Cited by 154Memory and Neural MechanismsStress Responses and CortisolMemory Processes and Influences

Adrenal stress hormones, amygdala activation, and memory for emotionally arousing experiences

Roozendaal, Benno, Barsegyan, Areg, Lee, Sangkwan·2007·Progress in Brain Research

Abstract

Extensive evidence indicates that stress hormones released from the adrenal glands are critically involved in memory consolidation of emotionally arousing experiences. Epinephrine or glucocorticoids administered after exposure to emotionally arousing experiences enhance the consolidation of long-term memories of these experiences. Our findings indicate that adrenal stress hormones influence memory consolidation via interactions with arousal-induced activation of noradrenergic mechanisms within the amygdala. In turn, the amygdala regulates memory consolidation via its efferent projections to many other brain regions. In contrast to the enhancing effects on consolidation, high circulating levels of stress hormones impair memory retrieval and working memory. Such effects also require noradrenergic activation of the amygdala and interactions with other brain regions.

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Crossref · 10.1016/s0079-6123(07)67006-x

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160 of 160 references verified0 citation errors · 0 not checkable

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Authors
Roozendaal, B., Barsegyan, A., & Lee, S.
Affiliations
University of California, Irvine (US)
Corresponding author
Roozendaal, Benno
Venue
Progress in Brain Research
Publisher
Elsevier
Published
2007
Volume
167
Pages
79-97
ISSN
0079-6123 (ISSN-L)
OpenAlex
W1543075896
Cited by
154
References
160
Citations by year
2026: 4 · 2025: 1 · 2024: 2 · 2023: 6 · 2022: 12 · 2021: 9 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 6 · 2016: 10 · 2015: 9 · 2014: 7 · 2013: 11 · 2012: 7
FWCI
23.02
Type
book chapter
Language
en
Open access
closed
Locations
  • Progress in brain research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation
  • National Institute of Mental Health (MH12526)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
amygdala, memory consolidation, emotional arousal, epinephrine, glucocorticoids, noradrenergic activation, memory retrieval, working memory, efferent projections
MeSH terms
Adrenal Cortex Hormones, Amygdala, Animals, Arousal, Brain, Emotions, Humans, Memory, Memory, Short-Term, Mental Recall, Stress, Physiological

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