The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Impact of Methylphenidate Delivery Profiles on Driving Performance of Adolescents With Attention-Deficit/Hyperactivity Disorder: A Pilot Study
Abstract
Objective Adolescents with attention-deficit/hyperactivity disorder (ADHD) are at high risk for driving accidents. One dose of methylphenidate (MPH) improves simulator driving performances of ADHD-diagnosed adolescents at 1.5 hours post-dose. However, little is known about the effects of different MPH delivery profiles on driving performance throughout the day.Method This randomized, crossover, single-blind study compared osmotic, controlled-release oral system (OROS) MPH (Concerta) given q.d. to immediate-release MPH (Ritalin) given in equal doses t.i.d. on driving performance among six male ADHD-diagnosed adolescent drivers aged 16 to 19 years. Under each treatment condition, participants were maintained on their medication dosage for 7 days, then drove a sophisticated driving simulator at 2 p.m., 5 p.m., 8 p.m., and 11 p.m. The primary outcome measure was each participant's computer-quantified Impaired Driving Score (IDS).Results IDS worsened in the evenings for participants receiving MPH t.i.d. but remained stable when they received once-daily OROS MPH. Participants performed significantly better when receiving OROS MPH q.d. compared with MPH t.i.d. (F = 9.3, df = 1, p =.004). When MPH was given t.i.d., IDS significantly worsened beginning at 8 p.m. compared to OROS MPH (p =.01).Conclusions Participants demonstrated significantly less variability and better driving performance when receiving OROS MPH q.d. compared to MPH t.i.d., particularly in the evenings.
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“However, unlike some previous studies, we found no associations between adherence and demographic factors such as age, sex, 17,22 family income, and single-parent status 1, 16,18,29,30”
From Medication Adherence in the MTA: Saliva Methylphenidate Samples Versus Parent Report and Mediating Effect of Concomitant Behavioral Treatment (2009) · cites this paper as [1]
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“Despite our high reported adherence rates, our physiological adherence findings are consistent with studies 1, 16,18,29 that have linked poor adherence to adverse outcomes.”
From Medication Adherence in the MTA: Saliva Methylphenidate Samples Versus Parent Report and Mediating Effect of Concomitant Behavioral Treatment (2009) · cites this paper as [1]
Citations
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Research works printed but not linked: 2
- Cox, 2002, Specific driving impairments with progressive age, Adv Med Psychother Psychodiag, 11, 107
- Guerrier JH, Cox DJ (in press), The validity of a low-cost driving simulator in assessing driving performance. Proc Hum Factors Ergonom Soc
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Disorders of extreme stress: The empirical foundation of a complex adaptation to trauma
van der Kolk, B. A., Roth, S., Pelcovitz, D., Sunday, S., & Spinazzola, J. (2005) · Journal of Traumatic Stress · doi:10.1002/jts.20047 · Cited by 1,284
Harpin, V. A. (2005) · Archives of Disease in Childhood · doi:10.1136/adc.2004.059006 · Cited by 789
3-year follow-up of the NIMH MTA study
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Metadata
- Authors
- Cox, D. J., Merkel, R. L., Penberthy, J. K., Kovatchev, B., & Hankin, C. S.
- Affiliations
- University of Virginia Health System (US)
- Corresponding author
- Cox, Daniel J.
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 2004-03
- Volume
- 43
- Issue
- 3
- Pages
- 269-275
- ISSN
- 0890-8567 (ISSN-L)
- OpenAlex
- W2010345730
- Cited by
- 120
- References
- 31
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 3 · 2013: 6 · 2012: 6
- FWCI
- 10.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Physical Sciences › Engineering › Safety, Risk, Reliability and Quality › Traffic and Road Safety
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Keywords
- methylphenidate, attention deficit hyperactivity disorder, adolescents, driving performance, impaired driving, osmotic-release oral system, controlled-release formulation, immediate-release formulation, dosing frequency, driving simulator
- MeSH terms
- Adolescent, Adult, Central Nervous System Stimulants, Analysis of Variance, Attention Deficit Disorder with Hyperactivity, Automobile Driving, Delayed-Action Preparations, Humans, Male, Methylphenidate, Pilot Projects, Single-Blind Method, Cross-Over Studies
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