

Accelerating Amyloid-β Fibrillization Reduces Oligomer Levels and Functional Deficits in Alzheimer Disease Mouse Models

Cheng, I. H.-J., Scearce-Levie, K. A., Legleiter, J. A., Palop, J. J., Gerstein, H., Bien‐Ly, N., Puolivaöli, J., Lesné, S., Ashe, K. H., Muchowski, P. J., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701078200 · Cited by 403 · see citing works

The molecular bases of Alzheimer’s disease and other neurodegenerative disorders

Maccioni, R. B., Muñoz, J. P., & Barbeito, L. (2001) · Archives of Medical Research · doi:10.1016/s0188-4409(01)00316-2 · Cited by 474 · see citing works

Estrogen Modulates Neuronal Bcl‐x l Expression and β‐Amyloid‐Induced Apoptosis

Pike, C. J. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.721552.x · Cited by 387 · see citing works

Alzheimer Disease: Mechanistic Understanding Predicts Novel Therapies

Selkoe, D. J. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-8-200404200-00047 · Cited by 381 · see citing works

Reassessing the amyloid cascade hypothesis of Alzheimer's disease

Pimplikar, S. W. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.12.015 · Cited by 373 · see citing works

Progressive age‐related development of Alzheimer‐like pathology in APP/PS1 mice

Trinchese, F., Liu, S., Battaglia, F., Walter, S., Mathews, P. M., & Arancio, O. (2004) · Annals of Neurology · doi:10.1002/ana.20101 · Cited by 369 · see citing works

Absence of C1q Leads to Less Neuropathology in Transgenic Mouse Models of Alzheimer's Disease

Fonseca, M. I., Zhou, J., Botto, M., & Tenner, A. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0901-04.2004 · Cited by 345 · see citing works

Structural and functional imaging with carbon nanotube AFM probes

Hafner, J. H., Cheung, C. L., Woolley, A. T., & Lieber, C. M. (2001) · Progress in Biophysics and Molecular Biology · doi:10.1016/s0079-6107(01)00011-6 · Cited by 344 · see citing works

Amyloid imaging in mild cognitive impairment subtypes

Wolk, D. A., Price, J. C., Saxton, J. A., Snitz, B. E., James, J. A., López, O. L., Aizenstein, H. J., Cohen, A. D., Weissfeld, L. A., Mathis, C. A., et al. (2009) · Annals of Neurology · doi:10.1002/ana.21598 · Cited by 339 · see citing works

Past, present and future of therapeutic strategies against amyloid-β peptides in Alzheimer’s disease: a systematic review

Jeremic, D., Jiménez-Díaz, L., & Navarro-López, J. D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101496 · Cited by 306 · see citing works

Butyrylcholinesterase in the life cycle of amyloid plaques

Guillozet-Bongaarts, A. L., Mesulam, M. M., Smiley, J. F., & Mash, D. C. (1997) · Annals of Neurology · doi:10.1002/ana.410420613 · Cited by 312 · see citing works

Alzheimer's disease: synapses gone cold

Koffie, R. M., Hyman, B. T., & Spires‐Jones, T. L. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-63 · Cited by 302 · see citing works

Wnt signaling function in Alzheimer’s disease

Ferrari, G. V. D., & Inestrosa, N. C. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00021-7 · Cited by 288 · see citing works

Aβ deposits in older non-demented individuals with cognitive decline are indicative of preclinical Alzheimer's disease

Villemagne, V. L., Pike, K. E., Darby, D., Maruff, P. T., Savage, G. R., Ng, S., Ackermann, U., Cowie, T., Currie, J. N., Chan, S. G., et al. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2008.02.008 · Cited by 291 · see citing works

The Origins of Alzheimer Disease

Selkoe, D. J. (2000) · JAMA · doi:10.1001/jama.283.12.1615 · Cited by 285 · see citing works

Structural and kinetic features of amyloid β-protein fibrillogenesis

Teplow, D. B. (1998) · Amyloid · doi:10.3109/13506129808995290 · Cited by 280 · see citing works

