Allocation of perineuronal nets and parvalbumin-, calbindin-D28k- and glutamic acid decarboxylase-immunoreactivity in the amygdala of the rhesus monkey
Abstract
Lattice-like coatings, known as perineuronal nets, were lectin-cytochemically stained with the Wisteria floribunda agglutinin in the lateral nucleus and the intermediate division of the basal nucleus of the amygdala in rhesus monkeys. Perineuronal nets were demonstrated around neurons with parvalbumin- or calbindin-D28k-immunoreactivity, but not around calretinin-containing cells. In parallel dual-peroxidase staining experiments, it was demonstrated that lattice-like coatings exclusively surround GABAergic neurons in this brain region. The novel finding of calbindin-D28k-immunoreactivity in neurons ensheathed by perineuronal nets amplifies the panel of revealed markers in such nerve cells and indicates their cytochemical heterogeneity.
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In the amygdala of rhesus monkey, the overwhelming majority of WFA-positive PNNs ensheath neurons expressing glutamic acid decarboxylase, with many also expressing parvalbumin and/or calbindin.
“As an example, in the amygdala of rhesus monkey, the overwhelming majority of WFA-positive PNNs ensheath neurons expressing glutamic acid decarboxylase (GAD), a typical marker for GABAergic neurons, with many of these neurons also expressing PVB and/or calbindin (Hartig et al., 1995).”
From Losing the sugar coating: Potential impact of perineuronal net abnormalities on interneurons in schizophrenia (2015) · cites this paper as Hartig et al., 1995
A large population of WFA-labeled PNNs ensheaths fast-firing inhibitory interneurons expressing parvalbumin and Kv3.1b.
“Several studies in rodent, human and non-human primates have shown that a large population of WFA-labeled PNNs ensheaths fast-firing inhibitory interneurons expressing the calcium binding protein parvalbumin (PVB) and Kv3.1b, a subunit of voltage gated potassium channels typically expressed in fast-firing neurons (Brauer et al., 1993; Hartig et al., 1995; Morris and Henderson, 2000; Pantazopoulos”
From Losing the sugar coating: Potential impact of perineuronal net abnormalities on interneurons in schizophrenia (2015) · cites this paper as Hartig et al., 1995
PNN-bearing neurons are predominantly GABAergic, including but not restricted to those expressing parvalbumin and somatostatin.
“As discussed, these are predominantly represented by GABAergic neurons, including, but not restricted to, those expressing PVB and somatostatin (Adams et al., 2001; Brauer et al., 1993; Bruckner et al., 1993; Hartig et al., 1995; Hartig et al., 2001; Haunso et al., 1999; Morris and Henderson, 2000; Pantazopoulos et al., 2006; Wintergerst et al., 1996) (Pantazopoulos et al., unpublished”
From Losing the sugar coating: Potential impact of perineuronal net abnormalities on interneurons in schizophrenia (2015) · cites this paper as Hartig et al., 1995
Cites
Brückner, G., Brauer, K., Härtig, W., Wolff, J. R., Rickmann, M. J., Derouiche, A., Delpech, B., Girard, N., Oertel, W. H., & Reichenbach, A. (1993) · Glia · doi:10.1002/glia.440080306 · Cited by 358 · see citing works
Self-citationHa¨rtig, W., Brauer, K., Bigl, V., & Bru¨ckner, G. (1994) · Brain Research · doi:10.1016/0006-8993(94)91452-4 · Cited by 147 · see citing works
Self-citationBrückner, G., Seeger, G., Brauer, K., Härtig, W., Kacza, J., & Bigl, V. (1994) · Brain Research · doi:10.1016/s0006-8993(09)90012-9 · Cited by 132 · see citing works
Self-citationPerineuronal nets of extracellular matrix around parvalbumin‐containing neurons of the hippocampus
Celio, M. R. (1993) · Hippocampus · doi:10.1002/hipo.1993.4500030709 · Cited by 89 · see citing works
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Extracellular matrix abnormalities in schizophrenia
Berretta, S. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.010 · Cited by 179 · see citing works
Morawski, M., Brückner, G., Jäger, C., Seeger, G., & Arendt, T. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.05.022 · Cited by 156 · see citing works
Self-citationBerretta, S., Pantazopoulos, H., Markota, M., Brown, C., & Batzianouli, E. T. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2014.12.040 · Cited by 152 · see citing works
Modulation of semaphorin3A in perineuronal nets during structural plasticity in the adult cerebellum
Carulli, D., Foscarin, S., Faralli, A., Pajaj, E., & Rossi, F. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2013.08.003 · Cited by 59 · see citing works
Subpopulations of neurons expressing parvalbumin in the human amygdala
Pantazopoulos, H., Lange, N., Hassinger, L., & Berretta, S. (2006) · Journal of Comparative Neurology · doi:10.1002/cne.20961 · Cited by 45 · see citing works
Pantazopoulos, H., Murray, E. A., & Berretta, S. (2008) · Brain Research · doi:10.1016/j.brainres.2008.02.036 · Cited by 34 · see citing works
Neuronal Pentraxin 2 Binds PNNs and Enhances PNN Formation
Van’t Spijker, H. M., Rowlands, D., Rossier, J., Haenzi, B., Fawcett, J. W., & Kwok, J. C. F. (2019) · Neural Plasticity · doi:10.1155/2019/6804575 · Cited by 31 · see citing works
- Authors
- Härtig, W., Brückner, G., Brauer, K., Schmidt, C., & Bigl, V.
- Affiliations
- Leipzig University (DE)
- Corresponding author
- Härtig, Wolfgang
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1995-11
- Volume
- 698
- Issue
- 1-2
- Pages
- 265-269
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2051890767
- Cited by
- 39
- References
- 4
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 5 · 2013: 3 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- perineuronal nets, amygdala, parvalbumin, calbindin-D28k, glutamic acid decarboxylase, GABAergic neurons, calretinin, lateral amygdala, basal amygdala, rhesus monkeys, neuronal heterogeneity, lectin cytochemistry
- MeSH terms
- Amygdala, Animals, Glutamate Decarboxylase, Immunoenzyme Techniques, Macaca mulatta, Nerve Net, Nerve Tissue Proteins, Parvalbumins, Calbindins, S100 Calcium Binding Protein G
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