Interleukin-8 is increased in cerebrospinal fluid of children with severe head injury

Whalen, Michael J.; Carlos, Timothy M.; Kochanek, Patrick M.; Wisniewski, Stephen R.; Bell, Michael J.; Clark, Robert S.B.; DeKosky, Steven T.; Marion, Donald W.; Adelson, David P.

doi:10.1097/00003246-200004000-00003

Cited by 175Traumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury ResearchInflammation biomarkers and pathways

Interleukin-8 is increased in cerebrospinal fluid of children with severe head injury

Whalen, Michael J., Carlos, Timothy M., Kochanek, Patrick M., Wisniewski, Stephen R., Bell, Michael J., Clark, Robert S.B., DeKosky, Steven T., Marion, Donald W. +1 more·2000·Critical Care Medicine

DOI 10.1097/00003246-200004000-00003

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Abstract

OBJECTIVE: To determine interleukin (IL)-8 concentrations in ventricular cerebrospinal fluid from children with severe traumatic brain injury (TBI). DESIGN: Prospective study. SETTING: University children's hospital. PATIENTS: Twenty-seven children hospitalized with severe TBI (Glasgow Coma Scale score < or =8), seven children with cerebrospinal fluid culture-positive bacterial meningitis, and twenty-four age-equivalent controls. INTERVENTIONS: Placement of an intraventricular catheter and continuous drainage of cerebrospinal fluid. MEASUREMENTS AND MAIN RESULTS: Median [range] cerebrospinal fluid IL-8 concentration in children with TBI (0-12 hrs) (4,452.5 [0-20,000] pg/mL) was markedly greater than that in controls (14.5 [0-250]) (p < .0001) and equivalent to concentrations in children with meningitis (5,300 [1,510-22,000] pg/mL) (p = .33). Cerebrospinal fluid IL-8 remained increased in children with severe TBI for up to 108 hrs after injury. Univariate logistic regression analysis demonstrated an association between cerebrospinal fluid IL-8 and child abuse (p = .07) and mortality (p = .01). Multivariate analysis demonstrated a strong, independent association between cerebrospinal fluid IL-8 and mortality (p = .01). CONCLUSIONS: The data are consistent with an acute inflammatory component of TBI in children and suggest an association between cerebrospinal fluid IL-8 and outcome after TBI. IL-8 may represent a potential target for anti-inflammatory therapy.

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Child abuse resulting in pediatric traumatic brain injury is associated with elevated IL-4, IL-12, and IL-8.
“Child abuse that results in pediatric traumatic brain injury has also been associated with elevated IL-4, IL-12 (Amick et al., 2001), and IL-8 (Whalen et al., 2000).”
From Developmental psychoneuroendocrine and psychoneuroimmune pathways from childhood adversity to disease (2017) · cites this paper as Whalen et al., 2000

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Authors: Whalen, M. J., Carlos, T. M., Kochanek, P. M., Wisniewski, S. R., Bell, M. J., Clark, R. S. B., DeKosky, S. T., Marion, D. W., & Adelson, D. P.
Affiliations: University of Pittsburgh (US)
ORCID: Whalen, Michael J.
Kochanek, Patrick M.
Wisniewski, Stephen R.
Bell, Michael J.
Clark, Robert S.B.
DeKosky, Steven T.
Marion, Donald W.
Venue: Critical Care Medicine
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2000-04
Volume: 28
Issue: 4
Pages: 929-934
ISSN: 0090-3493 (ISSN-L)
DOI: 10.1097/00003246-200004000-00003
OpenAlex: W2030688762
Cited by: 175
References: 66
Citations by year: 2026: 1 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 9 · 2016: 3 · 2015: 9 · 2014: 4 · 2013: 11 · 2012: 13
FWCI: 7.68
Type: journal article
Language: en
Open access: closed
Locations: Critical Care Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (NS-30318)
Topics: Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords: interleukin-8, cerebrospinal fluid, severe traumatic brain injury, pediatric head injury, bacterial meningitis, intraventricular catheter, mortality, child abuse, neuroinflammation, anti-inflammatory therapy
MeSH terms: Acute Disease, Adolescent, Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Female, Craniocerebral Trauma, Humans, Infant, Male, Prospective Studies, Time Factors, Biomarkers, Logistic Models, Interleukin-8, Meningitis, Bacterial

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Interleukin-8 is increased in cerebrospinal fluid of children with severe head injury

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