Co-occurrence of perineuronal nets with GABAA receptor α1 subunit-immunoreactive neurones in the rat septal region
Abstract
The immunocytochemical demonstration of the GABAA receptor alpha 1 subunit was combined with the Wisteria floribunda agglutinin staining of lattice-like extracellular matrix components--known as perineuronal nets--in the rat basal forebrain. Both were found to be co-localized in the septal-diagonal band region (e.g. in the medial septum, 96%), but only exceptionally in the ventral pallidum (3-10%) and nowhere in other basal forebrain subdivisions. This co-occurrence of perineuronal nets with septo-hippocampal projection neurones--previously characterized as GABAergic--expressing the GABAA receptor alpha 1 subunit- as well as parvalbumin-immunoreactivity, suggests the involvement of these intra- and extraneuronal components in the fast spiking neuronal activity essential for the generation and maintenance of hippocampal theta rhythm.
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WFA-labeled PNNs are associated with more heterogeneous neuronal phenotypes than previously thought, including several subgroups of interneurons, a small subset of cortico-cortical pyramidal cells, spinal cord motor neurons, and cerebellum Purkinje cells.
“More recent evidence indicates that WFA-labeled PNNs are associated with more heterogeneous neuronal phenotypes than previously thought, including several subgroups of interneurons, a small subset of cortico-cortical pyramidal cells, spinal cord motor neurons and cerebellum Purkinje cells (Ajmo et al., 2008; Brauer et al., 1995; Bruckner et al., 1993; Gati and Lendvai, 2013; Hartig et al., 1995;”
From Losing the sugar coating: Potential impact of perineuronal net abnormalities on interneurons in schizophrenia (2015) · cites this paper as Brauer et al., 1995
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“PNNs are found in the LS in rodents and other mammals [17, 18, 20].”
Distribution of perineuronal nets in the adult rat neocortex
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- Authors
- Brauer, K., Härtig, W., Fritschy, J.-M., Brückner, G., & Bigl, V.
- Affiliations
- Leipzig University (DE)
- Venue
- Neuroreport
- Published
- 1995-03
- Volume
- 6
- Issue
- 5
- Pages
- 733-736
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2004045689
- Cited by
- 18
- References
- 0
- Citations by year
- 2025: 2 · 2015: 2
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- perineuronal nets, GABA-A receptor alpha1 subunit, medial septum, ventral pallidum, parvalbumin, fast spiking, hippocampal theta rhythm, extracellular matrix, basal forebrain
- MeSH terms
- Animals, Immunohistochemistry, Male, Nerve Net, Neurons, Parvalbumins, Peptide Fragments, Receptors, GABA-A, Septum Pellucidum, Rats, Wistar, Receptors, N-Acetylglucosamine, Lectins, Plant Lectins, Rats
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