Severity of Depression and Response to Antidepressants and Placebo: An Analysis of the Food and Drug Administration Database

A rating scale for depression

Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works

National Institute of Mental Health Treatment of Depression Collaborative Research Program: General Effectiveness of Treatments

Elkin, I. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110013002 · Cited by 2,300 · see citing works

Symptom Reduction and Suicide Risk in Patients Treated With Placebo in Antidepressant Clinical Trials

Khan, A., Warner, H. A., & Brown, W. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.4.311 · Cited by 475 · see citing works

Prediction of Tricyclic Antidepressant Response

Bielski, R. J. (1976) · Archives of General Psychiatry · doi:10.1001/archpsyc.1976.01770120083009 · Cited by 349 · see citing works

Predictors of Drug Response in Depression

Joyce, P. R. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810010091014 · Cited by 279 · see citing works

Clinical pharmacology of imipramine and related antidepressant compounds.

KLERMAN, G. L., & Jo, C. (1967) · PubMed · Cited by 273 · see citing works

Which depressions respond to placebo?

Fairchild, C., Rush, A. J., Vasavada, N., Giles, D. E., & Khatami, M. (1986) · Psychiatry Research · doi:10.1016/0165-1781(86)90109-5 · Cited by 105 · see citing works

Clinical features of depressed patients who do and do not improve with placebo

Brown, W. A., Johnson, M. F. K., & Chen, M.-G. (1992) · Psychiatry Research · doi:10.1016/0165-1781(92)90002-k · Cited by 102 · see citing works

Neurophysiologic predictors of treatment response to fluoxetine in major depression

Cook, I. A., Leuchter, A. F., Witte, E. A., Abrams, M., Uijtdehaage, S. H. J., Stubbeman, W. F., Rosenberg-Thompson, S., & Anderson‐Hanley, C. (1999) · Psychiatry Research · doi:10.1016/s0165-1781(99)00010-4 · Cited by 70 · see citing works

Predictors of placebo response: a retrospective analysis.

Wilcox, C. S., Cohn, J. B., Rd, L., Heiser, J. F., Lucas, P. B., Morgan, D. L., & Defrancisco, D. F. (1992) · PubMed · Cited by 59 · see citing works

The Impact of Restrictive Entry Criterion During the Placebo Lead‐in Period

Landin, R., DeBrota, D. J., DeVries, T. A., Potter, W. Z., & Demitrack, M. A. (2000) · Biometrics · doi:10.1111/j.0006-341x.2000.00271.x · Cited by 57 · see citing works

PREDICTORS OF RESPONSE TO AMITRIPTYLINE AND PLACEBO IN THREE OUTPATIENT TREATMENT SETTINGS

Downing, R. W., & Rickels, K. (1973) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-197302000-00004 · Cited by 53 · see citing works

Severity at baseline and onset of improvement in depression. Meta-analysis of imipramine and moclobemide versus placebo

Stassen, H., Angst, J., & Delini‐Stula, A. (1994) · European Psychiatry · doi:10.1017/s0924933800001097 · Cited by 53 · see citing works

Placedo response in depression: A search for predictors

Brown, W. A., Dornseif, B. E., & Wernicke, J. F. (1988) · Psychiatry Research · doi:10.1016/0165-1781(88)90119-9 · Cited by 46 · see citing works

Response patterns of depressed outpatients with and without melancholia: a double-blind, placebo-controlled trial of fluoxetine versus placebo

Heiligenstein, J. H., Tollefson, G. D., & Faries, D. E. (1994) · Journal of Affective Disorders · doi:10.1016/0165-0327(94)90077-9 · Cited by 43 · see citing works

Predictors of placebo response in depression.

Wa, B. (1988) · PubMed · Cited by 33 · see citing works

Latency to rapid eye movement sleep as a predictor of treatment response to fluoxetine and placebo in nonpsychotic depressed outpatients

Heiligenstein, J. H., Faries, D. E., Rush, A. J., Andersen, J. S., Pande, A. C., Roffwarg, H. P., Dünner, D. L., Gillin, J. C., JAMES, S. P., Lahmeyer, H. W., et al. (1994) · Psychiatry Research · doi:10.1016/0165-1781(94)90078-7 · Cited by 32 · see citing works

Comparative Onset of Improvement in Depressive Symptomatology with Drug Treatment, Electroconvulsive Therapy, and Placebo

Small, J. G., Milstein, V., Kellams, J. J., & Small, I. F. (1981) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-198111001-00012 · Cited by 19 · see citing works

Which Depressed Patients Should Receive Antidepressants?

