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Scopolamine affects short-term memory but not inferior temporal neurons
Abstract
Effects of scopolamine on performance of a delayed matching-to-sample task and on the properties of neurons in anterior-ventral inferior temporal (IT) cortex were examined in two monkeys. Both monkeys were impaired on the task after systemic administration of scopolamine, suggesting that scopolamine disrupts recency memory. Despite the behavioral deficit, neurons in IT cortex, a region having an important role in visual memory and neuronal properties consistent with that role, were largely unaffected by scopolamine. This dissociation between the behavioral and neuronal effects of scopolamine indicates that the drug either acts at a different site or disrupts unobserved mechanisms at the IT site.
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Pharmacological blockade of muscarinic cholinergic receptors impairs performance in delayed match to sample tasks in non-human primates and humans.
“This is consistent with some data showing that pharmacological blockade of muscarinic cholinergic receptors impairs performance in delayed match to sample tasks in non-human primates (Penetar and McDonough, 1983; Miller and Desimone, 1993) and humans (Robbins et al., 1997).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Miller and Desimone, 1993
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“Another potential puzzle concerns the effect of the cholinergic drug scopolamine on haemodynamic repetition effects (Thiel et al., 2001), but not neural response suppression (Miller and Desimone, 1993).”
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Metadata
- Authors
- Miller, E. K., & Desimone, R.
- Affiliations
- National Institutes of Health (US)
- Venue
- NeuroReport
- Published
- 1993-01
- Volume
- 4
- Issue
- 1
- Pages
- 81
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2072825985
- Cited by
- 66
- References
- 0
- Citations by year
- 2022: 1 · 2021: 2 · 2020: 1 · 2018: 3 · 2017: 1 · 2015: 4 · 2013: 1 · 2012: 4
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- scopolamine, short-term memory, inferior temporal cortex, delayed matching-to-sample, visual memory, cholinergic antagonism, neuronal activity, memory impairment
- MeSH terms
- Algorithms, Animals, Behavior, Animal, Cerebral Cortex, Macaca mulatta, Memory, Short-Term, Neurons, Psychomotor Performance, Scopolamine, Temporal Lobe
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