Amygdala β-noradrenergic influence on hippocampal longterm potentiation in vivo
Abstract
We have previously shown that hippocampal long-term potentiation (LTP), one form of synaptic plasticity that may underlie learning and memory, is attenuated by blocking neuron activity of the basolateral amygdala (BLA). In the present study we investigated the amygdala noradrenergic or cholinergic contribution to hippocampal LTP formation. When propranolol, a beta-adrenoceptor antagonist, was injected into the BLA 10 min before tetanus, the formation of LTP in the perforant path-dentate granule cell synapses was significantly impaired. Scopolamine, a muscarinic cholinergic receptor antagonist, did not affect the formation of LTP. These results suggest that amygdala beta-noradrenergic activity plays a critical role in modulation of hippocampal LTP.
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Input from the hypothalamus and the locus coeruleus, via activation of β-adrenergic receptors, as well as dopaminergic innervation of the hippocampus from the VTA and local release of CRH, all appear to contribute to the rapid stress-induced enhancement of hippocampal LTP.
“In addition, input from the hypothalamus (Nakanishi et al. [216]) and the locus coeruleus (Harley and Sara [217]; Sara et al. [218]; Kitchigina et al. [219]; Bouret and Sara [220]), via activation of β-adrenergic receptors (Ikegaya et al. [221]; Vermetten and Bremner [8]; Strange and Dolan [222]; Nathan et al. [189]; Hurlemann et al. [223]), as well as the dopaminergic innervation of the”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Ikegaya et al. [221]
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- Authors
- Ikegaya, Y., Nakanishi, K., Saito, H., & Abe, K.
- Affiliations
- The University of Tokyo (JP)
- Venue
- NeuroReport
- Published
- 1997-09
- Volume
- 8
- Issue
- 14
- Pages
- 3143-3146
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2120526824
- Cited by
- 98
- References
- 1
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 2 · 2018: 3 · 2017: 2 · 2014: 6 · 2013: 3 · 2012: 2
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- hippocampal long-term potentiation, basolateral amygdala, beta-adrenergic modulation, noradrenergic neurotransmission, propranolol, synaptic plasticity, learning and memory, cholinergic modulation, scopolamine
- MeSH terms
- Adrenergic beta-Antagonists, Amygdala, Animals, Hippocampus, Male, Propranolol, Scopolamine, Rats, Wistar, Long-Term Potentiation, Muscarinic Antagonists, Rats
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