Brown, W. A., & Khan, A. (1994) · CNS Drugs · doi:10.2165/00023210-199401050-00004 · Cited by 16 · see citing works

The Predictive Value of the Dexamethasone Suppression Test

Peselow, E. D., Stanley, M., Filippi, A.-M., Barouche, F., Goodnick, P. J., & Fieve, R. R. (1989) · The British Journal of Psychiatry · doi:10.1192/bjp.155.5.667 · Cited by 10 · see citing works

Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice

Trivedi, M. H., Rush, A. J., Wisniewski, S. R., Nierenberg, A. A., Warden, D., Ritz, L., Norquist, G., Howland, R. H., Lebowitz, B., McGrath, P. J., et al. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.1.28 · Cited by 3,879 · see citing works

Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration

Kirsch, I., Deacon, B. J., Huedo-Medina, T. B., Scoboria, A., Moore, T. J., & Johnson, B. T. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050045 · Cited by 2,442 · see citing works

Antidepressant Drug Effects and Depression Severity: A Patient-Level Meta-analysis

Fournier, J. C., DeRubeis, R. J., Hollon, S. D., Dimidjian, S., Amsterdam, J. D., Shelton, R. C., & Fawcett, J. (2010) · JAMA · doi:10.1001/jama.2009.1943 · Cited by 2,009 · see citing works

PRACTICE GUIDELINE FOR THE Treatment of Patients With Major Depressive Disorder

Gelenberg, A. J., Freeman, P. B., Markowitz, J. C., Rosenbaum, J. F., Thase, M. E., Trivedi, M. H., & Rhoads, R. S. (2010) · Cited by 1,372 · see citing works

Severity classification on the Hamilton depression rating scale

Zimmerman, M., Martinez, J. H., Young, D., Chelminski, I., & Dalrymple, K. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.04.028 · Cited by 1,199 · see citing works

Depression and coronary heart disease

Carney, R. M., & Freedland, K. E. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.181 · Cited by 705 · see citing works

Placebo and Nocebo Effects

Colloca, L., & BARSKY, A. J. (2020) · New England Journal of Medicine · doi:10.1056/nejmra1907805 · Cited by 695 · see citing works

Depression Screening and Patient Outcomes in Cardiovascular Care: A Systematic Review

Thombs, B. D., de Jonge, P., Coyne, J. C., Whooley, M. A., Frasure-Smith, N., Mitchell, A. J., Zuidersma, M., Eze-Nliam, C., Lima, B. B., Smith, C. G., et al. (2008) · JAMA · doi:10.1001/jama.2008.667 · Cited by 472 · see citing works

Treatment selection in depression.

Cohen, Z. D., & DeRubeis, R. J. (2018) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050817-084746 · Cited by 435 · see citing works

The clinical characterization of the adult patient with depression aimed at personalization of management

Maj, M., Stein, D. J., Parker, G., Zimmerman, M., Fava, G. A., De Hert, M., Demyttenaere, K., McIntyre, R. S., Widiger, T., & Wittchen, H. (2020) · World Psychiatry · doi:10.1002/wps.20771 · Cited by 435 · see citing works

Personalized Medicine for Depression: Can We Match Patients With Treatments?

Simon, G. E., & Perlis, R. H. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09111680 · Cited by 365 · see citing works

Does the probability of receiving placebo influence clinical trial outcome? A meta-regression of double-blind, randomized clinical trials in MDD

Papakostas, G. I., & D, M. F. M. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.08.009 · Cited by 383 · see citing works

Voice acoustic measures of depression severity and treatment response collected via interactive voice response (IVR) technology

Mundt, J. C., Snyder, P. J., Cannizzaro, M. S., Chappie, K., & Geralts, D. S. (2007) · Journal of Neurolinguistics · doi:10.1016/j.jneuroling.2006.04.001 · Cited by 380 · see citing works

Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder. A systematic review with meta-analysis and trial sequential analysis

