Medikamentöse Behandlungsalgorithmen bei Aufmerksamkeitsdefizit-Hyperaktivitätsstörungen unter Berücksichtigung spezifischer Komorbiditäten
Abstract
Hintergrund: Die Aufmerksamkeitsdefizit-Hyperaktivitätsstörung (ADHS) geht mit einer Vielzahl unterschiedlicher Komorbiditäten einher, die sich zum Teil als Komplikation und in Folge der Kernsymptomatik, aber auch parallel zusammen mit der Grunderkrankung entwickeln können. Eine wichtige Säule im Rahmen des multimodalen Konzepts zur Behandlung der ADHS stellt die medikamentöse Behandlung, v. a. mit Psychostimulanzien, dar. Verschränkt mit psychotherapeutischen und psychosozialen Maßnahmen bewirkt eine Stimulanzienmedikation in vielen Fällen einen zufriedenstellenden Rückgang der Hauptsymptome des Störungsbildes und kann hierdurch auch zu einer Verminderung der Komorbiditäten führen. Gelingt dies nicht ausreichend, dann sollten medikamentöse Behandlungsstrategien mit anderen Substanzen überlegt werden, die zunehmend als Alternative oder in Kombination mit den Stimulanzien die komorbiden Symptome positiv beeinflussen. Fragestellung: Der vorliegende Beitrag gibt eine Übersicht der medikamentösen Behandlungsoptionen für verschiedene Komorbiditäten, d. h. affektive Störungen, aggressive Verhaltensstörungen sowie Ticstörungen. Besondere Beachtung kommt dabei der Möglichkeit kombinierter Behandlungsmöglichkeiten mit Psychostimulanzien zu. Darüber hinaus werden in Form von Algorithmen Vorschläge zu medikamentösen Behandlungsstrategien unterbreitet, die sich an den im Vordergrund stehenden klinischen Leitsymptomen orientieren. Methodik: Auf der Basis einer Medline-Recherche erfolgt eine kritische Übersicht der evidenzbasierten Literatur und praktischer Erfahrungen. Ergebnisse: Im Ergebnis bewirkt der individuell titrierte Einsatz von Stimulanzien zur Behandlung der Kernsymptome der ADHS oft zugleich einen zufrieden stellenden Rückgang der komorbiden Symptome. Stehen diese aber zunehmend im Vordergrund des klinischen Beschwerdebildes, kann der Einsatz von Antidepressiva oder Neuroleptika zur primären oder gleichberechtigten Behandlungsoptionen werden. Schlussfolgerung: Gegenstand der Diskussion muss v. a. sein, dass die gewählten Substanzen zumeist keine Zulassung zur Behandlung bei Kindern in Deutschland besitzen, dass Wirksamkeitsnachweise für dieses Altersspektrum fehlen, häufiger mit Nebenwirkungen zu rechnen ist und v. a. für die Kombination mit Stimulanzien nur sehr wenige Daten vorliegen.
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Treatment of ADHD can result in alleviation of comorbid depression, anxiety, oppositional defiant disorder and/or aggression.
“Treatment of ADHD can result in alleviation of comorbid depression, anxiety, oppositional defiant disorder and/or aggression [98].”
From Advances in understanding and treating ADHD (2011) · cites this paper as [98]
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Renaud, J., Birmaher, B., Wassick, S., & Bridge, J. (1999) · Journal of child and adolescent psychopharmacology · doi:10.1089/cap.1999.9.73 · Cited by 39 · see citing works
Dr. Stoll and Colleagues Reply
Stoll, A. L., Pillay, S. S., Diamond, L. M., Workum, S. B., & Cole, J. O. (1996) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v57n1109c · Cited by 39 · see citing works
Roessner, V., Banaschewski, T., & Rothenberger, A. (2004) · Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie · doi:10.1024/1422-4917.32.4.245 · Cited by 36 · see citing works
STIMULANT-ATYPICAL ANTIPSYCHOTIC INTERACTION AND ACUTE DYSTONIA
Benjamin, E., & Salek, S. (2005) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000159166.96967.13 · Cited by 34 · see citing works
Four-year follow-up of children with low intelligence and ADHD: a replication
Aman, M. G., Armstrong, S. C., Buican, B., & Sillick, T. (2002) · Research in Developmental Disabilities · doi:10.1016/s0891-4222(02)00090-2 · Cited by 33 · see citing works
An Exaggerated Cardiovascular Response to Methylphenidate in ADHD Children with Anxiety
URMAN, R., Ickowicz, A., FULFORD, P., & Tannock, R. (1995) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.1995.5.29 · Cited by 31 · see citing works
The treatment of Tourette’s syndrome: current opinions
Müller‐Vahl, K. (2002) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.3.7.899 · Cited by 30 · see citing works
Childhood Anxiety Disorders: Lessons from the Literature
Manassis, K. (2000) · The Canadian Journal of Psychiatry · doi:10.1177/070674370004500805 · Cited by 30 · see citing works
Aripiprazole in patients with Tourette syndrome
