The Link Between Health-Related Quality of Life and Clinical Symptoms Among Children with Attention-Deficit Hyperactivity Disorder
Abstract
Clinical research on attention-deficit hyperactivity disorder (ADHD) has begun to integrate measures of health-related quality of life (HRQL) as part of the overall assessment of treatment outcomes. This study examines the association between HRQL and measures of clinical symptoms of ADHD. Data were gathered from 297 children and adolescents in an 8-week, randomized, double-blind, placebo-controlled, clinical trial of atomoxetine treatment for ADHD. HRQL was assessed with the Child Health Questionnaire 50-item Parent Form. ADHD symptoms were assessed with the ADHD Rating Scale-IV; Parent Version and Clinical Global Impressions-ADHD-Severity. Associations between HRQL and clinical symptoms were assessed with correlations, analyses of variance with post hoc comparisons, and t tests. The Child Health Questionnaire 50-item Parent Form scales assessing psychosocial domains of HRQL were significantly negatively correlated with clinical measures. Improvement in clinical symptoms was associated with corresponding improvement in psychosocial aspects of HRQL. The findings suggest that HRQL instruments can add important information to efficacy measures in clinical trials of ADHD treatment.
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QOL is negatively correlated with ADHD symptom severity.
“Decreased QOL among individuals with ADHD is well established (Klassen et al. 2004; Topolski et al. 2004; Zambrano-Sanchez et al. 2012), with QOL negatively correlated with symptom severity (Klassen et al. 2004; Matza et al. 2004).”
From Participant-Perceived Quality of Life in a Long-Term, Open-Label Trial of Lisdexamfetamine Dimesylate in Adolescents with Attention-Deficit/Hyperactivity Disorder (2014) · cites this paper as Matza et al. 2004
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- Authors
- MATZA, L. S., RENTZ, A. M., SECNIK, K., SWENSEN, A. R., REVICKI, D. A., MICHELSON, D., SPENCER, T., NEWCORN, J. H., & KRATOCHVIL, C. J.
- Affiliations
- United BioSource Corporation (United Kingdom) (GB)
- Eli Lilly (United States) (US)
- Harvard University (US)
- Icahn School of Medicine at Mount Sinai (US)
- University of Nebraska Medical Center (US)
- ORCID
- Venue
- Journal of Developmental & Behavioral Pediatrics
- Published
- 2004-06
- Volume
- 25
- Issue
- 3
- Pages
- 166-174
- ISSN
- 0196-206X (ISSN-L)
- OpenAlex
- W2034939353
- Cited by
- 119
- References
- 1
- Citations by year
- 2025: 1 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 7 · 2017: 2 · 2016: 3 · 2015: 6 · 2014: 6 · 2013: 8 · 2012: 4
- FWCI
- 4.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Developmental & Behavioral Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- attention deficit hyperactivity disorder, health-related quality of life, atomoxetine, ADHD symptoms, psychosocial functioning, treatment outcome measures, ADHD Rating Scale-IV, children and adolescents
- MeSH terms
- Adolescent, Attention Deficit Disorder with Hyperactivity, Child, Double-Blind Method, Female, Follow-Up Studies, Health Status, Humans, Male, Quality of Life, Surveys and Questionnaires, Severity of Illness Index, Outcome Assessment, Health Care
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