Jakobsen, J. C., Katakam, K. K., Schou, A., Hellmuth, S. G., Stallknecht, S. E., Leth-Møller, K., Iversen, M., Banke, M. B., Petersen, I. J., Klingenberg, S. L., et al. (2017) · BMC Psychiatry · doi:10.1186/s12888-016-1173-2 · Cited by 366 · see citing works

Efficacy of antidepressants in adults

Moncrieff, J., & Kirsch, I. (2005) · BMJ · doi:10.1136/bmj.331.7509.155 · Cited by 329 · see citing works

Vocal Acoustic Biomarkers of Depression Severity and Treatment Response

Mundt, J. C., Vogel, A. P., Feltner, D. E., & Lenderking, W. R. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.03.015 · Cited by 325 · see citing works

National trends in the treatment for depression from 1998 to 2007

Marcus, S. C., & Olfson, M. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.151 · Cited by 312 · see citing works

A systematic review of comparative efficacy of treatments and controls for depression

Khan, A., Faucett, J., Lichtenberg, P., Kirsch, I., & Brown, W. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041778 · Cited by 288 · see citing works

Is serotonin an upper or a downer? The evolution of the serotonergic system and its role in depression and the antidepressant response.

Andrews, P. W., Bharwani, A., Lee, K. R., Fox, M., & Thomson, J. A. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.01.018 · Cited by 281 · see citing works

Guidelines for Rehabilitation in Patients With Cardiovascular Disease (JCS 2012)

JCS Joint Working Group (2014) · Circulation Journal · doi:10.1253/circj.cj-66-0094 · Cited by 283 · see citing works

Australian and New Zealand Clinical Practice Guidelines for the Treatment of Depression

Ellis, P., & Australian, R. (2004) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/j.1440-1614.2004.01377.x · Cited by 231 · see citing works

Sex Differences in Antidepressant Response in Recent Antidepressant Clinical Trials

Khan, A., Brodhead, A. E., Schwartz, K. A., Kolts, R. L., & Brown, W. A. (2005) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000168879.03169.ce · Cited by 255 · see citing works

Comorbid psychiatric disorders in depressed outpatients: Demographic and clinical features

Rush, A. J., Zimmerman, M. A., Wisniewski, S. R., D, M. F. M., Hollon, S. D., Warden, D., Biggs, M. M., Shores‐Wilson, K., Shelton, R. C., Luther, J. F., et al. (2005) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.03.005 · Cited by 252 · see citing works

Antidepressants versus placebo in major depression: an overview

Khan, A., & Brown, W. A. (2015) · World Psychiatry · doi:10.1002/wps.20241 · Cited by 235 · see citing works

The severity of psychiatric disorders

Zimmerman, M., Morgan, T. A., & Stanton, K. (2018) · World Psychiatry · doi:10.1002/wps.20569 · Cited by 227 · see citing works

Placebo effects in psychiatry: mediators and moderators

Weimer, K., Colloca, L., & Enck, P. (2015) · The Lancet Psychiatry · doi:10.1016/s2215-0366(14)00092-3 · Cited by 222 · see citing works

Rethinking recommendations for screening for depression in primary care

Thombs, B. D., Coyne, J. C., Cuijpers, P. J., de Jonge, P., Gilbody, S. M., Ioannidis, J. P. A., Johnson, B. T., Patten, S. B., Turner, E. H., & Ziegelstein, R. C. (2011) · Canadian Medical Association Journal · doi:10.1503/cmaj.111035 · Cited by 221 · see citing works

Does pretreatment severity moderate the efficacy of psychological treatment of adult outpatient depression? A meta-analysis.

Driessen, E., Cuijpers, P., Hollon, S. D., & Dekker, J. J. M. (2010) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0020570 · Cited by 208 · see citing works

Treatments for Later-Life Depressive Conditions: A Meta-Analytic Comparison of Pharmacotherapy and Psychotherapy

Pinquart, M., Duberstein, P. R., & Lyness, J. M. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1493 · Cited by 204 · see citing works

Subthreshold psychiatric disorders in primary care: prevalence and associated characteristics

Rucci, P. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00087-3 · Cited by 204 · see citing works

Consistent superiority of selective serotonin reuptake inhibitors over placebo in reducing depressed mood in patients with major depression

Hieronymus, F., Emilsson, J. F., Nilsson, S., & Eriksson, E. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.53 · Cited by 204 · see citing works

The drugs don’t work? antidepressants and the current and future pharmacological management of depression

