The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Stimulation of Growth Factor Synthesis by Electric and Electromagnetic Fields
Abstract
Biophysical input, including electric and electromagnetic fields, regulate the expression of genes in connective tissue cells for structural extracellular matrix (ECM) proteins resulting in an increase in cartilage and bone production. In in vivo models and clinical situations, this can be manifested as enhanced repair and a gain in mechanical properties of the repairing tissues. The mechanisms by which cell functions are regulated by biophysical input is the subject of this review. Biophysical interactions of electric and electromagnetic fields at the cell membrane are not well understood and require considerable additional study. We review information on transmembrane signaling, channel activation and receptor stimulation or blockade. Understanding physical interactions and transmembrane signaling will most likely be necessary to establish dosing paradigms and improve therapeutic efficacy. Considerable information has been generated on an intermediary mechanism of activity - growth factor stimulation. Electric and electromagnetic fields increase gene expression for, and synthesis of, growth factors and this may function to amplify field effects through autocrine and paracrine signaling. Electric and electromagnetic fields can produce a sustained upregulation of growth factors, which enhance, but do not disorganize endochondral bone formation. Progress in the areas of signal transduction and growth factor synthesis is very rapid and future directions are suggested.
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Cites
Mechanism for action of electromagnetic fields on cells
Panagopoulos, D. J., Karabarbounis, A., & Margaritis, L. H. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02393-8 · Cited by 337
Biological responses to electromagnetic fields 1
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Signal Transduction in Electrically Stimulated Bone Cells
Brighton, C. T., Wang, W., Seldes, R., Zhang, G., & Pollack, S. R. (2001) · The Journal of Bone and Joint Surgery-American Volume · doi:10.2106/00004623-200110000-00009 · Cited by 294
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Treatment of Nonunions With Electric and Electromagnetic Fields
Aaron, R. K., Ciombor, D. M., & Simon, B. J. (2004) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-200402000-00005 · Cited by 275
Self-citationMagnetic fields increase cell survival by inhibiting apoptosis via modulation of Ca 2+ influx
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Self-citationLohmann, C. H., Schwartz, Z., Liu, Y., Guerkov, H., Dean, D. D., Simon, B., & Boyan, B. D. (2000) · Journal of Orthopaedic Research · doi:10.1002/jor.1100180417 · Cited by 172
Self-citationLow frequency EMF regulates chondrocyte differentiation and expression of matrix proteins
Ciombor, D. M., Lester, G. E., Aaron, R. K., et al. (2002) · Journal of Orthopaedic Research® · doi:10.1016/s0736-0266(01)00071-7 · Cited by 139
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Cited by
Alford, J. W., & Cole, B. J. (2005) · The American Journal of Sports Medicine · doi:10.1177/0363546504273510 · Cited by 435
Treatment of Nonunions With Electric and Electromagnetic Fields
Aaron, R. K., Ciombor, D. M., & Simon, B. J. (2004) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-200402000-00005 · Cited by 275
Self-citationBhavsar, M. B., Han, Z., DeCoster, T., Leppik, L., Costa Oliveira, K. M., & Barker, J. H. (2020) · European Journal of Trauma and Emergency Surgery · doi:10.1007/s00068-019-01127-z · Cited by 66
Metadata
- Authors
- Aaron, R. K., Boyan, B. D., Ciombor, D. M., Schwartz, Z., & Simon, B. J.
- Venue
- Clinical Orthopaedics and Related Research
- Published
- 2004-02
- Volume
- 419
- Issue
- 419
- Pages
- 30-37
- ISSN
- 0009-921X (ISSN-L)
- OpenAlex
- W2030598727
- Cited by
- 270
- References
- 24
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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