A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer’s disease dementia

Pontecorvo, M. J., Devous, M. D., Kennedy, I., Navitsky, M., Lu, M., Galante, N., Salloway, S., Doraiswamy, P. M., Southekal, S., Arora, A. K., et al. (2019) · Brain · doi:10.1093/brain/awz090 · Cited by 249 · see citing works

The cause of neuronal degeneration in Alzheimer’s disease

Vickers, J. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00023-4 · Cited by 254 · see citing works

Neuroinflammation: An Integrating Overview of Reactive‐Neuroimmune Cell Interactions in Health and Disease

Kölliker-Frers, R., Udovin, L., Otero-Losada, M., Kobiec, T., Herrera, M. I., Palacios, J., Razzitte, G., & Capani, F. (2021) · Mediators of Inflammation · doi:10.1155/2021/9999146 · Cited by 258 · see citing works

Modeling the Association between 43 Different Clinical and Pathological Variables and the Severity of Cognitive Impairment in a Large Autopsy Cohort of Elderly Persons

Nelson, P. T., Abner, E. L., Schmitt, F. A., Kryscio, R. J., Jicha, G. A., Smith, C. D., Davis, D. G., Poduska, J. W., Patel, E., Mendiondo, M. S., et al. (2010) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00244.x · Cited by 239 · see citing works

Entorhinal Cortex β-Amyloid Load in Individuals with Mild Cognitive Impairment

Mufson, E. J., Chen, E.-Y., Cochran, E. J., Beckett, L. A., Bennett, D. A., & Kordower, J. H. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7086 · Cited by 237 · see citing works

The channel hypothesis of Alzheimer’s disease: current status

Kagan, B. L., Hirakura, Y., Azimov, R., Azimova, R., & Lin, M. (2002) · Peptides · doi:10.1016/s0196-9781(02)00067-0 · Cited by 230 · see citing works

β‐amyloid burden is not associated with rates of brain atrophy

Josephs, K. A., Whitwell, J. L., Ahmed, Z., Shiung, M. M., Weigand, S. D., Knopman, D. S., Boeve, B. F., Parisi, J. E., Petersen, R. C., Dickson, D. W., et al. (2007) · Annals of Neurology · doi:10.1002/ana.21223 · Cited by 224 · see citing works

Learning and Memory in Transgenic Mice Modeling Alzheimer's Disease

Ashe, K. H. (2001) · Learning &amp; Memory · doi:10.1101/lm.43701 · Cited by 224 · see citing works

Astrocytic dysfunction: Insights on the role in neurodegeneration

Rossi, D., & Volterra, A. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.07.012 · Cited by 219 · see citing works

MicroRNA: Implications for Alzheimer Disease and other Human CNS Disorders

Maes, O. C., Chertkow, H. M., Wang, E., & Schipper, H. M. (2009) · Current Genomics · doi:10.2174/138920209788185252 · Cited by 217 · see citing works

The evolution of Alzheimer disease, the reproductive schedule, and apoE isoforms☆

Finch, C. E., & Sapolsky, R. M. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00053-6 · Cited by 204 · see citing works

Soluble Amyloid β-Oligomers Affect Dielectric Membrane Properties by Bilayer Insertion and Domain Formation: Implications for Cell Toxicity

Valinčius, G., Heinrich, F., Budvytytė, R., Vanderah, D. J., McGillivray, D. J., Sokolov, Y., Hall, J. E., & Lösche, M. (2008) · Biophysical Journal · doi:10.1529/biophysj.108.130997 · Cited by 199 · see citing works

Correlation between cognitive deficits and Aβ deposits in transgenic APP+PS1 mice

Gordon, M. N., King, D. L., Diamond, D. M., Jantzen, P. T., Boyett, K. W., Hope, C. E., Hatcher-Martin, J. M., DiCarlo, G., Gottschall, W. P. E., Morgan, D., et al. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00249-9 · Cited by 199 · see citing works

Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activity

Oh, M., Houghton, P. J., Whang, W. K., & Cho, J. (2004) · Phytomedicine · doi:10.1016/j.phymed.2004.03.001 · Cited by 194 · see citing works

