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Cited by 56Stress Responses and CortisolAdrenal Hormones and DisordersChild and Adolescent Psychosocial and Emotional Development

Response to oCRH in depressed and nondepressed adolescents: does gender make a difference?

DORN, LORAH D., BURGESS, ELLEN S., SUSMAN, ELIZABETH J., von EYE, ALEXANDER, DeBELLIS, MICHAEL D., GOLD, PHILIP W., CHROUSOS, GEORGE P.·1996·Journal of the American Academy of Child & Adolescent Psychiatry
DOI 10.1097/00004583-199606000-00016
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Abstract

Objective To examine the hypothesis that hypothalamic-pituitary-adrenal responses to stress vary across gender, contributing to gender differences in the prevalence of depression.Method This study examined gender differences between depressed (n = 21) and control (n = 20) adolescents in adrenocorticotropic hormone (ACTH) and cortisol response to two ovine corticotropin-releasing hormone (oCRH) tests, at baseline and following a cognitive stressor.Results Boys had higher (p < .05) measures of ACTH than girls, regardless of depression status, whereas corresponding cortisol parameters were similar in both groups. Cortisol measures were higher (p < .05) at time 1 than at time 2 in both groups, a phenomenon that might reflect the novelty of the situation.Conclusions Gender differences in hormone responses may be related to differences in peripheral metabolism of ACTH, resulting in changes of immunoreactivity but not bioactivity or a different set point of the hypothalamic-pituitary-adrenal axis. The pattern of ACTH and cortisol responses to oCRH and the 24-hour excretion of free cortisol was normal in adolescents with depression, probably reflecting normal negative feedback mechanisms at this age or that most of these patients suffer from atypical rather than melancholic depression.

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  • Four CRH infusion studies found no significant difference in cortisol or ACTH secretion between MDD and non-MDD groups.

    “Four studies compared cortisol levels post CRH infusion, but none found a significant difference in cortisol or ACTH secretion between MDD and non-MDD groups (Birmaher et al., 1996; Dorn et al., 1996; Kaufman et al., 1997; Ronsaville et al., 2006).”

    From Hypothalamic–pituitary–adrenal axis dysregulation in depressed children and adolescents: A meta-analysis (2009) · cites this paper as Dorn et al., 1996

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Authors
DORN, L. D., BURGESS, E. S., SUSMAN, E. J., von EYE, A., DeBELLIS, M. D., GOLD, P. W., & CHROUSOS, G. P.
Affiliations
Pennsylvania State University (US)
Corresponding author
DORN, LORAH D.
ORCID
Venue
Journal of the American Academy of Child & Adolescent Psychiatry
Publisher
Elsevier BV
Published
1996-06
Volume
35
Issue
6
Pages
764-773
ISSN
0890-8567 (ISSN-L)
DOI
10.1097/00004583-199606000-00016
OpenAlex
W1982686484
Cited by
56
References
73
Citations by year
2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 1
FWCI
1.51
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords
adolescent depression, gender differences, hypothalamic-pituitary-adrenal axis, ACTH, cortisol, cognitive stressors, atypical depression, negative feedback
MeSH terms
Adolescent, Adrenocorticotropic Hormone, Arousal, Circadian Rhythm, Corticotropin-Releasing Hormone, Depressive Disorder, Feedback, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Pituitary-Adrenal System, Sex Factors

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