Enhancement of slow-wave sleep by tumor necrosis factor-α is mediated by cyclooxygenase-2 in rats
Abstract
Tumor necrosis factor-alpha (TNFalpha) was infused into the subarachnoid space of the rat rostral basal forebrain, which was previously defined as a prostaglandin (PG) D2-sensitive, sleep-promoting zone. TNFalpha increased the amount of slow-wave sleep (SWS), decreased that of paradoxical sleep (PS), and caused fever and anorexia. The TNFalpha-induced SWS enhancement, fever and anorexia were all blocked by co-infusion of diclofenac, a non-selective cyclooxygenase (COX) inhibitor, and by pretreatment with NS-398, a COX-2-specific inhibitor. In striking contrast, the TNFalpha-induced suppression of PS was not affected by the inhibitors. These results indicate that COX-2-mediated hyperproduction of PGs is critically involved in the enhancement of SWS, fever, and anorexia but not in the suppression of PS, caused by TNFalpha infused into the PGD2-sensitive zone.
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The longer sleep duration-mortality relationship is thought to be due to residual confounders such as uncontrolled comorbidities and illness-related longer sleep duration in the last months of life.
“It is thought to be due to residual confounders, such as uncontrolled comorbidities (429), illness-related longer sleep duration in the last months of life (537), among many other factors”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [537]
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The Sleep-Immune Crosstalk in Health and Disease
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- Authors
- Terao, A., Matsumura, H., Yoneda, H., & Saito, M.
- Affiliations
- Hokkaido University (JP)
- Venue
- NeuroReport
- Published
- 1998-12
- Volume
- 9
- Issue
- 17
- Pages
- 3791-3796
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W1974452299
- Cited by
- 60
- References
- 6
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 6 · 2018: 1 · 2017: 2 · 2016: 2 · 2014: 1 · 2012: 5
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Keywords
- TNF-α, cyclooxygenase-2, slow-wave sleep, REM sleep, prostaglandin D2, fever, anorexia, diclofenac, NS-398, basal forebrain, sleep regulation, prostaglandin synthesis
- MeSH terms
- Animals, Diclofenac, Interleukin-1, Isoenzymes, Male, Prostaglandin-Endoperoxide Synthases, Recombinant Proteins, Sleep, Tumor Necrosis Factor-alpha, Prostaglandin D2, Prosencephalon, Cyclooxygenase Inhibitors, Rats, Sprague-Dawley, Rats, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors
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