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Primary Motor Cortex Involvement in Alzheimer Disease
Abstract
In Alzheimer disease (AD) the involvement of entorhinal cortex, hippocampus, and associative cortical areas is well established. Regarding the involvement of the primary motor cortex the reported data are contradictory. In order to determine whether the primary motor cortex is involved in AD, the brains of 29 autopsy cases were studied, including, 17 cases with severe cortical AD-type changes with definite diagnoses of AD, 7 age-matched cases with discrete to moderate cortical AD-type changes, and 5 control cases without any AD-type cortical changes. Morphometric analysis of the cortical surface occupied by senile plaques (SPs) on beta-amyloid-immunostained sections and quantitative analysis of neurofibrillary tangles (NFTs) on Gallyas-stained sections was performed in 5 different cortical areas including the primary motor cortex. The percentage of cortical surface occupied by SPs was similar in all cortical areas, without significant difference and corresponded to 16.7% in entorhinal cortex, 21.3% in frontal associative, 16% in parietal associative, and 15.8% in primary motor cortex. The number of NFTs in the entorhinal cortex was significantly higher (41 per 0.4 mm2), compared with those in other cortical areas (20.5 in frontal, 17.9 in parietal and 11.5 in the primary motor cortex). Our findings indicate that the primary motor cortex is significantly involved in AD and suggest the appearance of motor dysfunction in late and terminal stages of the disease.
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The widespread cerebral distribution of Aβ in later AD stages is well-established.
“The widespread cerebral distribution of Aβ in later AD stages is well-established3, 4”
From Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity (2017) · cites this paper as [3]
As hypothesized, known regions of late stage Aβ accumulation were identified, including the sensorimotor cortex and occipital lobe.
“As hypothesized, we identified known regions of late stage Aβ accumulation, including the sensorimotor cortex and occipital lobe (Fig. 3, Supplementary Movie 2 and Table 3)3, 19.”
From Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity (2017) · cites this paper as [3]
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Palmqvist, S., Schöll, M., Strandberg, O., Mattsson, N., Stomrud, E., Zetterberg, H., Blennow, K., Landau, S., Jagust, W., & Hansson, O. (2017) · Nature Communications · doi:10.1038/s41467-017-01150-x · Cited by 911
Sterniczuk, R., Antle, M. C., LaFerla, F. M., & Dyck, R. H. (2010) · Brain Research · doi:10.1016/j.brainres.2010.06.011 · Cited by 228
Parker, T. D., Slattery, C. F., Zhang, J., Nicholas, J. M., Paterson, R. W., Foulkes, A. J. M., Malone, I. B., Thomas, D. L., Modat, M., Cash, D. M., et al. (2018) · Human Brain Mapping · doi:10.1002/hbm.24056 · Cited by 122
Dietary Regulation of Gut-Brain Axis in Alzheimer’s Disease: Importance of Microbiota Metabolites
Frausto, D. M., Forsyth, C. B., Keshavarzian, A., & Voigt, R. M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.736814 · Cited by 61
Metadata
- Authors
- Suvà, D., Favre, I., Kraftsik, R., Esteban, M., Lobrinus, A., & Miklossy, J.
- Affiliations
- Centre Hospitalier Universitaire Vaudois (CH)
- University of Lausanne (CH)
- Corresponding author
- Suvà, Domizio
- ORCID
- Favre, Isabelle
- Venue
- Journal of Neuropathology and Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-11
- Volume
- 58
- Issue
- 11
- Pages
- 1125-1134
- ISSN
- 0022-3069 (ISSN-L)
- OpenAlex
- W2025311531
- Cited by
- 108
- References
- 0
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 8 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 8 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 1 · 2014: 4 · 2013: 5 · 2012: 3
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuropathology & Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, primary motor cortex, amyloid plaques, neurofibrillary tangles, entorhinal cortex, cortical involvement, motor impairment
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alzheimer Disease, Brain Chemistry, Humans, Middle Aged, Motor Cortex, Parietal Lobe, Somatosensory Cortex, Amyloid beta-Peptides, Neurofibrillary Tangles, Entorhinal Cortex, Plaque, Amyloid
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