Diclofenac sodium (Voltaren) reduced exercise-induced injury in human skeletal muscle
Abstract
PURPOSE: To examine the effects of prolonged systemic administration of diclofenac sodium (Voltaren), a nonsteroidal anti-inflammatory drug, on objective indices of exercise-induced muscle damage in humans. METHODS: Fifty-four volunteers (mean age, 26.4 yr; range, 18-35) participated in this randomized double-blind, placebo-controlled trial. To achieve steady-state tissue levels, either placebo or diclofenac was orally administered two times a day for 27 consecutive days. A strenuous 20-min stepping exercise program, about which the subjects were unfamiliar, was conducted on day 15. Creatine kinase (CK) activities were measured immediately before the exercise session and on days 16, 18, and 27. Vastus lateralis muscle samples were obtained immediately before exercise and on day 27 for subsequent histological characterization of muscle inflammation. RESULTS: The preexercise muscle samples revealed no difference in muscle damage between the two groups. However, the postexercise muscle samples showed that the diclofenac-treated group demonstrated less muscle tissue damage than placebo-treated subjects (P = 0.002). The administration of diclofenac also resulted in a significant lowering of post-/pre-exercise CK ratios on days 18 (P = 0.03) and 27 (P = 0.02) compared with the placebo group, an indirect finding that supports the possibility of diclofenac reducing exercise-induced muscle damage. CONCLUSION: These findings demonstrate preadministration of diclofenac (in accordance with tissue half-life pharmacokinetics) significantly reduces quantitative indices of exercise-induced skeletal muscle damage in human muscle.
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Several reports show attenuated exercise-induced muscle inflammation, circulating creatine kinase levels, and muscle soreness when NSAIDs were administered prophylactically before exercise.
“There are several reports of attenuated exercise-induced muscle inflammation, circulating creatine kinase levels, and muscle soreness when NSAIDs were administered prophylactically before exercise [182, 183].”
From International Society of Sports Nutrition Position Stand: nutritional considerations for single-stage ultra-marathon training and racing (2019) · cites this paper as [182]
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- Authors
- O???GRADY, M., HACKNEY, A. C., SCHNEIDER, K., BOSSEN, E., STEINBERG, K., DOUGLAS, J. M., MURRAY, W. J., & WATKINS, W. D.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- ORCID
- STEINBERG, KARL
- Venue
- Medicine & Science in Sports & Exercise
- Published
- 2000-07
- Volume
- 32
- Issue
- 7
- Pages
- 1191-1196
- ISSN
- 0195-9131 (ISSN-L)
- OpenAlex
- W1978926968
- Cited by
- 63
- References
- 20
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 1 · 2022: 3 · 2020: 3 · 2019: 6 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 1 · 2013: 5 · 2012: 4
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medicine & Science in Sports & Exercise (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Surgery › Muscle and Compartmental Disorders
- Keywords
- diclofenac sodium, exercise-induced muscle damage, nonsteroidal anti-inflammatory drugs, creatine kinase, vastus lateralis, muscle inflammation, skeletal muscle, muscle histology
- MeSH terms
- Administration, Oral, Adolescent, Adult, Anti-Inflammatory Agents, Non-Steroidal, Diclofenac, Double-Blind Method, Humans, Male, Exercise, Muscle, Skeletal
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