Navigating from hippocampus to parietal cortex

Whitlock, Jonathan R.; Sutherland, Robert J.; Witter, Menno P.; Moser, May-Britt; Moser, Edvard I.

doi:10.1073/pnas.0804216105

Cited by 267Memory and Neural MechanismsSpatial Cognition and NavigationVestibular and auditory disorders

Navigating from hippocampus to parietal cortex

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Whitlock, Jonathan R., Sutherland, Robert J., Witter, Menno P., Moser, May-Britt, Moser, Edvard I.·2008·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0804216105PMC PMC2567440

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Abstract

The navigational system of the mammalian cortex comprises a number of interacting brain regions. Grid cells in the medial entorhinal cortex and place cells in the hippocampus are thought to participate in the formation of a dynamic representation of the animal's current location, and these cells are presumably critical for storing the representation in memory. To traverse the environment, animals must be able to translate coordinate information from spatial maps in the entorhinal cortex and hippocampus into body-centered representations that can be used to direct locomotion. How this is done remains an enigma. We propose that the posterior parietal cortex is critical for this transformation.

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Similar and aligned fMRI responses from subicular, posterior/medial parietal, lateral temporal, and medial prefrontal cortices suggest that populations with similar properties also exist elsewhere.
“Our finding of similar and aligned fMRI responses from subicular, posterior/medial parietal, lateral temporal, and medial prefrontal cortices suggest that populations with similar proporties also exist elsewhere, a prediction directly testable in rodents (see also refs.7,8).”
From Evidence for grid cells in a human memory network (2010) · cites this paper as [8]

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Authors: Whitlock, J. R., Sutherland, R. J., Witter, M. P., Moser, M.-B., & Moser, E. I.
Affiliations: Norwegian University of Science and Technology (NO)
University of Lethbridge (CA)
ORCID: Whitlock, Jonathan R.
Sutherland, Robert J.
Witter, Menno P.
Moser, May-Britt
Moser, Edvard I.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2008-09-30
Volume: 105
Issue: 39
Pages: 14755-14762
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0804216105
PMC: PMC2567440
OpenAlex: W2123039986
Cited by: 267
References: 122
Citations by year: 2026: 17 · 2025: 22 · 2024: 14 · 2023: 19 · 2022: 21 · 2021: 18 · 2020: 14 · 2019: 8 · 2018: 26 · 2017: 10 · 2016: 22 · 2015: 12 · 2014: 14 · 2013: 16 · 2012: 8
FWCI: 4.48
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
Pure Amsterdam UMC (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
Keywords: posterior parietal cortex, hippocampus, medial entorhinal cortex, grid cells, place cells, spatial navigation, coordinate transformation, spatial memory, locomotion
MeSH terms: Animals, Behavior, Animal, Brain Mapping, Hippocampus, Memory, Parietal Lobe, Spatial Behavior, Entorhinal Cortex, Rats

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Navigating from hippocampus to parietal cortex

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