APOE ε2 is associated with intact cognition but increased Alzheimer pathology in the oldest old

Berlau, D. J., Corrada, M. M., Head, E., & Kawas, C. H. (2009) · Neurology · doi:10.1212/01.wnl.0000343853.00346.a4 · Cited by 185 · see citing works

Astrocyte physiopathology: At the crossroads of intercellular networking, inflammation and cell death

Rossi, D. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.04.003 · Cited by 178 · see citing works

Cognitive disturbances in old dogs suffering from the canine counterpart of Alzheimer's disease

Rofina, J., van Ederen, A. M., Toussaint, M. J. M., Secrève, M., van der Spek, A., van der Meer, I., Eerdenburg, F. J. C. M. V., & Gruys, E. (2006) · Brain Research · doi:10.1016/j.brainres.2005.11.021 · Cited by 178 · see citing works

The complement cascade: Yin-Yang in neuroinflammation—neuro-protection and -degeneration

Alexander, J. J., Anderson, A. J., Barnum, S. R., Stevens, B., & Tenner, A. J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05668.x · Cited by 177 · see citing works

Visual-discrimination learning ability and β-amyloid accumulation in the dog

Head, E., Callahan, H., Muggenburg, B. A., Cotman, C. W., & Milgram, N. W. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00084-0 · Cited by 176 · see citing works

The role of beta amyloid in Alzheimer?s disease: still a cause of everything or the only one who got caught?

Verdile, G. (2004) · Pharmacological Research · doi:10.1016/j.phrs.2003.12.028 · Cited by 177 · see citing works

Sleep and circadian abnormalities in a transgenic mouse model of Alzheimer’s disease: A role for cholinergic transmission

Wisor, J. P., Edgar, D. M., Yesavage, J. A., Ryan, H. S., McCormick, C. M., Lapustea, N., & Murphy, G. M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.11.018 · Cited by 169 · see citing works

Tau conformational changes correspond to impairments of episodic memory in mild cognitive impairment and Alzheimer's disease

Ghoshal, N. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.8014 · Cited by 192 · see citing works

Regulation of Bcl‐2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine

Bar‐Am, O., Weinreb, O., Amit, T., & Youdim, M. B. H. (2005) · The FASEB Journal · doi:10.1096/fj.05-3794fje · Cited by 164 · see citing works

Plaque-bearing mice with reduced levels of oligomeric amyloid-β assemblies have intact memory function

Lesné, S., Kotilinek, L., & Ashe, K. H. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.10.054 · Cited by 159 · see citing works

Is there a rationale for the use of acetylcholinesterase inhibitors in the therapy of Alzheimer's disease?

Benzi, G., & Moretti, A. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00093-4 · Cited by 156 · see citing works

Vascular and parenchymal Aβ deposition in the aging dog: correlation with behavior

Colle, M.-A. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00113-5 · Cited by 154 · see citing works

Aβ as a bioflocculant: implications for the amyloid hypothesis of Alzheimer’s disease

Robinson, S. R., & Bishop, G. M. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00342-6 · Cited by 153 · see citing works

The Oregon Brain Aging Study

Green, M. S., Kaye, J. A., & Ball, M. J. (2000) · Neurology · doi:10.1212/wnl.54.1.105 · Cited by 153 · see citing works

Astroglial Expression of Human α1-Antichymotrypsin Enhances Alzheimer-like Pathology in Amyloid Protein Precursor Transgenic Mice

Mucke, L., Yu, G.-Q., McConlogue, L., Rockenstein, E. M., Abraham, C. R., & Masliah, E. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64839-0 · Cited by 145 · see citing works

Aβ aggregation and possible implications in Alzheimer's disease pathogenesis

Bharadwaj, P. R., Dubey, A. K., Masters, C. L., Martins, R. N., & Macreadie, I. G. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00609.x · Cited by 147 · see citing works

THE GENETICS AND MOLECULAR PATHOLOGY OF ALZHEIMER'S DISEASE

Selkoe, D. J. (2000) · Neurologic Clinics · doi:10.1016/s0733-8619(05)70232-2 · Cited by 146 · see citing works

