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Cited by 275

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Treatment of Nonunions With Electric and Electromagnetic Fields

Aaron, Roy K, Ciombor, Deborah McK, Simon, Bruce J·2004·Clinical Orthopaedics and Related Research
DOI 10.1097/00003086-200402000-00005
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Abstract

Electric and electromagnetic fields are, collectively, one form of biophysical technique which regulate extracellular matrix (ECM) synthesis and may be useful in clinically stimulating repair of fractures and nonunions. Preclinical studies have shown that electric and electromagnetic fields regulate proteoglycan (PG) and collagen synthesis in models of endochondral ossification, and increase bone formation in vivo and in vitro. A substantial number of clinical studies have been done that suggest acceleration of bone formation and healing, particularly osteotomies and spine fusions, by electric and electromagnetic fields. Many of these studies have used randomized, placebo controlled designs. In osteotomy trials, greater bone density, trabecular maturation, and radiographic healing were observed in actively treated, compared with placebo-treated patients. In spine fusions, average union rates of 80% to 90% were observed in actively treated patients across numerous studies compared with 65% to 75% in placebo-treated patients. Uncontrolled, longitudinal cohort studies of delayed and nonunions report mean union rates of approximately 75% to 85% in fractures previously refractory to healing. The few randomized controlled studies in delayed and nonunions suggest improved results with electric and electromagnetic fields compared with placebo treatment, and equivalent to bone grafts.

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Metadata

Authors
Aaron, R. K., Ciombor, D. M., & Simon, B. J.
Venue
Clinical Orthopaedics and Related Research
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2004-02
Volume
419
Issue
419
Pages
21-29
ISSN
0009-921X (ISSN-L)
DOI
10.1097/00003086-200402000-00005
OpenAlex
W2076683520
Cited by
275
References
36
FWCI
9.23
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Treatment of Nonunions With Electric and Electromagnetic Fields. https://app.cochat.ai/papers/10.1097/00003086-200402000-00005
The paper
Aaron, R. K., Ciombor, D. M., & Simon, B. J. (2004). Treatment of Nonunions With Electric and Electromagnetic Fields. Clinical Orthopaedics and Related Research. https://doi.org/10.1097/00003086-200402000-00005

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.