Penn, E., & Tracy, D. K. (2012) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125312445469 · Cited by 207 · see citing works

The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2 Arg 439 His knockin mouse

Jacobsen, J. P. R., Medvedev, I. O., & Caron, M. G. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0109 · Cited by 182 · see citing works

Personalized prediction of antidepressant v. placebo response: evidence from the EMBARC study

Webb, C. A., Trivedi, M. H., Cohen, Z. D., Dillon, D. G., Fournier, J. C. J., Goer, F., D, M. F. M., McGrath, P. J., Weissman, M. M., Parsey, R. V., et al. (2018) · Psychological Medicine · doi:10.1017/s0033291718001708 · Cited by 172 · see citing works

Clinical trial outcome in neuropathic pain

Katz, J., Finnerup, N. B., & Dworkin, R. H. (2007) · Neurology · doi:10.1212/01.wnl.0000275528.01263.6c · Cited by 167 · see citing works

Mifepristone versus Placebo in the Treatment of Psychosis in Patients with Psychotic Major Depression

DeBattista, C., Belanoff, J., Glass, S., Khan, A., Horne, R. L., Blasey, C., Carpenter, L. L., & Alva, G. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.034 · Cited by 162 · see citing works

Relative sensitivity of the Montgomery-Asberg Depression Rating Scale, the Hamilton Depression rating scale and the Clinical Global Impressions rating scale in antidepressant clinical trials

Khan, A., Khan, S., Shankles, E. B., & Polissar, N. L. (2002) · International Clinical Psychopharmacology · doi:10.1097/00004850-200211000-00003 · Cited by 162 · see citing works

Treating major depression with yoga: A prospective, randomized, controlled pilot trial

Prathikanti, S., Rivera, R., Cochran, A., Tungol, J. G., Fayazmanesh, N., & Weinmann, E. (2017) · PLOS ONE · doi:10.1371/journal.pone.0173869 · Cited by 157 · see citing works

Does Study Design Influence Outcome?

Rutherford, B. R., Sneed, J. R., & Roose, S. P. (2009) · Psychotherapy and Psychosomatics · doi:10.1159/000209348 · Cited by 160 · see citing works

Neural markers of symptomatic improvement during antidepressant therapy in severe depression: subgenual cingulate and visual cortical responses to sad, but not happy, facial stimuli are correlated with changes in symptom score

Keedwell, P., Drapier, D., Surguladze, S., Giampietro, V, Brammer, M., & Phillips, M. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881108093589 · Cited by 149 · see citing works

An adaptationist perspective on the etiology of depression

Durisko, Z., Mulsant, B. H., & Andrews, P. W. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.09.032 · Cited by 140 · see citing works

Empirically derived criteria cast doubt on the clinical significance of antidepressant-placebo differences

Moncrieff, J., & Kirsch, I. (2015) · Contemporary Clinical Trials · doi:10.1016/j.cct.2015.05.005 · Cited by 145 · see citing works

Depression in epilepsy: a critical review from a clinical perspective

Hoppe, C., & Elger, C. E. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.104 · Cited by 140 · see citing works

Potential Mechanisms and Clinical Effectiveness of Acupuncture in Depression

Yang, N.-N., Lin, L.-L., Li, Y.-J., Li, H.-P., Cao, Y., Tan, C.-X., Hao, X.-W., Ma, S.-M., Wang, L., & Liu, C.-Z. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210609162809 · Cited by 145 · see citing works

Why Do So Many Drugs for Alzheimer's Disease Fail in Development? Time for New Methods and New Practices?

Becker, R. E., Greig, N. H., & Giacobini, E. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-15213 · Cited by 141 · see citing works

Meta-analysis comparing different behavioral treatments for late-life anxiety

Thorp, S. R., Ayers, C. R., Nuevo, R., Stoddard, J. A., Sorrell, J. T., & Wetherell, J. L. (2009) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31818b3f7e · Cited by 134 · see citing works

Efficacy, safety, and tolerability of desvenlafaxine 50 mg/day and 100 mg/day in outpatients with major depressive disorder

Liebowitz, M. R., Manley, A. L., Padmanabhan, S. K., Ganguly, R., Tummala, R., & Tourian, K. A. (2008) · Current Medical Research and Opinion · doi:10.1185/03007990802161923 · Cited by 134 · see citing works