Neuroinflammation and anti-inflammatory therapy for Alzheimer’s disease

Moore, A. H., & O’Banion, M. K. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00162-x · Cited by 146 · see citing works

Synaptic proteins, neuropathology and cognitive status in the oldest-old

Head, E., Corrada, M. M., Kahle-Wrobleski, K., Kim, R. C., Sarsoza, F., Goodus, M., & Kawas, C. H. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.10.001 · Cited by 145 · see citing works

Cognition, glucose metabolism and amyloid burden in Alzheimer's disease

Furst, A. J., Rabinovici, G. D., Rostomian, A. H., Steed, T., Alkalay, A., Racine, C. A., Miller, B. L., & Jagust, W. J. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.03.011 · Cited by 144 · see citing works

The neuropathological profile of mild cognitive impairment (MCI): a systematic review

Stephan, B. C. M., Hunter, S., Harris, D., Llewellyn, D. J., Siervo, M., Matthews, F. E., & Brayne, C. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.147 · Cited by 139 · see citing works

Positron emission tomography imaging and clinical progression in relation to molecular pathology in the first Pittsburgh Compound B positron emission tomography patient with Alzheimer’s disease

Kadir, A., Marutle, A., Gonzalez, D., Schöll, M., Almkvist, O., Mousavi, M. T., Mustafiz, T., Darreh‐Shori, T., Nennesmo, I., & Nordberg, A. K. (2010) · Brain · doi:10.1093/brain/awq349 · Cited by 139 · see citing works

Biochemistry and Molecular Biology of Amyloid β‐Protein and the Mechanism of Alzheimer's Disease

(2008) · Handbook of Clinical Neurology · doi:10.1016/s0072-9752(07)01223-7 · Cited by 137 · see citing works

Effect of phenserine treatment on brain functional activity and amyloid in Alzheimer's disease

Kadir, A., Andreasen, N., Almkvist, O., Wall, A. E., Forsberg, A., Engler, H., Hagman, G., Lärksäter, M., Winblad, B. G., Zetterberg, H., et al. (2008) · Annals of Neurology · doi:10.1002/ana.21345 · Cited by 133 · see citing works

Dissociation of neuropathology from severity of dementia in late-onset Alzheimer disease

Prohovnik, I., Perl, D. P., Davis, K. L., Libow, L. S., Lesser, G. T., & Haroutunian, V. H. (2006) · Neurology · doi:10.1212/01.wnl.0000191298.68045.50 · Cited by 129 · see citing works

Detection and quantification of endoplasmic reticulum stress in living cells using the fluorescent compound, Thioflavin T

Beriault, D. R., & Werstuck, G. H. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.05.020 · Cited by 127 · see citing works

The Gut-Brain Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review

Ambrosini, Y. M., Borcherding, D. C., Kanthasamy, A., Kim, H. J., Willette, A., Jergens, A., Allenspach, K., & Mochel, J. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00130 · Cited by 116 · see citing works

Microglia, amyloid and dementia in Alzheimer disease

Arends, Y. M., Duyckaerts, C., Rozemuller, J. M., Eikelenboom, P., & Hauw, J.-J. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00094-4 · Cited by 139 · see citing works

Tau and Axonopathy in Neurodegenerative Disorders

Higuchi, M., Lee, V. M.-Y., & Trojanowski, J. Q. (2002) · NeuroMolecular Medicine · doi:10.1385/nmm:2:2:131 · Cited by 134 · see citing works

The brain RAS and Alzheimer's disease

Wright, J. W., & Harding, J. W. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.09.012 · Cited by 109 · see citing works

Stereologic assessment of the total cortical volume occupied by amyloid deposits and its relationship with cognitive status in aging and Alzheimer’s disease

Bussière, T., Friend, P. D., Sadeghi, N., Wicinski, B. A., Lin, G. I., Bouras, C., Giannakopoulos, P., Robakis, N. K. R. K., Morrison, J. H., Perl, D. P., et al. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00056-8 · Cited by 108 · see citing works

