Effects of Clonidine and Methylphenidate on Family Quality of Life in Attention-Deficit/Hyperactivity Disorder
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Objective: The aim of this study was to determine the effect on family quality of life (QOL) of clonidine (CLON) and methylphenidate (MPH), used alone and in combination, in treating attention-deficit/hyperactivity disorder (ADHD). Methods: Two proxy QOL measures were used in a multicenter, double-blind, placebo-controlled 16-week trial of 122 children, ages 7–12 years, with ADHD. Children were randomized to one of four groups in which they received MPH, CLON, a combination of drugs, or placebo. QOL was measured with the Daily Hassles Scale and the Impact on Family Scale at baseline and at 16 weeks. Results: In a general linear model repeated measures analysis, treatment groups improved over a 16-week period compared to placebo for Daily Hassles and Impact on Family, as well as in symptoms measured by the ADHD Rating Scale. QOL measures correlated moderately with efficacy and symptom measures. Conclusion: This study provides evidence that measures of QOL for the family are sensitive to pharmacological treatment of ADHD. The correlation pattern of the QOL measures with symptom and efficacy variables supported family QOL as a related but separate construct. Clonidine for Attention-Deficit/Hyperactivity Disorder Treatment Study (CAT) Trial Registry Name: Clinicaltrials.gov; ID Number, NCT00031395; URL, http://clinicaltrials.gov/ct/show/NCT00031395?order=8/ .
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The broad improvements in participant-perceived QOL observed in this trial are in line with those previously described with psychostimulant and nonstimulant treatment in children, adolescents, and adults with ADHD.
“The broad improvements in participant-perceived QOL observed currently are in line with those described previously with psychostimulant and nonstimulant treatment in children, adolescents, and adults with ADHD (Spencer et al. 2008; Cannon et al. 2009; Gerwe et al. 2009; Brown and Landgraf 2010; Wehmeier et al. 2010; Berek et al. 2011; Brams et al. 2011).”
From Participant-Perceived Quality of Life in a Long-Term, Open-Label Trial of Lisdexamfetamine Dimesylate in Adolescents with Attention-Deficit/Hyperactivity Disorder (2014) · cites this paper as Cannon et al. 2009
Adding clonidine to methylphenidate, extended-release guanfacine to stimulants, or OROS methylphenidate to atomoxetine improved residual ADHD symptoms and was well tolerated.
“Recent studies have shown that adding clonidine to methylphenidate [95], extended-release guanfacine to stimulants [96], or OROS methylphenidate to atomoxetine [97] improved residual ADHD symptoms and was well tolerated.”
From Advances in understanding and treating ADHD (2011) · cites this paper as [95]
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Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)
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- Authors
- Cannon, M., Pelham, W. H., Sallee, F. R., Palumbo, D. R., Bukstein, O., & Daviss, W. B.
- Affiliations
- University of Cincinnati (US)
- SUNY Buffalo
- Pfizer (United States) (US)
- University of Pittsburgh (US)
- University of Texas Health Science Center at San Antonio
- Corresponding author
- Cannon, Michael
- Venue
- Journal of Child and Adolescent Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2009-10
- Volume
- 19
- Issue
- 5
- Pages
- 511-517
- ISSN
- 1044-5463 (ISSN-L)
- 1557-8992
- PMC
- PMC2830226
- OpenAlex
- W1964396391
- Cited by
- 29
- References
- 30
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2019: 3 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Child and Adolescent Psychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS039087)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Keywords
- attention deficit hyperactivity disorder, clonidine, methylphenidate, family quality of life, combination pharmacotherapy, children, family impact, daily hassles, ADHD medication
- MeSH terms
- Adrenergic alpha-Agonists, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Child, Clonidine, Double-Blind Method, Drug Therapy, Combination, Family Health, Female, Humans, Male, Methylphenidate, Psychiatric Status Rating Scales, Quality of Life, Linear Models
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