Response to acute monotherapy for major depressive disorder in randomized, placebo controlled trials submitted to the US Food and Drug Administration: individual participant data analysis

Stone, M. B., Yaseen, Z. S., Miller, B. J., Richardville, K., Kalaria, S. N., & Kirsch, I. (2022) · BMJ · doi:10.1136/bmj-2021-067606 · Cited by 131 · see citing works

Randomised controlled trials of selective serotonin reuptake inhibitors in treating depression in children and adolescents: A systematic review and meta-analysis

Usala, T., Clavenna, A., Zuddas, A., & Bonati, M. R. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.06.001 · Cited by 119 · see citing works

Primum Non Nocere: An Evolutionary Analysis of Whether Antidepressants Do More Harm than Good

Andrews, P. W., Thomson, J. A., Amstadter, A., & Neale, M. C. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00117 · Cited by 120 · see citing works

Is the significant superiority of escitalopram compared with other antidepressants clinically relevant?

Montgomery, S. A., & Möller, H.-J. (2009) · International Clinical Psychopharmacology · doi:10.1097/yic.0b013e32832a8eb2 · Cited by 121 · see citing works

The clinical effectiveness of sertraline in primary care and the role of depression severity and duration (PANDA): a pragmatic, double-blind, placebo-controlled randomised trial

Lewis, G., Duffy, L., Ades, A., Amos, R., Araya, R., Brabyn, S., Button, K. S., Churchill, R., Derrick, C., Dowrick, C., et al. (2019) · The Lancet Psychiatry · doi:10.1016/s2215-0366(19)30366-9 · Cited by 120 · see citing works

A regulatory Apologia — A review of placebo-controlled studies in regulatory submissions of new-generation antidepressants

Melander, H., Salmonson, T., Abadie, E., & van Zwieten-Boot, B. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.06.003 · Cited by 117 · see citing works

Adjunctive Lanicemine (AZD6765) in Patients with Major Depressive Disorder and History of Inadequate Response to Antidepressants: A Randomized, Placebo-Controlled Study

Sanacora, G., Johnson, M. R., Khan, A., Atkinson, S. D., Riesenberg, R. R., Schronen, J. P., Burke, M. A., Zajecka, J. M., Barra, L., Su, H.-L., et al. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.224 · Cited by 120 · see citing works

Initial Severity of Schizophrenia and Efficacy of Antipsychotics

Furukawa, T. A., Levine, S. Z., Tanaka, S., Goldberg, Y., Samara, M. T., Davis, J. M., Cipriani, A., & Leucht, S. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.2127 · Cited by 116 · see citing works

Severity of depressive symptoms and response to antidepressants and placebo in antidepressant trials

Khan, A., Brodhead, A. E., Kolts, R. L., & Brown, W. A. (2004) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2004.06.005 · Cited by 115 · see citing works

Comparative effectiveness of exercise, antidepressants and their combination in treating non-severe depression: a systematic review and network meta-analysis of randomised controlled trials

Recchia, F., Leung, C. K., Chin, E. C., Fong, D. Y., Montero, D., Cheng, C. P., Yau, S. Y., & Siu, P. M. (2022) · British Journal of Sports Medicine · doi:10.1136/bjsports-2022-105964 · Cited by 117 · see citing works

Efficacy of Duloxetine and Selective Serotonin Reuptake Inhibitors

Thase, M. E., Pritchett, Y., Ossanna, M. J., Swindle, R. W., Xu, J., & Detke, M. J. (2007) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31815a4412 · Cited by 113 · see citing works

A comparative study of the efficacy of long-term treatment with escitalopram and paroxetine in severely depressed patients

Boulenger, J.-P., Huusom, A. K. T., Florea, I., Bækdal, T. A., & Sarchiapone, M. (2006) · Current Medical Research and Opinion · doi:10.1185/030079906x115513 · Cited by 112 · see citing works

Why Do Clinical Trials Fail?

