Perineuronal nets in the rat medial nucleus of the trapezoid body surround neurons immunoreactive for various amino acids, calcium-binding proteins and the potassium channel subunit Kv3.1b
Abstract
Perineuronal nets (PNs) are known as chondroitin sulfate-rich, lattice-like coatings of the extracellular matrix ensheathing mainly GABAergic, parvalbumin-containing neurons especially in the cerebral cortex. PNs have also been detected around GABA-immunonegative cells which were shown to be not aminergic, cholinergic, nitrinergic or peptidergic in various brain regions of some mammalian species. To find out whether glycine and aspartate may occur in net-bearing neurons the present study was focused on the rat medial nucleus of the trapezoid body (MNTB) which contains a large portion of cells immunoreactive for these amino acids, but appears to be devoid of GABA-immunoreactive cell bodies. PNs were detected around many glycine- and aspartate-immunopositive neurons in the MNTB by carbocyanine double labeling and confocal laser scanning microscopy. An additional finding was that the lectin-cytochemically stained extracellular matrix surrounds the calretinin-immunoreactive calyces of Held known as giant glutamatergic endbulbs which cover glycinergic principal cells in the MNTB. As elucidated by triple fluorescence labeling, the vast majority of somata co-expressed the calcium-binding proteins parvalbumin and calbindin, but not calretinin. The observed co-localization of PNs and immunoreactivity for the voltage-dependent potassium channel Kv3.1b - as an established marker of fast-firing parvalbumin-containing neurons - supports the assumed function of PNs as a cation exchanger ensuring rapid ion transport as required by highly active nerve cells.
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Iron ions are involved in generating oxidative stress.
“the polyanionic components might also interact with ions of potential pathophysiological relevance such as iron ions involved in generating oxidative stress.20, 22, 26, 27”
From Aggrecan, link protein and tenascin-R are essential components of the perineuronal net to protect neurons against iron-induced oxidative stress (2014) · cites this paper as [26]
WFA-positive nets are localized around different neuronal types, including parvalbumin-expressing GABAergic neurons in cortical areas, cortical pyramidal neurons, glutamatergic neurons in cerebellar nuclei, and glycinergic neurons of the medial nucleus of the trapezoid body.
“WFA-positive nets are localised around different neuronal types, such as parvalbumin-expressing GABAergic neurons in cortical areas (see above), as well as cortical pyramidal neurons (Alpár et al., 2006;Hartig et al., 2001;Takahashi-Iwanaga et al., 1998;Wegner et al., 2003), glutamatergic neurons in the cerebellar nuclei (Carulli et al., 2006) and glycinergic neurons of the medial nucleus of the”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Hartig et al., 2001
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- Authors
- Härtig, W., Singer, A., Grosche, J., Brauer, K., Ottersen, O. P., & Brückner, G.
- Affiliations
- Leipzig University (DE)
- University of Oslo (NO)
- Corresponding author
- Härtig, Wolfgang
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2001-04
- Volume
- 899
- Issue
- 1-2
- Pages
- 123-133
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1985604909
- Cited by
- 62
- References
- 81
- Citations by year
- 2024: 3 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 4 · 2016: 5 · 2015: 5 · 2014: 4 · 2013: 2 · 2012: 6
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Keywords
- perineuronal nets, medial nucleus of the trapezoid body, parvalbumin, calbindin, calretinin, calcium-binding proteins, extracellular matrix, chondroitin sulfate, ion transport, rats
- MeSH terms
- Amino Acids, Animals, Calcium-Binding Proteins, Extracellular Matrix, Female, Immunohistochemistry, Male, Nerve Net, Nerve Tissue Proteins, Neurons, Pons, Potassium Channels, Rats, Wistar, Potassium Channels, Voltage-Gated, Rats, Shaw Potassium Channels
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