Simulations of the Role of the Muscarinic-Activated Calcium-Sensitive Nonspecific Cation Current INCMin Entorhinal Neuronal Activity during Delayed Matching Tasks
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Entorhinal lesions impair performance in delayed matching tasks, and blockade of muscarinic cholinergic receptors also impairs performance in these tasks. Physiological data demonstrate that muscarinic cholinergic receptor stimulation activates intrinsic cellular currents in entorhinal neurons that could underlie the role of entorhinal cortex in performance of these tasks. Here we use a network biophysical simulation of the entorhinal cortex to demonstrate the potential role of this cellular mechanism in the behavioral tasks. Simulations demonstrate how the muscarinic-activated calcium-sensitive nonspecific cation current I(NCM) could provide a cellular mechanism for features of the neuronal activity observed during performance of delayed matching tasks. In particular, I(NCM) could underlie (1) the maintenance of sustained spiking activity during the delay period, (2) the enhancement of spiking activity during the matching period relative to the sample period, and (3) the resistance of sustained activity to distractors. Simulation of a larger entorhinal network with connectivity chosen randomly within constraints on number, distribution, and weight demonstrates appearance of other phenomena observed in unit recordings from awake animals, including match suppression, non-match enhancement, and non-match suppression.
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The loading of a signal or a sample stimulus into active maintenance requires temporal specificity of the cholinergic transient.
“The loading of a signal or a sample stimulus into active maintenance requires temporal specificity of the cholinergic transient (Fransen et al, 2002).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Fransen et al, 2002
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- Authors
- Fransén, E., Alonso, A. A., & Hasselmo, M. E.
- Affiliations
- KTH Royal Institute of Technology (SE)
- Montreal Neurological Institute and Hospital (CA)
- Boston University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-02-01
- Volume
- 22
- Issue
- 3
- Pages
- 1081-1097
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6758499
- OpenAlex
- W2095984446
- Cited by
- 137
- References
- 63
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 2 · 2022: 3 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 6 · 2013: 3 · 2012: 9
- FWCI
- 6.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (9996177, MH60013, MH61492)
- National Institutes of Health (MH60013)
- National Institute of Mental Health (MH 60013, MH61492, R01MH060013, R01MH061492)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- entorhinal cortex, muscarinic receptors, neuronal activity, cholinergic modulation
- MeSH terms
- Action Potentials, Animals, Behavior, Animal, Biophysics, Calcium, Computer Simulation, Interneurons, Memory, Short-Term, Models, Neurological, Synaptic Transmission, Neurons, Potassium, Sodium, Wakefulness, Reproducibility of Results, Neural Networks, Computer, Ion Transport, Pyramidal Cells, Muscarinic Agonists, Entorhinal Cortex, Cation Transport Proteins, Rats, Biophysical Phenomena
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