Proton Magnetic Resonance Spectroscopy Investigation of the Right Frontal Lobe in Children With Attention-Deficit/Hyperactivity Disorder
Open accessAbstract
Objective To investigate neurometabolite concentrations in right prefrontal white matter in children with attention-deficit/hyperactivity disorder (ADHD) and relations of neurometabolites with attention skill and frontal anatomy.Method Single voxel proton magnetic resonance spectroscopy ( H-MRS), quantitative morphometric analysis of left and right dorsolateral frontal volumes, and assessment of attentional problems with the Conners Continuous Performance Test were undertaken in 23 children (17 male) with ADHD (with no comorbid learning disabilities) and 24 matched controls (16 male).Results No overall group differences were found for any neurometabolite. However, a group by sex interaction was noted for -acetylaspartate, such that girls with ADHD had especially low concentrations. Morphological analyses revealed smaller right (but not left) dorsolateral volumes in children with ADHD, and in the ADHD group this volume correlated with neurometabolite concentrations. In the ADHD group Continuous Performance Test performance was related to both dorsolateral volume and the creatine-phosphocreatine peak from H-MRS.Conclusions These results add to a growing body of evidence suggesting sex-specific neurobiological differences in ADHD and draw attention to relationships between neurochemistry, neuroanatomy, and performance in children with ADHD. Study limitations include small sample size and clinical heterogeneity among the children with ADHD.
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A small-sample study in children using single-voxel proton MRS found a sex/gender-by-diagnosis interaction for N-acetylaspartate concentration in right dorsolateral frontal white matter, with especially low concentrations in ADHD females.
“One small-sample study in children using single-voxel proton MRS found a sex/gender-by-diagnosis interaction effect for N-acetylaspartate concentration in the right dorsolateral frontal white matter, with especially low concentrations in ADHD females, potentially indicating elevated levels of neuronal death or injury211.”
From Sex and gender in neurodevelopmental conditions (2023) · cites this paper as [211]
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- Authors
- YEO, R. A., HILL, D. E., CAMPBELL, R. A., VIGIL, J., PETROPOULOS, H., HART, B., ZAMORA, L., & BROOKS, W. M.
- Affiliations
- University of New Mexico (US)
- Corresponding author
- YEO, RONALD A.
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 2003-03
- Volume
- 42
- Issue
- 3
- Pages
- 303-310
- ISSN
- 0890-8567 (ISSN-L)
- OpenAlex
- W1976592434
- Cited by
- 107
- References
- 44
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 6 · 2014: 9 · 2013: 2 · 2012: 11
- FWCI
- 6.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- attention deficit hyperactivity disorder, neurometabolites, sex differences, creatine/phosphocreatine, attentional performance
- MeSH terms
- Aspartic Acid, Attention Deficit Disorder with Hyperactivity, Child, Female, Frontal Lobe, Humans, Functional Laterality, Male, Neuropsychological Tests, Magnetic Resonance Spectroscopy, Protons
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