The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Blood Pressure Changes During Short-Term Fluoxetine Treatment
Abstract
Recent reports of sustained hypertension in some patients receiving venlafaxine have rekindled concerns about antidepressant-induced hypertension. This study examined sitting and standing systolic and diastolic blood pressure, pulse rate, and rate of sustained hypertension in 796 depressed patients (mean +/- SD age, 40 +/- 11 years) taking fluoxetine 20 mg daily for up to 12 weeks. A modest reduction in sitting and standing systolic (p < 0.001) and diastolic (p < 0.001) blood pressure measures were observed in the entire patient sample. Patients with pretreatment diastolic blood pressure < 60 mmHg (N = 32) showed a modest increase in mean diastolic blood pressure (p < 0.001), whereas patients with pretreatment diastolic blood pressure > or = 90 mmHg and < or = 95 mmHg (N = 57) had a modest reduction in mean diastolic blood pressure (p < 0.001). Patients with preexisting, stable cardiovascular disease (including hypertension) (N = 35) showed no significant blood pressure change (p = not significant). Of the patients receiving fluoxetine, 1.7% had sustained hypertension for > or = 3 consecutive clinic visits-a rate significantly lower than that previously reported with venlafaxine (4.8%) (chi2 = 13.3, p < 0.001) and similar to that previously seen with placebo (2.1%). In conclusion, these data demonstrate a low rate of sustained hypertension (1.7%) during short-term fluoxetine treatment.
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“Severe hypertension has also been identified in patients treated with antidepressants such as fluoxetine.248”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [248]
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Carey, R. M., Calhoun, D. A., Bakris, G. L., Brook, R. D., Daugherty, S. L., Dennison-Himmelfarb, C. R., Egan, B. M., Flack, J. M., Gidding, S. S., Judd, E., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000084 · Cited by 1,153
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Metadata
- Authors
- Amsterdam, J. D., Garcia-Espana, F., Fawcett, J., Quitkin, F. M., Reimherr, F. W., Rosenbaum, J. F., & Beasley, C.
- Affiliations
- University of Utah (US)
- ORCID
- Beasley, Charles
- Venue
- Journal of Clinical Psychopharmacology
- Published
- 1999-02
- Volume
- 19
- Issue
- 1
- Pages
- 9-14
- ISSN
- 0271-0749 (ISSN-L)
- OpenAlex
- W2319421857
- Cited by
- 51
- References
- 21
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 3 · 2015: 2 · 2014: 5 · 2013: 1 · 2012: 1
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- fluoxetine, blood pressure, venlafaxine, depression, sustained hypertension, diastolic blood pressure, cardiovascular adverse events, antidepressants
- MeSH terms
- Adolescent, Adult, Aged, Blood Pressure, Depression, Double-Blind Method, Female, Fluoxetine, Humans, Hypertension, Male, Middle Aged, Antidepressive Agents, Second-Generation
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