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Branched-chain amino acids prolong exercise during heat stress in men and women
Abstract
To assess the effect of branched-chain amino acids (BCAA) supplementation on endurance performance in the heat, six women and seven men participated in two trials of rest in the heat (Ta = 34.4 +/- 1.8 degrees C; rh = 39 +/- 14%), followed by 40% VO2peak exercise to exhaustion. Subjects ingested 5 mL x kg(-1) of a placebo (PLAC) or BCAA drink every 30 min. Cycle time to exhaustion increased during BCAA (153.1 +/- 13.3 vs 137.0 +/- 12.2 min, P < 0.05) for men and women. Plasma glucose was maintained at baseline values for both drinks; however, women had significantly higher concentrations (5.9 +/- 0.6 vs 4.0 +/- 0.2 mM, P < 0.05). Plasma free fatty acids and ammonia were not influenced by drink or gender but increased over time. BCAA resulted in a significant (P < 0.05) increase in plasma BCAA (1209 +/- 119 vs 496 +/- 44 microM), while F-TRP (9.6 +/- 0.9 vs 12.0 +/- 1.3 microM) and F-TRP:BCAA were decreased (0.009 +/- 0.001 vs 0.024 +/- 0.003 ND) in both men and women. Cardiovascular and thermoregulatory data were similar between treatments for all subjects. Psychological data were not influenced by BCAA. These results indicate BCAA supplementation prolongs moderate exercise performance in the heat.
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“Moreover, when trained cyclists undertook several hours of exercise in the heat to exacerbate the central component of fatigue, BCAA supplementation prolonged time to exhaustion [112].”
From International Society of Sports Nutrition Position Stand: nutritional considerations for single-stage ultra-marathon training and racing (2019) · cites this paper as [112]
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Metadata
- Authors
- MITTLEMAN, K. D., RICCI, M. R., & BAILEY, S. P.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- ORCID
- RICCI, MATTHEW R.
- Venue
- Medicine & Science in Sports & Exercise
- Published
- 1998-01
- Volume
- 30
- Issue
- 1
- Pages
- 83-91
- ISSN
- 0195-9131 (ISSN-L)
- OpenAlex
- W2017293576
- Cited by
- 155
- References
- 37
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 5 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 1 · 2017: 4 · 2016: 7 · 2015: 6 · 2014: 7 · 2013: 4 · 2012: 7
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medicine & Science in Sports & Exercise (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- branched-chain amino acids, heat stress, endurance exercise, time to exhaustion, exercise performance, plasma free tryptophan, plasma amino acids, plasma glucose, sex differences, thermoregulation, cardiovascular response
- MeSH terms
- Adolescent, Adult, Amino Acids, Branched-Chain, Ammonia, Blood Glucose, Exercise Test, Fatigue, Fatty Acids, Female, Humans, Male, Physical Endurance, Sex Factors, Tryptophan, Exercise, Heat Stress Disorders, Dietary Supplements
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