Dissociation of inhibition from error processing using a parametric inhibitory task during functional magnetic resonance imaging
Abstract
Inhibition, the process that overrides and reverses the execution of a thought, action, or emotion, is important in daily life. Sixteen healthy volunteers performed a parametrically modulated motor inhibition task during functional magnetic resonance imaging. Two results were observed: (1) increased error-related anterior cingulate cortex activation and, (2) increased inferior frontal gyrus and medial prefrontal cortex activation during inhibition, irrespective of errors. Thus, the parametric nature of the task elucidated a functional dissociation of brain structures involved in motor inhibition from those involved in error processing. Additionally, this task allowed the identification of unique areas of increased activation within specific subregions of the anterior cingulate cortex related to errors made during trials with a high (dorsal anterior cingulate cortex) and low (ventral anterior cingulate cortex) inhibitory load.
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The right cuneus cortex (extrastriate region) has been implicated in response inhibition, particularly involving motor reactions.
“This extrastriate region has been implicated in response inhibition in particular those involving motor reactions (Booth et al., 2005; Matthews et al., 2005).”
From Meta-analyses of the neural mechanisms and predictors of response to psychotherapy in depression and anxiety (2018) · cites this paper as Matthews et al., 2005
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- Authors
- Matthews, S. C., Simmons, A. N., Arce, E., & Paulus, M. P.
- Affiliations
- University of California San Diego (US)
- Venue
- Neuroreport
- Published
- 2005-05
- Volume
- 16
- Issue
- 7
- Pages
- 755-760
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2067920474
- Cited by
- 90
- References
- 23
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 8 · 2020: 4 · 2019: 4 · 2018: 8 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 4 · 2012: 3
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- University of California, San Diego
- National Institute of Mental Health (5T32 MH 18399, T32MH018399)
- National Institute on Drug Abuse (R21 DA 13186, R01DA016663, R01DA13186, R21DA013186)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Free Will and Agency
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Keywords
- motor inhibition, error processing, anterior cingulate cortex, inferior frontal gyrus, medial prefrontal cortex, dorsal anterior cingulate cortex, ventral anterior cingulate cortex, functional dissociation
- MeSH terms
- Adult, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neural Inhibition, Photic Stimulation, Psychomotor Performance, Prefrontal Cortex
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