Kobak, K. A., Kane, J., Thase, M. E., & Nierenberg, A. A. (2007) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31802eb4b7 · Cited by 112 · see citing works

Toward personalizing treatment for depression: predicting diagnosis and severity

Huang, S. H., LePendu, P., Iyer, S. V., Tai‐Seale, M., Carrell, D., & Shah, N. H. (2014) · Journal of the American Medical Informatics Association · doi:10.1136/amiajnl-2014-002733 · Cited by 108 · see citing works

Has the rising placebo response impacted antidepressant clinical trial outcome? Data from the US Food and Drug Administration 1987‐2013

Khan, A., Mar, K. F., Faucett, J., Schilling, S., & Brown, W. A. (2017) · World Psychiatry · doi:10.1002/wps.20421 · Cited by 107 · see citing works

Treatment of Depression in Cancer

Fisch, M. J. (2004) · JNCI Monographs · doi:10.1093/jncimonographs/lgh011 · Cited by 109 · see citing works

Innovative Drugs to Treat Depression: Did Animal Models Fail to Be Predictive or Did Clinical Trials Fail to Detect Effects?

Belzung, C. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.342 · Cited by 106 · see citing works

Comparing the Effects of Antidepressants: Consensus Guidelines for Evaluating Quantitative Reviews of Antidepressant Efficacy

Lieberman, J. A., Greenhouse, J. B., Hamer, R. M., Krishnan, K. R. R., Nemeroff, C. B., Sheehan, D. V., Thase, M. E., & Keller, M. B. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300571 · Cited by 105 · see citing works

A Systematic Review of Cognitive Predictors of Treatment Outcome in Major Depression

Groves, S. J., Douglas, K. M., & Porter, R. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00382 · Cited by 111 · see citing works

Guidelines for Rehabilitation in Patients With Cardiovascular Disease (JCS 2012):– Digest Version –

JCSJointWorkingGroup (2014) · Circulation · Cited by 104 · see citing works

The role of adipokines in the rapid antidepressant effects of ketamine

Machado-Vieira, R., Gold, P. W., Luckenbaugh, D. A., Ballard, E. D., Richards, E. M., Henter, I. D., De Sousa, R. T., Niciu, M. J., Yuan, P., & Zarate, C. A. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.36 · Cited by 102 · see citing works

Age and Sex as Moderators of the Placebo Response - An Evaluation of Systematic Reviews and Meta-Analyses across Medicine

Weimer, K., Colloca, L., & Enck, P. (2014) · Gerontology · doi:10.1159/000365248 · Cited by 103 · see citing works

There are no randomized controlled trials that support the United States Preventive Services Task Force guideline on screening for depression in primary care: a systematic review

Thombs, B. D., Ziegelstein, R. C., Roseman, M., Kloda, L. A., & Ioannidis, J. P. (2014) · BMC Medicine · doi:10.1186/1741-7015-12-13 · Cited by 100 · see citing works

Treatment of unipolar psychotic depression: a randomized, double‐blind study comparing imipramine, venlafaxine, and venlafaxine plus quetiapine

Wijkstra, J., Burger, H., van den Broek, W. W., Birkenhäger, T. K., Janzing, J., Boks, M. P., Bruijn, J. A., van der Loos, M. L. M., Breteler, L. M. T., RAMAEKERS, G. M. G. I., et al. (2009) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2009.01464.x · Cited by 99 · see citing works

A prognostic index (PI) as a moderator of outcomes in the treatment of depression: A proof of concept combining multiple variables to inform risk-stratified stepped care models

Lorenzo‐Luaces, L., DeRubeis, R. J., van Straten, A., & Tiemens, B. G. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.02.010 · Cited by 96 · see citing works

Effects of anxiety on the long-term course of depressive disorders

Coryell, W., Fiedorowicz, J. G., Solomon, D., Leon, A. C., Rice, J. P., & Keller, M. B. (2012) · British Journal of Psychiatry · doi:10.1192/bjp.bp.110.081992 · Cited by 92 · see citing works

Research Design Features and Patient Characteristics Associated With the Outcome of Antidepressant Clinical Trials

Khan, A., Kolts, R. L., Thase, M. E., Krishnan, K., & Brown, W. A. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.11.2045 · Cited by 93 · see citing works

Treatment response in melancholia

Brown, W. A. (2007) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2007.00970.x · Cited by 91 · see citing works

Antidepressants in elderly: Metaregression of double-blind, randomized clinical trials

Calati, R., Signorelli, M. S., Balestri, M., Marsano, A., Ronchi, D. D., Aguglia, E., & Serretti, A. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.11.053 · Cited by 91 · see citing works

St John??s wort versus placebo in obsessive???compulsive disorder: results from a double-blind study

