Characterization of the 3xTg-AD mouse model of Alzheimer’s disease: Part 2. Behavioral and cognitive changes
Abstract
Alzheimer's disease (AD) is characterized by distinct behavioral and cognitive deficits that differ from those observed in normal aging. Transgenic models of AD are a promising tool in understanding the underlying mechanisms and cause of disease. The triple-transgenic mouse model of AD (3xTg-AD) is the only model to exhibit both Abeta and tau pathology that is characteristic of the human form. The present study characterized the performance of 3xTg-AD mice on several tasks measuring behavioral and cognitive ability. Aged 3xTg-AD females exhibited a higher level of fear and anxiety demonstrated by increased restlessness, startle responses, and freezing behaviors. No differences were observed in muscle strength and visuo-motor coordination. Understanding the behavioral manifestations that occur in this model of AD may aid in the early diagnosis and appropriate treatment of AD symptomology.
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At 2 months of age, Aβ deposition has not altered hippocampal functioning and the animals do not display long term memory alterations.
“Here Aβ deposition has not altered hippocampal functioning and the animals do not display long term memory alterations (Sterniczuk et al., 2010).”
From Early stage alterations in white matter and decreased functional interhemispheric hippocampal connectivity in the 3xTg mouse model of Alzheimer’s disease. (2019) · cites this paper as Sterniczuk et al., 2010
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- Authors
- Sterniczuk, R., Antle, M. C., LaFerla, F. M., & Dyck, R. H.
- Affiliations
- University of Calgary (CA)
- University of California, Irvine (US)
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 1348
- Pages
- 149-155
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1967375871
- Cited by
- 228
- References
- 43
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 14 · 2023: 17 · 2022: 18 · 2021: 24 · 2020: 20 · 2019: 13 · 2018: 10 · 2017: 12 · 2016: 11 · 2015: 16 · 2014: 19 · 2013: 12 · 2012: 12
- FWCI
- 7.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NSERC
- CIHR
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- Alzheimer's disease, 3xTg-AD mice, triple transgenic mice, amyloid-beta pathology, tau pathology, cognitive impairment, behavioral deficits, anxiety, fear, startle response, freezing behavior, visuomotor coordination, muscle strength, aging
- MeSH terms
- Alzheimer Disease, Animals, Avoidance Learning, Behavioral Symptoms, Cognition Disorders, Disease Models, Animal, Exploratory Behavior, Female, Humans, Male, Mice, Inbred C57BL, Motor Activity, Neurologic Examination, Psychomotor Performance, Reaction Time, Time Factors, Amyloid beta-Protein Precursor, Statistics, Nonparametric, Maze Learning, Animals, Genetically Modified, Mice, Presenilin-1, Amyloid Precursor Protein Secretases
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