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Cited by 57Chronic Obstructive Pulmonary Disease (COPD) ResearchCardiovascular and exercise physiologyMuscle Physiology and Disorders

Alterations in the Muscle-to-Capillary Interface in Patients with Different Degrees of Chronic Obstructive Pulmonary Disease

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Eliason, Gabriella, Abdel-Halim, Samy M, Piehl-Aulin, Karin, Kadi, Fawzi·2010·Respiratory Research
DOI 10.1186/1465-9921-11-97PMC PMC2912824
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Abstract

BACKGROUND: It is hypothesized that decreased capillarization of limb skeletal muscle is implicated in the decreased exercise tolerance in COPD patients. We have recently demonstrated decreased number of capillaries per muscle fibre (CAF) but no changes in CAF in relation to fibre area (CAFA), which is based on the diffusion distance between the capillary and muscle fibre. The aim of the current study is to investigate the muscle-to-capillary interface which is an important factor involved in oxygen supply to the muscle that has previously been suggested to be a more sensitive marker for changes in the capillary bed compared to CAF and CAFA. METHODS: 23 COPD patients and 12 age-matched healthy subjects participated in the study. Muscle-to-capillary interface was assessed in muscle biopsies from the tibialis anterior muscle using the following parameters:1) The capillary-to-fibre ratio (C:Fi) which is defined as the sum of the fractional contributions of all capillary contacts around the fibre2) The ratio between C:Fi and the fibre perimeter (CFPE-index)3) The ratio between length of capillary and fibre perimeter (LC/PF) which is also referred to as the index of tortuosity.Exercise capacity was determined using the 6-min walking test. RESULTS: A positive correlation was found between CFPE-index and ascending disease severity with CFPE-index for type I fibres being significantly lower in patients with moderate and severe COPD. Furthermore, a positive correlation was observed between exercise capacity and CFPE-index for both type I and type IIa fibres. CONCLUSION: It can be concluded that the muscle-to-capillary interface is disturbed in the tibialis anterior muscle in patients with COPD and that interface is strongly correlated to increased disease severity and to decreased exercise capacity in this patient group.

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  • Capillarization has been found impaired specifically in type I muscle fibers in COPD, which has a deep impact on the muscle's oxidative capacity.

    “Capillarization has notably been found impaired specifically in type I muscle fibers, which has a deep impact on the muscle’s oxidative capacity [14,15]”

    From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [14]

    The Discussion reports that the muscle-to-capillary interface measure was significantly reduced in type I, but not type IIa, fibres in patients with moderate or severe COPD. The Introduction links capillary supply to oxidative metabolism, but the paper does not establish that this finding had a deep impact on muscle oxidative capacity. (LLM, conf=0.85)

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Authors
Eliason, G., Abdel-Halim, S. M., Piehl-Aulin, K., & Kadi, F.
Affiliations
Örebro University (SE)
Corresponding author
Eliason, Gabriella
ORCID
Venue
Respiratory Research
Publisher
Springer Science and Business Media LLC
Published
2010-07-15
Volume
11
Issue
1
Pages
97-97
ISSN
  • 1465-9921 (ISSN-L)
  • 1465-993X
DOI
10.1186/1465-9921-11-97
PMC
PMC2912824
OpenAlex
W2165025822
Cited by
57
References
39
Citations by year
2026: 3 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 8 · 2014: 6 · 2013: 6 · 2012: 3
FWCI
3.47
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Respiratory Research (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
chronic obstructive pulmonary disease, capillarization, tibialis anterior, exercise capacity, disease severity, capillary tortuosity, type I muscle fibers
MeSH terms
Aged, Biopsy, Capillaries, Exercise Test, Female, Forced Expiratory Volume, Humans, Lung, Male, Microcirculation, Middle Aged, Oxygen, Severity of Illness Index, Case-Control Studies, Walking, Exercise Tolerance, Muscle, Skeletal, Muscle Fibers, Fast-Twitch, Muscle Fibers, Slow-Twitch, Pulmonary Disease, Chronic Obstructive

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