Kobak, K. A., Taylor, L. V. H., Bystritsky, A., Kohlenberg, C. J., Greist, J. H., Tucker, P. M., Warner, G., Futterer, R., & Vapnik, T. (2005) · International Clinical Psychopharmacology · doi:10.1097/00004850-200511000-00003 · Cited by 88 · see citing works

Randomised controlled trial to determine the clinical effectiveness and cost-effectiveness of selective serotonin reuptake inhibitors plus supportive care, versus supportive care alone, for mild to moderate depression with somatic symptoms in primary care: the THREAD (THREshold for AntiDepressant response) study

Kendrick, T., Chatwin, J., Dowrick, C., Tylee, A., Morriss, R., Peveler, R., Leese, M., McCrone, P., Harris, T., Moore, M., et al. (2009) · Health Technology Assessment · doi:10.3310/hta13220 · Cited by 86 · see citing works

Baseline depression severity as a predictor of single and combination antidepressant treatment outcome: Results from the CO-MED trial

Friedman, E. S., Davis, L. L., Zisook, S., Wisniewski, S. R., Trivedi, M. H., Fava, M., & Rush, A. J. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.07.010 · Cited by 81 · see citing works

Performance of a shortened Scale for Assessment of Positive Symptoms for Parkinson's disease psychosis

Voss, T., Bahr, D., Cummings, J. L., Mills, R., Ravina, B. M., & Williams, H. (2012) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2012.10.022 · Cited by 85 · see citing works

Why Has the Antidepressant–Placebo Difference in Antidepressant Clinical Trials Diminished over the Past Three Decades?

Khan, A., Bhat, A., Kolts, R., Thase, M. E., & Brown, W. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00151.x · Cited by 78 · see citing works

Pilot Randomized Clinical Trial of an SSRI vs Bupropion: Effects on Suicidal Behavior, Ideation, and Mood in Major Depression

Grunebaum, M. F., Ellis, S. P., Duan, N., Burke, A. K., Oquendo, M. A., & John Mann, J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.247 · Cited by 79 · see citing works

Efficacy and Safety of Levomilnacipran Sustained Release in Moderate to Severe Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled, Proof-of-Concept Study

Montgomery, S. A., Mansuy, L., Ruth, A., Bose, A., Li, H., & Li, D. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12m08141 · Cited by 78 · see citing works

The History and Current State of Antidepressant Clinical Trial Design

Gelenberg, A. J., Thase, M. E., Meyer, R. E., Goodwin, F. K., Katz, M. M., KRAEMER, H. C., Potter, W. Z., Shelton, R. C., D, M. F. M., Khan, A., et al. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n1001 · Cited by 77 · see citing works

Influence of baseline severity on the effects of SSRIs in depression: an item-based, patient-level post-hoc analysis

Hieronymus, F., Lisinski, A., Nilsson, S., & Eriksson, E. (2019) · The Lancet Psychiatry · doi:10.1016/s2215-0366(19)30216-0 · Cited by 73 · see citing works

Amygdala subregions tied to SSRI and placebo response in patients with social anxiety disorder

Faria, V., Appel, L., Åhs, F., Linnman, C., Pissiota, A., Frans, Ö., Bani, M., Bettica, P., Pich, E. M., Jacobsson, E., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.72 · Cited by 73 · see citing works

A direct comparison of presenting characteristics of depressed outpatients from primary vs. specialty care settings: preliminary findings from the STAR*D clinical trial

Gaynes, B. N., Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Balasubramani, G. K., Spencer, D. C., Petersen, T., Klinkman, M. S., Warden, D., Schneider, R. K., et al. (2005) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2004.10.003 · Cited by 72 · see citing works

A Randomized, Double-Blind, Placebo-Controlled Trial of Desvenlafaxine Succinate in Adult Outpatients With Major Depressive Disorder

Liebowitz, M. R., & Yeung, P. P. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n1105 · Cited by 73 · see citing works

A Meta-analysis of Factors Impacting Detection of Antidepressant Efficacy in Clinical Trials: The Importance of Academic Sites

Dunlop, B. W., Thase, M. E., Wun, C., Fayyad, R. S., Guico‐Pabia, C. J., Musgnung, J. J., & Ninan, P. T. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.153 · Cited by 72 · see citing works

An Epidemic of Depression or the Medicalization of Distress?