Review: Model Peptides and the Physicochemical Approach to β-Amyloids

Lynn, D. G., & Meredith, S. C. (2000) · Journal of Structural Biology · doi:10.1006/jsbi.2000.4287 · Cited by 103 · see citing works

Defensive effect of microRNA-200b/c against amyloid-beta peptide-induced toxicity in Alzheimer's disease models

Higaki, S., Muramatsu, M., Matsuda, A., Matsumoto, K., Satoh, J., Michikawa, M., & Niida, S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196929 · Cited by 101 · see citing works

β-Amyloid Converts an Acute Phase Injury Response to Chronic Injury Responses

Cotman, C. W., Tenner, A. J., & Cummings, B. J. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00117-0 · Cited by 102 · see citing works

Salvia lavandulaefolia essential oil inhibits cholinesterase in vivo

Perry, N. S. L., Houghton, P. J., Jenner, P. G., Keith, A. B., & Perry, E. K. (2002) · Phytomedicine · doi:10.1078/0944-7113-00082 · Cited by 98 · see citing works

Assessing the cognitive impact of Alzheimer disease pathology and vascular burden in the aging brain: the Geneva experience

Giannakopoulos, P., Gold, G., Kövari, E., von Gunten, A., Imhof, A., Bouras, C., & Hof, P. R. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0144-y · Cited by 95 · see citing works

Treatment with controlled-release lovastatin decreases serum concentrations of human β-amyloid (Aβ) peptide

Friedhoff, L. T., Cullen, E. I., Geoghagen, N. S. M., & Buxbaum, J. D. (2001) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145701002310 · Cited by 97 · see citing works

The neuropathological diagnosis of Alzheimer disease

Jellinger, K. A. (1998) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6467-9_9 · Cited by 97 · see citing works

Aging, Amyloid, and Alzheimer's Disease: A Perspective in Honor of Carl Cotman

Selkoe, D. J. (2003) · Neurochemical Research · doi:10.1023/a:1026065122854 · Cited by 96 · see citing works

Differential regulation of glial cell line-derived neurotrophic factor (GDNF) expression in human neuroblastoma and glioblastoma cell lines

Verity, A. N., Wyatt, T., Lee, W., Hajos, B., Baecker, P. A., Eglen, R. M., & Johnson, R. M. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990115)55:2 · Cited by 74 · see citing works

Activity changes and marked stereotypic behavior precede Aβ pathology in TgCRND8 Alzheimer mice

Ambrée, O., Touma, C., Görtz, N., Keyvani, K., Paulus, W., Palme, R., & Sachser, N. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.05.009 · Cited by 93 · see citing works

Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease

Giannakopoulos, P., Herrmann, F. R., Bussière, T., Bouras, C., Kövari, E., Perl, D. P., Morrison, J. H., Gold, G., & Hof, P. R. (2003) · Neurology · doi:10.1212/01.wnl.0000063311.58879.01 · Cited by 1,118 · see citing works

Relative Roles of Plaques and Tangles in the Dementia of Alzheimer's Disease: Correlations Using Three Sets of Neuropathological Criteria

Nagy, Z., Esiri, M. M., Jobst, K. A., Morris, J. H., King, E. M.-F., McDonald, B., Litchfield, S., Smith, A. D., Barnetson, L. P. D., & Smith, A. D. (1995) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106918 · Cited by 283 · see citing works

Pathological Substrates of Cognitive Decline in Alzheimer&amp;rsquo;s Disease

Giannakopoulos, P., K&ouml;vari, E., Gold, G., von Gunten, A., Hof, P. R., & Bouras, C. (2009) · Frontiers of Neurology and Neuroscience · doi:10.1159/000197881 · Cited by 101 · see citing works

Tangles and neuron numbers but not amyloid load predict cognitive status in Alzheimer's disease

Giannacopoulos, P. (2003) · Annals of General Hospital Psychiatry · doi:10.1186/1475-2832-2-s1-s18 · Cited by 7 · see citing works

Image analysis of β-amyloid load in Alzheimer's disease and relation to dementia severity

Cummings, B. J., & Cotman, C. W. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92053-6 · Cited by 260 · see citing works