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An Intrathecal Bolus of Cyclosporin a before Injury Preserves Mitochondrial Integrity and Attenuates Axonal Disruption in Traumatic Brain Injury
Open accessAbstract
Traumatic brain injury evokes multiple axonal pathologies that contribute to the ultimate disconnection of injured axons. In severe traumatic brain injury, the axolemma is perturbed focally, presumably allowing for the influx of Ca 2+ and initiation of Ca 2+-sensitive, proaxotomy processes. Mitochondria in foci of axolemmal failure may act as Ca 2+ sinks that sequester Ca 2+ to preserve low cytoplasmic calcium concentrations. This Ca 2+ load within mitochondria, however, may cause colloid osmotic swelling and loss of function by a Ca 2+-induced opening of the permeability transition pore. Local failure of mitochondria, in turn, can decrease production of high-energy phosphates necessary to maintain membrane pumps and restore ionic balance in foci of axolemmal permeability change. The authors evaluated the ability of the permeability transition pore inhibitor cyclosporin A (CsA) to prevent mitochondrial swelling in injured axonal segments demonstrating altered axolemmal permeability after impact acceleration injury in rat. At the electron microscopic level, statistically fewer abnormal mitochondria were seen in traumatically injured axons from CsA-pretreated injured animals. Further, this mitochondrial protection translated into axonal protection in a second group of injured rats, whose brains were reacted with antibodies against amyloid precursor protein, a known marker of injured axons. Pretreatment with CsA significantly reduced the number of axons undergoing delayed axotomy, as evidenced by a decrease in the density of amyloid precursor protein-immunoreactive axons. Collectively, these studies demonstrate that CsA protects both mitochondria and the related axonal shaft, suggesting that this agent may be of therapeutic use in traumatic brain injury.
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Cites
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Cited by
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Altered Mitochondrial Dynamics and TBI Pathophysiology
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Metadata
- Authors
- Okonkwo, D. O., & Povlishock, J. T.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 1999-04
- Volume
- 19
- Issue
- 4
- Pages
- 443-451
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2000057840
- Cited by
- 265
- References
- 4
- FWCI
- 9.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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