Bubl, E., Perlov, E., & van Elst, L. T. (2006) · The World Journal of Biological Psychiatry · doi:10.1080/15622970500474770 · Cited by 27 · see citing works
Early augmentation of sertraline with methylphenidate
Postolache, T. T., Rosenthal, R. N., Hellerstein, D. J., Aromin, R., Kelton, G. M., Muran, J. C., & Londono, J. H. (1999) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v60n0210c · Cited by 26 · see citing works
Günther, T., Herpertz‐Dahlmann, B., JOLLES, J., & Konrad, K. (2006) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2006.16.725 · Cited by 26 · see citing works
Risperidone-to-methylphenidate switch reaction in children: three cases
Sabuncuoğlu, O. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881107069466 · Cited by 21 · see citing works
Holtmann, M. H., Bölte, S., & Poustka, F. (2005) · Der Nervenarzt · doi:10.1007/s00115-005-1952-3 · Cited by 21 · see citing works
Herpertz‐Dahlmann, B., Fegert, J. M., & Herpertz‐Dahlmann, B. (2004) · Der Nervenarzt · doi:10.1007/s00115-004-1792-6 · Cited by 17 · see citing works
Antidepressiva und Suizidalität
Hegerl, U. (2006) · Der Nervenarzt · doi:10.1007/s00115-006-2109-8 · Cited by 13 · see citing works
Selecting an Antidepressant for the Treatment of Pediatric Depression
Kratochvil, C. J., Vitiello, B., Brent, D. A., Bostic, J. Q., & Naylor, M. W. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000197029.87378.1c · Cited by 13 · see citing works
Pharmacotherapy of Aggression in a 9-Year-Old With ADHD
Findling, R. L., Newcorn, J. H., Malone, R. P., Waheed, A., Prince, J. B., & Kratochvil, C. J. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3180335b4a · Cited by 10 · see citing works
Serotoninwiederaufnahmehemmer im Kindes- und Jugendalter
Fegert, J. M., & Herpertz‐Dahlmann, B. (2005) · Der Nervenarzt · doi:10.1007/s00115-005-1969-7 · Cited by 9 · see citing works
Hebebrand, J. (2004) · Monatsschrift Kinderheilkunde · doi:10.1007/s00112-004-1050-9 · Cited by 3 · see citing works
Klinische Symptome des Tourette-Syndroms: eine prospektive Studie bei 480 Patienten
Müller‐Vahl, K., Makowski, L., Geomelas, M., Emrich, H. M., & KOLBE, H. (2005) · Aktuelle Neurologie · doi:10.1055/s-2005-919281 · Cited by 2 · see citing works
Flagged first, then by citations
3 of the 111 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Advances in understanding and treating ADHD
Antshel, K. M., Hargrave, T. M., Simonescu, M., Kaul, P., Hendricks, K., & Faraone, S. V. (2011) · BMC Medicine · doi:10.1186/1741-7015-9-72 · Cited by 140 · see citing works
Defizitäre adaptive Emotions- regulation bei Kindern mit ADHS
Schmitt, K. D., Gold, A. W., & Rauch, W. A. (2012) · Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie · doi:10.1024/1422-4917/a000156 · Cited by 49 · see citing works
Psychische Störungen und umschriebene Entwicklungsstörungen im Kindes- und Jugendalter
Blank, R., Fricke-Oerkermann, L., Lehmkuhl, G., Lehmkuhl, U., Mitschke, A., Roessner, V., Röhling, D., Rothenberger, A., Salbach‐Andrae, H., Sinzig, J., et al. (2014) · Elsevier eBooks · doi:10.1016/b978-3-437-23076-9.00019-x · Cited by 1 · see citing works
Self-citationLepach, A. C., Lehmkuhl, G., & Petermann, F. (2012) · Zeitschrift für Psychiatrie Psychologie und Psychotherapie · doi:10.1024/1661-4747/a000129 · Cited by 1 · see citing works
Self-citationPsychische Störungen im Kindes- und Jugendalter
(2009) · Elsevier eBooks · doi:10.1016/b978-343723075-2.10020-2
- Authors
- Frölich, J., Lehmkuhl, G., & Döpfner, M.
- Affiliations
- University of Cologne (DE)
- ORCID
- Döpfner, Manfred
- Venue
- Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie
- Publisher
- Hogrefe Publishing Group
- Published
- 2010-01
- Volume
- 38
- Issue
- 1
- Pages
- 7-20
- ISSN
- 1422-4917 (ISSN-L)
- 1664-2880
- OpenAlex
- W2071124740
- Cited by
- 5
- References
- 111
- Citations by year
- 2014: 1 · 2012: 2
- FWCI
- 0.82
- Type
- journal article
- Language
- de
- Open access
- closed
- Locations
- Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
- Keywords
- attention deficit hyperactivity disorder, comorbidities, psychostimulants, antidepressants, atypical antipsychotics, serotonin reuptake inhibitors, Tourette syndrome, depression, anxiety disorders, impulsive aggression, pediatric pharmacotherapy, adverse effects
- MeSH terms
- Adolescent, Aggression, Algorithms, Anxiety Disorders, Attention Deficit Disorder with Hyperactivity, Child, Child, Preschool, Depressive Disorder, Drug Therapy, Combination, Humans, Psychotropic Drugs, Tic Disorders, Comorbidity, Controlled Clinical Trials as Topic
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