Mulder, R. (2008) · Perspectives in biology and medicine · doi:10.1353/pbm.0.0009 · Cited by 71 · see citing works

Assessing the ‘true’ effect of active antidepressant therapy v. placebo in major depressive disorder: use of a mixture model

Thase, M. E., Larsen, K. G., & Kennedy, S. H. (2011) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.111.093336 · Cited by 70 · see citing works

Have Treatment Studies of Depression Become Even Less Generalizable? A Review of the Inclusion and Exclusion Criteria Used in Placebo-Controlled Antidepressant Efficacy Trials Published During the Past 20 Years

Zimmerman, M. A., Clark, H., Multach, M. D., Walsh, E. K., Rosenstein, L. K., & Gazarian, D. (2015) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2015.06.016 · Cited by 70 · see citing works

The risks of selective serotonin reuptake inhibitor use in infertile women: a review of the impact on fertility, pregnancy, neonatal health and beyond

Domar, A. D., Moragianni, V. A., Ryley, D. A., & Urato, A. C. (2012) · Human Reproduction · doi:10.1093/humrep/des383 · Cited by 70 · see citing works

Desvenlafaxine 50 and 100 mg/d in the treatment of major depressive disorder: An 8-week, phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group trial and a post hoc pooled analysis of three studies

Tourian, K. A., Padmanabhan, S. K., Groark, J., Brisard, C., & Farrington, D. (2009) · Clinical Therapeutics · doi:10.1016/j.clinthera.2009.07.006 · Cited by 69 · see citing works

Hypericum extract LI 160 and fluoxetine in mild to moderate depression

Bjerkenstedt, L., Edman, G., Alken, R. G., & Mannel, M. (2004) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-004-0532-z · Cited by 68 · see citing works

Do recent efficacy data on the drug treatment of acute bipolar depression support the position that drugs other than antidepressants are the treatment of choice?

Möller, H. ‐., Grunze, H., & Broich, K. (2005) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-005-0591-9 · Cited by 64 · see citing works

Site Versus Centralized Raters in a Clinical Depression Trial

Kobak, K. A., Leuchter, A. F., DeBrota, D. J., Engelhardt, N., Williams, J. B. W., Cook, I. A., Leon, A. C., & Alpert, J. E. (2010) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3181d20912 · Cited by 67 · see citing works

No role for initial severity on the efficacy of antidepressants: results of a multi-meta-analysis

Fountoulakis, K. Ν., Veroniki, A. A., Siamouli, M., & Möller, H. (2013) · Annals of General Psychiatry · doi:10.1186/1744-859x-12-26 · Cited by 66 · see citing works

ABCB1 gene variants and antidepressant treatment outcome: A meta‐analysis

Breitenstein, B., Brückl, T. M., Ising, M., Müller‐Myhsok, B., Holsboer, F., & Czamara, D. (2015) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32309 · Cited by 66 · see citing works

Unipolar Depression

Härter, M. C., Klesse, C., Bermejo, I., Schneider, F. W., & Berger, T. (2010) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2010.0700 · Cited by 70 · see citing works

Severity of depressive symptoms and response to antidepressants and placebo in antidepressant trials

Khan, A., Brodhead, A. E., Kolts, R. L., & Brown, W. A. (2004) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2004.06.005 · Cited by 115 · see citing works

Placebo Response and Antidepressant Clinical Trial Outcome

Khan, A., Detke, M. J., Khan, S., & Mallinckrodt, C. H. (2003) · The Journal of Nervous and Mental Disease · doi:10.1097/01.nmd.0000061144.16176.38 · Cited by 154 · see citing works

Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration

Kirsch, I., Deacon, B. J., Huedo-Medina, T. B., Scoboria, A., Moore, T. J., & Johnson, B. T. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050045 · Cited by 2,442 · see citing works

Initial depression severity and response to antidepressants v. placebo: patient-level data analysis from 34 randomised controlled trials

Rabinowitz, J., Werbeloff, N., Mandel, F. S., Ménard, F., Marangell, L. B., & Kapur, S. (2016) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.115.173906 · Cited by 59 · see citing works

Why Has the Antidepressant–Placebo Difference in Antidepressant Clinical Trials Diminished over the Past Three Decades?

Khan, A., Bhat, A., Kolts, R., Thase, M. E., & Brown, W. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00151.x · Cited by 78 · see citing works