A Double-Blind Pilot Study of Risperidone in the Treatment of Conduct Disorder
Abstract
Objective To examine whether risperidone is superior to placebo in the treatment of youths with conduct disorder.Method This was a 10-week, randomized, double-blind, placebo-controlled study with 2 parallel arms. Ten youths were randomly assigned to receive placebo and 10 youths were randomly assigned to receive risperidone. Patients were seen weekly throughout the trial. Medications could be increased at weekly intervals during the first 6 weeks of the study from an initial dose of 0.25 mg or 0.50 mg each morning, depending on patient weight. Patients weighing less than 50 kg had a maximum total daily dose of risperidone of 1.5 mg. Patients weighing 50 kg or greater had a maximum total daily dose of risperidone of 3.0 mg. The primary outcome measure was the Rating of Aggression Against People and/or Property Scale.Results Risperidone was superior to placebo in ameliorating aggression on most measures. Risperidone was reasonably well tolerated, with none of the risperidone-treated patients developing extrapyramidal side effects.Conclusions These data provide preliminary evidence that risperidone may have efficacy in the treatment of youths with conduct disorder. Because of the small sample size and the brief length of this study, further research is necessary to confirm these findings.
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Risperidone was found to be well-tolerated and superior to placebo in reducing aggressive behaviors in children with CD.
“Risperidone was found to be well-tolerated and superior to placebo in reducing aggressive behaviors in children with CD [664-666].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [665]
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- Authors
- FINDLING, R. L., McNAMARA, N. K., BRANICKY, L. A., SCHLUCHTER, M. D., LEMON, E., & BLUMER, J. L.
- Affiliations
- University Hospitals of Cleveland (US)
- Corresponding author
- FINDLING, ROBERT L.
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 2000-04
- Volume
- 39
- Issue
- 4
- Pages
- 509-516
- ISSN
- 0890-8567 (ISSN-L)
- OpenAlex
- W2076287319
- Cited by
- 309
- References
- 23
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 3 · 2019: 5 · 2018: 6 · 2017: 10 · 2016: 6 · 2015: 11 · 2014: 11 · 2013: 14 · 2012: 14
- FWCI
- 26.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NICHD Pediatric Pharmacology Research Unit (HD 31323-05)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- risperidone, conduct disorder, youth, aggression, antipsychotic drugs, placebo comparison, drug tolerability, extrapyramidal symptoms
- MeSH terms
- Adolescent, Aggression, Child, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Male, Pilot Projects, Psychiatric Status Rating Scales, Antipsychotic Agents, Treatment Outcome, Risperidone, Conduct Disorder
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