Phosphacan immunoreactivity is associated with perineuronal nets around parvalbumin-expressing neurones
Abstract
A special feature of the extracellular matrix in adult brains of various species is the concentration of certain components around different sub-populations of neurones, giving rise to net-like structures termed perineuronal nets. Recently, some of these components have been identified but the function of these nets has yet to be resolved. Using immunofluorescence microscopy, we report here that phosphacan, a chondroitin sulphate proteoglycan, is an additional component of Wisteria floribunda labelled perineuronal nets surrounding parvalbumin-expressing neurones in rat cerebral cortex. Glycoproteins such as tenascin-C and -R have been identified in perineuronal nets and the present detection of phosphacan immunoreactivity in the same entity is of potential physiological importance because of their previously described interactions.
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Phosphacan is involved in CNS development, including neuronal migration, axon outgrowth, synapse formation, synaptic activity, and myelin formation.
“The spatiotemporal expression pattern of phosphacan within the CNS suggests potential roles for this protein in various developmental processes, including cell migration (Maeda et al., 1996), neurite growth (Garwood et al., 2003), synaptogenesis (Haunso et al., 1999), synaptic function (Murai et al., 2002), and myelination (Harroch et al., 2000)(Garwood et al., 2001)”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Haunso et al., 1999
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Self-citation
- Authors
- Haunsø, A., Celio, M. R., Margolis, R. K., & Menoud, P.-A.
- Affiliations
- University of Fribourg (CH)
- State University of New York (US)
- Corresponding author
- Menoud, Pierre-Alain
- ORCID
- Celio, Marco R.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1999-07
- Volume
- 834
- Issue
- 1-2
- Pages
- 219-222
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1997720118
- Cited by
- 52
- References
- 19
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- phosphacan, perineuronal nets, chondroitin sulfate proteoglycans, extracellular matrix, Wisteria floribunda, tenascin-C, tenascin-R, cerebral cortex
- MeSH terms
- Animals, Cerebral Cortex, Female, Fluorescent Antibody Technique, Male, Nerve Net, Neurons, Parvalbumins, Chondroitin Sulfate Proteoglycans, Rats, Wistar, Receptors, N-Acetylglucosamine, Lectins, Plant Lectins, Rats, Receptor-Like Protein Tyrosine Phosphatases, Class 5
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